EA038301B1 - Антитела, которые эффективно нейтрализуют вирус гепатита в, и их применение - Google Patents
Антитела, которые эффективно нейтрализуют вирус гепатита в, и их применение Download PDFInfo
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- EA038301B1 EA038301B1 EA201890874A EA201890874A EA038301B1 EA 038301 B1 EA038301 B1 EA 038301B1 EA 201890874 A EA201890874 A EA 201890874A EA 201890874 A EA201890874 A EA 201890874A EA 038301 B1 EA038301 B1 EA 038301B1
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- antibody
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- 238000000844 transformation Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
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- 230000014616 translation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 108010045269 tryptophyltryptophan Proteins 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 230000006648 viral gene expression Effects 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000009265 virologic response Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2015/001970 WO2017059878A1 (en) | 2015-10-07 | 2015-10-07 | Antibodies that potently neutralize hepatitis b virus and uses thereof |
| PCT/EP2016/074114 WO2017060504A1 (en) | 2015-10-07 | 2016-10-07 | Antibodies that potently neutralize hepatitis b virus and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201890874A1 EA201890874A1 (ru) | 2018-11-30 |
| EA038301B1 true EA038301B1 (ru) | 2021-08-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890874A EA038301B1 (ru) | 2015-10-07 | 2016-10-07 | Антитела, которые эффективно нейтрализуют вирус гепатита в, и их применение |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10683344B2 (OSRAM) |
| EP (2) | EP3359564B1 (OSRAM) |
| JP (4) | JP6869968B2 (OSRAM) |
| KR (1) | KR102725168B1 (OSRAM) |
| CN (3) | CN108137675B (OSRAM) |
| AU (1) | AU2016334735B2 (OSRAM) |
| BR (1) | BR112018002406A2 (OSRAM) |
| CA (1) | CA2993745A1 (OSRAM) |
| CY (1) | CY1123462T1 (OSRAM) |
| DK (1) | DK3359564T3 (OSRAM) |
| EA (1) | EA038301B1 (OSRAM) |
| ES (1) | ES2813927T3 (OSRAM) |
| HR (1) | HRP20201345T1 (OSRAM) |
| HU (1) | HUE050231T2 (OSRAM) |
| IL (1) | IL258326B (OSRAM) |
| LT (1) | LT3359564T (OSRAM) |
| MX (1) | MX2018004127A (OSRAM) |
| MY (1) | MY187161A (OSRAM) |
| PH (1) | PH12018500199A1 (OSRAM) |
| PL (1) | PL3359564T3 (OSRAM) |
| PT (1) | PT3359564T (OSRAM) |
| SI (1) | SI3359564T1 (OSRAM) |
| WO (2) | WO2017059878A1 (OSRAM) |
| ZA (1) | ZA201800710B (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017059878A1 (en) * | 2015-10-07 | 2017-04-13 | Humabs Biomed Sa | Antibodies that potently neutralize hepatitis b virus and uses thereof |
| ES2985391T3 (es) | 2018-05-10 | 2024-11-05 | Melbourne Health | Métodos y composiciones para el tratamiento de la infección por hepatitis B |
| EP3793603A4 (en) * | 2018-05-16 | 2022-01-26 | Chang Gung Memorial Hospital, Linkou | Novel leucine-rich repeat neuronal protein 1 (lrrn1) antibodies and uses thereof |
| CN112165974B (zh) | 2018-05-31 | 2024-11-08 | 诺华股份有限公司 | 乙型肝炎抗体 |
| WO2020117715A1 (en) | 2018-12-03 | 2020-06-11 | Board Of Regents, The University Of Texas System | Oligo-benzamide analogs and their use in cancer treatment |
| EP4292659A3 (en) * | 2018-12-19 | 2024-03-20 | Humabs Biomed SA | Antibodies that neutralize hepatitis b virus and uses thereof |
| HRP20231338T1 (hr) * | 2018-12-20 | 2024-02-16 | Vir Biotechnology, Inc. | Kombinirana terapija hbv |
| KR102084912B1 (ko) * | 2019-01-17 | 2020-03-05 | 주식회사 녹십자 | B형 간염 바이러스 표면 항원의 입체 에피토프 및 이에 특이적으로 결합하는 항체 |
| CN114174332A (zh) * | 2019-07-20 | 2022-03-11 | 华辉安健（北京）生物科技有限公司 | 通过使用抗pre-S1 HBV抗体治疗HBV感染的方法 |
| US20220380441A1 (en) * | 2019-08-29 | 2022-12-01 | Vir Biotechnology, Inc. | Antibody compositions and methods for treating hepatitis b virus infection |
| CN113717283B (zh) * | 2020-05-25 | 2023-05-26 | 厦门万泰凯瑞生物技术有限公司 | 一种抗乙型肝炎病毒e抗原的单克隆抗体及其应用 |
| IL298302A (en) * | 2020-06-08 | 2023-01-01 | Hoffmann La Roche | Anti-hbv antibodies and methods of use |
| US20210403908A1 (en) * | 2020-06-22 | 2021-12-30 | Janssen Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis d virus infection |
| IL299201A (en) * | 2020-06-24 | 2023-02-01 | Vir Biotechnology Inc | Transgenic hepatitis B virus neutralizing antibodies and their uses |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| JP2024504167A (ja) | 2021-01-26 | 2024-01-30 | ヴィア・バイオテクノロジー・インコーポレイテッド | Ｂ型肝炎ウイルス感染を処置するための抗体組成物および方法 |
| CN113234144B (zh) * | 2021-05-26 | 2022-02-25 | 武汉工程大学 | 一种人源性抗乙肝表面抗原的单链抗体、制剂、编码基因、载体质粒及宿主细胞 |
| WO2023287352A2 (en) * | 2021-07-15 | 2023-01-19 | National University Of Singapore | Anti-hbv antibodies and uses thereof |
| CN113777312B (zh) * | 2021-09-03 | 2024-02-02 | 普十生物科技(北京)有限公司 | 乙肝抗体片段的制备方法、乙肝抗体片段、试剂盒及应用 |
| US20240391979A1 (en) * | 2021-09-13 | 2024-11-28 | Achelois Biopharma, Inc. | Hepatitis b virus antivirus (hbv-antivirus) compositions and methods of use |
| KR20240125969A (ko) * | 2021-12-21 | 2024-08-20 | 에이치비브이테크, 엘엘씨. | B형 간염 바이러스 cccdna 및 rcdna의 제거 방법 및 이의 방법에서 사용된 b형 간염 약물 |
| WO2023230439A1 (en) | 2022-05-23 | 2023-11-30 | Vir Biotechnology, Inc. | Fc-engineered hepatitis b virus neutralizing antibodies and uses thereof |
| CN116162153B (zh) * | 2022-09-01 | 2024-09-10 | 复旦大学附属中山医院 | 一种乙肝病毒表面抗原的单克隆抗体及其应用 |
| CN118725092B (zh) * | 2023-03-28 | 2025-08-12 | 东莞市朋志生物科技有限公司 | 抗HBs-Ag抗体、检测HBs-Ag的试剂和试剂盒 |
| US20240400650A1 (en) * | 2023-05-31 | 2024-12-05 | Bluejay Therapeutics, Inc. | Anti-HBsAg antibody for treatment of chronic hepatitis D |
| CN119143869A (zh) * | 2023-06-16 | 2024-12-17 | 复旦大学 | 乙肝病毒表面抗体及其应用 |
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| WO2015107126A1 (en) * | 2014-01-16 | 2015-07-23 | Mondelli Mario Umberto Francesco | Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen |
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-
2015
- 2015-10-07 WO PCT/EP2015/001970 patent/WO2017059878A1/en not_active Ceased
-
2016
- 2016-10-07 CN CN201680055161.8A patent/CN108137675B/zh active Active
- 2016-10-07 CN CN202210187026.6A patent/CN114539392B/zh active Active
- 2016-10-07 WO PCT/EP2016/074114 patent/WO2017060504A1/en not_active Ceased
- 2016-10-07 PL PL16779075T patent/PL3359564T3/pl unknown
- 2016-10-07 US US15/766,703 patent/US10683344B2/en active Active
- 2016-10-07 HR HRP20201345TT patent/HRP20201345T1/hr unknown
- 2016-10-07 EA EA201890874A patent/EA038301B1/ru unknown
- 2016-10-07 JP JP2018514962A patent/JP6869968B2/ja active Active
- 2016-10-07 LT LTEP16779075.7T patent/LT3359564T/lt unknown
- 2016-10-07 BR BR112018002406-6A patent/BR112018002406A2/pt not_active Application Discontinuation
- 2016-10-07 MX MX2018004127A patent/MX2018004127A/es unknown
- 2016-10-07 HU HUE16779075A patent/HUE050231T2/hu unknown
- 2016-10-07 CA CA2993745A patent/CA2993745A1/en active Pending
- 2016-10-07 KR KR1020187012979A patent/KR102725168B1/ko active Active
- 2016-10-07 DK DK16779075.7T patent/DK3359564T3/da active
- 2016-10-07 EP EP16779075.7A patent/EP3359564B1/en active Active
- 2016-10-07 EP EP20177206.8A patent/EP3753949A1/en active Pending
- 2016-10-07 SI SI201630896T patent/SI3359564T1/sl unknown
- 2016-10-07 AU AU2016334735A patent/AU2016334735B2/en active Active
- 2016-10-07 CN CN202210185497.3A patent/CN114539391A/zh active Pending
- 2016-10-07 ES ES16779075T patent/ES2813927T3/es active Active
- 2016-10-07 PT PT167790757T patent/PT3359564T/pt unknown
- 2016-10-07 MY MYPI2018700678A patent/MY187161A/en unknown
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2018
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2020
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2021
- 2021-04-14 JP JP2021068062A patent/JP7171809B2/ja active Active
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2022
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- 2022-11-02 JP JP2022175909A patent/JP2023011809A/ja not_active Withdrawn
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2024
- 2024-05-01 JP JP2024074160A patent/JP2024097078A/ja active Pending
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