EA199800861A1 - Твердая лекарственная форма, содержащая производные цизаприда, способ ее получения, продукт, содержащий твердую лекарственную форму, фармацевтическая упаковка - Google Patents
Твердая лекарственная форма, содержащая производные цизаприда, способ ее получения, продукт, содержащий твердую лекарственную форму, фармацевтическая упаковкаInfo
- Publication number
- EA199800861A1 EA199800861A1 EA199800861A EA199800861A EA199800861A1 EA 199800861 A1 EA199800861 A1 EA 199800861A1 EA 199800861 A EA199800861 A EA 199800861A EA 199800861 A EA199800861 A EA 199800861A EA 199800861 A1 EA199800861 A1 EA 199800861A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cisapride
- solid
- cyzprid
- preparation
- product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение относится к твердым лекарственным формам некоторых солей цизаприда, конкретнее - цизаприд-(L)-тартрата, цизаприд-(D)-тартрата, цизаприд сульфата, цизаприд цитрата, которые не вступают во взаимодействие с пищей и допускают одновременное назначение лекарственных средств, повышающих pH в желудке. Это изобретение в особенности относится к твердым лекарственным формам, способным быстро растворяться. Настоящее изобретение также относится к таблеткам, которые можно изготавливать путем непосредственного прессования.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96201078 | 1996-04-23 | ||
PCT/EP1997/001462 WO1997039744A1 (en) | 1996-04-23 | 1997-03-20 | Immediate release ph-independent solid dosage form of cisapride |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199800861A1 true EA199800861A1 (ru) | 1999-02-25 |
EA000804B1 EA000804B1 (ru) | 2000-04-24 |
Family
ID=8223900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199800861A EA000804B1 (ru) | 1996-04-23 | 1997-03-20 | Твердая лекарственная форма, содержащая производные цизаприда, способ ее получения, продукт, содержащий твердую лекарственную форму, фармацевтическая упаковка |
Country Status (23)
Country | Link |
---|---|
US (1) | US6030988A (ru) |
JP (1) | JPH10510559A (ru) |
KR (1) | KR100204115B1 (ru) |
CN (1) | CN1216467A (ru) |
AR (1) | AR006790A1 (ru) |
AT (1) | ATE220543T1 (ru) |
AU (1) | AU720582B2 (ru) |
BG (1) | BG102812A (ru) |
BR (1) | BR9708585A (ru) |
CA (1) | CA2201264C (ru) |
CZ (1) | CZ332598A3 (ru) |
DE (1) | DE69713948D1 (ru) |
EA (1) | EA000804B1 (ru) |
EE (1) | EE03552B1 (ru) |
ID (1) | ID16666A (ru) |
IL (1) | IL125979A0 (ru) |
NO (1) | NO984016L (ru) |
NZ (1) | NZ331705A (ru) |
PL (1) | PL328917A1 (ru) |
SK (1) | SK144698A3 (ru) |
TR (1) | TR199802139T2 (ru) |
WO (1) | WO1997039744A1 (ru) |
ZA (1) | ZA973449B (ru) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US20030138485A1 (en) * | 1998-01-14 | 2003-07-24 | Daiichi Pharmaceutical Co., Ltd. | Disintegrant |
CN1141097C (zh) * | 1998-04-20 | 2004-03-10 | 卫材株式会社 | 含有稳定化的苯并咪唑类化合物的组合物 |
TW407058B (en) * | 1998-07-17 | 2000-10-01 | Dev Center Biotechnology | Oral cisapride dosage forms with an extended duration |
US6353005B1 (en) * | 1999-03-02 | 2002-03-05 | Sepracor, Inc. | Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist |
WO2001028559A1 (fr) | 1999-10-20 | 2001-04-26 | Eisai Co., Ltd. | Procede de stabilisation de composes benzimidazoles |
GB0001621D0 (en) * | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
SE0100200D0 (sv) * | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
US6407128B1 (en) | 2001-12-03 | 2002-06-18 | Elan Pharmaceuticals, Inc. | Method for increasing the bioavailability of metaxalone |
US7714006B1 (en) | 2001-12-03 | 2010-05-11 | King Pharmaceuticals Research & Development, Inc. | Methods of modifying the bioavailability of metaxalone |
DE10164510A1 (de) * | 2001-12-20 | 2003-07-10 | Schering Ag | Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes |
EP1321142A1 (en) * | 2001-12-21 | 2003-06-25 | Novartis AG | Solid pharmaceutical composition for oral administration of Tegaserod |
HRP20020124A2 (en) * | 2002-02-11 | 2003-10-31 | Pliva D D | Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping |
GB2390541A (en) * | 2002-07-12 | 2004-01-14 | Reckitt Benckiser Healthcare | Medicinal composition comprising fibre or saccharide bulking agents |
AU2003276688A1 (en) * | 2002-09-02 | 2004-03-19 | Sun Pharmaceutical Industries Limited | Pharmaceutical composition of metaxalone with enhanced oral bioavailability |
US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
WO2005007117A2 (en) * | 2003-07-18 | 2005-01-27 | Santarus, Inc. | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
JP2006528181A (ja) * | 2003-07-18 | 2006-12-14 | サンタラス インコーポレイティッド | 酸分泌を阻害するために有用な薬学的製剤ならびにそれらを作製および使用する方法 |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
US8524736B2 (en) | 2004-01-07 | 2013-09-03 | Armetheon, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
US8138204B2 (en) * | 2004-01-07 | 2012-03-20 | Aryx Therapeutics, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
US20050249806A1 (en) * | 2004-02-10 | 2005-11-10 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory drug |
EP1742630A4 (en) * | 2004-04-16 | 2010-01-20 | Santarus Inc | COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND PROKINETIC AGENT |
US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8022053B2 (en) * | 2004-11-02 | 2011-09-20 | Bayer Schering Pharma Aktiengesellschaft | Oral solid dosage forms containing a low dose of estradiol |
EA015155B1 (ru) * | 2005-05-26 | 2011-06-30 | Тева Вуменс Хелс, Инк. | Дозированные формы для перорального применения, содержащие прогестерон, и способы их изготовления и использования |
CN1935264B (zh) * | 2005-09-23 | 2010-05-05 | 北京德众万全医药科技有限公司 | 一种用于缓控释片的含有hpmc的新型复合辅料 |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
TW200843802A (en) * | 2007-02-09 | 2008-11-16 | Drugtech Corp | Compositions for improving gastrointestinal nutrient and drug absorption |
CN104352465B (zh) * | 2014-11-17 | 2017-04-12 | 成都新恒创药业有限公司 | 一种不含二氧化硅的琥珀酸普芦卡必利药物组合物及其制备方法 |
CN109394711A (zh) * | 2018-11-06 | 2019-03-01 | 威海贯标信息科技有限公司 | 一种酒石酸西尼必利片组合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
AU4770593A (en) * | 1992-07-07 | 1994-01-31 | Sepracor, Inc. | Methods of using (+) cisapride for the treatment of gastro-esophageal reflux disease and other disorders |
AU4666393A (en) * | 1992-07-07 | 1994-01-31 | Sepracor, Inc. | Methods of using (-) cisapride for the treatment of gastro-esophageal reflux disease and other disorders |
JPH08512322A (ja) * | 1993-07-06 | 1996-12-24 | メルク エンド カンパニー インコーポレーテッド | H▲下2▼拮抗剤−胃腸運動性の薬剤組合せ物 |
DE69419492T2 (de) * | 1994-03-01 | 2000-02-03 | Gerhard Gergely | Ein Brausesystem und einen Arzneiwirkstoff enthaltendes granuläres Produkt bzw. Tablette sowie Verfahren zu deren Herstellung |
CH686865A5 (de) * | 1994-06-15 | 1996-07-31 | Gergely Gerhard | Pharmazeutische Zubereitung mit einem hydrophoben Wirkstoff und einem Brausesystem, sowie Verfahren zur Herstellung der Zubereitung. |
ZA959221B (en) * | 1994-11-02 | 1997-04-30 | Janssen Pharmaceutica Nv | Cisapride extended release |
-
1997
- 1997-03-11 DE DE69713948T patent/DE69713948D1/de not_active Expired - Lifetime
- 1997-03-11 AT AT97200715T patent/ATE220543T1/de not_active IP Right Cessation
- 1997-03-20 EE EE9800269A patent/EE03552B1/xx not_active IP Right Cessation
- 1997-03-20 WO PCT/EP1997/001462 patent/WO1997039744A1/en not_active Application Discontinuation
- 1997-03-20 BR BR9708585A patent/BR9708585A/pt not_active IP Right Cessation
- 1997-03-20 AU AU22904/97A patent/AU720582B2/en not_active Ceased
- 1997-03-20 PL PL97328917A patent/PL328917A1/xx unknown
- 1997-03-20 CZ CZ983325A patent/CZ332598A3/cs unknown
- 1997-03-20 IL IL12597997A patent/IL125979A0/xx unknown
- 1997-03-20 SK SK1446-98A patent/SK144698A3/sk unknown
- 1997-03-20 CN CN97193987A patent/CN1216467A/zh active Pending
- 1997-03-20 JP JP9537646A patent/JPH10510559A/ja active Pending
- 1997-03-20 TR TR1998/02139T patent/TR199802139T2/xx unknown
- 1997-03-20 EA EA199800861A patent/EA000804B1/ru not_active IP Right Cessation
- 1997-03-20 US US08/821,151 patent/US6030988A/en not_active Expired - Fee Related
- 1997-03-20 NZ NZ331705A patent/NZ331705A/xx unknown
- 1997-03-27 CA CA002201264A patent/CA2201264C/en not_active Expired - Fee Related
- 1997-04-08 KR KR1019970012865A patent/KR100204115B1/ko not_active IP Right Cessation
- 1997-04-22 AR ARP970101627A patent/AR006790A1/es unknown
- 1997-04-22 ZA ZA973449A patent/ZA973449B/xx unknown
- 1997-04-22 ID IDP971336A patent/ID16666A/id unknown
-
1998
- 1998-09-01 NO NO984016A patent/NO984016L/no not_active Application Discontinuation
- 1998-10-01 BG BG102812A patent/BG102812A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NZ331705A (en) | 1999-11-29 |
CZ332598A3 (cs) | 1999-01-13 |
EE03552B1 (et) | 2001-12-17 |
SK144698A3 (en) | 1999-05-07 |
DE69713948D1 (de) | 2002-08-22 |
BG102812A (en) | 1999-05-31 |
NO984016D0 (no) | 1998-09-01 |
CA2201264A1 (en) | 1997-10-23 |
ZA973449B (en) | 1998-10-22 |
NO984016L (no) | 1998-12-23 |
KR970069038A (ko) | 1997-11-07 |
EA000804B1 (ru) | 2000-04-24 |
AR006790A1 (es) | 1999-09-29 |
PL328917A1 (en) | 1999-03-01 |
JPH10510559A (ja) | 1998-10-13 |
TR199802139T2 (xx) | 1999-03-22 |
AU720582B2 (en) | 2000-06-08 |
BR9708585A (pt) | 1999-08-03 |
CN1216467A (zh) | 1999-05-12 |
US6030988A (en) | 2000-02-29 |
AU2290497A (en) | 1997-11-12 |
ATE220543T1 (de) | 2002-08-15 |
IL125979A0 (en) | 1999-04-11 |
WO1997039744A1 (en) | 1997-10-30 |
ID16666A (id) | 1997-10-30 |
KR100204115B1 (ko) | 1999-06-15 |
CA2201264C (en) | 1999-08-10 |
EE9800269A (et) | 1999-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |