EA200100982A1 - Полиморфные модификации кристаллического цитрата (2-бензгидрил-1-азабицикло[2.2.2]окт-3-ил)-(5-изопропил-2-метоксибензил)-амина в качестве антагонистов рецепторов нейрокинина 1 (nk1) - Google Patents

Полиморфные модификации кристаллического цитрата (2-бензгидрил-1-азабицикло[2.2.2]окт-3-ил)-(5-изопропил-2-метоксибензил)-амина в качестве антагонистов рецепторов нейрокинина 1 (nk1)

Info

Publication number
EA200100982A1
EA200100982A1 EA200100982A EA200100982A EA200100982A1 EA 200100982 A1 EA200100982 A1 EA 200100982A1 EA 200100982 A EA200100982 A EA 200100982A EA 200100982 A EA200100982 A EA 200100982A EA 200100982 A1 EA200100982 A1 EA 200100982A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzhydryl
azabicyclo
methoxybenzyl
oct
isopropyl
Prior art date
Application number
EA200100982A
Other languages
English (en)
Other versions
EA004206B1 (ru
Inventor
Стивен Сарджент Массетт
Джордж Джозеф Куоллич
Питер Роберт Роуз
Льюин Теофилус Уинт
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200100982A1 publication Critical patent/EA200100982A1/ru
Publication of EA004206B1 publication Critical patent/EA004206B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Двумя кристаллическими полиморфными формами моногидрата цитрата (2-бензгидрил-1-азабицикло[2.2.2]окт-3-ил)-(5-изопропил-2-метоксибензил)-амина (моногидратами) являются форма А и форма Б. Фармацевтическая композиция, содержащая, по меньшей мере, одну из этих полиморфных модификаций, обладает полезной стабильностью для приготовления препаратов для лечения острой рвоты у пациентов, получающих химиотерапию. Введение этой фармацевтической композиции осуществляется обычно перорально предпочтительно в виде таблетки или капсулы и внутривенно. Также раскрыт способ получения форм А и Б.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100982A 1999-06-01 2000-05-17 Полиморфные модификации кристаллического цитрата (2-бензгидрил-1-азабицикло[2.2.2]окт-3-ил)-(5-изопропил-2-метоксибензил)амина в качестве антагонистов рецепторов нейрокинина 1 (nk1) EA004206B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13699599P 1999-06-01 1999-06-01
PCT/IB2000/000663 WO2000073303A1 (en) 1999-06-01 2000-05-17 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2.2.2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-amine citrate as nk-1 receptor antagonists

Publications (2)

Publication Number Publication Date
EA200100982A1 true EA200100982A1 (ru) 2002-06-27
EA004206B1 EA004206B1 (ru) 2004-02-26

Family

ID=22475353

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100982A EA004206B1 (ru) 1999-06-01 2000-05-17 Полиморфные модификации кристаллического цитрата (2-бензгидрил-1-азабицикло[2.2.2]окт-3-ил)-(5-изопропил-2-метоксибензил)амина в качестве антагонистов рецепторов нейрокинина 1 (nk1)

Country Status (38)

