WO2003030989A2 - Dispositif de delivrance de medicaments par iontophorese transpalpebrale - Google Patents
Dispositif de delivrance de medicaments par iontophorese transpalpebrale Download PDFInfo
- Publication number
- WO2003030989A2 WO2003030989A2 PCT/FR2002/003472 FR0203472W WO03030989A2 WO 2003030989 A2 WO2003030989 A2 WO 2003030989A2 FR 0203472 W FR0203472 W FR 0203472W WO 03030989 A2 WO03030989 A2 WO 03030989A2
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- WO
- WIPO (PCT)
- Prior art keywords
- layer
- main electrode
- electrode
- active principle
- adhesive
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
Definitions
- the invention relates to devices for delivering active ingredients, in particular by transpalpebral iontophoresis.
- Iontophoresis uses electric current to allow the diffusion of an ionized molecule through a biological membrane for therapeutic purposes. Under the effect of the electric current, the permeability of the biological membrane is increased, which allows the passage of larger molecules within the cell, and the electric field pushes the molecules through this membrane.
- This technique has the advantage compared to a conventional topical application of increasing the penetration depth of the active principle in proportion to the current intensity used and the application time.
- photodynamic therapy is a technique which consists of systemically injecting an active ingredient and activating it locally using a laser with a certain wave length.
- the major drawback of this therapy is that the patient must remain in the dark for several days, the active principle must be modified by the addition of agents, one photosensitive blocking its activity until the laser proceeds. its activation, the other which allows its fixation on specific biological compounds of the human body.
- topical anesthesia consists in instilling in a topical manner 1 ' anesthetic in conjunctival cul-de-sacs. This technique gives a short anesthesia but sufficient for many operations, but of lower quality, because there is more ocular mobility, and it leads to an increase in postoperative pain. It is common when using this technique to use sedatives administered intravenously and which can lead to complications such as respiratory arrest.
- retrobulbar anesthesia consists of injecting the anesthetic using a needle at the back of the eyeball, inside the space formed by the oculomotor muscles.
- This anesthesia technique presents risks of perforation of the eyeball itself, risks of retrobulbar hemorrhage, risks of injuries to the optic nerve, risks of cardiac or respiratory arrest, risks of accidental intravascular injection of 1 anesthetic, as well as risks of retinal vascular occlusion.
- the quality and duration of the anesthesia is good, - the peribulbar anesthesia consists of injecting the anesthetic using a needle of the eyeball and outside the space formed by the oculomotor muscles.
- retrobulbar anesthesia by catheter is a technique consisting in placing a catheter of the epidural type (between 0.4mm and 1mm diameter) using a needle, within the retrobulbar or peribulbar space so as to be able to inject the anesthetic for long-term operations or else to administer it continuously even post-operatively.
- the risks involved in this anesthesia technique are identical to the two previous ones.
- An object of the present invention is to provide a device for delivering ocular active principles which is very simple to use and capable of targeting the anatomical areas of the eye to be treated while being non-invasive.
- an ocular application device of an active principle comprising a main electrode comprising an insulating layer, an adhesive layer capable of bonding the insulating layer to a conductive layer, the main electrode having furthermore an area capable of coming into contact with an eyelid of one eye.
- the main electrode is placed directly on the eyelid of the eye to be treated. It thus makes it possible to treat the area of the sclera which is the most permeable and which presents the least risk for vision (because there is no functional retina inside the eye around the cornea).
- the functional electrode does not come into direct contact with the eyeball.
- the device is based on the fact that the thickness of the skin at the level of the eyelid is the least significant in the body. Thus, the patient can use the device alone without requiring the presence of a doctor, which is advantageous for iontophoresis of very long duration to be performed (up to 18 hours). This makes it possible to treat pathologies of the ocular annexes and the glands of the eyelids.
- the anomalies of the palpebral glands are responsible for anomalies or decrease in the quality of the tear film, responsible for pathologies of the ocular surface.
