EA199900624A1 - Диазепино-индоловые ингибиторы фосфодиэстераз iv - Google Patents

Диазепино-индоловые ингибиторы фосфодиэстераз iv

Info

Publication number
EA199900624A1
EA199900624A1 EA199900624A EA199900624A EA199900624A1 EA 199900624 A1 EA199900624 A1 EA 199900624A1 EA 199900624 A EA199900624 A EA 199900624A EA 199900624 A EA199900624 A EA 199900624A EA 199900624 A1 EA199900624 A1 EA 199900624A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nr2r3
pcooh
ch2och2
nhr2
diazepine
Prior art date
Application number
EA199900624A
Other languages
English (en)
Other versions
EA002189B1 (ru
Inventor
Ив Паскаль
Анри Жакобелли
Ален Кальве
Адриан Пен
Свен Ж. Даль
Original Assignee
Парк-Дэвис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Парк-Дэвис filed Critical Парк-Дэвис
Publication of EA199900624A1 publication Critical patent/EA199900624A1/ru
Publication of EA002189B1 publication Critical patent/EA002189B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)

Abstract

Предложено применение диазепино-индола формулы (I), его рацемических форм, его изомеров и их фармацевтически приемлемых солей для приготовления лекарственного продукта, который делает возможным лечение заболеваний, подпадающих под объем терапии ингибитором фосфодиэстеразы IV.
EA199900624A 1996-03-29 1997-03-27 Применение диазепиноиндолов для приготовления лекарственного продукта, ингибирующего фосфодиэстеразу 4 EA002189B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9604013A FR2746800B1 (fr) 1996-03-29 1996-03-29 Diazepino-indoles inhibiteurs de phosphodiesterases 4
PCT/FR1997/000557 WO1997036905A1 (fr) 1996-03-29 1997-03-27 Diazepino-indoles inhibiteurs de phosphodiesterases 4

Publications (2)

Publication Number Publication Date
EA199900624A1 true EA199900624A1 (ru) 2000-06-26
EA002189B1 EA002189B1 (ru) 2002-02-28

Family

ID=9490742

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199900624A EA002189B1 (ru) 1996-03-29 1997-03-27 Применение диазепиноиндолов для приготовления лекарственного продукта, ингибирующего фосфодиэстеразу 4
EA199700346A EA001593B1 (ru) 1996-03-29 1997-03-27 Диазепино-индоловые ингибиторы фосфодиэстераз iv

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA199700346A EA001593B1 (ru) 1996-03-29 1997-03-27 Диазепино-индоловые ингибиторы фосфодиэстераз iv

Country Status (19)

Country Link
US (1) US5972927A (ru)
EP (2) EP1132390A3 (ru)
JP (1) JP2001510441A (ru)
KR (1) KR19990022100A (ru)
CN (1) CN1066149C (ru)
AT (1) ATE211141T1 (ru)
AU (1) AU735631B2 (ru)
BR (1) BR9702180A (ru)
CA (1) CA2220407A1 (ru)
DE (1) DE69709272T2 (ru)
DK (1) DK0828742T3 (ru)
EA (2) EA002189B1 (ru)
ES (1) ES2168627T3 (ru)
FR (1) FR2746800B1 (ru)
HK (1) HK1018051A1 (ru)
IL (1) IL122291A (ru)
NZ (1) NZ329532A (ru)
PT (1) PT828742E (ru)
WO (1) WO1997036905A1 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2193808A1 (en) 1999-08-21 2010-06-09 Nycomed GmbH Synergistic combination
CA2401697A1 (en) * 2000-03-03 2001-09-07 Pfizer Products Inc. Pyrazole ether derivatives as anti-inflammatory/analgesic agents
EP1161950A1 (en) * 2000-06-09 2001-12-12 Warner-Lambert Company Use of diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
KR101179012B1 (ko) 2003-03-10 2012-09-03 니코메드 게엠베하 로플루미라스트 신규한 제조 방법
CN102718665B (zh) 2003-08-29 2015-09-16 三井化学株式会社 农园艺用杀虫剂的制备中间体
AU2006224619B2 (en) 2005-03-16 2012-06-07 Takeda Gmbh Taste masked dosage form containing roflumilast
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
CA2682730A1 (en) * 2007-04-11 2008-10-23 Alcon Research, Ltd. Use of an inhibitor of tnf.alpha. plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
RU2012117141A (ru) * 2009-10-01 2013-11-10 Алькон Рисерч, Лтд. Композиции олопатадина и способы их применения
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840947A (en) * 1986-10-14 1989-06-20 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
IL122291A (en) 2000-12-06
EP1132390A2 (fr) 2001-09-12
HK1018051A1 (en) 1999-12-10
US5972927A (en) 1999-10-26
NZ329532A (en) 2000-03-27
CN1066149C (zh) 2001-05-23
IL122291A0 (en) 1998-04-05
DE69709272D1 (de) 2002-01-31
ES2168627T3 (es) 2002-06-16
CA2220407A1 (fr) 1997-10-09
FR2746800B1 (fr) 1998-06-05
EP0828742A1 (fr) 1998-03-18
DK0828742T3 (da) 2002-04-15
ATE211141T1 (de) 2002-01-15
EA002189B1 (ru) 2002-02-28
KR19990022100A (ko) 1999-03-25
CN1189832A (zh) 1998-08-05
BR9702180A (pt) 1999-12-28
WO1997036905A1 (fr) 1997-10-09
DE69709272T2 (de) 2002-08-08
EA001593B1 (ru) 2001-06-25
AU2391397A (en) 1997-10-22
AU735631B2 (en) 2001-07-12
PT828742E (pt) 2002-06-28
EP0828742B1 (fr) 2001-12-19
JP2001510441A (ja) 2001-07-31
EP1132390A3 (fr) 2001-10-10
EA199700346A1 (ru) 1998-10-29
FR2746800A1 (fr) 1997-10-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU