EA035761B1 - Композиция для получения лиофильных форм наночастиц и способ получения лиофильных форм наночастиц - Google Patents
Композиция для получения лиофильных форм наночастиц и способ получения лиофильных форм наночастиц Download PDFInfo
- Publication number
- EA035761B1 EA035761B1 EA201890367A EA201890367A EA035761B1 EA 035761 B1 EA035761 B1 EA 035761B1 EA 201890367 A EA201890367 A EA 201890367A EA 201890367 A EA201890367 A EA 201890367A EA 035761 B1 EA035761 B1 EA 035761B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- cyclodextrin
- composition
- nucleic acid
- dextrin
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 294
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 177
- 238000000034 method Methods 0.000 title claims description 84
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- 150000001875 compounds Chemical class 0.000 claims abstract description 157
- -1 saccharide compound Chemical class 0.000 claims abstract description 104
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 97
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 96
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 96
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- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims abstract description 9
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| CN113679689B (zh) * | 2015-07-22 | 2023-09-01 | 日东电工株式会社 | 用于纳米粒冷冻干燥物形式的组合物及方法 |
| US20210069121A1 (en) | 2017-12-12 | 2021-03-11 | Lead Biotherapeutics Ltd | Solid lipid nanoparticle for intracellular release of active substances and method for production the same |
| CN108813619A (zh) * | 2018-07-19 | 2018-11-16 | 广州市汉廷食品有限公司 | 一种无公害食品添加剂及其制备工艺 |
| US20210322575A1 (en) | 2018-09-28 | 2021-10-21 | Nutcracker Therapeutics, Inc. | Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery |
| EP4365289A3 (en) * | 2018-11-16 | 2024-07-10 | Nitto Denko Corporation | Rna interference delivery formulation and methods for malignant tumors |
| WO2021060440A1 (ja) * | 2019-09-26 | 2021-04-01 | 日油株式会社 | 脂質ナノ粒子の凍結乾燥組成物 |
| CA3173554A1 (en) * | 2020-02-28 | 2021-09-02 | Microcures, Inc. | Fidgetin-like 2 as a target to enhance wound healing |
| KR20230005244A (ko) * | 2020-04-20 | 2023-01-09 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 생물학적 활성 건조 분말 조성물 및 이의 제조 및 사용 방법 |
| US12178921B2 (en) | 2020-08-14 | 2024-12-31 | Arcturus Therapeutics, Inc. | Method of lyophilizing lipid nanoparticles |
| US12458605B2 (en) | 2020-10-02 | 2025-11-04 | National University Corporation Hokkaido University | Lipid nanoparticle |
| EP4416287A1 (en) | 2021-10-14 | 2024-08-21 | Hemoshear Therapeutics, Inc. | Compositions and methods of treating diseases associated with bile acid transporter |
| EP4426271B1 (en) * | 2021-11-02 | 2025-07-23 | Ziphius Nv | Lipid nanoparticles for oligonucleotide delivery |
| KR102712873B1 (ko) * | 2021-12-20 | 2024-10-04 | 고려자연식품(주) | 과일향기 포집을 위한 나노 지질 전달체 제조와 분말화 방법 |
| CN116643056B (zh) * | 2022-02-15 | 2025-02-18 | 厦门万泰凯瑞生物技术有限公司 | 促甲状腺激素受体复合物、试剂盒、制备方法和用途 |
| JP2025515480A (ja) * | 2022-04-28 | 2025-05-15 | カンザス、ステート、ユニバーシティ、リサーチ、ファウンデーション | 封じ込める両親媒性ペプチドコロイド |
| US20240254485A1 (en) | 2023-01-13 | 2024-08-01 | Hemoshear Therapeutics, Inc. | Sirnas targeting slc10a1 transcripts, compositions and uses thereof |
| EP4743061A1 (en) * | 2023-07-13 | 2026-05-20 | Comanche Biopharma Corp. | Formulations of nucleic acid compounds and uses thereof |
| CN121909225A (zh) | 2023-09-27 | 2026-04-21 | 日油株式会社 | 用于核酸溶液的稳定剂 |
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