- the device for ocular application of an active principle has at least one of the following characteristics: the main electrode is of general oval shape, the oval shape of the electrode has a large outside diameter at most equal to approximately 40mm and a small outside diameter at most equal to about 35mm, the zone has a non-functional central zone surrounded by a functional peripheral zone, the non-functional central zone is circular in shape, the circular shape of the non-functional central zone has a diameter at most equal to approximately 13mm, the non-functional central zone is an orifice passing through the electrode, the main electrode is flexible, the main electrode also has a layer of skin adhesive, the main electrode also has a layer of foam linked to the conductive layer by a layer of conductive adhesive, the layer of foam is an absorbent layer capable of acting as a reservoir for the active principle, the insulating layer is a rigid shell , and the active ingredient is applied by iontophoresis.
- An electrode is also provided according to the invention comprising an insulating layer and an adhesive layer capable of bonding the insulating layer to a conductive layer, characterized in that it has a non-functional central zone surrounded by a functional peripheral zone capable of coming into contact with it. contact with an eyelid of the eye.
- a method of ocular application of an active principle comprising steps of placing a reservoir of medicaments comprising a main electrode on the eyelids, of placing a return electrode on the adjacent tissues. to the eyeball to be treated, penetration through the eyelid of the active principle under the effect of a current of energy circulating between the electrodes.
- the method has one of the following characteristics: prior to the application of the active electrode to the eyelids, the active principle is placed under the eyelids, the main electrode exhibits at least one of the abovementioned characteristics, the active ingredient is in a topical form (liquid, suspension, gel), the active ingredient is in the form of an insert.
- FIG. 1 is a schematic representation of a device for applying an ocular active principle according to the invention
- FIG. 2 is a representation in top view of a main electrode according to the invention
- the Figure 3 is a schematic sectional representation of the main electrode of Figure 2
- - Figure 4 is a schematic sectional view of the main electrode of Figure 2 according to an alternative embodiment
- Figures 5a and 5b are a representation of a first alternative embodiment of a device for applying an ocular active principle according to the invention
- FIGS. 6a, 6b and 6c are a representation of a second alternative embodiment of an application device of an ocular active principle according to the invention
- FIG. 7 is a representation of a third alternative embodiment of a device for applying an ocular active principle according to the invention.
- the device 1 comprises a current generator 4 connected on the one hand to a return electrode 3 and on the other hand to a main electrode 2.
- the current generator 4 delivers a continuous current s of between 0.5 mA and 5 mA preferably, or even up to 10 mA, and this for a time between approximately 0.5 and approximately 30 minutes preferably, or even up to 18 hours. about.
- the voltage delivered by this current generator can never exceed 80V.
- an AC generator so as to avoid a pH increase in the phenomenon of effect one oxidation-reduction at the electrode, particularly in case of prolonged treatment.
- the 0 frequency range of these currents is chosen in order to allow a maximum increase in the permeability of the active ingredient tissues.
- the return electrode 3 must be of the electrocardiogram type and composed of an adhesive and an Ag / AgCl film of low impedance.
- the generator can use a current profile having very high voltage peaks, between approximately 50 and 2500V, over very short periods of the order of 0.01 to 0.1 seconds, and this, at low intensity (like those 0 described for electroporation).
- a device according to the invention uses iontophoresis or 1 electroporation.
- the general shape of the main electrode 2 is oval.
- its large outer diameter corresponds substantially to the large diameter of the eye socket, or about 40mm.
- its small outside diameter corresponds to the small diameter of the orbit, that is to say about 35mm. These dimensions correspond to the current adult size of the orbit. Other sizes and shapes can be considered depending on the age and morphology of the patient to be treated.
- the electrode 2 has a central non-functional area 21.
- this non-functional central zone will be circular in shape, the diameter of which corresponds substantially to the diameter of the cornea, that is to say approximately 13 mm.
- the electrode has a central through hole acting as a non-functional area 21.
- the functional peripheral zone surrounding the central non-functional zone has two sub-zones 22 and 23.
- the functional sub-zone 22 is able to come opposite the surface of the sclera situated around the cornea.
- the functional sub-zone 23 is able to cover the surface of the eyelid where the attachments of the oculomotor muscles are located.
- This particular shape of the main electrode 2 makes it possible, during use, to cover the maximum surface area of the sclera around the cornea and the maximum surface area of the eyelid where the attachments of the oculomotor muscles are located. It should be noted that the surface of the sclera located around the cornea is the most permeable and presents the least risk for vision because there is no retina inside the eye around said cornea.
