EA200000167A1 - Способ получения циклопропилацетилена - Google Patents

Способ получения циклопропилацетилена

Info

Publication number
EA200000167A1
EA200000167A1 EA200000167A EA200000167A EA200000167A1 EA 200000167 A1 EA200000167 A1 EA 200000167A1 EA 200000167 A EA200000167 A EA 200000167A EA 200000167 A EA200000167 A EA 200000167A EA 200000167 A1 EA200000167 A1 EA 200000167A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyclopropylethylene
halogen
cyclopropylacetylene
acid
cyclopropyl
Prior art date
Application number
EA200000167A
Other languages
English (en)
Inventor
Джозеф М. Фортунак
Зхе Ванг
Дзиангуо Йин
Original Assignee
Дюпон Фармасьютикалз Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дюпон Фармасьютикалз Компани filed Critical Дюпон Фармасьютикалз Компани
Publication of EA200000167A1 publication Critical patent/EA200000167A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/02—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/04—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
    • C07C1/30—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Данное изобретение относится к новым способам синтеза циклопропилацетилена, который является существенным реагентом в асимметрическом синтезе (S)-6-хлор-4-циклопропилэтинил-4-трифторметил-1,4-дигидро-2H-3,1-бензоксазин-2-она; полезного ингибитора обратной транскриптазы вируса иммунодефицита (ВИЧ) человека. В этом способе циклопропанкарбоксальдегид конденсируется с малоновой кислотой, образуя 3-циклопропилакриловую кислоту; 3-циклопропилакриловая кислота галогенируется с образованием (E,Z)-1-галоген-2-циклопропилэтилен, и (E,Z)-1-галоген-2-циклопропилэтилен дегидрогалогенируется с образованием циклопропилацетилена. Данное усовершенствование обеспечивает высокую конверсию недорогих, легко доступных исходных материалов в циклопропилацетилен, высокие общие выходы, и способы могут проводиться в промышленном масштабе.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000167A 1997-07-31 1998-07-29 Способ получения циклопропилацетилена EA200000167A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5440297P 1997-07-31 1997-07-31
PCT/US1998/015765 WO1999006341A1 (en) 1997-07-31 1998-07-29 A process for the preparation of cyclopropylacetylene

Publications (1)

Publication Number Publication Date
EA200000167A1 true EA200000167A1 (ru) 2000-10-30

Family

ID=21990831

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000167A EA200000167A1 (ru) 1997-07-31 1998-07-29 Способ получения циклопропилацетилена

Country Status (21)

Country Link
US (2) US6049019A (ru)
EP (1) EP1000001A1 (ru)
JP (1) JP2001512091A (ru)
KR (1) KR20010022443A (ru)
CN (1) CN1265087A (ru)
AR (1) AR016572A1 (ru)
AU (1) AU734578B2 (ru)
BR (1) BR9810842A (ru)
CA (1) CA2298626A1 (ru)
EA (1) EA200000167A1 (ru)
EE (1) EE200000055A (ru)
HR (1) HRP980419A2 (ru)
HU (1) HUP0003293A2 (ru)
IL (1) IL133932A0 (ru)
NO (1) NO20000355D0 (ru)
NZ (1) NZ503035A (ru)
PL (1) PL338455A1 (ru)
SK (1) SK1022000A3 (ru)
UA (1) UA58470C2 (ru)
WO (1) WO1999006341A1 (ru)
ZA (1) ZA986885B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100350752B1 (ko) * 1998-02-06 2002-08-28 가부시키가이샤 구라레 시클로프로필아세틸렌 유도체의 제조방법
WO2000018706A1 (en) * 1998-10-01 2000-04-06 Du Pont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6288297B1 (en) * 1998-10-01 2001-09-11 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
EP1018503B1 (en) * 1999-01-07 2003-08-13 Sumitomo Chemical Company, Limited Process of producing cyclopropanecarboxylate compounds
US6610878B1 (en) 1999-05-10 2003-08-26 Eastman Chemical Company Poly(3-cyclopropyl-3-hydroxypropionate) and processes for its preparation and derivatives thereof
GB2355988A (en) * 1999-10-28 2001-05-09 Merck & Co Inc Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate
GB2355724A (en) 1999-10-28 2001-05-02 Merck & Co Inc Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid)
US6353140B1 (en) * 2000-10-19 2002-03-05 Eastman Chemical Company Process for the purification of cyclopropanecarboxaldehyde
EP3186343B1 (en) * 2014-08-28 2019-10-09 The Lubrizol Corporation Lubricating composition with seals compatibility
CN106278792B (zh) * 2016-08-10 2019-01-22 裴卿 一种环丙基乙炔的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407599A (en) * 1987-11-25 1995-04-18 Hoechst Aktiengesellschaft Cyclopropylaklyl or -alkenyl or heterocyclic compounds, process for their preparation and their use in liquid-crystalline mixtures
DE4120322A1 (de) * 1991-06-20 1992-12-24 Bayer Ag Aminomethyl-substituierte 2,3-dihydropyrano(2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
US5663467A (en) * 1995-01-23 1997-09-02 Merck & Co., Inc. Synthesis of cyclopropylacetylene
US5955627A (en) * 1996-12-16 1999-09-21 Kuraray Co., Ltd. Process for the preparation of cyclopropylacetylene derivatives
JPH11124345A (ja) * 1997-10-17 1999-05-11 Kuraray Co Ltd シクロプロピルアセチレン誘導体の製造法

Also Published As

Publication number Publication date
IL133932A0 (en) 2001-04-30
NO20000355L (no) 2000-01-24
HRP980419A2 (en) 1999-04-30
JP2001512091A (ja) 2001-08-21
WO1999006341A1 (en) 1999-02-11
HUP0003293A2 (hu) 2001-02-28
SK1022000A3 (en) 2000-09-12
NO20000355D0 (no) 2000-01-24
NZ503035A (en) 2000-10-27
AR016572A1 (es) 2001-07-25
AU734578B2 (en) 2001-06-14
US6049019A (en) 2000-04-11
AU8670998A (en) 1999-02-22
ZA986885B (en) 2000-01-31
PL338455A1 (en) 2000-11-06
EE200000055A (et) 2000-10-16
US6297410B1 (en) 2001-10-02
BR9810842A (pt) 2000-07-25
UA58470C2 (ru) 2003-08-15
CN1265087A (zh) 2000-08-30
CA2298626A1 (en) 1999-02-11
KR20010022443A (ko) 2001-03-15
EP1000001A1 (en) 2000-05-17

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