EA199700116A1 - Трициклические бензазепины как антагонисты вазопрессина, способ их получения, фармкомпозиция на их основе и способ лечения - Google Patents
Трициклические бензазепины как антагонисты вазопрессина, способ их получения, фармкомпозиция на их основе и способ леченияInfo
- Publication number
- EA199700116A1 EA199700116A1 EA199700116A EA199700116A EA199700116A1 EA 199700116 A1 EA199700116 A1 EA 199700116A1 EA 199700116 A EA199700116 A EA 199700116A EA 199700116 A EA199700116 A EA 199700116A EA 199700116 A1 EA199700116 A1 EA 199700116A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- tricyclic
- pharmocomposition
- benzezepins
- vazopressin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Трициклическое соединение определенной в описании общей формулы I, обладающее антагонистической активностью в отношении Vи/или Vрецепторов и вазопрессин-антагонистической активностью, способы применения таких соединений в лечении заболеваний, характеризуемых избыточной почечной реабсорбцией воды, и способ получения таких соединений.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37316995A | 1995-01-17 | 1995-01-17 | |
US08/548,805 US5849735A (en) | 1995-01-17 | 1995-12-22 | Tricyclic benzazepine vasopressin antagonists |
PCT/US1996/001051 WO1996022282A1 (en) | 1995-01-17 | 1996-01-16 | Tricyclic benzazepine vasopressin antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199700116A1 true EA199700116A1 (ru) | 1997-12-30 |
EA000752B1 EA000752B1 (ru) | 2000-04-24 |
Family
ID=27006077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199700116A EA000752B1 (ru) | 1995-01-17 | 1996-01-16 | Трициклические бензазепины как антагонисты вазопрессина, способ их получения, фармкомпозиция на их основе и способ лечения |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0804420A1 (ru) |
JP (1) | JPH10512865A (ru) |
CN (1) | CN1190391A (ru) |
AR (1) | AR002459A1 (ru) |
AU (1) | AU4904296A (ru) |
BR (1) | BR9606977A (ru) |
CA (1) | CA2210688A1 (ru) |
CZ (1) | CZ224597A3 (ru) |
EA (1) | EA000752B1 (ru) |
HU (1) | HUP9801219A3 (ru) |
IL (1) | IL116777A (ru) |
NZ (1) | NZ302881A (ru) |
TW (1) | TW449584B (ru) |
WO (1) | WO1996022282A1 (ru) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5693635A (en) * | 1993-07-29 | 1997-12-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
WO1997047624A1 (en) * | 1996-06-13 | 1997-12-18 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
DK1000059T3 (da) * | 1997-07-30 | 2005-01-10 | Wyeth Corp | Tricycliske vasopressin-agonister |
US6194407B1 (en) | 1997-07-30 | 2001-02-27 | American Home Products Corporation | Tricyclic pyrido vasopressin agonists |
AR018818A1 (es) * | 1998-04-03 | 2001-12-12 | Yamano Masaki | Una composicion farmaceutica para la terapia de un edema. |
US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
US6090803A (en) * | 1998-07-24 | 2000-07-18 | American Home Products Corporation | Tricyclic vasopressin agonists |
US6297234B1 (en) | 1999-02-04 | 2001-10-02 | American Home Products Corporation | Arylthiophene vasopressin agonists |
WO2001017971A1 (fr) * | 1999-09-06 | 2001-03-15 | Takeda Chemical Industries, Ltd. | Procede de preparation de derives 2,3-dihydroazepine |
US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
US7326700B2 (en) | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7064120B2 (en) | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
CN1294134C (zh) | 2001-04-12 | 2007-01-10 | 惠氏公司 | 环己基苯基血管升压素激动剂 |
