DE69709272D1 - Diazepino-indole als phosphodiesterase iv inhibitoren - Google Patents

Diazepino-indole als phosphodiesterase iv inhibitoren

Info

Publication number
DE69709272D1
DE69709272D1 DE69709272T DE69709272T DE69709272D1 DE 69709272 D1 DE69709272 D1 DE 69709272D1 DE 69709272 T DE69709272 T DE 69709272T DE 69709272 T DE69709272 T DE 69709272T DE 69709272 D1 DE69709272 D1 DE 69709272D1
Authority
DE
Germany
Prior art keywords
nr2r3
diazepino
pcooh
ch2och2
nhr2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69709272T
Other languages
English (en)
Other versions
DE69709272T2 (de
Inventor
Yves Pascal
Henry Jacobelli
Alain Calvet
Adrian Payne
G Dahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut de Recherche Jouveinal
Original Assignee
Institut de Recherche Jouveinal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut de Recherche Jouveinal filed Critical Institut de Recherche Jouveinal
Publication of DE69709272D1 publication Critical patent/DE69709272D1/de
Application granted granted Critical
Publication of DE69709272T2 publication Critical patent/DE69709272T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
DE69709272T 1996-03-29 1997-03-27 Diazepino-indole als phosphodiesterase iv inhibitoren Expired - Fee Related DE69709272T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9604013A FR2746800B1 (fr) 1996-03-29 1996-03-29 Diazepino-indoles inhibiteurs de phosphodiesterases 4
PCT/FR1997/000557 WO1997036905A1 (fr) 1996-03-29 1997-03-27 Diazepino-indoles inhibiteurs de phosphodiesterases 4

Publications (2)

Publication Number Publication Date
DE69709272D1 true DE69709272D1 (de) 2002-01-31
DE69709272T2 DE69709272T2 (de) 2002-08-08

Family

ID=9490742

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69709272T Expired - Fee Related DE69709272T2 (de) 1996-03-29 1997-03-27 Diazepino-indole als phosphodiesterase iv inhibitoren

Country Status (19)

Country Link
US (1) US5972927A (de)
EP (2) EP1132390A3 (de)
JP (1) JP2001510441A (de)
KR (1) KR19990022100A (de)
CN (1) CN1066149C (de)
AT (1) ATE211141T1 (de)
AU (1) AU735631B2 (de)
BR (1) BR9702180A (de)
CA (1) CA2220407A1 (de)
DE (1) DE69709272T2 (de)
DK (1) DK0828742T3 (de)
EA (2) EA001593B1 (de)
ES (1) ES2168627T3 (de)
FR (1) FR2746800B1 (de)
HK (1) HK1018051A1 (de)
IL (1) IL122291A (de)
NZ (1) NZ329532A (de)
PT (1) PT828742E (de)
WO (1) WO1997036905A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU777012B2 (en) 1999-08-21 2004-09-30 Takeda Gmbh Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
AU3217501A (en) * 2000-03-03 2001-09-12 Pfizer Prod Inc Pyrazole ether derivatives as anti-inflammatory/analgesic agents
EP1161950A1 (de) * 2000-06-09 2001-12-12 Warner-Lambert Company Verwendung von Diazepinoindolen zur Behandlung von chronisch obstruktiver Lungenkrankheiten
EP1161949A1 (de) 2000-06-09 2001-12-12 Warner-Lambert Company Verwendung von diazepinoindolen zur behandlung von chronisch obstruktiver lungenkrankheiten
US6953774B2 (en) * 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
EP1199074A1 (de) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
EP1188438A1 (de) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
PT1606261E (pt) 2003-03-10 2010-01-11 Nycomed Gmbh Novo processo para a preparação de roflumilast
CN100554249C (zh) 2003-08-29 2009-10-28 三井化学株式会社 农园艺用杀虫剂及其使用方法
CA2601250C (en) 2005-03-16 2014-10-28 Nycomed Gmbh Taste masked dosage form containing roflumilast
EP2258358A3 (de) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP2275095A3 (de) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008127975A2 (en) * 2007-04-11 2008-10-23 Alcon Research, Ltd. Use of an inhibitor of tnfa plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP5721722B2 (ja) * 2009-10-01 2015-05-20 アルコン リサーチ， リミテッド オロパタジン組成物およびその使用
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
CN117757730B (zh) * 2023-12-26 2024-06-07 浙江普罗亭健康科技有限公司 一种人心脏组织消化专用试剂盒及消化方法、检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840947A (en) * 1986-10-14 1989-06-20 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv

Also Published As

Publication number Publication date
CA2220407A1 (fr) 1997-10-09
CN1066149C (zh) 2001-05-23
PT828742E (pt) 2002-06-28
FR2746800A1 (fr) 1997-10-03
JP2001510441A (ja) 2001-07-31
DK0828742T3 (da) 2002-04-15
AU735631B2 (en) 2001-07-12
EA199900624A1 (ru) 2000-06-26
FR2746800B1 (fr) 1998-06-05
CN1189832A (zh) 1998-08-05
EA199700346A1 (ru) 1998-10-29
EP1132390A3 (de) 2001-10-10
EP0828742A1 (de) 1998-03-18
AU2391397A (en) 1997-10-22
KR19990022100A (ko) 1999-03-25
EA001593B1 (ru) 2001-06-25
HK1018051A1 (en) 1999-12-10
DE69709272T2 (de) 2002-08-08
EP1132390A2 (de) 2001-09-12
US5972927A (en) 1999-10-26
ES2168627T3 (es) 2002-06-16
EP0828742B1 (de) 2001-12-19
IL122291A (en) 2000-12-06
EA002189B1 (ru) 2002-02-28
WO1997036905A1 (fr) 1997-10-09
NZ329532A (en) 2000-03-27
ATE211141T1 (de) 2002-01-15
IL122291A0 (en) 1998-04-05
BR9702180A (pt) 1999-12-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee