EA039630B1 - N-замещенные индольные производные - Google Patents

N-замещенные индольные производные Download PDF

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Publication number
EA039630B1
EA039630B1 EA201992679A EA201992679A EA039630B1 EA 039630 B1 EA039630 B1 EA 039630B1 EA 201992679 A EA201992679 A EA 201992679A EA 201992679 A EA201992679 A EA 201992679A EA 039630 B1 EA039630 B1 EA 039630B1
Authority
EA
Eurasian Patent Office
Prior art keywords
cancer
pharmaceutically acceptable
acceptable salt
compound according
treatment
Prior art date
Application number
EA201992679A
Other languages
English (en)
Russian (ru)
Other versions
EA201992679A1 (ru
Inventor
Хайнц Фретц
Изабелла Лиотье
Жюльен Потье
Сильвия Рихард-Бильдштайн
Тьерри Сифферлен
Original Assignee
Идорсия Фармасьютиклз Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Идорсия Фармасьютиклз Лтд filed Critical Идорсия Фармасьютиклз Лтд
Publication of EA201992679A1 publication Critical patent/EA201992679A1/ru
Publication of EA039630B1 publication Critical patent/EA039630B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201992679A 2017-05-18 2018-05-17 N-замещенные индольные производные EA039630B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017062008 2017-05-18
PCT/EP2018/062865 WO2018210995A1 (en) 2017-05-18 2018-05-17 N-substituted indole derivatives

Publications (2)

Publication Number Publication Date
EA201992679A1 EA201992679A1 (ru) 2020-05-06
EA039630B1 true EA039630B1 (ru) 2022-02-18

Family

ID=62186481

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992679A EA039630B1 (ru) 2017-05-18 2018-05-17 N-замещенные индольные производные

Country Status (32)

Country Link
US (2) US20200069686A1 (https=)
EP (1) EP3625224B1 (https=)
JP (1) JP7065117B2 (https=)
KR (1) KR102650756B1 (https=)
CN (1) CN110621666A (https=)
AR (1) AR111806A1 (https=)
AU (1) AU2018269667B2 (https=)
BR (1) BR112019024114A2 (https=)
CA (1) CA3063637A1 (https=)
CL (1) CL2019003257A1 (https=)
CO (1) CO2019010804A2 (https=)
CR (1) CR20190567A (https=)
CY (1) CY1124528T1 (https=)
DK (1) DK3625224T3 (https=)
EA (1) EA039630B1 (https=)
ES (1) ES2894124T3 (https=)
HR (1) HRP20211532T1 (https=)
HU (1) HUE056406T2 (https=)
IL (1) IL270616B (https=)
LT (1) LT3625224T (https=)
MA (1) MA49127B1 (https=)
MX (1) MX394108B (https=)
PE (1) PE20191787A1 (https=)
PH (1) PH12019502562B1 (https=)
PL (1) PL3625224T3 (https=)
PT (1) PT3625224T (https=)
RS (1) RS62441B1 (https=)
SG (1) SG11201908660RA (https=)
SI (1) SI3625224T1 (https=)
TW (1) TWI768043B (https=)
UA (1) UA124748C2 (https=)
WO (1) WO2018210995A1 (https=)

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US11839613B2 (en) 2017-05-18 2023-12-12 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
PE20191814A1 (es) 2017-05-18 2019-12-27 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
TW201900179A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 作為pge2受體調節劑之苯并呋喃及苯并噻吩衍生物
KR102612140B1 (ko) 2017-05-18 2023-12-08 이도르시아 파마슈티컬스 리미티드 피리미딘 유도체
WO2021060281A1 (ja) * 2019-09-24 2021-04-01 Ａｇｃ株式会社 プロスタグランジンｅ２レセプターｅｐ２／ｅｐ４デュアルアンタゴニスト
CN115697317A (zh) * 2020-04-08 2023-02-03 株式会社AskAt Ep4受体拮抗剂用于治疗肝癌、黑色素瘤、淋巴瘤和白血病的应用
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor
WO2025229177A1 (en) 2024-05-02 2025-11-06 Idorsia Pharmaceuticals Ltd Crystalline forms of an n-substituted indole derivative

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Publication number Priority date Publication date Assignee Title
EP1661896A1 (en) * 2003-08-26 2006-05-31 Teijin Pharma Limited Pyrrolopyrimidinethione derivative
EP2014657A1 (de) * 2007-06-21 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Diaminopyrimidine als Modulatoren des EP2-Rezeptors
WO2012127032A1 (en) * 2011-03-24 2012-09-27 Chemilia Ab Novel pyrimidine derivatives

Also Published As

Publication number Publication date
AR111806A1 (es) 2019-08-21
PL3625224T3 (pl) 2022-01-10
MX2019013639A (es) 2020-01-21
WO2018210995A1 (en) 2018-11-22
PH12019502562B1 (en) 2024-06-14
US20200069686A1 (en) 2020-03-05
US20230165859A1 (en) 2023-06-01
SI3625224T1 (sl) 2021-11-30
PH12019502562A1 (en) 2020-07-20
LT3625224T (lt) 2021-10-25
ES2894124T3 (es) 2022-02-11
TW201900637A (zh) 2019-01-01
MA49127A (fr) 2021-05-26
SG11201908660RA (en) 2019-10-30
TWI768043B (zh) 2022-06-21
EA201992679A1 (ru) 2020-05-06
MA49127B1 (fr) 2022-05-31
RS62441B1 (sr) 2021-11-30
CO2019010804A2 (es) 2019-10-09
KR102650756B1 (ko) 2024-03-22
IL270616B (en) 2022-01-01
HRP20211532T1 (hr) 2022-01-07
CR20190567A (es) 2020-02-10
PE20191787A1 (es) 2019-12-24
EP3625224A1 (en) 2020-03-25
PT3625224T (pt) 2021-10-06
EP3625224B1 (en) 2021-08-04
JP7065117B2 (ja) 2022-05-11
HUE056406T2 (hu) 2022-02-28
BR112019024114A2 (pt) 2020-06-02
CL2019003257A1 (es) 2020-03-27
CN110621666A (zh) 2019-12-27
CA3063637A1 (en) 2018-11-22
UA124748C2 (uk) 2021-11-10
MX394108B (es) 2025-03-21
JP2020520359A (ja) 2020-07-09
KR20200006589A (ko) 2020-01-20
AU2018269667B2 (en) 2022-02-03
CY1124528T1 (el) 2022-07-22
AU2018269667A1 (en) 2019-10-24
DK3625224T3 (da) 2021-11-08

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