EA030005B1 - Композиции и способы лечения грибковых и бактериальных патогенов - Google Patents

Композиции и способы лечения грибковых и бактериальных патогенов Download PDF

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Publication number
EA030005B1
EA030005B1 EA201591808A EA201591808A EA030005B1 EA 030005 B1 EA030005 B1 EA 030005B1 EA 201591808 A EA201591808 A EA 201591808A EA 201591808 A EA201591808 A EA 201591808A EA 030005 B1 EA030005 B1 EA 030005B1
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EA
Eurasian Patent Office
Prior art keywords
thb
polypeptide
sequence
amino acid
azp
Prior art date
Application number
EA201591808A
Other languages
English (en)
Russian (ru)
Other versions
EA201591808A1 (ru
Inventor
Ашраф С. Ибрагим
Майкл Р. Йиман
Скотт Дж. Филлер
Джон Е. Джр. Эдвардс
Джон П. Джр. Хеннеси
Original Assignee
Лос-Анджелес Биомедикал Ресерч Институт Эт Харбор-Укла Медикал Центер
Новадигм Терапьютикс, Инк.
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Publication of EA201591808A1 publication Critical patent/EA201591808A1/ru
Publication of EA030005B1 publication Critical patent/EA030005B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0002Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/104Pseudomonadales, e.g. Pseudomonas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C07K14/212Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/14Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/16Yeasts; Culture media therefor
    • C12N1/165Yeast isolates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi
    • C12R2001/72Candida
    • C12R2001/725Candida albicans

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EA201591808A 2013-03-15 2014-03-14 Композиции и способы лечения грибковых и бактериальных патогенов EA030005B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361789091P 2013-03-15 2013-03-15
PCT/US2014/028521 WO2014144211A2 (en) 2013-03-15 2014-03-14 Compositions and methods for treating fungal and bacterial pathogens

Publications (2)

Publication Number Publication Date
EA201591808A1 EA201591808A1 (ru) 2016-02-29
EA030005B1 true EA030005B1 (ru) 2018-06-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591808A EA030005B1 (ru) 2013-03-15 2014-03-14 Композиции и способы лечения грибковых и бактериальных патогенов

Country Status (12)

Country Link
US (2) US10130691B2 (enExample)
EP (1) EP2968497B1 (enExample)
JP (2) JP6591961B2 (enExample)
CN (1) CN105407915A (enExample)
AU (1) AU2014227748B2 (enExample)
BR (1) BR112015022963A8 (enExample)
CA (1) CA2906771A1 (enExample)
EA (1) EA030005B1 (enExample)
MD (1) MD20150098A2 (enExample)
MX (1) MX2015012681A (enExample)
RU (1) RU2717306C2 (enExample)
WO (1) WO2014144211A2 (enExample)

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US20070077256A1 (en) 1999-11-19 2007-04-05 Los Angeles Biomedical Research Institute Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents
RU2717306C2 (ru) 2013-03-15 2020-03-19 Лос-Анджелес Биомедикал Ресерч Институт Эт Харбор-Укла Медикал Центер Композиции и способы лечения грибковых и бактериальных патогенов
JP2019507759A (ja) * 2016-03-09 2019-03-22 ロサンゼルス バイオメディカル リサーチ インスティテュート アット ハーバー− ユーシーエルエー メディカル センター 外陰部膣カンジダ症の予防及び治療で使用するための方法及びキット
US12324830B2 (en) 2018-04-10 2025-06-10 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Methods of treatment for Candida auris infections
US20220125651A1 (en) 2019-02-28 2022-04-28 Universidade Do Minho Antisense oligomers for controlling candida albicans infections
US20220354935A1 (en) * 2021-04-21 2022-11-10 Lundquist Institute For Biomedical Innovation At Harbor-Ucla Medical Center Vaccination against fungal epitopes to prevent inflammatory bowel diseases

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WO2013015831A1 (en) * 2011-07-22 2013-01-31 Novadigm Therapeutics, Inc. Methods and compositions for vaccinating against staphylococcus aureus

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WO2013015831A1 (en) * 2011-07-22 2013-01-31 Novadigm Therapeutics, Inc. Methods and compositions for vaccinating against staphylococcus aureus

Also Published As

Publication number Publication date
MX2015012681A (es) 2018-05-17
WO2014144211A2 (en) 2014-09-18
JP2019110918A (ja) 2019-07-11
JP6591961B2 (ja) 2019-10-16
WO2014144211A3 (en) 2015-11-19
RU2015144090A (ru) 2017-04-19
US10130691B2 (en) 2018-11-20
BR112015022963A8 (pt) 2018-01-16
EP2968497B1 (en) 2020-08-12
US20190030141A1 (en) 2019-01-31
BR112015022963A2 (pt) 2017-11-14
CA2906771A1 (en) 2014-09-18
EP2968497A4 (en) 2016-11-30
US20160030534A1 (en) 2016-02-04
RU2717306C2 (ru) 2020-03-19
MD20150098A2 (ro) 2016-02-29
WO2014144211A8 (en) 2015-10-08
EP2968497A2 (en) 2016-01-20
JP2016515516A (ja) 2016-05-30
EA201591808A1 (ru) 2016-02-29
AU2014227748A1 (en) 2015-10-08
CN105407915A (zh) 2016-03-16
AU2014227748B2 (en) 2019-02-14

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