EA200100494A1 - Синтез 1,3-оксаселеноланнуклеозидов, обладающих активностью против вируса иммунодефицита человека и против вируса гипатита-b - Google Patents
Синтез 1,3-оксаселеноланнуклеозидов, обладающих активностью против вируса иммунодефицита человека и против вируса гипатита-bInfo
- Publication number
- EA200100494A1 EA200100494A1 EA200100494A EA200100494A EA200100494A1 EA 200100494 A1 EA200100494 A1 EA 200100494A1 EA 200100494 A EA200100494 A EA 200100494A EA 200100494 A EA200100494 A EA 200100494A EA 200100494 A1 EA200100494 A1 EA 200100494A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- virus
- hepatitis
- synthesis
- human immunodeficiency
- activities
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 2
- 206010061598 Immunodeficiency Diseases 0.000 title 1
- 208000029462 Immunodeficiency disease Diseases 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 230000007813 immunodeficiency Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 1,3-oxaselenolane nucleoside Chemical class 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
- C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
- C07D421/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Представляется способ получения 1,3-оксаселеноланнуклеозида или его фармацевтически приемлемой соли, эффективного при лечении инфекций ВИЧ, инфекций вируса гепатита-В или аномальной пролиферации клеток у человека и других животных.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4126597P | 1997-03-19 | 1997-03-19 | |
PCT/US1998/005517 WO1998041522A1 (en) | 1997-03-19 | 1998-03-19 | Synthesis, anti-human immunodeficiency virus and anti-hepatitis b virus activities of 1,3-oxaselenolane nucleosides |
Publications (3)
Publication Number | Publication Date |
---|---|
EA200100494A1 true EA200100494A1 (ru) | 2001-10-22 |
EA200100494A3 EA200100494A3 (ru) | 2002-02-28 |
EA005097B1 EA005097B1 (ru) | 2004-10-28 |
Family
ID=21915638
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900843A EA001920B1 (ru) | 1997-03-19 | 1998-03-19 | Синтез 1,3-оксаселеноланнуклеозидов, их активность против вируса иммунодефицита человека и против вируса гепатита-b |
EA200100494A EA005097B1 (ru) | 1997-03-19 | 1998-03-19 | Синтез 1,3-оксаселеноланнуклеозидов, обладающих активностью против вируса иммунодефицита человека и против вируса гепатита-b |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900843A EA001920B1 (ru) | 1997-03-19 | 1998-03-19 | Синтез 1,3-оксаселеноланнуклеозидов, их активность против вируса иммунодефицита человека и против вируса гепатита-b |
Country Status (10)
Country | Link |
---|---|
US (3) | US6071922A (ru) |
EP (1) | EP0970078B1 (ru) |
CN (1) | CN1196701C (ru) |
AT (1) | ATE267198T1 (ru) |
AU (1) | AU739240B2 (ru) |
CA (1) | CA2287370C (ru) |
DE (1) | DE69823984T2 (ru) |
EA (2) | EA001920B1 (ru) |
ES (1) | ES2221164T3 (ru) |
WO (1) | WO1998041522A1 (ru) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL142910A0 (en) | 1998-11-02 | 2002-04-21 | Triangle Pharmaceuticals Inc | Combination therapy to treat hepatitis b virus |
NO20001904L (no) | 1999-04-14 | 2000-10-16 | Dow Chemical Co | Polyuretanfilmer fremstilt ved elektrolytisk utfelling fra polyuretandispersjoner |
NO20001903L (no) | 1999-04-14 | 2000-10-16 | Dow Chemical Co | Polyuretan-filmer fremstilt fra polyuretan-dispersjoner |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
EA200601591A1 (ru) | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций |
JP5105689B2 (ja) | 2001-03-01 | 2012-12-26 | ギリード・サイエンシズ・インコーポレーテッド | 多形型および他の結晶型のシス−ftc |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
US20070026090A1 (en) * | 2003-09-05 | 2007-02-01 | Oren Tirosh | Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium |
ES2568467T3 (es) * | 2004-02-03 | 2016-04-29 | Emory University | Métodos para la fabricación de nucleósidos de 1,3-dioxolano |
WO2008030488A2 (en) | 2006-09-06 | 2008-03-13 | Med Institute, Inc. | Stents with connectors and stabilizing biodegradable elements |
BR112012024661A2 (pt) | 2010-04-01 | 2015-09-15 | Centre Nat Rech Scient | composto, composição farmacêutica e método de tratamento de um hospedeiro infectado com vírus de hepatite c |
KR101021294B1 (ko) * | 2010-10-11 | 2011-03-11 | 공주대학교 산학협력단 | 신규한 셀레닐 메틸 우라실 화합물 및 이를 이용한 방사선 치료 증진제 및 의약 조성물 |
WO2012154321A1 (en) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
