IN2014DN03325A - - Google Patents
Info
- Publication number
- IN2014DN03325A IN2014DN03325A IN3325DEN2014A IN2014DN03325A IN 2014DN03325 A IN2014DN03325 A IN 2014DN03325A IN 3325DEN2014 A IN3325DEN2014 A IN 3325DEN2014A IN 2014DN03325 A IN2014DN03325 A IN 2014DN03325A
- Authority
- IN
- India
- Prior art keywords
- compound
- directed
- composition
- sulphur
- selene
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical group NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 abstract 1
- 241000791876 Selene Species 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
The invention is directed to a compound according to the formula [1] wherein R 1 and R2 are branched or straight groups having up to 17 atoms selected from carbon, nitrogen, oxygen and sulphur, n is 0 to and including 18, Y is sulphur or selene, X is S or 0 and R is -OH or an organic group comprising one or more peptides, one or more nucleic acids, one or more antibodies or combinations thereof. The invention is also directed to process for preparing said compound and the use of said compound as an adjuvant. The invention is also directed to a composition comprising said compound and the use of said composition, for example as a vaccine composition.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161543510P | 2011-10-05 | 2011-10-05 | |
| NL2007536A NL2007536C2 (en) | 2011-10-05 | 2011-10-05 | Adjuvant compound. |
| US201261615566P | 2012-03-26 | 2012-03-26 | |
| PCT/NL2012/050694 WO2013051936A1 (en) | 2011-10-05 | 2012-10-04 | Adjuvant compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN03325A true IN2014DN03325A (en) | 2015-06-26 |
Family
ID=48043964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3325DEN2014 IN2014DN03325A (en) | 2011-10-05 | 2012-10-04 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9314521B2 (en) |
| EP (1) | EP2763697B9 (en) |
| JP (1) | JP6099210B2 (en) |
| KR (1) | KR102053699B1 (en) |
| CN (1) | CN104244976B (en) |
| AU (1) | AU2012319265B2 (en) |
| BR (1) | BR112014008214B1 (en) |
| CA (1) | CA2886631C (en) |
| EA (1) | EA030741B1 (en) |
| ES (1) | ES2952644T3 (en) |
| IL (1) | IL231951B (en) |
| IN (1) | IN2014DN03325A (en) |
| MX (1) | MX356028B (en) |
| NL (1) | NL2007536C2 (en) |
| SG (1) | SG11201401291XA (en) |
| WO (1) | WO2013051936A1 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2976325B1 (en) | 2013-03-21 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Synthesis of cyclic imide containing peptide products |
| HK1219477A1 (en) | 2013-03-21 | 2017-04-07 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| CN105555756B (en) | 2013-06-28 | 2018-12-07 | 奥克兰联合服务有限公司 | Amino acid conjugates and peptide conjugates and methods of conjugation |
| CA2950863C (en) | 2014-06-02 | 2023-01-17 | Isa Pharmaceuticals B.V. | Synthetic long peptides (slp) for therapeutic vaccination against hepatitis b virus infection |
| KR20170094449A (en) | 2014-12-23 | 2017-08-17 | 마가렛 앤 브림블 | Amino acid and peptide conjugates and uses thereof |
| HK1255541A1 (en) | 2015-12-11 | 2019-08-23 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
| GB201521894D0 (en) * | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
| BR112018017174A2 (en) | 2016-02-26 | 2019-01-02 | Auckland Uniservices Ltd | amino acid and peptide conjugates and conjugation process |
| AU2017281389B2 (en) | 2016-06-20 | 2024-02-22 | Isa Pharmaceuticals B.V. | Formulation of a peptide vaccine |
| WO2018009916A1 (en) | 2016-07-07 | 2018-01-11 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody adjuvant conjugates |
| AU2018250226B2 (en) | 2017-04-04 | 2025-04-24 | Barinthus Biotherapeutics North America, Inc. | Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response |
| WO2019122050A1 (en) | 2017-12-22 | 2019-06-27 | Isa Pharmaceuticals B.V. | Methods of immunization |
