EA200000845A1 - Ген, кодирующий новый маркер рака - Google Patents
Ген, кодирующий новый маркер ракаInfo
- Publication number
- EA200000845A1 EA200000845A1 EA200000845A EA200000845A EA200000845A1 EA 200000845 A1 EA200000845 A1 EA 200000845A1 EA 200000845 A EA200000845 A EA 200000845A EA 200000845 A EA200000845 A EA 200000845A EA 200000845 A1 EA200000845 A1 EA 200000845A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- lab
- cancer
- preventing
- protein
- mentioned
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Выделяют молекулу кДНК, кодирующую белок, обозначенный как Labyrinthin (Lab), и определяют ее нуклеотидную последовательность. Упомянутый белок либо пептиды, полученные из упомянутого белка, являются маркерами, пригодными для определения раковых опухолей новых классов. В диагностических пробах для определения упомянутых раковых опухолей используются антитела к Lab либо нуклеотидные зонды, которые гибридизуются с упомянутым lab геном либо его фрагментом. В вакцинах, пригодных для предупреждения рецидива раковых опухолей у субъекта с положительной реакцией на Lab (либо lab) либо для профилактики начального возникновения раковой опухоли, используются белки либо пептиды, полученные из Lab. Экспрессия Lab посредством иммуногенных проб используется для контролирования результатом лечения рака. При лечении используются антисмысловые молекулы против lab. Смысловые молекулы lab используются для восстановления утраченной функции lab в нормальных больных клетках, например в железистых клетках.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/040,485 US6166176A (en) | 1998-03-17 | 1998-03-17 | Cancer marker protein and peptides thereof |
PCT/US1999/005365 WO1999047683A1 (en) | 1998-03-17 | 1999-03-11 | Gene encoding labyrinthin, a marker for cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200000845A1 true EA200000845A1 (ru) | 2001-08-27 |
EA003735B1 EA003735B1 (ru) | 2003-08-28 |
Family
ID=21911225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000845A EA003735B1 (ru) | 1998-03-17 | 1999-03-11 | Ген, кодирующий новый маркер рака |
Country Status (15)
Country | Link |
---|---|
US (7) | US6166176A (ru) |
EP (1) | EP1062346B1 (ru) |
JP (2) | JP2002512005A (ru) |
CN (2) | CN101260401A (ru) |
AP (1) | AP2000001917A0 (ru) |
AT (1) | ATE337400T1 (ru) |
AU (2) | AU762758B2 (ru) |
BR (1) | BR9908886A (ru) |
CA (1) | CA2323494A1 (ru) |
DE (1) | DE69932926T2 (ru) |
EA (1) | EA003735B1 (ru) |
HK (1) | HK1033151A1 (ru) |
IL (1) | IL138208A0 (ru) |
OA (1) | OA11487A (ru) |
WO (1) | WO1999047683A1 (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6166176A (en) * | 1998-03-17 | 2000-12-26 | Immvarx, Inc. | Cancer marker protein and peptides thereof |
US6835370B2 (en) * | 1999-11-08 | 2004-12-28 | Rhode Island Hospital | Diagnosis and treatment of malignant neoplasms |
US20030031670A1 (en) * | 1999-11-08 | 2003-02-13 | Jack R. Wands | Diagnosis and treatment of malignant neoplasms |
US20050123545A1 (en) * | 1999-11-08 | 2005-06-09 | Wands Jack R. | Diagnosis and treatment of malignant neoplasms |
US6682902B2 (en) * | 1999-12-16 | 2004-01-27 | Schering Aktiengesellschaft | DNA encoding a novel RG1 polypeptide |
US7306919B1 (en) | 2001-10-31 | 2007-12-11 | Thornthwaite Jerry T | Antigen-antibody cancer recognition system |
EP1536814A4 (en) * | 2002-07-03 | 2006-02-15 | Immunogen Inc | ANTIBODIES AGAINST MUC1 AND MUC16 NOT RELEASED AND USES THEREOF |
EP1512695B1 (en) * | 2003-09-04 | 2008-11-19 | Biomay AG | Hypoallergenic polypeptides based on fish parvalbumin |
WO2005049802A2 (en) * | 2003-11-14 | 2005-06-02 | Massachusetts Institute Of Technology | Anti-hydroxylase antibodies and uses thereof |
CN100457922C (zh) * | 2005-10-20 | 2009-02-04 | 康哲医药研究(深圳)有限公司 | 检测酪丝亮肽抗肝癌效果的方法及所用试剂盒与基因芯片 |
GB201002627D0 (en) | 2010-02-16 | 2010-03-31 | Loxbridge Res Llp | Aptamer based analyte detection method |
AU2019397539A1 (en) * | 2018-12-13 | 2021-07-15 | Labyrx Immunologic Therapeutics (Usa) Limited | Labyrinthin-based peptides for cancer immunotherapies and uses thereof |
CN113993892A (zh) * | 2019-01-08 | 2022-01-28 | 莱比锡免疫治疗(美国)有限公司 | 靶向迷路蛋白或其部分的构建体以及所述构建体的用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816402A (en) * | 1986-01-07 | 1989-03-28 | Northwestern University | Murine hybridoma and diagnostic antibody produced thereby |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5223604A (en) * | 1991-06-25 | 1993-06-29 | S.P.I. Synthetic Peptides Incorporated | Pseudomonas exoenzyme s peptide composition and method |
US5728819A (en) * | 1996-08-02 | 1998-03-17 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
US5994062A (en) * | 1995-10-02 | 1999-11-30 | The United States Of America As Represented By The Department Of Health And Human Services | Epithelial protein and DNA thereof for use in early cancer detection |
US6166176A (en) * | 1998-03-17 | 2000-12-26 | Immvarx, Inc. | Cancer marker protein and peptides thereof |
US6344548B1 (en) * | 1998-06-24 | 2002-02-05 | The Regents Of The University Of California | Diacylglycerol o-acyltransferase |
US7135617B2 (en) * | 1998-07-02 | 2006-11-14 | Calgene Llc | Diacylglycerol acyl transferase proteins |
US6100077A (en) * | 1998-10-01 | 2000-08-08 | The Trustees Of Columbia University In The City Of New York | Isolation of a gene encoding diacylglycerol acyltransferase |
US20030161831A1 (en) * | 2001-02-23 | 2003-08-28 | Sylvaine Cases | Mono-and diacylglycerol acyltransferases and methods of use thereof |
US7045326B2 (en) * | 2001-02-23 | 2006-05-16 | The Regents Of The University Of California | Mono- and diacylglycerol acyltransferases and methods of use thereof |
BR0313536A (pt) * | 2002-07-31 | 2005-06-14 | Monsanto Technology Llc | Sequencias de ácido nucléico de diacilglicerol acetiltransferase e produtos associados |
US8685679B2 (en) * | 2004-11-04 | 2014-04-01 | E I Du Pont De Nemours And Company | Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms |
US8507754B2 (en) * | 2009-01-31 | 2013-08-13 | University Of North Texas | Engineering lipids in vegetative tissues of plants |
CN103201379B (zh) * | 2010-06-28 | 2015-08-19 | 联邦科学技术研究组织 | 生产脂质的方法 |
-
1998
- 1998-03-17 US US09/040,485 patent/US6166176A/en not_active Expired - Fee Related
-
1999
- 1999-03-11 AU AU29996/99A patent/AU762758B2/en not_active Ceased
- 1999-03-11 DE DE69932926T patent/DE69932926T2/de not_active Expired - Lifetime
- 1999-03-11 AP APAP/P/2000/001917A patent/AP2000001917A0/en unknown
- 1999-03-11 CN CNA2008100031485A patent/CN101260401A/zh active Pending
- 1999-03-11 JP JP2000536866A patent/JP2002512005A/ja active Pending
- 1999-03-11 AT AT99911331T patent/ATE337400T1/de not_active IP Right Cessation
- 1999-03-11 BR BR9908886-0A patent/BR9908886A/pt not_active Application Discontinuation
- 1999-03-11 EA EA200000845A patent/EA003735B1/ru not_active IP Right Cessation
- 1999-03-11 WO PCT/US1999/005365 patent/WO1999047683A1/en active IP Right Grant
- 1999-03-11 CN CNB998061697A patent/CN100372938C/zh not_active Expired - Fee Related
- 1999-03-11 CA CA002323494A patent/CA2323494A1/en not_active Abandoned
- 1999-03-11 EP EP99911331A patent/EP1062346B1/en not_active Expired - Lifetime
- 1999-03-11 IL IL13820899A patent/IL138208A0/xx unknown
-
2000
- 2000-09-12 US US09/659,521 patent/US6727080B1/en not_active Expired - Fee Related
- 2000-09-18 OA OA1200000256A patent/OA11487A/en unknown
-
2001
- 2001-06-04 HK HK01103831A patent/HK1033151A1/xx not_active IP Right Cessation
-
2003
- 2003-05-22 AU AU2003204331A patent/AU2003204331B2/en not_active Ceased
-
2004
- 2004-04-23 US US10/830,702 patent/US7329743B2/en not_active Expired - Fee Related
-
2008
- 2008-02-11 US US12/029,113 patent/US7635759B2/en not_active Expired - Fee Related
-
2009