EP2755985B1 (en) | 2011-09-12 | 2017-11-01 | Idenix Pharmaceuticals LLC | Compounds and pharmaceutical compositions for the treatment of viral infections |
WO2016072863A1 (en) * | 2014-11-03 | 2016-05-12 | Nicolai Vladimirovich Bovin | Antimicrobial surface treatment |
Family Cites Families (27)
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US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
DE3732761A1 (de) * | 1986-09-30 | 1988-03-31 | Zahnradfabrik Friedrichshafen | Fahrzeuggetriebe mit integrierter bremse |
NZ228645A (en) * | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US5041449A (en) * | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US5194654A (en) * | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
US5463092A (en) * | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
JP2567536B2 (ja) * | 1989-12-20 | 1996-12-25 | バイオテック オーストラリア プロプライアタリィ リミティド | Paiー2の変異体 |
US6642245B1 (en) * | 1990-02-01 | 2003-11-04 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US6346627B1 (en) * | 1990-02-01 | 2002-02-12 | Emory University | Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers |
US5700937A (en) * | 1990-02-01 | 1997-12-23 | Emory University | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
US5543389A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
US5149794A (en) * | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
US5256641A (en) * | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
US5543390A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5925643A (en) * | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
WO1992010496A1 (en) * | 1990-12-05 | 1992-06-25 | University Of Georgia Research Foundation, Inc. | ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES |
US5179104A (en) * | 1990-12-05 | 1993-01-12 | University Of Georgia Research Foundation, Inc. | Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides |
NZ241625A (en) * | 1991-02-22 | 1996-03-26 | Univ Emory | 1,3-oxathiolane derivatives, anti-viral compositions containing such and method of resolving racemic mixture of enantiomers |
GB9104740D0 (en) * | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
ATE219366T1 (de) * | 1991-03-06 | 2002-07-15 | Univ Emory | Verwendung von 5-fluoro-2'-deoxy-3'-thiacytidin zur behandlung von hepatitis b |
WO1992018517A1 (en) * | 1991-04-17 | 1992-10-29 | Yale University | Method of treating or preventing hepatitis b virus |
GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
US5554728A (en) * | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
-
1998
- 1998-03-19 EA EA199900843A patent/EA001920B1/ru not_active IP Right Cessation
- 1998-03-19 DE DE69823984T patent/DE69823984T2/de not_active Expired - Lifetime
- 1998-03-19 AT AT98914266T patent/ATE267198T1/de not_active IP Right Cessation
- 1998-03-19 EP EP98914266A patent/EP0970078B1/en not_active Expired - Lifetime
- 1998-03-19 CN CNB988049341A patent/CN1196701C/zh not_active Expired - Fee Related
- 1998-03-19 ES ES98914266T patent/ES2221164T3/es not_active Expired - Lifetime
- 1998-03-19 CA CA2287370A patent/CA2287370C/en not_active Expired - Fee Related
- 1998-03-19 EA EA200100494A patent/EA005097B1/ru not_active IP Right Cessation
- 1998-03-19 WO PCT/US1998/005517 patent/WO1998041522A1/en active IP Right Grant
- 1998-03-19 AU AU68665/98A patent/AU739240B2/en not_active Ceased
- 1998-03-19 US US09/044,558 patent/US6071922A/en not_active Expired - Fee Related
-
2000
- 2000-03-03 US US09/517,955 patent/US6197777B1/en not_active Expired - Fee Related
-
2001
- 2001-03-05 US US09/799,327 patent/US6590107B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2287370C (en) | 2010-02-09 |
AU6866598A (en) | 1998-10-12 |
EA005097B1 (ru) | 2004-10-28 |
DE69823984D1 (de) | 2004-06-24 |
US6590107B1 (en) | 2003-07-08 |
EA001920B1 (ru) | 2001-10-22 |
DE69823984T2 (de) | 2005-05-12 |
EA200100494A3 (ru) | 2002-02-28 |
EP0970078B1 (en) | 2004-05-19 |
CN1196701C (zh) | 2005-04-13 |
CA2287370A1 (en) | 1998-09-24 |
ATE267198T1 (de) | 2004-06-15 |
EP0970078A1 (en) | 2000-01-12 |
WO1998041522A1 (en) | 1998-09-24 |
EA199900843A1 (ru) | 2000-04-24 |
US6197777B1 (en) | 2001-03-06 |
ES2221164T3 (es) | 2004-12-16 |
AU739240B2 (en) | 2001-10-04 |
US6071922A (en) | 2000-06-06 |
CN1255132A (zh) | 2000-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |