DE69840851D1 - Kleine peptide und methoden zur behandlung von asthma und entzündungen - Google Patents

Kleine peptide und methoden zur behandlung von asthma und entzündungen

Info

Publication number
DE69840851D1
DE69840851D1 DE69840851T DE69840851T DE69840851D1 DE 69840851 D1 DE69840851 D1 DE 69840851D1 DE 69840851 T DE69840851 T DE 69840851T DE 69840851 T DE69840851 T DE 69840851T DE 69840851 D1 DE69840851 D1 DE 69840851D1
Authority
DE
Germany
Prior art keywords
phe
methods
tyr
asthma
ignition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69840851T
Other languages
English (en)
Inventor
John C Houck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mowycal Lending LLC
Original Assignee
Mowycal Lending LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mowycal Lending LLC filed Critical Mowycal Lending LLC
Application granted granted Critical
Publication of DE69840851D1 publication Critical patent/DE69840851D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69840851T 1997-11-13 1998-07-07 Kleine peptide und methoden zur behandlung von asthma und entzündungen Expired - Lifetime DE69840851D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6533697P 1997-11-13 1997-11-13
PCT/US1998/014103 WO1999025372A1 (en) 1997-11-13 1998-07-07 Small peptides and methods for treatment of asthma and inflammation

Publications (1)

Publication Number Publication Date
DE69840851D1 true DE69840851D1 (de) 2009-07-09

Family

ID=22062006

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69840851T Expired - Lifetime DE69840851D1 (de) 1997-11-13 1998-07-07 Kleine peptide und methoden zur behandlung von asthma und entzündungen

Country Status (12)

Country Link
US (17) US6462020B1 (de)
EP (1) EP1037651B1 (de)
JP (1) JP2002516820A (de)
KR (1) KR100629546B1 (de)
CN (1) CN1282253A (de)
AT (1) ATE432078T1 (de)
AU (1) AU8477998A (de)
BR (1) BR9815288A (de)
CA (1) CA2309639C (de)
DE (1) DE69840851D1 (de)
ES (1) ES2326500T3 (de)
WO (1) WO1999025372A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8477998A (en) 1997-11-13 1999-06-07 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation
CA2353550A1 (en) * 1998-12-03 2000-06-08 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation
AU3765100A (en) * 1999-03-22 2000-10-09 Histatek, Llc Treatment with small peptides to effect antifibrotic activity
AU6351500A (en) * 1999-07-16 2001-02-05 Histatek, Llc Small peptides and methods for downregulation of ige
JP5038568B2 (ja) * 1999-08-21 2012-10-03 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 協力剤の組合せ物
PL356096A1 (en) * 1999-10-15 2004-06-14 Histatek, Llc N-formyl peptide receptor complex with a g-protein kinase signal pathway modification agent
EP1578252A4 (de) * 2002-12-30 2009-11-25 Yeda Res & Dev Verfahren zur auswertung der genetischen anfälligkeit und therapie für chronische entzündungskrankheiten
US20060241130A1 (en) * 2003-01-31 2006-10-26 Ehud Keinan Anti-inflammatory compositions and uses thereof
CN1882344A (zh) 2003-11-18 2006-12-20 诺瓦提斯公司 Kit突变形式的抑制剂
EP1737475A4 (de) * 2004-03-19 2009-08-05 Xiu-Min Li Pflanzliche therapie zur behandlung von asthma
JP5129123B2 (ja) 2005-05-02 2013-01-23 ノバルティス アーゲー 全身性肥満細胞症の処置のためのピリミジルアミノベンズアミド誘導体の使用
KR20080068136A (ko) * 2005-11-15 2008-07-22 백스터 인터내셔널 인코포레이티드 리폭시게나제 억제제 및 시클로덱스트린을 포함하는 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI91859C (fi) * 1987-06-17 1994-08-25 Eisai Co Ltd Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
NZ233601A (en) 1989-05-09 1997-06-24 Gen Hospital Corp N-terminal acylated peptides having an initial sequence met (or nle) -leu-phe and having a detectable label bound through dtpa or edta to a c-terminal lys or pu residue
GB8919504D0 (en) * 1989-08-29 1989-10-11 Leo Pharm Prod Ltd Chemical compounds
US5776892A (en) * 1990-12-21 1998-07-07 Curative Health Services, Inc. Anti-inflammatory peptides
GB2292079B (en) * 1994-08-12 1998-07-15 Flexpharm Ltd Coated prednisolone preparation for the treatment of inflamatory bowel disease
AU8477998A (en) * 1997-11-13 1999-06-07 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation
CA2353550A1 (en) 1998-12-03 2000-06-08 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation

Also Published As

Publication number Publication date
ES2326500T3 (es) 2009-10-13
KR20010032072A (ko) 2001-04-16
US7994137B2 (en) 2011-08-09
JP2002516820A (ja) 2002-06-11
US20080187994A1 (en) 2008-08-07
US6391856B1 (en) 2002-05-21
US6462020B1 (en) 2002-10-08
US20080214478A1 (en) 2008-09-04
WO1999025372A1 (en) 1999-05-27
US20120094938A1 (en) 2012-04-19
US8012934B2 (en) 2011-09-06
US20080214474A1 (en) 2008-09-04
BR9815288A (pt) 2001-02-13
US20030013658A1 (en) 2003-01-16
CN1282253A (zh) 2001-01-31
KR100629546B1 (ko) 2006-09-27
US8097589B2 (en) 2012-01-17
US20130252907A1 (en) 2013-09-26
CA2309639C (en) 2010-03-23
US20080214477A1 (en) 2008-09-04
US20080214472A1 (en) 2008-09-04
US20120058958A1 (en) 2012-03-08
ATE432078T1 (de) 2009-06-15
EP1037651A4 (de) 2001-12-19
US20130274208A1 (en) 2013-10-17
US20080214475A1 (en) 2008-09-04
US20080214473A1 (en) 2008-09-04
US20140127245A1 (en) 2014-05-08
EP1037651B1 (de) 2009-05-27
EP1037651A1 (de) 2000-09-27
US20080214476A1 (en) 2008-09-04
US8809281B2 (en) 2014-08-19
AU8477998A (en) 1999-06-07
US20030130200A1 (en) 2003-07-10
CA2309639A1 (en) 1999-05-27

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Marks Specificity of breakdown based on the inactivation of active proteins and peptides by brain proteolytic enzymes

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