- the main electrode 2 is flexible.
- the main electrode 2 conforms to the eyelid when it is put in place so as to conform as closely as possible to the eyelid tissues and thus allow good electrical contact with the eyelid.
- the electrode 2 can be rigid.
- it is in the form of a shell 320, the internal face of which is coated with a flexible material 360 capable of absorbing the anatomical differences, so as to conform as closely as possible to the palpebral tissues and thus allow a good electrical contact.
- the first layer 32 is an insulating layer. It is the part of the main electrode 2 which is able to be in contact with the operator. It isolates the rest of the electrode from the latter. This layer can be flexible and flat or rigid and shell-shaped.
- the layer 33 is an adhesive layer which provides the bonding function between the insulating layer 32, a conductive layer 34 described below. On the other hand, this adhesive layer 33 makes it possible to maintain on the conductive layer 34 an electrical cord 31 connecting the main electrode 2 to the generator 4.
- Layer 34 is a conductive layer. This layer is composed of a silver film and a carbon film and has the role of distributing the electric current over the entire surface of the functional area of the main electrode 2.
- the silver film of this layer conductive is located opposite the adhesive layer 33. It allows a good distribution of the current on the surface of the carbon film and ensures optimum electrical contact with the electrical cord 31.
- the carbon film is arranged opposite a layer of absorbent foam 36 described below. This layer of carbon resists oxidation in an aqueous medium under a direct electric current.
- the most suitable material is 0.2mm thick Silver / Carbon film (Rexam conductive film reference 2252 from Rexam Image Products).
- Layer 36 is an optional layer.
- this absorbent foam layer is an absorbent foam layer capable of being impregnated with the active principle or with a solution comprising the active principle before use. Therefore, this absorbent foam layer must be very absorbent and include pores of small dimensions of the order of 100 to 500 micrometers.
- the most suitable material is, for example, low density open cell hydrophilic polyurethane foam of the order of 0.05 to 0.1 g / cm 3 (Hydrocrest TM from Crest Foam Ind, Capu-cell ® from TMP Technologies inc., Amrel ® from Rynel, Medicell TM Foam from Hydromer). This layer is optional depending on whether the active ingredient is placed in the foam before use or placed directly under the eyelid before the electrode is placed on the eyelid.
- This absorbent foam layer 36 is bonded to the carbon film of the conductive layer 34 by a layer of conductive adhesive 35.
- This conductive adhesive must not be soluble in water.
- layer 37 is a layer of skin adhesive. This layer is optional depending on whether the main electrode is adhesive or not. The type of adhesive chosen must conduct electrical current on the one hand and must allow the passage of the active ingredient while adhering as little as possible to the skin so that it can be removed easily after use. This layer of skin adhesive can be located on the absorbent foam layer if this is present or else directly on the carbon film of the conductive layer 34.
- One of the embodiments is to replace the adhesive layers 33, conductor 34 and conductive adhesive 35 by a single layer of conductive adhesive (ARcare ® 8881 from Adhesive Research Inc.) which advantageously meets all the aforementioned functions.
- the first embodiment of the main electrode 2 is a flexible electrode comprising a layer of skin adhesive 37, a conductive layer 34, a layer of adhesive 33 and an insulating layer 32.
- the second embodiment of the main electrode 2 is a flexible electrode comprising a layer of skin adhesive 37, a layer of absorbent foam 36, a layer of conductive adhesive 35, a layer of conductive 34, a layer of adhesive 33 and an insulating layer 32.
- the third embodiment of the main electrode 2 is a rigid shell-shaped electrode comprising a layer of skin adhesive 37, a layer of foam 36 acting as a flexible material intended to absorb the anatomical differences and to marry as intimately as possible. the eyelid tissues during use, a layer of conductive adhesive 35, a conductive layer 34, a layer of adhesive 33 and a rigid insulating layer 32 forming the shell.
- the fourth embodiment of the main electrode 2 is identical to the third embodiment described above, the foam layer being replaced by the absorbent foam layer 36. We will now describe the use of the electrode and its device according to the invention.
