EA199600029A2 - Оральная композиция, содержащая s(+)-этодолак, способ ее получения - Google Patents

Оральная композиция, содержащая s(+)-этодолак, способ ее получения

Info

Publication number
EA199600029A2
EA199600029A2 EA199600029A EA199600029A EA199600029A2 EA 199600029 A2 EA199600029 A2 EA 199600029A2 EA 199600029 A EA199600029 A EA 199600029A EA 199600029 A EA199600029 A EA 199600029A EA 199600029 A2 EA199600029 A2 EA 199600029A2
Authority
EA
Eurasian Patent Office
Prior art keywords
etodolac
oral formulations
pharmaceutical composition
tetrahydropyrano
indole
Prior art date
Application number
EA199600029A
Other languages
English (en)
Other versions
EA199600029A3 (ru
EA000047B1 (ru
Inventor
Лесли Джордж Хамбер
Джеральд Луис Ройтер
Original Assignee
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Американ Хоум Продактс Корпорейшн filed Critical Американ Хоум Продактс Корпорейшн
Publication of EA199600029A2 publication Critical patent/EA199600029A2/ru
Publication of EA199600029A3 publication Critical patent/EA199600029A3/ru
Publication of EA000047B1 publication Critical patent/EA000047B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)

Abstract

Изобретение относится к фармацевтической композиции, используемой для профилактики и лечения людей и животных, и способу ее получения. Сущность изобретения заключается в создании фармацевтической композиции, органолептически пригодной для перорального введения, содержащей S(+)-1,8-диэтил-1,3,4,9-тетрагидропирано[3,4-b]индол-1-уксусную кислоту и кислотный компонент.
EA199600029A 1995-06-13 1996-06-11 Оральная композиция, содержащая s(+)- этодолак, и способ ее получения EA000047B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17195P 1995-06-13 1995-06-13

Publications (3)

Publication Number Publication Date
EA199600029A2 true EA199600029A2 (ru) 1996-12-30
EA199600029A3 EA199600029A3 (ru) 1997-03-31
EA000047B1 EA000047B1 (ru) 1998-04-30

Family

ID=21690247

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199600029A EA000047B1 (ru) 1995-06-13 1996-06-11 Оральная композиция, содержащая s(+)- этодолак, и способ ее получения

Country Status (26)

Country Link
US (1) US5958445A (ru)
EP (1) EP0748628A3 (ru)
JP (1) JPH093071A (ru)
KR (1) KR970000228A (ru)
CN (1) CN1152434A (ru)
AR (1) AR003435A1 (ru)
AU (1) AU711853B2 (ru)
BR (1) BR9602758A (ru)
CA (1) CA2178686A1 (ru)
CO (1) CO4700456A1 (ru)
CZ (1) CZ170296A3 (ru)
EA (1) EA000047B1 (ru)
EE (1) EE9600067A (ru)
HU (1) HUP9601635A3 (ru)
IL (1) IL118636A (ru)
IN (1) IN182040B (ru)
MA (1) MA23907A1 (ru)
NO (1) NO962491L (ru)
NZ (1) NZ286791A (ru)
PE (1) PE10898A1 (ru)
PL (1) PL314732A1 (ru)
SG (1) SG46737A1 (ru)
SK (1) SK74396A3 (ru)
SV (1) SV1996000051A (ru)
TR (1) TR199600499A2 (ru)
ZA (1) ZA964928B (ru)

