EA033357B1 - Способ создания персонализированного ген-активированного имплантата для регенерации костной ткани - Google Patents
Способ создания персонализированного ген-активированного имплантата для регенерации костной тканиInfo
- Publication number
- EA033357B1 EA033357B1 EA201600607A EA201600607A EA033357B1 EA 033357 B1 EA033357 B1 EA 033357B1 EA 201600607 A EA201600607 A EA 201600607A EA 201600607 A EA201600607 A EA 201600607A EA 033357 B1 EA033357 B1 EA 033357B1
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- Eurasian Patent Office
- Prior art keywords
- bone
- biocompatible carrier
- implant
- creating
- computed tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Botany (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
Abstract
Изобретение относится к медицине, а именно к созданию остеопластических материалов, эффективных в замещении протяженных (объемных) костных дефектов. Разработанный способ получения персонализированного ген-активированного имплантата для замещения костных дефектов у млекопитающего предусматривает проведение компьютерной томографии области костной пластики, моделирование на основании данных компьютерной томографии костного дефекта, трехмерную печать формы для изготовления биосовместимого носителя или самого биосовместимого носителя, при этом в биосовместимый носитель добавляют генетические конструкции, содержащие гены, кодирующие белки VEGF и SDF, и получают имплантат, который изготовлен таким образом, что после имплантации в область реципиентного ложа диастаз между введенным материалом и костными стенками не превышает 1 мм на всем протяжении. Полученное таким способом медицинское изделие может составить эффективную альтернативу костным аутотрансплантатам.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2015104291/15A RU2597786C2 (ru) | 2015-02-10 | 2015-02-10 | Способ создания персонализированного ген-активированного имплантата для регенерации костной ткани |
PCT/RU2015/000667 WO2016130041A1 (ru) | 2015-02-10 | 2015-10-13 | Способ создания персонализированного ген-активированного имплантата для регенерации костной ткани |
Publications (2)
Publication Number | Publication Date |
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EA201600607A1 EA201600607A1 (ru) | 2016-12-30 |
EA033357B1 true EA033357B1 (ru) | 2019-10-31 |
Family
ID=56614923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201600607A EA033357B1 (ru) | 2015-02-10 | 2015-10-13 | Способ создания персонализированного ген-активированного имплантата для регенерации костной ткани |
Country Status (11)
Country | Link |
---|---|
US (1) | US11406739B2 (ru) |
EP (1) | EP3130342B1 (ru) |
JP (1) | JP6631924B2 (ru) |
CN (1) | CN106488771B (ru) |
BR (1) | BR112016027050B1 (ru) |
CA (1) | CA2946389A1 (ru) |
EA (1) | EA033357B1 (ru) |
ES (1) | ES2714782T3 (ru) |
MX (1) | MX2016016081A (ru) |
RU (1) | RU2597786C2 (ru) |
WO (1) | WO2016130041A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7098611B2 (ja) * | 2017-06-16 | 2022-07-11 | 株式会社ジーシー | 第八リン酸カルシウム成形体の製造方法 |
RU2683852C1 (ru) * | 2018-01-22 | 2019-04-02 | Общество с ограниченной ответственностью "Северо-Кавказское медицинское малое инновационное предприятие" | Способ расчета объема костнозамещающего материала при планировании операции направленной регенерации костной ткани |
RU2688699C1 (ru) * | 2018-01-22 | 2019-05-22 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СтГМУ Минздрава России) | Способ планирования операции синус-лифтинг |
RU2696204C1 (ru) * | 2018-04-26 | 2019-07-31 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СтГМУ Минздрава России) | Способ расчёта площади барьерных и каркасных мембран при планировании направленной регенерации костной ткани |