- the operator who may be a doctor or the patient himself, has the active principle or a solution comprising the active principle under the eyelid of the eye to be treated then places the main electrode 2 on the eyelid and the return electrode 3 on the adjacent tissues of the eyeball to be treated.
- the electrodes are then connected to the generator and the entire circuit is energized according to a defined intensity and a defined application time. Then the electrodes are removed.
- the operator soaks the absorbent foam layer with the active principle or a solution comprising the active principle. Then position the main electrode on the eyelid of the eyeball to be treated and place the return electrode on the tissues surrounding the eyeball to be treated. Then the operator performs the same operations as previously described.
- the various drugs or active ingredients capable of being administered by a device according to the invention are those requiring regular application or over a long period. This is the case, for example, of corticosteroids or non-steroidal anti-inflammatory drugs (dexamet azone, methylprednisolone hemisuccinate, etc.), the administration of which must be prolonged over very long periods in cases of chronic inflammation. There are also anti-allergic, neuroprotective, neuromodulatory, anti-glaucomatous, antibiotics, anti-angiogenic, neurotropic factors, anesthetics. Many other molecules are being developed to slow down or even stop the neovascularization observed in degenerative pathologies of the retina. The molecules can be transferred transclerally by iontophoresis or by vitreous injection then iontophoresis.
- the iontophoresis device according to the invention makes it possible to simplify the administration of these drugs as we have seen above.
- Another indication of the device for applying an active principle according to the invention relates to the local anesthesia of the eyelid or of the oculomotor muscles located in the orbit, which are six in number and which allow the rotational movements of the eye. These are the internal right muscle, the external right muscle, the upper right muscle, the lower right muscle, the large oblique and the small oblique. To these are added the levator muscle of the eyelid and the orbicular muscle (may be of interest for cosmetic surgery, the treatment of exophthalmi or ptosis). This indication makes it possible to immobilize the eyelid and / or an inesia of the eye during surgical operations.
- ocular application device of an active principle relate to active principles which do not require a recurrent application but which cannot be administered by a device having direct corneal contact or sawing for a physiological reason such as, for example, trauma to the surface of the eyeball or following surgical sequelae.
- active ingredients identified there may be mentioned antibiotics, antivirals, anti-inflammatories or antifungals for example.
- the return electrode 3 placed on the tissues adjacent to the eyeball can be connected to the main electrode 2 by means of a non-conductive film 50 and placed on the temple of the patient to be treated as illustrated in Figures 5a and 5b.
- the main electrodes 2 can be two in number (one for each eye) and arranged on a mask 100 (such as a night mask used in air transport for example), the return electrode 3 associated with the generator ( part 43) can be preferably placed on the patient's forehead, and connected to the main electrodes by means of the electrical cords 31, as illustrated in FIG. 6a. It should be noted that the mask 100 is held on the patient's head by elastic means such as a headband.
- an electrode return and the generator can be advantageously placed inside the elastic band for holding the mask 100 comprising the two main electrodes 2 so that the return electrode is on one of the temples (or both in a variant arrangement where there would be two return electrodes).
- the elastic holding means also serves as an electrical cord which is produced in the form of conductive tracks for example.
- FIG. 6c a pair of glasses 120 comprising two main electrodes 2 situated in place of the glasses of the pair of glasses 120.
- a generator 4 is installed on the frame of the pair of glasses 120 and connected, on the one hand , to the two electrodes 2 and, on the other hand, to the return electrodes 30 which are preferably located under the main electrodes 2 so as to be in contact (while being isolated from these main electrodes) with the skins at the top cheeks of the patient or situated on the ends of the branches of the pair of glasses 120 so as to be in contact with the skin situated behind the ears of the patient.
- FIG. 7 is illustrated another alternative embodiment in which the two main electrodes 2 are mounted on a cap 110 as well as the part 43 comprising the generator and the return electrode.
- the return electrode can be placed on the tissues of the face surrounding the eyeball such as the temples, the forehead, the cheeks, etc.
- the generator can be associated with it or not. It is possible, in variants, to deport the generator connected to the main 2 and return 3 electrodes by means of electrical wires. Otherwise, the connection wires are integrated into the device in the form of conductive tracks for example.
