EA034992B1 - Комбинации лекарственных средств для лечения множественной миеломы - Google Patents

Комбинации лекарственных средств для лечения множественной миеломы Download PDF

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Publication number
EA034992B1
EA034992B1 EA201790312A EA201790312A EA034992B1 EA 034992 B1 EA034992 B1 EA 034992B1 EA 201790312 A EA201790312 A EA 201790312A EA 201790312 A EA201790312 A EA 201790312A EA 034992 B1 EA034992 B1 EA 034992B1
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Eurasian Patent Office
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compound
administered
inclusive
cancer
combination
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EA201790312A
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English (en)
Russian (ru)
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EA201790312A1 (ru
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Дана Т. Афтаб
Питер Лэмб
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Экселиксис, Инк.
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Publication of EA201790312A1 publication Critical patent/EA201790312A1/ru
Publication of EA034992B1 publication Critical patent/EA034992B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201790312A 2014-08-05 2015-08-05 Комбинации лекарственных средств для лечения множественной миеломы EA034992B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462033386P 2014-08-05 2014-08-05
PCT/US2015/043825 WO2016022697A1 (en) 2014-08-05 2015-08-05 Drug combinations to treat multiple myeloma

Publications (2)

Publication Number Publication Date
EA201790312A1 EA201790312A1 (ru) 2017-06-30
EA034992B1 true EA034992B1 (ru) 2020-04-15

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EA201790312A EA034992B1 (ru) 2014-08-05 2015-08-05 Комбинации лекарственных средств для лечения множественной миеломы

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US (1) US11065240B2 (cg-RX-API-DMAC7.html)
EP (1) EP3177311B1 (cg-RX-API-DMAC7.html)
JP (2) JP6892381B2 (cg-RX-API-DMAC7.html)
KR (1) KR102634247B1 (cg-RX-API-DMAC7.html)
CN (1) CN106573042A (cg-RX-API-DMAC7.html)
AU (1) AU2015301097B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017002318A2 (cg-RX-API-DMAC7.html)
CA (1) CA2957466C (cg-RX-API-DMAC7.html)
EA (1) EA034992B1 (cg-RX-API-DMAC7.html)
MA (1) MA40457A (cg-RX-API-DMAC7.html)
MX (1) MX382904B (cg-RX-API-DMAC7.html)
UA (1) UA121482C2 (cg-RX-API-DMAC7.html)
WO (1) WO2016022697A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
EA201790312A1 (ru) 2017-06-30
UA121482C2 (uk) 2020-06-10
BR112017002318A2 (pt) 2018-07-17
EP3177311A1 (en) 2017-06-14
JP2020002179A (ja) 2020-01-09
MA40457A (fr) 2017-06-14
JP2017526662A (ja) 2017-09-14
AU2015301097A1 (en) 2017-03-02
MX382904B (es) 2025-03-13
AU2015301097B2 (en) 2021-03-04
MX2017001490A (es) 2017-05-11
CA2957466C (en) 2023-10-17
KR20170031786A (ko) 2017-03-21
CA2957466A1 (en) 2016-02-11
KR102634247B1 (ko) 2024-02-05
CN106573042A (zh) 2017-04-19
WO2016022697A1 (en) 2016-02-11
US11065240B2 (en) 2021-07-20
JP6892381B2 (ja) 2021-06-23
EP3177311B1 (en) 2024-10-30
EP3177311C0 (en) 2024-10-30
US20170224672A1 (en) 2017-08-10

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