EP1222199A4 - N-formyl peptide receptor complex with a g-protein kinase signal pathway modification agent - Google Patents

N-formyl peptide receptor complex with a g-protein kinase signal pathway modification agent

Info

Publication number
EP1222199A4
EP1222199A4 EP00970817A EP00970817A EP1222199A4 EP 1222199 A4 EP1222199 A4 EP 1222199A4 EP 00970817 A EP00970817 A EP 00970817A EP 00970817 A EP00970817 A EP 00970817A EP 1222199 A4 EP1222199 A4 EP 1222199A4
Authority
EP
European Patent Office
Prior art keywords
protein kinase
receptor complex
modification agent
signal pathway
peptide receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00970817A
Other languages
German (de)
French (fr)
Other versions
EP1222199A1 (en
Inventor
James A Clagett
Craig Palmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mowycal Lending LLC
Original Assignee
Histatek LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Histatek LLC filed Critical Histatek LLC
Publication of EP1222199A1 publication Critical patent/EP1222199A1/en
Publication of EP1222199A4 publication Critical patent/EP1222199A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
EP00970817A 1999-10-15 2000-10-12 N-formyl peptide receptor complex with a g-protein kinase signal pathway modification agent Withdrawn EP1222199A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15967799P 1999-10-15 1999-10-15
US159677P 1999-10-15
PCT/US2000/028183 WO2001029069A1 (en) 1999-10-15 2000-10-12 N-formyl peptide receptor complex with a g-protein kinase signal pathway modification agent

Publications (2)

Publication Number Publication Date
EP1222199A1 EP1222199A1 (en) 2002-07-17
EP1222199A4 true EP1222199A4 (en) 2003-03-12

Family

ID=22573520

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00970817A Withdrawn EP1222199A4 (en) 1999-10-15 2000-10-12 N-formyl peptide receptor complex with a g-protein kinase signal pathway modification agent

Country Status (16)

Country Link
EP (1) EP1222199A4 (en)
JP (1) JP2004507441A (en)
KR (1) KR20020057972A (en)
CN (1) CN100497374C (en)
AU (1) AU8014200A (en)
BR (1) BR0014742A (en)
CA (1) CA2387559A1 (en)
CZ (1) CZ20021342A3 (en)
EA (1) EA200200451A1 (en)
HU (1) HUP0203688A2 (en)
IL (1) IL149125A0 (en)
MX (1) MXPA02003782A (en)
NO (1) NO20021732L (en)
PL (1) PL356096A1 (en)
WO (1) WO2001029069A1 (en)
ZA (1) ZA200202937B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844315B2 (en) 1998-05-20 2005-01-18 Erasmus Universiteit Rotterdam Immunoregulator
EP1138692A1 (en) 2000-03-29 2001-10-04 Erasmus Universiteit Rotterdam Fragments of human chorionic gonadotropin (hcg) as immunoregulator
US20030220258A1 (en) 2001-12-21 2003-11-27 Robbert Benner Treatment of ischemic events
US8680059B2 (en) 1998-05-20 2014-03-25 Biotempt B.V. Oligopeptide acetate and formulations thereof
EP1300418A1 (en) * 2001-10-04 2003-04-09 Erasmus Universiteit Rotterdam Gene regulation by oligopeptides
US7358330B2 (en) 2001-03-29 2008-04-15 Biotempt B.V. Immunoregulatory compositions
USRE43279E1 (en) 2000-03-29 2012-03-27 Biotemp B.V. Compositions capable of reducing elevated blood urea concentration
US7786084B2 (en) 2001-12-21 2010-08-31 Biotempt B.V. Treatment of burns
US20070116687A1 (en) * 2003-05-13 2007-05-24 Medvet Science Pty, Ltd. Method of modulating cellular transmigration and agents for use therein
WO2007004869A2 (en) 2005-07-05 2007-01-11 Biotempt B.V. Treatment of tumors
EP1864692A1 (en) 2006-06-07 2007-12-12 Biotempt B.V. Use of peptides for the control of radiation injury
CN102597768B (en) * 2009-09-28 2015-01-07 希拉麦博股份有限公司 Method for preclinical testing of immunomodulatory drugs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025372A1 (en) * 1997-11-13 1999-05-27 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025372A1 (en) * 1997-11-13 1999-05-27 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALI H ET AL: "Chemoattractant receptor cross-desensitization.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 5 MAR 1999, vol. 274, no. 10, 5 March 1999 (1999-03-05), pages 6027 - 6030, XP002226343, ISSN: 0021-9258 *
DENG X ET AL: "A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R.", BLOOD. UNITED STATES 15 AUG 1999, vol. 94, no. 4, 15 August 1999 (1999-08-15), pages 1165 - 1173, XP002226344, ISSN: 0006-4971 *
GRONERT K ET AL: "Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release.", THE JOURNAL OF EXPERIMENTAL MEDICINE. UNITED STATES 20 APR 1998, vol. 187, no. 8, 20 April 1998 (1998-04-20), pages 1285 - 1294, XP002226394, ISSN: 0022-1007 *
KANAHO Y ET AL: "COMPARISON OF STIMULATION BY CHEMOTACTIC FORMYL PEPTIDE ANALOGS BETWEEN GTPASE ACTIVITY IN NEUTROPHIL PLASMA MEMBRANES AND GRANULE ENZYME RELEASE FROM INTACT NEUTROPHILS", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 47, no. 5, 1990, pages 420 - 428, XP008012138, ISSN: 0741-5400 *
See also references of WO0129069A1 *
TORRES M ET AL: "Activation of the mitogen-activated protein kinase pathway by fMet-leu-Phe in the absence of Lyn and tyrosine phosphorylation of SHC in transfected cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 31 MAY 1996, vol. 271, no. 22, 31 May 1996 (1996-05-31), pages 13244 - 13249, XP002226470, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
HUP0203688A2 (en) 2003-02-28
IL149125A0 (en) 2002-11-10
CN100497374C (en) 2009-06-10
JP2004507441A (en) 2004-03-11
KR20020057972A (en) 2002-07-12
BR0014742A (en) 2002-08-27
CN1633447A (en) 2005-06-29
PL356096A1 (en) 2004-06-14
CA2387559A1 (en) 2001-04-26
EA200200451A1 (en) 2002-10-31
CZ20021342A3 (en) 2003-01-15
WO2001029069A1 (en) 2001-04-26
NO20021732D0 (en) 2002-04-12
MXPA02003782A (en) 2002-12-13
NO20021732L (en) 2002-06-12
ZA200202937B (en) 2003-09-23
AU8014200A (en) 2001-04-30
EP1222199A1 (en) 2002-07-17