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Abstract
Description
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Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2463362A CA2463362C (fr) | 2001-10-12 | 2002-10-11 | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
DK02790508T DK1434622T3 (da) | 2001-10-12 | 2002-10-11 | Anordninger til frigörelse af lægemidler ved transpalpebral iontoforese |
EP02790508A EP1434622B1 (fr) | 2001-10-12 | 2002-10-11 | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
BR0213249-4A BR0213249A (pt) | 2001-10-12 | 2002-10-11 | Dispositivo e eletrodo para a aplicação ocular de um princìpio ativo |
MXPA04003438A MXPA04003438A (es) | 2001-10-12 | 2002-10-11 | Dispositivo para suministrar medicamentos a traves de electroforesis transpalpebral. |
JP2003534018A JP4184275B2 (ja) | 2001-10-12 | 2002-10-11 | 薬剤を経眼瞼電気泳動によって送出するための装置 |
US10/492,494 US7848800B2 (en) | 2001-10-12 | 2002-10-11 | Device for delivering medicines by transpalpebral electrophoresis |
IL16129802A IL161298A0 (en) | 2001-10-12 | 2002-10-11 | Device for delivering medicines by transpalpebral electrophoresis |
DE60219336T DE60219336T2 (de) | 2001-10-12 | 2002-10-11 | Vorrichtung zur iontophoretischen verabreichung von medikamenten durch das augenlid |
CY20071100830T CY1106671T1 (el) | 2001-10-12 | 2007-06-21 | Συσκευη για τη χορηγηση φαρμακων μεσω διαβλεφαρικης ηλεκτροφορησης |
US12/913,065 US8771256B2 (en) | 2001-10-12 | 2010-10-27 | Device delivering medicines by transpalpebral electrophoresis |
US14/286,544 US9192512B2 (en) | 2001-10-12 | 2014-05-23 | Device for delivering medicines by transpalpebral electrophoresis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR01/13176 | 2001-10-12 | ||
FR0113176A FR2830766B1 (fr) | 2001-10-12 | 2001-10-12 | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/492,494 A-371-Of-International US7848800B2 (en) | 2001-10-12 | 2002-10-11 | Device for delivering medicines by transpalpebral electrophoresis |
US10492494 A-371-Of-International | 2002-10-11 | ||
US12/913,065 Continuation US8771256B2 (en) | 2001-10-12 | 2010-10-27 | Device delivering medicines by transpalpebral electrophoresis |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003030989A2 true WO2003030989A2 (fr) | 2003-04-17 |
WO2003030989A3 WO2003030989A3 (fr) | 2003-10-30 |
Family
ID=8868226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2002/003472 WO2003030989A2 (fr) | 2001-10-12 | 2002-10-11 | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
Country Status (16)
Country | Link |
---|---|
US (3) | US7848800B2 (fr) |
EP (1) | EP1434622B1 (fr) |
JP (1) | JP4184275B2 (fr) |
KR (1) | KR20050035158A (fr) |
AT (1) | ATE358510T1 (fr) |
BR (1) | BR0213249A (fr) |
CA (1) | CA2463362C (fr) |
CY (1) | CY1106671T1 (fr) |
DE (1) | DE60219336T2 (fr) |
DK (1) | DK1434622T3 (fr) |
ES (1) | ES2283628T3 (fr) |
FR (1) | FR2830766B1 (fr) |
IL (1) | IL161298A0 (fr) |
MX (1) | MXPA04003438A (fr) |
PT (1) | PT1434622E (fr) |
WO (1) | WO2003030989A2 (fr) |
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WO2010111471A2 (fr) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | Inhibition par interférence arn de l'expression du gène du signal transducteur et activateur de la transcription 1 (stat1) au moyen d'un acide nucléique interférent court (ansi) |
WO2010111490A2 (fr) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | Inhibition à médiation par l'interférence arn de l'expression du gène de la lymphopoïétine stromale thymique (tslp) faisant appel à de courts acides nucléiques interférents (ansi) |
WO2010111497A2 (fr) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | Inhibition à médiation par l'interférence arn de l'expression du gène de la molécule d'adhésion intercellulaire 1 (icam-1) faisant appel à de courts acides nucléiques interférents (ansi) |
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JP2011018873A (ja) * | 2009-05-22 | 2011-01-27 | Sony Ericsson Mobilecommunications Japan Inc | 電磁シールド方法および電磁シールド用フィルム |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
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US11318043B2 (en) | 2016-04-20 | 2022-05-03 | Dose Medical Corporation | Bioresorbable ocular drug delivery device |
IT201700014315A1 (it) * | 2017-02-09 | 2018-08-09 | Bruno Massimo Cetroni | Dispositivo per il trasporto intracellulare in biorisonanza |
KR101889357B1 (ko) * | 2017-09-20 | 2018-08-17 | (주)휴비딕 | 눈의 나노 약물 전달용 이온공급 장치 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6154671A (en) | 1998-01-05 | 2000-11-28 | Optisinvest | Device for the intraocular transfer of active products by iontophoresis |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845757A (en) * | 1972-07-12 | 1974-11-05 | Minnesota Mining & Mfg | Biomedical monitoring electrode |
US4564016A (en) * | 1982-05-24 | 1986-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus for introducing ionized drugs into the posterior segment of the eye and method |
US4603076A (en) * | 1985-03-04 | 1986-07-29 | Norwood Industries, Inc. | Hydrophilic foam |
US5320597A (en) * | 1991-02-08 | 1994-06-14 | Becton, Dickinson And Company | Device and method for renewing electrodes during iontophoresis |
US5169384A (en) * | 1991-08-16 | 1992-12-08 | Bosniak Stephen L | Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue |
US5356632A (en) * | 1991-09-12 | 1994-10-18 | S.I. Scientific Innovations Ltd. | Transdermal drug delivery device |
AU652494B2 (en) * | 1991-11-15 | 1994-08-25 | Minnesota Mining And Manufacturing Company | Solid state conductive polymer compositions, biomedical electrodes containing such compositions, and method of preparing same |
US5450845A (en) * | 1993-01-11 | 1995-09-19 | Axelgaard; Jens | Medical electrode system |
US5522864A (en) * | 1994-10-25 | 1996-06-04 | Wallace; Larry B. | Apparatus and method for ocular treatment |
AUPM982694A0 (en) * | 1994-12-02 | 1995-01-05 | University Of Queensland, The | Iontophoresis method and apparatus |
IL123290A (en) * | 1998-02-13 | 2001-12-23 | Hadasit Med Res Service | Iontophoretic device |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6477410B1 (en) * | 2000-05-31 | 2002-11-05 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US6277401B1 (en) * | 1999-05-07 | 2001-08-21 | U.S. Dermatologics, Inc. | Drug delivery device |
US6728573B1 (en) * | 2000-02-23 | 2004-04-27 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US6546284B2 (en) * | 2001-01-25 | 2003-04-08 | Iomed, Inc. | Fluid retention assembly for an iontophoretic delivery device and associated method for preparing the same |
US6697668B2 (en) * | 2001-01-25 | 2004-02-24 | Iomed, Inc. | Ocular iontophoretic device and method for using the same |
US20040106965A1 (en) * | 2001-06-29 | 2004-06-03 | Chow Alan Y. | Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation |
US20030023228A1 (en) * | 2001-07-20 | 2003-01-30 | Parkinson Thomas M. | Ocular iontophoretic device and method for using the same |
US6694193B2 (en) * | 2001-09-14 | 2004-02-17 | Koninklijke Philips Electronics N.V. | Medical electrode and release liner configurations facilitating packaged electrode characterization |
-
2001
- 2001-10-12 FR FR0113176A patent/FR2830766B1/fr not_active Expired - Fee Related
-
2002
- 2002-10-11 EP EP02790508A patent/EP1434622B1/fr not_active Expired - Lifetime
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- 2002-10-11 DE DE60219336T patent/DE60219336T2/de not_active Expired - Lifetime
- 2002-10-11 US US10/492,494 patent/US7848800B2/en not_active Expired - Fee Related
- 2002-10-11 BR BR0213249-4A patent/BR0213249A/pt not_active Application Discontinuation
- 2002-10-11 KR KR1020047005390A patent/KR20050035158A/ko not_active Application Discontinuation
- 2002-10-11 ES ES02790508T patent/ES2283628T3/es not_active Expired - Lifetime