US6900200B2 (en) | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7202239B2 (en) | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
US6977254B2 (en) | 2001-04-12 | 2005-12-20 | Wyeth | Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
JP2004530668A (ja) | 2001-04-12 | 2004-10-07 | ワイス | バソプレッシンアゴニストとしてのn−ビフェニルカルボニル−およびn−フェニルピリジルカルボニル置換二および三環アゼピンおよびジアゼピン |
SE0102299D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
US8461145B2 (en) * | 2007-12-05 | 2013-06-11 | Janssen Pharmaceutica Nv | Dibenzoazepine and dibenzooxazepine TRPA1 agonists |
CL2008003749A1 (es) | 2007-12-17 | 2010-01-15 | Janssen Pharmaceutica Nv | Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras. |
AR076221A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
CA2942522A1 (en) * | 2014-03-12 | 2015-09-17 | The Trustees Of Columbia University In The City Of New York | 5,5-dioxo-11h-benzo[c][2,1]benzothiazepine derivatives and their use as mu-opioid receptor agonists |
TWI698430B (zh) * | 2015-02-13 | 2020-07-11 | 南北兄弟藥業投資有限公司 | 三環化合物及其在藥物中的應用 |
IL267276B1 (en) | 2016-12-12 | 2024-05-01 | Univ Sydney | Non-peptide oxytocin receptor agonists |
PE20201164A1 (es) | 2017-07-11 | 2020-10-28 | Vertex Pharma | Carboxamidas como moduladores de los canales de sodio |
CN115916754A (zh) | 2020-05-05 | 2023-04-04 | 纽威伦特公司 | 杂芳族大环醚化学治疗剂 |
EP4146205A4 (en) | 2020-05-05 | 2024-05-29 | Nuvalent Inc | HETEROAROMATIC MACROCYCLIC ETHER-BASED CHEMOTHERAPY AGENTS |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0450097T3 (da) * | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
US5258510A (en) * | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
ATE239726T1 (de) * | 1993-07-21 | 2003-05-15 | Yamanouchi Pharma Co Ltd | Verschmolzene benzazepinderivate und diese enthaltende pharmazeutische zubereitungen |
US5512563A (en) * | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
-
1996
- 1996-01-15 AR ARP960101027A patent/AR002459A1/es unknown
- 1996-01-16 IL IL11677796A patent/IL116777A/xx not_active IP Right Cessation
- 1996-01-16 BR BR9606977A patent/BR9606977A/pt not_active Application Discontinuation
- 1996-01-16 CZ CZ972245A patent/CZ224597A3/cs unknown
- 1996-01-16 AU AU49042/96A patent/AU4904296A/en not_active Abandoned
- 1996-01-16 TW TW085100462A patent/TW449584B/zh not_active IP Right Cessation
- 1996-01-16 WO PCT/US1996/001051 patent/WO1996022282A1/en not_active Application Discontinuation
- 1996-01-16 CA CA002210688A patent/CA2210688A1/en not_active Abandoned
- 1996-01-16 JP JP8522448A patent/JPH10512865A/ja not_active Ceased
- 1996-01-16 CN CN96192568A patent/CN1190391A/zh active Pending
- 1996-01-16 NZ NZ302881A patent/NZ302881A/xx unknown
- 1996-01-16 EP EP96905227A patent/EP0804420A1/en not_active Withdrawn
- 1996-01-16 EA EA199700116A patent/EA000752B1/ru not_active IP Right Cessation
- 1996-01-16 HU HU9801219A patent/HUP9801219A3/hu unknown
Also Published As
Publication number | Publication date |
---|---|
WO1996022282A1 (en) | 1996-07-25 |
BR9606977A (pt) | 1997-11-04 |
IL116777A (en) | 2000-11-21 |
IL116777A0 (en) | 1996-05-14 |
EA000752B1 (ru) | 2000-04-24 |
HUP9801219A2 (hu) | 1998-10-28 |
HUP9801219A3 (en) | 2000-07-28 |
CA2210688A1 (en) | 1996-07-25 |
AR002459A1 (es) | 1998-03-25 |
JPH10512865A (ja) | 1998-12-08 |
CN1190391A (zh) | 1998-08-12 |
TW449584B (en) | 2001-08-11 |
NZ302881A (en) | 1999-03-29 |
EP0804420A1 (en) | 1997-11-05 |
CZ224597A3 (en) | 1997-12-17 |
AU4904296A (en) | 1996-08-07 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ BY KZ KG TJ TM RU |