EA200100271A1 - Соединения карбамата и карбамида и их применение в качестве нейротрофических агентов - Google Patents

Соединения карбамата и карбамида и их применение в качестве нейротрофических агентов

Info

Publication number
EA200100271A1
EA200100271A1 EA200100271A EA200100271A EA200100271A1 EA 200100271 A1 EA200100271 A1 EA 200100271A1 EA 200100271 A EA200100271 A EA 200100271A EA 200100271 A EA200100271 A EA 200100271A EA 200100271 A1 EA200100271 A1 EA 200100271A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbamide
carbamate
compounds
application
neurotrophic agents
Prior art date
Application number
EA200100271A
Other languages
English (en)
Inventor
Джиа-Хе Ли
Джозеф П. Стейнер
Грегори С. Гамильтон
Original Assignee
Гпи Нил Холдингс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гпи Нил Холдингс, Инк. filed Critical Гпи Нил Холдингс, Инк.
Publication of EA200100271A1 publication Critical patent/EA200100271A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к фармацевтическим композициям и способам воздействия на нейронную активность с использованием низкомолекулярных карбаматов и карбамидов, имеющих молекулы малого размера и обладающих сродством к иммунофилинам FKBP-типа.Отчет о международном поиске был опубликован 2000.05.18.
EA200100271A 1998-08-25 1999-08-24 Соединения карбамата и карбамида и их применение в качестве нейротрофических агентов EA200100271A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/139,672 US6242468B1 (en) 1997-02-27 1998-08-25 Carbamate and urea compositions and neurotrophic uses
PCT/US1999/019261 WO2000010553A2 (en) 1998-08-25 1999-08-24 Carbamate and urea compositions and neurotrophic uses

Publications (1)

Publication Number Publication Date
EA200100271A1 true EA200100271A1 (ru) 2001-10-22

Family

ID=22487769

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100271A EA200100271A1 (ru) 1998-08-25 1999-08-24 Соединения карбамата и карбамида и их применение в качестве нейротрофических агентов

Country Status (18)

Country Link
US (1) US6242468B1 (ru)
EP (1) EP1107757A2 (ru)
JP (1) JP2002523367A (ru)
KR (1) KR20010072992A (ru)
CN (1) CN1313767A (ru)
AU (1) AU5687999A (ru)
BG (1) BG105340A (ru)
BR (1) BR9912988A (ru)
CA (1) CA2341530A1 (ru)
CZ (1) CZ2001274A3 (ru)
EA (1) EA200100271A1 (ru)
HU (1) HUP0103166A3 (ru)
IL (1) IL140958A0 (ru)
MX (1) MXPA01001937A (ru)
NO (1) NO20010946L (ru)
PL (1) PL346759A1 (ru)
SK (1) SK2562001A3 (ru)
WO (1) WO2000010553A2 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008960B1 (en) 1999-03-02 2006-03-07 Vitreo-Retinal Technologies, Inc. Agents for intravitreal administration to treat or prevent disorders of the eye
EP1196386A2 (en) * 1999-07-06 2002-04-17 Vertex Pharmaceuticals Incorporated N-substituted glycine derivatives
US20030199574A1 (en) * 2000-03-02 2003-10-23 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives
US7977385B2 (en) * 2000-03-02 2011-07-12 Numoda Biotechnologies, Inc. Agents for corneal or intrastromal administration to treat or prevent disorders of the eye
US20050137124A1 (en) * 2002-08-09 2005-06-23 Vitreo-Retinal Technologies, Inc. A California Corporation Agents for intravitreal administration to treat or prevent disorders of the eye
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
US20050197356A1 (en) * 2004-03-02 2005-09-08 Wyeth Non-immunosuppressive immunophilin ligands as neuroprotective and/or neuroregenerative agents
EP1720886A1 (en) 2004-03-02 2006-11-15 Wyeth Macrolides and methods for producing same
WO2007061554A2 (en) * 2005-10-21 2007-05-31 Purdue Research Foundation Dosage of 4-aminopyridine derivatives for treatment of central nervous system injuries
CN104136413B (zh) * 2011-12-27 2016-10-26 比皮艾思药物研发有限公司 用于预防或治疗癫痫症的苯基氨基甲酸酯化合物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI874163A (fi) 1986-09-26 1988-03-27 Mitsui Toatsu Chemicals Katekolderivat samt preparat innehaollande desamma foer haemmande och botande av regressiva sjukdomar i det centrala nervsystemet.
US5214034A (en) 1986-09-26 1993-05-25 Mitsui Toatsu Chemicals, Incorporated Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same
IT1206078B (it) 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
US5232923A (en) 1988-03-18 1993-08-03 Mitsui Toatsu Chemicals, Incorporated Catechol derivatives and pharmaceutical preparations containing same
US5166317A (en) 1988-10-31 1992-11-24 Houston Biotechnology Incorporated Neurotrophic factor
US5215969A (en) 1989-08-11 1993-06-01 Hahnemann University Dopaminergic neurotrophic factor for treatment of Parkinson's disease
US5620971A (en) 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
US5744485A (en) 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
IL115685A (en) * 1994-11-16 2000-08-31 Vertex Pharma Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
US6037370A (en) 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5717092A (en) 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity
US5811434A (en) 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
US5840736A (en) 1996-11-13 1998-11-24 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5780484A (en) 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
US5935989A (en) * 1996-12-31 1999-08-10 Gpi Nil Holdings Inc. N-linked ureas and carbamates of heterocyclic thioesters
ZA98825B (en) * 1997-02-27 1998-10-19 Guilford Pharm Inc Method of using neurotrophic carbamates and ureas

Also Published As

Publication number Publication date
EP1107757A2 (en) 2001-06-20
HUP0103166A3 (en) 2002-10-28
NO20010946D0 (no) 2001-02-23
CZ2001274A3 (cs) 2001-09-12
JP2002523367A (ja) 2002-07-30
IL140958A0 (en) 2002-02-10
MXPA01001937A (es) 2002-04-24
AU5687999A (en) 2000-03-14
SK2562001A3 (en) 2001-09-11
PL346759A1 (en) 2002-02-25
WO2000010553A2 (en) 2000-03-02
NO20010946L (no) 2001-02-23
US6242468B1 (en) 2001-06-05
CN1313767A (zh) 2001-09-19
BG105340A (en) 2001-12-29
BR9912988A (pt) 2001-10-02
HUP0103166A2 (hu) 2002-05-29
CA2341530A1 (en) 2000-03-02
KR20010072992A (ko) 2001-07-31
WO2000010553A3 (en) 2000-05-18

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