| CA3130794A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| CN115003685A (en) | 2019-12-07 | 2022-09-02 | Isa制药有限公司 | Treatment of hepatitis B virus related diseases |
| US20230087422A1 (en) | 2020-02-07 | 2023-03-23 | Isa Pharmaceuticals B.V. | Treatment of hpv-related diseases |
| WO2021214297A1 (en) | 2020-04-23 | 2021-10-28 | Isa Pharmaceuticals B.V. | Immunization against sars-cov-related diseases |
| KR20240029765A (en) | 2021-07-12 | 2024-03-06 | 아이에스에이 파마슈티컬즈 비.브이. | Improved substance quantification in complex mixtures |
| WO2024068636A1 (en) | 2022-09-27 | 2024-04-04 | Isa Pharmaceuticals B.V. | Adjuvanted immunogenic peptides for intradermal administration |
| EP4601685A1 (en) | 2022-10-13 | 2025-08-20 | Isabella Pharma B.V. | Modified long peptides suitable for use in immunisation |
| WO2024149888A1 (en) | 2023-01-12 | 2024-07-18 | Isa Pharmaceuticals B.V. | Improved lipopeptide quantification |
| WO2025008085A1 (en) | 2023-07-05 | 2025-01-09 | Isa Pharmaceuticals B.V. | Immunotherapy for the treatment of prame-expressing cancers |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0114787B1 (en) * | 1983-01-25 | 1991-09-25 | Ciba-Geigy Ag | Peptide derivatives |
| DE3937412A1 (en) * | 1989-11-10 | 1991-05-16 | Hoechst Ag | SYNTHETIC VACCINE FOR THE SPECIFIC INDUCTION OF CYTOTOXIC T-LYMPHOZYTES |
| US6024964A (en) * | 1985-06-24 | 2000-02-15 | Hoechst Aktiengesellschaft | Membrane anchor/active compound conjugate, its preparation and its uses |
| US5804381A (en) | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
| US6686447B1 (en) | 1999-06-30 | 2004-02-03 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6504010B1 (en) | 1999-06-30 | 2003-01-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20030211510A1 (en) | 1999-06-30 | 2003-11-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| JP2004500029A (en) | 1999-06-30 | 2004-01-08 | コリクサ コーポレイション | Compositions and methods for treatment and diagnosis of lung cancer |
| NL1012739C2 (en) | 1999-07-29 | 2001-01-30 | Maasland Nv | Feeding device, in particular for supplying concentrates. |
| JP2004525115A (en) | 2000-12-08 | 2004-08-19 | アカデミス ツィーケンホイス ライデン | Long peptide consisting of 22 to 45 amino acid residues for inducing and / or enhancing an antigen-specific immune response |
| MXNL04000056A (en) | 2004-06-30 | 2006-01-11 | Mario Alberto Aguilera Rico | Steel-soil constructive system. |
| AU2007284656A1 (en) * | 2006-08-14 | 2008-02-21 | Thymon, L.L.C. | Compositions and methods for the treatment and prophylaxis of multiple strains and subtypes of HIV-1 |
| CN106220721B (en) | 2007-03-26 | 2020-04-07 | 莱顿大学医学中心附属莱顿教学医院 | PRAME derived peptides and immunogenic compositions comprising the same |
| ES2406077T3 (en) | 2007-05-31 | 2013-06-05 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | P53 peptide vaccine |
| EP3584251A3 (en) | 2007-05-31 | 2020-01-29 | Academisch Ziekenhuis Leiden h.o.d.n. LUMC | Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines |
| KR100900837B1 (en) * | 2007-12-07 | 2009-06-04 | (주)두비엘 | Potent vaccine composition comprising lipopeptides and poly (I: C) as adjuvant |
| AU2011232421B2 (en) * | 2010-03-23 | 2015-08-13 | Novartis Ag | Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc. |
-
2011
- 2011-10-05 NL NL2007536A patent/NL2007536C2/en active
-
2012
- 2012-10-04 CN CN201280059738.4A patent/CN104244976B/en active Active
- 2012-10-04 EP EP12780309.6A patent/EP2763697B9/en active Active
- 2012-10-04 WO PCT/NL2012/050694 patent/WO2013051936A1/en active Application Filing
- 2012-10-04 MX MX2014004114A patent/MX356028B/en active IP Right Grant
- 2012-10-04 KR KR1020147012025A patent/KR102053699B1/en active Active
- 2012-10-04 CA CA2886631A patent/CA2886631C/en active Active
- 2012-10-04 US US14/349,652 patent/US9314521B2/en active Active
