EA030741B1 - Адъювантное соединение - Google Patents

Адъювантное соединение Download PDF

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Publication number
EA030741B1
EA030741B1 EA201490709A EA201490709A EA030741B1 EA 030741 B1 EA030741 B1 EA 030741B1 EA 201490709 A EA201490709 A EA 201490709A EA 201490709 A EA201490709 A EA 201490709A EA 030741 B1 EA030741 B1 EA 030741B1
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EA
Eurasian Patent Office
Prior art keywords
leu
ser
lys
antigen
glu
Prior art date
Application number
EA201490709A
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English (en)
Russian (ru)
Other versions
EA201490709A1 (ru
Inventor
Фердинанд Антониус Осендорп
Корнелис Йоханнес Мария Мелиф
Селина Кан
Дмитрий Викторович Филиппов
Гейсберт Ари Ван Дер Марел
Original Assignee
АйЭсЭй ФАРМАСЬЮТИКАЛЗ Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by АйЭсЭй ФАРМАСЬЮТИКАЛЗ Б.В. filed Critical АйЭсЭй ФАРМАСЬЮТИКАЛЗ Б.В.
Publication of EA201490709A1 publication Critical patent/EA201490709A1/ru
Publication of EA030741B1 publication Critical patent/EA030741B1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
EA201490709A 2011-10-05 2012-10-04 Адъювантное соединение EA030741B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161543510P 2011-10-05 2011-10-05
NL2007536A NL2007536C2 (en) 2011-10-05 2011-10-05 Adjuvant compound.
US201261615566P 2012-03-26 2012-03-26
PCT/NL2012/050694 WO2013051936A1 (en) 2011-10-05 2012-10-04 Adjuvant compound

Publications (2)

Publication Number Publication Date
EA201490709A1 EA201490709A1 (ru) 2014-09-30
EA030741B1 true EA030741B1 (ru) 2018-09-28

Family

ID=48043964

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490709A EA030741B1 (ru) 2011-10-05 2012-10-04 Адъювантное соединение

Country Status (16)

Country Link
US (2) US9314521B2 (OSRAM)
EP (1) EP2763697B9 (OSRAM)
JP (1) JP6099210B2 (OSRAM)
KR (1) KR102053699B1 (OSRAM)
CN (1) CN104244976B (OSRAM)
AU (1) AU2012319265B2 (OSRAM)
BR (1) BR112014008214B1 (OSRAM)
CA (1) CA2886631C (OSRAM)
EA (1) EA030741B1 (OSRAM)
ES (1) ES2952644T3 (OSRAM)
IL (1) IL231951B (OSRAM)
IN (1) IN2014DN03325A (OSRAM)
MX (1) MX356028B (OSRAM)
NL (1) NL2007536C2 (OSRAM)
SG (1) SG11201401291XA (OSRAM)
WO (1) WO2013051936A1 (OSRAM)

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AU2014234314B2 (en) 2013-03-21 2018-02-15 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
SG11201506804VA (en) 2013-03-21 2015-09-29 Sanofi Aventis Deutschland Synthesis of hydantoin containing peptide products
AU2014300503B2 (en) 2013-06-28 2018-11-22 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process
JP6780852B2 (ja) 2014-06-02 2020-11-04 アイエスエー ファーマシューティカルズ ビー.ヴイ.ISA Pharmaceuticals B.V. B型肝炎ウイルス感染に対する治療ワクチン接種のための合成長鎖ペプチド(slp)
RU2017126206A (ru) 2014-12-23 2019-01-25 Маргарет Анне БРИМБЛЕ Аминокислотные и пептидные конъюгаты и направления их использования
PE20230343A1 (es) 2015-12-11 2023-03-01 Immatics Biotechnologies Gmbh Peptidos que estimulan respuestas inmunitarias antitumorales
GB201521894D0 (en) * 2015-12-11 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against various cancers
KR20180128915A (ko) 2016-02-26 2018-12-04 오클랜드 유니서비시즈 리미티드 아미노산 및 펩티드 접합체 및 접합 방법
WO2017220463A1 (en) 2016-06-20 2017-12-28 Isa Pharmaceuticals B.V. Formulation of a peptide vaccine
WO2018009916A1 (en) 2016-07-07 2018-01-11 The Board Of Trustees Of The Leland Stanford Junior University Antibody adjuvant conjugates
EP3606551A1 (en) 2017-04-04 2020-02-12 Avidea Technologies, Inc. Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response
WO2019122050A1 (en) 2017-12-22 2019-06-27 Isa Pharmaceuticals B.V. Methods of immunization
AU2020241686A1 (en) 2019-03-15 2021-11-04 Bolt Biotherapeutics, Inc. Immunoconjugates targeting HER2
CN115003685A (zh) 2019-12-07 2022-09-02 Isa制药有限公司 乙型肝炎病毒相关疾病的治疗
WO2021156404A2 (en) 2020-02-07 2021-08-12 Isa Pharmaceuticals Treatment of hpv-related diseases
EP4138876A1 (en) 2020-04-23 2023-03-01 ISA Pharmaceuticals B.V. Immunization against sars-cov-related diseases
CA3223357A1 (en) 2021-07-12 2023-01-19 Brigitte Elisa Anna Burm Improved substance quantification in complex mixtures
WO2024068636A1 (en) 2022-09-27 2024-04-04 Isa Pharmaceuticals B.V. Adjuvanted immunogenic peptides for intradermal administration
EP4601685A1 (en) 2022-10-13 2025-08-20 Isabella Pharma B.V. Modified long peptides suitable for use in immunisation
WO2024149888A1 (en) 2023-01-12 2024-07-18 Isa Pharmaceuticals B.V. Improved lipopeptide quantification
WO2025008085A1 (en) 2023-07-05 2025-01-09 Isa Pharmaceuticals B.V. Immunotherapy for the treatment of prame-expressing cancers

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0431327A1 (de) * 1989-11-10 1991-06-12 Hoechst Aktiengesellschaft Synthetische Vakzine zur spezifischen Induktion zytotoxischer T-Lymphozyten

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Also Published As

Publication number Publication date
NL2007536C2 (en) 2013-04-08
MX356028B (es) 2018-05-09
CN104244976A (zh) 2014-12-24
CN104244976B (zh) 2017-05-31
IL231951A0 (en) 2014-05-28
EP2763697C0 (en) 2023-06-07
SG11201401291XA (en) 2014-05-29
KR102053699B1 (ko) 2019-12-09
US9314521B2 (en) 2016-04-19
AU2012319265A1 (en) 2014-05-22
EA201490709A1 (ru) 2014-09-30
ES2952644T3 (es) 2023-11-02
EP2763697B1 (en) 2023-06-07
EP2763697A1 (en) 2014-08-13
WO2013051936A9 (en) 2013-09-12
US20160250325A1 (en) 2016-09-01
AU2012319265B2 (en) 2016-10-13
WO2013051936A1 (en) 2013-04-11
MX2014004114A (es) 2014-10-17
NZ623869A (en) 2015-11-27
US9770506B2 (en) 2017-09-26
JP2014530808A (ja) 2014-11-20
EP2763697B9 (en) 2023-10-04
US20150104473A1 (en) 2015-04-16
KR20140093673A (ko) 2014-07-28
BR112014008214B1 (pt) 2022-07-05
IL231951B (en) 2019-08-29
JP6099210B2 (ja) 2017-03-22
BR112014008214A2 (pt) 2017-06-13
IN2014DN03325A (OSRAM) 2015-06-26
CA2886631C (en) 2019-06-11
EP2763697B8 (en) 2023-07-12
CA2886631A1 (en) 2013-04-11

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