EA199800377A1 - Антагонисты рецепторов возбудительной аминокислоты - Google Patents

Антагонисты рецепторов возбудительной аминокислоты

Info

Publication number
EA199800377A1
EA199800377A1 EA199800377A EA199800377A EA199800377A1 EA 199800377 A1 EA199800377 A1 EA 199800377A1 EA 199800377 A EA199800377 A EA 199800377A EA 199800377 A EA199800377 A EA 199800377A EA 199800377 A1 EA199800377 A1 EA 199800377A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptors
antagonists
amino acid
excitatory amino
modulators
Prior art date
Application number
EA199800377A
Other languages
English (en)
Other versions
EA001617B1 (ru
Inventor
Стивен М. Мэсси
Джеймс А. Монн
Мэттью Дж. Вэлли
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605434.1A external-priority patent/GB9605434D0/en
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199800377A1 publication Critical patent/EA199800377A1/ru
Publication of EA001617B1 publication Critical patent/EA001617B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Предложены соединения формулы (I), где X представляет собой O, NR, S, SO или SO, а заместитель R принимает значения, определенные в описании; а также их нетоксичные метаболитически неустойчивые сложные эфиры или амиды и их фармацевтически приемлемые соли, которые могут быть использованы в качестве модуляторов функции рецепторов метаботропного глутамата.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800377A 1995-11-16 1996-11-12 Антагонисты рецепторов возбудительной аминокислоты EA001617B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US686495P 1995-11-16 1995-11-16
GBGB9605434.1A GB9605434D0 (en) 1996-03-15 1996-03-15 Excitatory amino acid derivatives
PCT/US1996/018112 WO1997018199A1 (en) 1995-11-16 1996-11-12 Excitatory amino acid derivatives

Publications (2)

Publication Number Publication Date
EA199800377A1 true EA199800377A1 (ru) 1998-10-29
EA001617B1 EA001617B1 (ru) 2001-06-25

Family

ID=26308935

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800377A EA001617B1 (ru) 1995-11-16 1996-11-12 Антагонисты рецепторов возбудительной аминокислоты

Country Status (22)

Country Link
EP (1) EP0774461B1 (ru)
KR (1) KR19990067598A (ru)
CN (1) CN1202167A (ru)
AR (2) AR004602A1 (ru)
AT (1) ATE319685T1 (ru)
AU (1) AU703409B2 (ru)
BR (1) BR9611511A (ru)
CA (1) CA2237910C (ru)
CO (1) CO4770955A1 (ru)
CZ (1) CZ150198A3 (ru)
DE (1) DE69635886T2 (ru)
EA (1) EA001617B1 (ru)
ES (1) ES2258771T3 (ru)
HU (1) HUP9903459A3 (ru)
IL (1) IL124487A (ru)
NO (1) NO982202D0 (ru)
NZ (1) NZ323205A (ru)
PE (1) PE17798A1 (ru)
PL (1) PL326695A1 (ru)
TR (1) TR199800877T2 (ru)
WO (1) WO1997018199A1 (ru)
YU (1) YU60796A (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032436A1 (en) * 1997-01-29 1998-07-30 Eli Lilly And Company Treatment for premenstrual dysphoric disorder
US6825211B1 (en) 1997-07-18 2004-11-30 Georgetown University Bicyclic metabotropic glutamate receptor ligands
AU743899B2 (en) 1997-07-18 2002-02-07 Georgetown University Bicyclic metabotropic glutamate receptor ligands
DE19801647A1 (de) 1998-01-17 1999-07-22 Bayer Ag Substituierte beta,gamma-annellierte Lactone
DE19801636A1 (de) * 1998-01-17 1999-07-22 Bayer Ag Substituierte bicyclische Lactone
DE19801648A1 (de) * 1998-01-17 1999-07-22 Bayer Ag alpha-Substituierte Lactone
DE19801646A1 (de) * 1998-01-17 1999-07-22 Bayer Ag Substituierte alpha,beta-annellierte Butyrolactone
GB2355982A (en) * 1999-11-03 2001-05-09 Lilly Co Eli Heterocyclic amino acids
TW200833674A (en) * 2002-06-11 2008-08-16 Lilly Co Eli Prodrugs of excitatory amino acids
US8497384B2 (en) 2008-11-14 2013-07-30 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Process for the production of cyclopropane derivatives
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia
US8735397B2 (en) 2010-03-29 2014-05-27 Vanderbilt University Method for treating schizophrenia and related diseases
AU2012271024B2 (en) 2011-06-17 2015-07-09 Eli Lilly And Company Bicyclo (3.1.0) hexane- 2, 6 -dicarboxylic acid derivatives as mGlu2 receptor agonist
AR089718A1 (es) 2012-02-01 2014-09-10 Lilly Co Eli AGONISTAS DE mGlu2/3
KR20200036063A (ko) 2014-01-21 2020-04-06 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
PL3096790T3 (pl) 2014-01-21 2020-01-31 Janssen Pharmaceutica, N.V. Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2572842A (en) * 1947-08-05 1951-10-30 Du Pont The n-carboanhydride of 2-amino-4, 6, 6-trimethylheptanoic acid and polymers therefrom
US4536330A (en) * 1982-09-23 1985-08-20 International Flavors & Fragrances Inc. 1-Hydroxymethyl-2-acyl cyclopropane derivatives and esters and cyclic condensation products thereof, organoleptic uses of same and processes for preparing same
PL182285B1 (pl) * 1994-08-12 2001-12-31 Lilly Co Eli Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL
CA2195779A1 (en) * 1994-08-12 1996-02-22 David Reed Helton Composition and method for protection against drug dependency
JP3614435B2 (ja) * 1994-08-12 2005-01-26 イーライ・リリー・アンド・カンパニー 不安を処置するための組成物及び方法