- 2002-10-11 JP JP2003534018A patent/JP4184275B2/ja not_active Expired - Fee Related
- 2002-10-11 WO PCT/FR2002/003472 patent/WO2003030989A2/fr active IP Right Grant
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- 2002-10-11 DK DK02790508T patent/DK1434622T3/da active
- 2002-10-11 MX MXPA04003438A patent/MXPA04003438A/es active IP Right Grant
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-
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-
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- 2010-10-27 US US12/913,065 patent/US8771256B2/en not_active Expired - Fee Related
-
2014
- 2014-05-23 US US14/286,544 patent/US9192512B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6154671A (en) | 1998-01-05 | 2000-11-28 | Optisinvest | Device for the intraocular transfer of active products by iontophoresis |
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US9771588B2 (en) | 2002-02-20 | 2017-09-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9738899B2 (en) | 2002-02-20 | 2017-08-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
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WO2010111468A2 (fr) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | INHIBITION PAR INTERFÉRENCE ARN DE L'EXPRESSION DU GÈNE DE LA CHAÎNE BÊTA DU FACTEUR DE CROISSANCE DES NERFS (NGFß) AU MOYEN D'UN ACIDE NUCLÉIQUE INTERFÉRENT COURT (ANSI) |
WO2010111497A2 (fr) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | Inhibition à médiation par l'interférence arn de l'expression du gène de la molécule d'adhésion intercellulaire 1 (icam-1) faisant appel à de courts acides nucléiques interférents (ansi) |
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WO2012004416A2 (fr) | 2010-07-09 | 2012-01-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Traitement d'une maladie associée à un trouble dégénératif de la rétine |
WO2012018754A2 (fr) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | Inhibition à médiation par interférence arn de caténine (protéine associée à cadhérine), expression du gène bêta 1 (ctnnb1) à l'aide de petit acide nucléique interférent (sian) |
EP3330377A1 (fr) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Inhibition à médiation par interférence arn de caténine (protéine associée à cadhérine), expression du gène bêta 1 (ctnnb1) à l'aide de petit acide nucléique interférent (sian) |
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WO2012027467A1 (fr) | 2010-08-26 | 2012-03-01 | Merck Sharp & Dohme Corp. | Inhibition médiée par interférence arn de l'expression du gène phd2 (prolyl hydroxylase domaine 2) utilisant un petit acide nucléique interférent (pani) |
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WO2013165816A2 (fr) | 2012-05-02 | 2013-11-07 | Merck Sharp & Dohme Corp. | Compositions de petit acide nucléique interférent (sina) |
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Also Published As
Publication number | Publication date |
---|---|
WO2003030989A3 (fr) | 2003-10-30 |
EP1434622B1 (fr) | 2007-04-04 |
ES2283628T3 (es) | 2007-11-01 |
KR20050035158A (ko) | 2005-04-15 |
JP2005504612A (ja) | 2005-02-17 |
US7848800B2 (en) | 2010-12-07 |
US8771256B2 (en) | 2014-07-08 |
DK1434622T3 (da) | 2007-08-13 |
CA2463362A1 (fr) | 2003-04-17 |
DE60219336D1 (de) | 2007-05-16 |
EP1434622A2 (fr) | 2004-07-07 |
ATE358510T1 (de) | 2007-04-15 |
US20040267188A1 (en) | 2004-12-30 |
MXPA04003438A (es) | 2005-02-17 |
FR2830766B1 (fr) | 2004-03-12 |
IL161298A0 (en) | 2004-09-27 |
US20140323947A1 (en) | 2014-10-30 |
BR0213249A (pt) | 2004-09-28 |
CY1106671T1 (el) | 2012-05-23 |
FR2830766A1 (fr) | 2003-04-18 |
US20110098632A1 (en) | 2011-04-28 |
PT1434622E (pt) | 2007-07-11 |
DE60219336T2 (de) | 2007-12-20 |
CA2463362C (fr) | 2011-04-19 |
US9192512B2 (en) | 2015-11-24 |
JP4184275B2 (ja) | 2008-11-19 |
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