EA037448B1 - Способ доставки в легкие терапевтической мрнк с pei и фармацевтическая композиция - Google Patents
Способ доставки в легкие терапевтической мрнк с pei и фармацевтическая композиция Download PDFInfo
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- EA037448B1 EA037448B1 EA201401337A EA201401337A EA037448B1 EA 037448 B1 EA037448 B1 EA 037448B1 EA 201401337 A EA201401337 A EA 201401337A EA 201401337 A EA201401337 A EA 201401337A EA 037448 B1 EA037448 B1 EA 037448B1
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- Prior art keywords
- mrna
- pei
- pharmaceutical composition
- lungs
- lung
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| EP2338520A1 (de) | 2009-12-21 | 2011-06-29 | Ludwig Maximilians Universität | Konjugat mit Zielfindungsligand und dessen Verwendung |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
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| US20140206753A1 (en) | 2011-06-08 | 2014-07-24 | Shire Human Genetic Therapies, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| CA2904151C (en) | 2013-03-14 | 2023-09-12 | Shire Human Genetic Therapies, Inc. | Cftr mrna compositions and related methods and uses |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| BR112016009014B1 (pt) | 2013-10-22 | 2024-02-06 | Translate Bio, Inc | USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE |
| WO2015061491A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
| RS60902B1 (sr) | 2014-03-09 | 2020-11-30 | Univ Pennsylvania | Kompozicije korisne u lečenju nedostatka ornitinske transkarbamilaze (otc) |
| MX373952B (es) | 2014-04-25 | 2020-07-13 | Shire Human Genetic Therapies | Métodos de purificación de arn mensajero. |
| WO2016090262A1 (en) | 2014-12-05 | 2016-06-09 | Shire Human Genetic Therapies, Inc. | Messenger rna therapy for treatment of articular disease |
| EP3256487A4 (en) | 2015-02-09 | 2018-07-18 | Duke University | Compositions and methods for epigenome editing |
| WO2016176191A1 (en) | 2015-04-27 | 2016-11-03 | The Trustees Of The University Of Pennsylvania | Dual aav vector system for crispr/cas9 mediated correction of human disease |
| AU2016287436B2 (en) | 2015-06-30 | 2022-02-17 | Ethris Gmbh | UTRs increasing the translation efficiency of RNA molecules |
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| ES2826203T3 (es) | 2021-05-17 |
| AU2013273504B2 (en) | 2017-12-07 |
| DK2858677T3 (da) | 2020-08-31 |
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| EP3800254A1 (en) | 2021-04-07 |
| BR112014029807A2 (pt) | 2017-06-27 |
| US20150126589A1 (en) | 2015-05-07 |
| JP6208750B2 (ja) | 2017-10-04 |
| KR102087643B1 (ko) | 2020-03-11 |
| KR20190045403A (ko) | 2019-05-02 |
| IN2014DN09744A (enExample) | 2015-07-31 |
| WO2013182683A1 (en) | 2013-12-12 |
| EA201401337A1 (ru) | 2015-05-29 |
| ZA201408184B (en) | 2015-10-28 |
| JP2015518874A (ja) | 2015-07-06 |
| CN104349794A (zh) | 2015-02-11 |
| AU2013273504A1 (en) | 2014-11-27 |
| EP2858677B1 (en) | 2020-08-05 |
| CN104349794B (zh) | 2019-01-04 |
| KR20150020288A (ko) | 2015-02-25 |
| CA2873274C (en) | 2021-06-01 |
| HK1209340A1 (en) | 2016-04-01 |
| CA2873274A1 (en) | 2013-12-12 |
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