Country Link
US (1) US6387925B1 (ru)
EP (1) EP1181289A1 (ru)
JP (1) JP2003501353A (ru)
KR (1) KR20020005055A (ru)
CN (1) CN1353712A (ru)
AP (1) AP2001002350A0 (ru)
AR (1) AR029753A1 (ru)
AU (1) AU767331B2 (ru)
BG (1) BG106139A (ru)
BR (1) BR0011125A (ru)
CA (1) CA2372236A1 (ru)
CO (1) CO5170468A1 (ru)
CR (1) CR6513A (ru)
CZ (1) CZ20014270A3 (ru)
DZ (1) DZ3051A1 (ru)
EA (1) EA004206B1 (ru)
EE (1) EE200100655A (ru)
GT (1) GT200000086A (ru)
HK (1) HK1046407A1 (ru)
HN (1) HN2000000076A (ru)
HR (1) HRP20010884A2 (ru)
HU (1) HUP0201798A3 (ru)
IL (1) IL145952A0 (ru)
IS (1) IS6129A (ru)
MX (1) MXPA01012328A (ru)
NO (1) NO20015845L (ru)
NZ (1) NZ514762A (ru)
OA (1) OA11955A (ru)
PA (1) PA8496001A1 (ru)
PE (1) PE20010155A1 (ru)
PL (1) PL352715A1 (ru)
SK (1) SK17342001A3 (ru)
SV (1) SV2002000092A (ru)
TN (1) TNSN00119A1 (ru)
TR (1) TR200103472T2 (ru)
UY (1) UY26177A1 (ru)
WO (1) WO2000073303A1 (ru)
ZA (1) ZA200109839B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503859A (ja) * 2002-10-04 2006-02-02 メルク シャープ エンド ドーム リミテッド 受容体拮抗薬としてのアザ二環式スピロエーテル誘導体
JP2007524619A (ja) * 2003-06-18 2007-08-30 テバ ファーマシューティカル インダストリーズ リミティド フルバスタチンナトリウム結晶型、その調製方法、これを含有する組成物、およびその使用法
US7371906B2 (en) 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
US9446029B2 (en) 2010-07-27 2016-09-20 Colorado State University Research Foundation Use of NK-1 receptor antagonists in management of visceral pain
CN110577522B (zh) * 2018-06-07 2022-12-27 东莞市东阳光动物保健药品有限公司 马罗匹坦柠檬酸盐新晶型及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
WO1992021677A1 (en) * 1991-05-31 1992-12-10 Pfizer Inc. bibNUCLIDINE DERIVATIVES
EP0668863B1 (en) * 1992-11-12 1997-01-08 Pfizer Inc. Quinuclidine derivative as substance p antagonist
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
US6262067B1 (en) * 1999-06-22 2001-07-17 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo 2,2,2 OCT-3-yl amine dihydrochloride and their pharmaceutical compositions

Also Published As

Publication number Publication date
CA2372236A1 (en) 2000-12-07
US6387925B1 (en) 2002-05-14
OA11955A (en) 2006-04-13
HUP0201798A2 (en) 2002-09-28
EE200100655A (et) 2003-02-17
CZ20014270A3 (cs) 2002-08-14
ZA200109839B (en) 2003-01-29
PL352715A1 (en) 2003-09-08
BR0011125A (pt) 2002-02-19
DZ3051A1 (fr) 2004-03-27
AU767331B2 (en) 2003-11-06
AU4424600A (en) 2000-12-18
NO20015845D0 (no) 2001-11-30
CN1353712A (zh) 2002-06-12
TR200103472T2 (tr) 2002-05-21
IL145952A0 (en) 2002-07-25
AR029753A1 (es) 2003-07-16
TNSN00119A1 (fr) 2005-11-10
HK1046407A1 (zh) 2003-01-10
PA8496001A1 (es) 2002-07-30
HRP20010884A2 (en) 2003-04-30
UY26177A1 (es) 2000-12-29
IS6129A (is) 2001-10-26
MXPA01012328A (es) 2002-07-30
KR20020005055A (ko) 2002-01-16
EA004206B1 (ru) 2004-02-26
CR6513A (es) 2003-11-25
NO20015845L (no) 2002-01-30
SV2002000092A (es) 2002-02-05
NZ514762A (en) 2002-12-20
BG106139A (bg) 2002-05-31
WO2000073303A1 (en) 2000-12-07
SK17342001A3 (sk) 2002-10-08
GT200000086A (es) 2001-11-21
EP1181289A1 (en) 2002-02-27
PE20010155A1 (es) 2001-02-08
JP2003501353A (ja) 2003-01-14
HUP0201798A3 (en) 2002-10-28
AP2001002350A0 (en) 2001-12-31
HN2000000076A (es) 2001-02-02
CO5170468A1 (es) 2002-06-27

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU