EA037448B1 - Способ доставки в легкие терапевтической мрнк с pei и фармацевтическая композиция - Google Patents
Способ доставки в легкие терапевтической мрнк с pei и фармацевтическая композиция Download PDFInfo
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- EA037448B1 EA037448B1 EA201401337A EA201401337A EA037448B1 EA 037448 B1 EA037448 B1 EA 037448B1 EA 201401337 A EA201401337 A EA 201401337A EA 201401337 A EA201401337 A EA 201401337A EA 037448 B1 EA037448 B1 EA 037448B1
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- Prior art keywords
- mrna
- pei
- pharmaceutical composition
- lungs
- lung
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| EP2338520A1 (de) | 2009-12-21 | 2011-06-29 | Ludwig Maximilians Universität | Konjugat mit Zielfindungsligand und dessen Verwendung |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| EP4108671B1 (en) | 2010-10-01 | 2024-11-20 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| WO2012116715A1 (en) * | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
| EP3138577A1 (en) * | 2011-03-02 | 2017-03-08 | CureVac AG | Vaccination in elderly patients |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| PT2717893T (pt) | 2011-06-08 | 2019-08-20 | Translate Bio Inc | Composições de nanopartículas lipídicas e métodos para transferência de arnm |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PL3682905T3 (pl) | 2011-10-03 | 2022-04-04 | Modernatx, Inc. | Modyfikowane nukleozydy, nukleotydy i kwasy nukleinowe oraz ich zastosowania |
| PL2791160T3 (pl) | 2011-12-16 | 2022-06-20 | Modernatx, Inc. | Kompozycje zmodyfikowanego mrna |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF |
| RS63237B1 (sr) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminalno modifikovana rnk |
| ES2689523T3 (es) * | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Composiciones a base de ARNM del gen CFTR y métodos y usos relacionados |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| EA201690590A1 (ru) | 2013-10-22 | 2016-12-30 | Шир Хьюман Дженетик Терапис, Инк. | ТЕРАПИЯ НЕДОСТАТОЧНОСТИ АРГИНИНОСУКЦИНАТ-СИНТЕТАЗЫ С ПОМОЩЬЮ мРНК |
| CN105658242A (zh) | 2013-10-22 | 2016-06-08 | 夏尔人类遗传性治疗公司 | 用于苯丙酮尿症的mrna疗法 |
| HUE051311T2 (hu) | 2014-03-09 | 2021-03-01 | Univ Pennsylvania | Ornitin transzkarbamiláz (TC) deficiencia kezelésében alkalmas készítmények |
| CN110511927A (zh) | 2014-04-25 | 2019-11-29 | 川斯勒佰尔公司 | 信使rna的纯化方法 |
| JP6767976B2 (ja) | 2014-12-05 | 2020-10-14 | トランスレイト バイオ， インコーポレイテッド | 関節疾患の治療のためのメッセンジャーｒｎａ治療法 |
| EP3256487A4 (en) | 2015-02-09 | 2018-07-18 | Duke University | Compositions and methods for epigenome editing |
| EP3288594B1 (en) | 2015-04-27 | 2022-06-29 | The Trustees of The University of Pennsylvania | Dual aav vector system for crispr/cas9 mediated correction of human disease |
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| AU2013273504B2 (en) | 2017-12-07 |
| BR112014029807A2 (pt) | 2017-06-27 |
| ZA201408184B (en) | 2015-10-28 |
| JP2015518874A (ja) | 2015-07-06 |
| CN104349794A (zh) | 2015-02-11 |
| EP2858677A1 (en) | 2015-04-15 |
| EP2858677B1 (en) | 2020-08-05 |
| ES2826203T3 (es) | 2021-05-17 |
| EA201401337A1 (ru) | 2015-05-29 |
| JP6208750B2 (ja) | 2017-10-04 |
| KR20150020288A (ko) | 2015-02-25 |
| DK2858677T3 (da) | 2020-08-31 |
| IN2014DN09744A (enExample) | 2015-07-31 |
| CN104349794B (zh) | 2019-01-04 |
| HK1209340A1 (en) | 2016-04-01 |
| US20150126589A1 (en) | 2015-05-07 |
| KR102087643B1 (ko) | 2020-03-11 |
| CA2873274C (en) | 2021-06-01 |
| CA2873274A1 (en) | 2013-12-12 |
| EP3800254A1 (en) | 2021-04-07 |
| WO2013182683A1 (en) | 2013-12-12 |
| KR20190045403A (ko) | 2019-05-02 |
| AU2013273504A1 (en) | 2014-11-27 |
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