RU2726398C2 (ru) * | 2018-08-08 | 2020-07-13 | Федеральное государственное учреждение "Федеральный научно-исследовательский центр "Кристаллография и фотоника" Российской академии наук" (ФНИЦ "Кристаллография и фотоника" РАН) | Способ изготовления имплантата позвонка анатомической формы из костного материала, совместимого с иммунной системой больного |
US11090412B2 (en) | 2018-12-21 | 2021-08-17 | Zavation Medical Products Llc | Bone repair composition and kit |
RU2766978C1 (ru) * | 2021-01-13 | 2022-03-16 | Общество с ограниченной ответственностью "Медлайн Компани" | Многокомпонентный остеогенный трансплантат для хирургического устранения врождённых и приобретённых дефектов кости челюстей |
RU2764373C1 (ru) * | 2021-03-29 | 2022-01-17 | Федеральное государственное бюджетное военное образовательное учреждение высшего образования "Военно-медицинская академия имени С.М. Кирова" Министерства обороны Российской Федерации (ВМедА) | Способ применения ген-активированного материала при несращениях длинных костей |
CN116271222B (zh) * | 2023-03-28 | 2023-12-01 | 广东医科大学 | 一种骨组织工程支架及其制备方法和应用 |
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AU768641B2 (en) * | 1998-10-12 | 2003-12-18 | Massachusetts Institute Of Technology | Composites for tissue regeneration and methods of manufacture thereof |
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WO2010148229A1 (en) * | 2009-06-17 | 2010-12-23 | The Trustees Of Columbia University In The City Of New York | Tooth scaffolds |
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2015
- 2015-02-10 RU RU2015104291/15A patent/RU2597786C2/ru active
- 2015-10-13 EP EP15882179.3A patent/EP3130342B1/en active Active
- 2015-10-13 MX MX2016016081A patent/MX2016016081A/es active IP Right Grant
- 2015-10-13 BR BR112016027050-9A patent/BR112016027050B1/pt active IP Right Grant
- 2015-10-13 ES ES15882179T patent/ES2714782T3/es active Active
- 2015-10-13 WO PCT/RU2015/000667 patent/WO2016130041A1/ru active Application Filing
- 2015-10-13 JP JP2016560916A patent/JP6631924B2/ja active Active
- 2015-10-13 CA CA2946389A patent/CA2946389A1/en active Pending
- 2015-10-13 CN CN201580024656.XA patent/CN106488771B/zh active Active
- 2015-10-13 EA EA201600607A patent/EA033357B1/ru active IP Right Revival
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2017
- 2017-04-06 US US15/480,698 patent/US11406739B2/en active Active
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US20140011162A1 (en) * | 2012-07-06 | 2014-01-09 | Peter John Zegarelli | Oral appliance for delivery of medicaments and\or other substances |
Non-Patent Citations (2)
Title |
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BOZO I.IA. et al. Lokalnaia gennaia terapiia v kostnoi rekonstruktsii. Materialy 1-go Natsionalnogo Kongressa po regenerativnoi meditsine. M., "MEDI Ekspo", 4-6 December 2013 goda, p.30. Naideno iz Internet: URL: http://www.mediexpo.ru/fileadmin/user_upload/content/pdf/thesis/thesis_nkrm13.pdf, p.30 * |
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Also Published As
Publication number | Publication date |
---|---|
MX2016016081A (es) | 2017-03-10 |
CN106488771B (zh) | 2019-12-17 |
CN106488771A (zh) | 2017-03-08 |
EP3130342A1 (en) | 2017-02-15 |
EA201600607A1 (ru) | 2016-12-30 |
JP2018505701A (ja) | 2018-03-01 |
US11406739B2 (en) | 2022-08-09 |
WO2016130041A1 (ru) | 2016-08-18 |
JP6631924B2 (ja) | 2020-01-15 |
US20170209626A1 (en) | 2017-07-27 |
ES2714782T3 (es) | 2019-05-30 |
RU2015104291A (ru) | 2016-08-27 |
EP3130342A4 (en) | 2017-04-12 |
EP3130342B1 (en) | 2018-12-12 |
CA2946389A1 (en) | 2016-08-18 |
BR112016027050A2 (pt) | 2019-11-12 |
RU2597786C2 (ru) | 2016-09-20 |
BR112016027050B1 (pt) | 2021-01-19 |
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