Also Published As

Publication number Publication date
EP0774461B1 (en) 2006-03-08
IL124487A0 (en) 1998-12-06
AU703409B2 (en) 1999-03-25
NO982202L (no) 1998-05-14
CO4770955A1 (es) 1999-04-30
CA2237910C (en) 2005-12-27
AU7727996A (en) 1997-06-05
WO1997018199A1 (en) 1997-05-22
YU60796A (sh) 1998-12-23
HUP9903459A3 (en) 2001-08-28
PE17798A1 (es) 1998-04-18
HUP9903459A2 (hu) 2001-04-28
NZ323205A (en) 1999-06-29
DE69635886D1 (de) 2006-05-04
PL326695A1 (en) 1998-10-26
KR19990067598A (ko) 1999-08-25
CN1202167A (zh) 1998-12-16
AR006748A1 (es) 1999-09-29
EP0774461A1 (en) 1997-05-21
ATE319685T1 (de) 2006-03-15
NO982202D0 (no) 1998-05-14
ES2258771T3 (es) 2006-09-01
IL124487A (en) 2001-01-11
BR9611511A (pt) 1999-05-04
DE69635886T2 (de) 2006-10-19
CA2237910A1 (en) 1997-05-22
EA001617B1 (ru) 2001-06-25
AR004602A1 (es) 1998-12-16
TR199800877T2 (xx) 1998-09-21
CZ150198A3 (cs) 1998-10-14

Similar Documents

Publication Publication Date Title
EA199800377A1 (ru) Антагонисты рецепторов возбудительной аминокислоты
EA199901029A1 (ru) Модуляторы рецепторов возбуждающих аминокислот
EA200000391A1 (ru) Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
NO914356D0 (no) Mono n-substituerte 1,4,7,10-tetraazacyklododecan-derivater
EA199700425A1 (ru) Производные пиперазина
ES2131463B1 (es) Derivados de ciclopropilglicina con propiedades farmaceuticas.
EA200200619A1 (ru) Непептидильные ингибиторы vla-4-зависимого связывания клеток, применяемые при лечении воспалительных, аутоимунных и респираторных заболеваний
EA199800357A1 (ru) Фармацевтические ангиостатические дипептидные композиции и способы их применения
EA199800563A1 (ru) Антагонисты гормона, высвобождающего гонадотропин
EA200100194A1 (ru) КРИСТАЛЛИЧЕСКИЕ ФОРМЫ ETO2C-CH2-(R)Cgl-Aze-Pab-OH
EA199700160A1 (ru) Производные индола в качестве антагонистов eaa
HU9302007D0 (en) Method for producing pharmaceutical preparatives containing 2-|n-(2-amino-ethyl)-amino¨-acetic acid derivatives
EA199900279A1 (ru) Производные бензамида и их применение в качестве лекарственных средств с лтв4-антагонистической активностью
EA200000320A1 (ru) Изохинолины в качестве ингибиторов урокиназы
EA200000094A1 (ru) Способ получения замещенного пергидроизоиндола
SE8301008L (sv) Pyrrolacetamider med antiinflammatorisk verkan
EA199800230A1 (ru) Тетрагидрохинолины в качестве антагонистов nmda (n-метил-d-аспарагиновой кислоты)
EA199900385A1 (ru) Соединения 1-арил-2-ациламиноэтана и их применение в качестве антагонистов нейрокинина, в частности нейрокинина 1
EA199800280A1 (ru) Новые производные 5-0-дезозаминил-6-0-метилэритронолида а, способ их получения и их использование при получении биологически активных продуктов
SE9300758D0 (sv) Process for the production of clavulanic acid
EA199800380A1 (ru) Антагонисты рецептора возбуждающих аминокислот
IL109076A (en) 2-SUBSTITUTED 4,5-DIHYDROIMIDAZOLO £1,2-a| QUINOXALIN-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EA200201232A1 (ru) Производные сульфонамида
EA199700095A1 (ru) Фармацевтическая композиция для парентерального введения, содержащая индолкарбоновую кислоту
EA200201234A1 (ru) Производные сульфонамида

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU