EA029518B1 - Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора - Google Patents
Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора Download PDFInfo
- Publication number
- EA029518B1 EA029518B1 EA201790046A EA201790046A EA029518B1 EA 029518 B1 EA029518 B1 EA 029518B1 EA 201790046 A EA201790046 A EA 201790046A EA 201790046 A EA201790046 A EA 201790046A EA 029518 B1 EA029518 B1 EA 029518B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dihydro
- benzoxazin
- oxo
- carbonyl
- mmol
- Prior art date
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201462018790P | 2014-06-30 | 2014-06-30 | |
| PCT/GB2015/051860 WO2016001631A1 (en) | 2014-06-30 | 2015-06-26 | Benzoxazinone amides as mineralocorticoid receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201790046A1 EA201790046A1 (ru) | 2017-08-31 |
| EA029518B1 true EA029518B1 (ru) | 2018-04-30 |
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Family Applications (1)
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| EA201790046A EA029518B1 (ru) | 2014-06-30 | 2015-06-26 | Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора |
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| CN (1) | CN106536491B (https=) |
| AR (1) | AR101036A1 (https=) |
| AU (1) | AU2015282450C1 (https=) |
| CA (1) | CA2953655C (https=) |
| CY (1) | CY1121596T1 (https=) |
| DK (1) | DK3160948T3 (https=) |
| EA (1) | EA029518B1 (https=) |
| ES (1) | ES2707726T3 (https=) |
| HR (1) | HRP20190147T1 (https=) |
| HU (1) | HUE042370T2 (https=) |
| LT (1) | LT3160948T (https=) |
| ME (1) | ME03316B (https=) |
| MX (1) | MX367404B (https=) |
| PL (1) | PL3160948T3 (https=) |
| PT (1) | PT3160948T (https=) |
| RS (1) | RS58274B1 (https=) |
| SI (1) | SI3160948T1 (https=) |
| SM (1) | SMT201900039T1 (https=) |
| TR (1) | TR201900659T4 (https=) |
| TW (1) | TWI677498B (https=) |
| UY (1) | UY36195A (https=) |
| WO (1) | WO2016001631A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3160948B1 (en) * | 2014-06-30 | 2018-10-24 | Astrazeneca AB | Benzoxazinone amides as mineralocorticoid receptor modulators |
| MA53175A (fr) | 2018-07-19 | 2021-05-26 | Astrazeneca Ab | Méthodes de traitement de hfpef au moyen de dapagliflozine et compositions comprenant celle-ci |
| CN112107568B (zh) * | 2019-06-19 | 2022-03-25 | 北京龙嘉博创医药科技有限公司 | 二芳基酰胺类化合物及其应用 |
| PE20211267A1 (es) | 2019-08-30 | 2021-07-19 | Astrazeneca Ab | Metodos de tratamiento de la insuficiencia cardiaca con fraccion de eyeccion reducida con dapagliflozina |
| CN116392472B (zh) | 2020-07-27 | 2025-06-20 | 阿斯利康(瑞典)有限公司 | 用达格列净治疗慢性肾脏病的方法 |
| US12409186B2 (en) | 2020-07-27 | 2025-09-09 | Astrazeneca Ab | Methods of treating chronic kidney disease with dapagliflozin |
| MX2023015144A (es) | 2021-06-15 | 2024-01-22 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Derivados de benzoxazinona. |
| TW202409023A (zh) | 2022-07-14 | 2024-03-01 | 美商富曼西公司 | 除草苯并𠯤 |
| AU2023331475A1 (en) | 2022-09-01 | 2025-04-17 | Astrazeneca Ab | Combination of sglt2 inhibitors and mineralcorticoid receptor modulators for use in treatment of cardiorenal diseases |
| WO2024125591A1 (zh) * | 2022-12-15 | 2024-06-20 | 正大天晴药业集团股份有限公司 | 苯并恶嗪酮类化合物的结晶及其制备 |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2006015259A2 (en) * | 2004-07-28 | 2006-02-09 | Irm Llc | Compounds and compositions as modulators of steroid hormone nuclear receptors |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6951855B2 (en) * | 2001-04-23 | 2005-10-04 | Astrazeneca Ab | Benzoxazinone derivatives for use in the treatment of angiogenesis |
| CA2510851A1 (en) * | 2002-12-20 | 2004-07-08 | Warner-Lambert Company Llc | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
| CN101018552A (zh) * | 2004-07-14 | 2007-08-15 | 利亘制药公司 | 细胞内受体调节剂化合物和方法 |
| CA2635541A1 (en) | 2005-12-28 | 2007-07-12 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds and their use as mineralocorticoid receptor ligands |
| TWI385161B (zh) | 2006-02-02 | 2013-02-11 | Mitsubishi Tanabe Pharma Corp | 含氮雜雙環化合物 |
| DK2089367T3 (da) | 2006-10-31 | 2012-02-06 | Pfizer Prod Inc | Pyrazolinforbindelser som mineralocorticoidreceptor-antagonister |
| DE102007009494A1 (de) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
| EP2139489A4 (en) | 2007-03-23 | 2011-11-02 | Merck Sharp & Dohme | Mineralocorticoid receptor modulators |
| EP2133330B1 (en) | 2007-04-09 | 2014-01-01 | Daiichi Sankyo Company, Limited | Atropisomer of pyrrole derivative |
| JP5173653B2 (ja) * | 2007-08-01 | 2013-04-03 | 田辺三菱製薬株式会社 | 医薬組成物 |
| US8258131B2 (en) | 2007-08-01 | 2012-09-04 | Mitsubishi Tanabe Pharma Corporation | Fused bicyclic compound |
| TWI431010B (zh) | 2007-12-19 | 2014-03-21 | Lilly Co Eli | 礦皮質素受體拮抗劑及使用方法 |
| UY31905A (es) * | 2008-06-18 | 2010-01-29 | Astrazeneca Ab | Derivados de benzoxazinona, procesos de preparación, composiciones farmacéuticas conteniéndolos y aplicaciones. |
| US20100094000A1 (en) | 2008-09-03 | 2010-04-15 | Takeda Pharmaceutical Company Limited | Pyrazole compounds |
| WO2010098286A1 (ja) | 2009-02-25 | 2010-09-02 | 第一三共株式会社 | ミネラルコルチコイド受容体拮抗薬を含有する医薬 |
| WO2010104721A1 (en) | 2009-03-12 | 2010-09-16 | Eli Lilly And Company | Mineralocorticoid receptor antagonist and methods of use |
| JP2012523405A (ja) | 2009-04-10 | 2012-10-04 | ファイザー・インク | ４，５−ジヒドロ−１ｈ−ピラゾール化合物およびその薬学的使用 |
| WO2011141848A1 (en) | 2010-05-11 | 2011-11-17 | Pfizer Inc. | Morpholine compounds as mineralocorticoid receptor antagonists |
| WO2011141846A2 (en) | 2010-05-11 | 2011-11-17 | Koninklijke Philips Electronics N.V. | Lighting module |
| US20130116227A1 (en) | 2010-07-13 | 2013-05-09 | Dainippon Sumitomo Pharma Co., Ltd. | Biaryl amide derivative or pharmaceutically acceptable salt thereof |
| JP2013542255A (ja) | 2010-11-10 | 2013-11-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ミネラルコルチコイド受容体アンタゴニストとしてのピリジル尿素 |
| EP3160948B1 (en) * | 2014-06-30 | 2018-10-24 | Astrazeneca AB | Benzoxazinone amides as mineralocorticoid receptor modulators |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006015259A2 (en) * | 2004-07-28 | 2006-02-09 | Irm Llc | Compounds and compositions as modulators of steroid hormone nuclear receptors |
Non-Patent Citations (1)
| Title |
|---|
| HASUI TOMOAKI; OHRA TAIICHI; OHYABU NORIO; ASANO KOUHEI; MATSUI HIDEKI; MIZUKAMI ATSUSHI; HABUKA NORIYUKI; SOGABE SATOSHI; ENDO SA: "Design, synthesis, and structure–activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagon", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 21, no. 19, 1 January 1900 (1900-01-01), GB, pages 5983 - 5994, XP028706278, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2013.07.043 * |
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