- 2009-04-28 JP JP2009110164A patent/JP2009165492A/ja active Pending
- 2009-10-23 US US12/605,185 patent/US8163883B2/en not_active Expired - Fee Related
-
2010
- 2010-03-16 US US12/725,414 patent/US20100233711A1/en not_active Abandoned
- 2010-03-16 US US12/725,404 patent/US20110110963A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AP2000001917A0 (en) | 2000-09-30 |
US20050208508A1 (en) | 2005-09-22 |
JP2009165492A (ja) | 2009-07-30 |
US7635759B2 (en) | 2009-12-22 |
CN1301302A (zh) | 2001-06-27 |
US8163883B2 (en) | 2012-04-24 |
US20110110963A1 (en) | 2011-05-12 |
JP2002512005A (ja) | 2002-04-23 |
EP1062346B1 (en) | 2006-08-23 |
IL138208A0 (en) | 2001-10-31 |
WO1999047683A1 (en) | 1999-09-23 |
CN100372938C (zh) | 2008-03-05 |
US20100112582A1 (en) | 2010-05-06 |
AU762758B2 (en) | 2003-07-03 |
US20100233711A1 (en) | 2010-09-16 |
ATE337400T1 (de) | 2006-09-15 |
US20080249284A1 (en) | 2008-10-09 |
EA003735B1 (ru) | 2003-08-28 |
AU2003204331B2 (en) | 2008-02-07 |
BR9908886A (pt) | 2000-11-21 |
AU2999699A (en) | 1999-10-11 |
DE69932926D1 (de) | 2006-10-05 |
US7329743B2 (en) | 2008-02-12 |
US6166176A (en) | 2000-12-26 |
DE69932926T2 (de) | 2007-05-24 |
CA2323494A1 (en) | 1999-09-23 |
WO1999047683A9 (en) | 1999-11-18 |
CN101260401A (zh) | 2008-09-10 |
US6727080B1 (en) | 2004-04-27 |
OA11487A (en) | 2004-05-04 |
HK1033151A1 (en) | 2001-08-17 |
EP1062346A1 (en) | 2000-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Paucha et al. | Large and small tumor antigens from simian virus 40 have identical amino termini mapping at 0.65 map units. | |
JP6672411B2 (ja) | 癌療法を示すためのsrmアッセイ | |
Yu et al. | Update on proliferation-associated antibodies applicable to formalin-fixed paraffin-embedded tissue and their clinical applications | |
Vercoutter-Edouart et al. | Proteomic analysis reveals that 14-3-3σ is down-regulated in human breast cancer cells | |
EA200000845A1 (ru) | Ген, кодирующий новый маркер рака | |
Rauch et al. | Allogenic antibody-mediated identification of head and neck cancer antigens | |
CO4870792A1 (es) | Compuestos y conjunto de medios de diagnostico para detectar y vigilar la progresion de cancer de prostata | |
SE9500023D0 (sv) | Method of detecting cancer | |
BR0315666A (pt) | Dna de a34 e a33 do tipo 3, proteìnas, seus anticorpos e métodos de tratamento usando os mesmos | |
DK161015C (da) | Blanding til anvendelse ved ekstern paavisning og lokalisering af en blodprop | |
CA2954051A1 (en) | Srm assays to chemotherapy targets | |
Wu et al. | An approach to the proteomic analysis of a breast cancer cell line (SKBR‐3) | |
ES2327063T3 (es) | Determinacion de srl-alcohol deshidrogenasa de cadena corta (dhrs4) como biomarcador para inflamaciones e infecciones. | |
CN109517898B (zh) | 一种食管癌检测、诊断或者预后评价制剂,治疗食管癌的药物及rnd2基因的应用 | |
JP2019058171A (ja) | Pd−l1に対するsrmアッセイ | |
JP6441215B2 (ja) | 肺組織像を細分類するためのsrm/mrm分析 | |
Li et al. | Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cells | |
DE69126038T2 (de) | Diagnose von krebs-metastasen durch das mts-1 gen | |
WO1998010291A1 (en) | Biochemical markers of the human endometrium | |
CY1109254T1 (el) | Νεο αντιγονο ογκου χρησιμο στη διαγνωση και θεραπεια καρκινων της ουροδοχου κυστης, των ωοθηκων, του πνευμονα και του νεφρου | |
ES2673125T3 (es) | Ensayo SRM/MRM para medir el nivel de la proteína receptor 2 de efrina tipo A | |
DK0991945T3 (da) | Fremgangsmåde til identifikation af tumor-antigener med antistoffer i serum | |
CN106255766B (zh) | 针对雄激素受体(ar)蛋白质的srm/mrm测定 | |
Dall'Era et al. | HSP27 and HSP70 interact with CD10 in C4‐2 prostate cancer cells | |
Taniguchi et al. | Differential expression of smooth muscle α-like actin between benign and malignant human pigment tissues |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |
|
NF4A | Restoration of lapsed right to a eurasian patent |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM BY KZ MD TJ RU |