- 2012-10-04 BR BR112014008214-6A patent/BR112014008214B1/en active IP Right Grant
- 2012-10-04 AU AU2012319265A patent/AU2012319265B2/en active Active
- 2012-10-04 JP JP2014534504A patent/JP6099210B2/en active Active
- 2012-10-04 IN IN3325DEN2014 patent/IN2014DN03325A/en unknown
- 2012-10-04 EA EA201490709A patent/EA030741B1/en not_active IP Right Cessation
- 2012-10-04 SG SG11201401291XA patent/SG11201401291XA/en unknown
- 2012-10-04 ES ES12780309T patent/ES2952644T3/en active Active
-
2014
- 2014-04-03 IL IL231951A patent/IL231951B/en active IP Right Grant
-
2016
- 2016-03-07 US US15/062,589 patent/US9770506B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014008214B1 (en) | 2022-07-05 |
| AU2012319265A1 (en) | 2014-05-22 |
| EP2763697B9 (en) | 2023-10-04 |
| IL231951A0 (en) | 2014-05-28 |
| MX2014004114A (en) | 2014-10-17 |
| JP6099210B2 (en) | 2017-03-22 |
| ES2952644T3 (en) | 2023-11-02 |
| EP2763697C0 (en) | 2023-06-07 |
| WO2013051936A1 (en) | 2013-04-11 |
| CA2886631A1 (en) | 2013-04-11 |
| KR102053699B1 (en) | 2019-12-09 |
| CN104244976A (en) | 2014-12-24 |
| WO2013051936A9 (en) | 2013-09-12 |
| EA030741B1 (en) | 2018-09-28 |
| US20150104473A1 (en) | 2015-04-16 |
| JP2014530808A (en) | 2014-11-20 |
| CA2886631C (en) | 2019-06-11 |
| MX356028B (en) | 2018-05-09 |
| NL2007536C2 (en) | 2013-04-08 |
| KR20140093673A (en) | 2014-07-28 |
| EP2763697B1 (en) | 2023-06-07 |
| SG11201401291XA (en) | 2014-05-29 |
| US9314521B2 (en) | 2016-04-19 |
| BR112014008214A2 (en) | 2017-06-13 |
| NZ623869A (en) | 2015-11-27 |
| EP2763697A1 (en) | 2014-08-13 |
| AU2012319265B2 (en) | 2016-10-13 |
| US20160250325A1 (en) | 2016-09-01 |
| EP2763697B8 (en) | 2023-07-12 |
| CN104244976B (en) | 2017-05-31 |
| EA201490709A1 (en) | 2014-09-30 |
| US9770506B2 (en) | 2017-09-26 |
| IL231951B (en) | 2019-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014DN03325A (en) | ||
| WO2016077464A8 (en) | Amino acid derivatives and their uses | |
| MY200083A (en) | Cyclic dinucleotide compounds | |
| BR112012007411A2 (en) | compound, process for its preparation and pharmaceutical composition containing the same | |
| TR201900128T4 (en) | Cyclosporine analog molecules modified at amino acid 1 and 3. | |
| MX2010007587A (en) | Compounds comprising a cyclobutoxy group. | |
| PH12012501918A1 (en) | Process for preparation of dopo-derived compounds and compositions thereof | |
| MX2012002502A (en) | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids. | |
| BR112013020996A2 (en) | substituted aminobutyric derivatives as neprilysin inhibitors | |
| MY150596A (en) | Hsp90 inhibitors | |
| PH12012502352A1 (en) | Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application | |
| JO2910B1 (en) | Organic Compounds | |
| BR112015008037A2 (en) | compounds, process for preparing a compound, pharmaceutical composition, use of the compound, method for treating cancer and invention | |
| MX2011007952A (en) | Novel tricyanoborates. | |
| MX2013000295A (en) | Process of preparing a thrombin specific inhibitor. | |
| MX352607B (en) | Process for preparing benzoxaboroles. | |
| BR112013001132A2 (en) | process for preparation of antiviral compounds | |
| PH12013500694A1 (en) | Process for manufacturing dihydropteridinones and intermediates thereof | |
| MY167638A (en) | Treatment composition for textile goods | |
| WO2009137444A3 (en) | Cure accelerators for anaerobic curable compositions | |
| NZ704155A (en) | Method for preparing creatine fatty esters, creatine fatty esters thus prepared and uses thereof | |
| MY164880A (en) | Process for the preparation of isoxazolyl-methoxy-nicotinic acids | |
| MX2013003387A (en) | Process for the preparation of a reaction product of a cyclic urea and a multifunctional aldehyde. | |
| UY32975A (en) | AMINOPIRIDINE DERIVATIVES | |
| EA201390170A1 (en) | COMPOSITIONS |