Similar Documents

Publication Publication Date Title
ZA9811801B (en) Kappa receptor opioid peptides
IL143226A0 (en) Pyrrolidine derivatives-ccr-3 receptor antagonists
EP1104440A4 (en) A g-protein coupled 7tm receptor (axor-1)
AU1956701A (en) G-protein coupled receptors
IL149125A0 (en) N-formyl peptide receptor complex with a g-protein kinase signal pathway modification agent
EP1229910A4 (en) Integrin receptor antagonists
SG80041A1 (en) Muscarinic receptor antagonists
EP1194151A4 (en) Integrin receptor antagonists
EP1157038A4 (en) Cloning of a p2y-like 7tm receptor (axor17)
HK1042099A1 (en) Human g-protein coupled receptor
IL196053A0 (en) Novel human g-protein coupled receptor
IL148515A0 (en) Human g-protein coupled receptor
EP1233981A4 (en) G-protein coupled receptor
IL146146A0 (en) Integrin receptor antagonists
AU4511901A (en) Nonpeptide kappa opioid receptor antagonists
AU2574801A (en) Selective iGLUR5 receptor antagonists
AU5344799A (en) Kappa (op2) opioid receptor antagonists
EP1171467A4 (en) Axor-27, a g-protein coupled receptor
GB0026327D0 (en) Thrombin receptor antagonists
EP1129101A4 (en) A novel g-protein coupled 7tm receptor (axor15)
AU5572500A (en) Vegf receptor antagonists
AU5748300A (en) Il-8 receptor antagonists
PL357650A1 (en) Non peptide tachykinin receptor antagonists
EP1226435A4 (en) Axor35, a g-protein coupled receptor
AU8183601A (en) A g-protein coupled receptor

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020415

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 38/05 B

Ipc: 7C 07K 14/72 B

Ipc: 7C 07K 14/00 A

Ipc: 7G 01N 33/53 B

Ipc: 7A 61K 38/07 B

Ipc: 7G 01N 33/50 B

Ipc: 7A 61P 37/06 B

A4 Supplementary search report drawn up and despatched

Effective date: 20030123

17Q First examination report despatched

Effective date: 20031212

18D Application deemed to be withdrawn

Effective date: 20040623

18RA Request filed for re-establishment of rights before grant

Effective date: 20050329

R18Z Request filed for re-establishment of rights before grant (corrected)

Effective date: 20050329

D18D Application deemed to be withdrawn (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MOWYCAL LENDING, LLC

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

R18D Application deemed to be withdrawn (corrected)

Effective date: 20120503