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EP0974366B1 (en) 1997-03-28 2006-10-18 Eisai Co., Ltd. Oral pharmaceutical preparations decreased in bitterness by masking
AU6589200A (en) * 1999-09-10 2001-04-17 Ranbaxy Laboratories Limited Extended release formulation of etodolac
WO2001021178A2 (en) * 1999-09-22 2001-03-29 Akzo Nobel, N.V. Method of treating cognitive dysfunction syndrome in dogs and chewable tablet for dogs
KR100416242B1 (ko) * 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
DE60139379D1 (de) * 2000-03-01 2009-09-10 Eisai R&D Man Co Ltd Schnellzerfallende polyvinylhaltige tablette
US6514537B1 (en) 2000-06-02 2003-02-04 Cumberland Swan Holdings, Inc. Magnesium citrate solution
ES2265439T3 (es) * 2000-08-18 2007-02-16 Pharmacia Corporation Formulacion oral de valdecoxib que se desintegra rapidamente.
CN1638739A (zh) * 2000-08-18 2005-07-13 法玛西雅厄普约翰美国公司 治疗成瘾性障碍的化合物
HUP0400098A2 (hu) * 2001-02-27 2004-04-28 Ranbaxy Laboratories Limited Gyorsan kioldódó ciklooxigenáz-2 enzimgátló hatóanyagot tartalmazó tabletták és eljárás az előállításukra
KR20040058189A (ko) * 2001-09-26 2004-07-03 파마시아 코포레이션 관능상 허용가능한 경구내 붕해 조성물
US20040137052A1 (en) * 2001-12-25 2004-07-15 Yoshihiro Uchiyama Acid-containing preparations
US20040037869A1 (en) 2002-08-16 2004-02-26 Douglas Cleverly Non-animal product containing veterinary formulations
US20040151759A1 (en) * 2002-08-16 2004-08-05 Douglas Cleverly Non-animal product containing veterinary formulations
TWI366442B (en) 2003-07-30 2012-06-21 Novartis Ag Palatable ductile chewable veterinary composition
GB0320854D0 (en) * 2003-09-05 2003-10-08 Arrow No 7 Ltd Buccal drug delivery
ES2372959T3 (es) * 2004-01-29 2012-01-30 Medrx Co., Ltd. Analgésico anti-inflamatorio para uso externo.
EP1744757A4 (en) * 2004-05-04 2009-04-22 Equitech Corp IMPROVED ENHANCED COMPOSITION
BRPI0602825A2 (pt) * 2006-06-23 2012-04-24 Rhodia Br Ltda formulação de pó efervescente auto-refrigerante para bebidas e uso de formulação em pó efervescente
US20090258823A1 (en) * 2006-12-08 2009-10-15 George Caroline L S Composition and methods for the prevention and treatment of gastrointestinal infections
HUE041514T2 (hu) 2012-02-06 2019-05-28 Merial Inc Szisztémásan ható hatóanyagokat tartalmazó, parazitaellenes, szájon át adagolt állatgyógyászati készítmények, eljárások és alkalmazásuk
JP6088637B2 (ja) 2012-04-04 2017-03-01 インターベット インターナショナル ベー． フェー． イソオキサゾリン化合物のための固形経口医薬組成物
WO2013169218A1 (en) * 2012-05-08 2013-11-14 Mahmut Bilgic Pharmaceutical compositions of s-etodolac

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US2260148A (en) * 1939-06-19 1941-10-21 Frank H Fleer Corp Chewing gum material
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
US3939178A (en) * 1971-06-01 1976-02-17 American Home Products Corporation Certain pyrano [3,4-b]indoles and thiopyrano[3,4-b]indoles
GB1548022A (en) * 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
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Also Published As

Publication number Publication date
IL118636A0 (en) 1996-10-16
HU9601635D0 (en) 1996-08-28
EP0748628A3 (en) 1997-04-23
ZA964928B (en) 1997-12-10
KR970000228A (ko) 1997-01-21
EP0748628A2 (en) 1996-12-18
NO962491D0 (no) 1996-06-12
HUP9601635A3 (en) 2000-06-28
CA2178686A1 (en) 1996-12-14
TR199600499A2 (tr) 1996-12-21
SK74396A3 (en) 1997-04-09
US5958445A (en) 1999-09-28
SV1996000051A (es) 1997-02-17
EA199600029A3 (ru) 1997-03-31
JPH093071A (ja) 1997-01-07
EE9600067A (et) 1996-12-16
MA23907A1 (fr) 1996-12-31
CN1152434A (zh) 1997-06-25
CZ170296A3 (en) 1997-04-16
AU5588096A (en) 1997-01-02
CO4700456A1 (es) 1998-12-29
AU711853B2 (en) 1999-10-21
NO962491L (no) 1996-12-16
AR003435A1 (es) 1998-08-05
NZ286791A (en) 1998-01-26
PE10898A1 (es) 1998-03-20
PL314732A1 (en) 1996-12-23
BR9602758A (pt) 1998-04-22
EA000047B1 (ru) 1998-04-30
IN182040B (ru) 1998-12-12
HUP9601635A2 (en) 1997-04-28
SG46737A1 (en) 1998-02-20
IL118636A (en) 2000-02-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY MD RU