EA027770B1 - ПРИМЕНЕНИЕ ИНГИБИТОРА Wnt/β-КАТЕНИНОВОГО МЕХАНИЗМА ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЯ И РАССТРОЙСТВА, СВЯЗАННОГО С АКТИВНОСТЬЮ ТРАНСДУЦИН β-ПОДОБНОГО БЕЛКА 1 (TBL1), ПРЕДСТАВЛЯЮЩЕГО СОБОЙ МИЕЛОПРОЛИФЕРАТИВНУЮ НЕОПЛАЗИЮ ИЛИ ХРОНИЧЕСКИЙ МИЕЛОИДНЫЙ ЛЕЙКОЗ - Google Patents

ПРИМЕНЕНИЕ ИНГИБИТОРА Wnt/β-КАТЕНИНОВОГО МЕХАНИЗМА ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЯ И РАССТРОЙСТВА, СВЯЗАННОГО С АКТИВНОСТЬЮ ТРАНСДУЦИН β-ПОДОБНОГО БЕЛКА 1 (TBL1), ПРЕДСТАВЛЯЮЩЕГО СОБОЙ МИЕЛОПРОЛИФЕРАТИВНУЮ НЕОПЛАЗИЮ ИЛИ ХРОНИЧЕСКИЙ МИЕЛОИДНЫЙ ЛЕЙКОЗ Download PDF

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EA027770B1
EA027770B1 EA201490937A EA201490937A EA027770B1 EA 027770 B1 EA027770 B1 EA 027770B1 EA 201490937 A EA201490937 A EA 201490937A EA 201490937 A EA201490937 A EA 201490937A EA 027770 B1 EA027770 B1 EA 027770B1
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Eurasian Patent Office
Prior art keywords
cells
compound
catenin
treatment
activity
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EA201490937A
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English (en)
Russian (ru)
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EA201490937A1 (ru
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Капил Н. Бхалла
Стефен Хорриган
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БЕТА КЭТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Publication of EA201490937A1 publication Critical patent/EA201490937A1/ru
Publication of EA027770B1 publication Critical patent/EA027770B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201490937A 2011-11-06 2012-11-06 ПРИМЕНЕНИЕ ИНГИБИТОРА Wnt/β-КАТЕНИНОВОГО МЕХАНИЗМА ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЯ И РАССТРОЙСТВА, СВЯЗАННОГО С АКТИВНОСТЬЮ ТРАНСДУЦИН β-ПОДОБНОГО БЕЛКА 1 (TBL1), ПРЕДСТАВЛЯЮЩЕГО СОБОЙ МИЕЛОПРОЛИФЕРАТИВНУЮ НЕОПЛАЗИЮ ИЛИ ХРОНИЧЕСКИЙ МИЕЛОИДНЫЙ ЛЕЙКОЗ EA027770B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161556245P 2011-11-06 2011-11-06
PCT/US2012/063746 WO2013067547A1 (en) 2011-11-06 2012-11-06 METHODS FOR TREATMENT OF DISEASES AND DISORDERS RELATED TO TRANSDUCIN β-LIKE PROTEIN 1 (TBL 1) ACTIVITY, INCLUDING MYELOPROLIFERATIVE NEOPLASIA AND CHRONIC MYELOID LEUKEMIA

Publications (2)

Publication Number Publication Date
EA201490937A1 EA201490937A1 (ru) 2014-08-29
EA027770B1 true EA027770B1 (ru) 2017-08-31

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Application Number Title Priority Date Filing Date
EA201490937A EA027770B1 (ru) 2011-11-06 2012-11-06 ПРИМЕНЕНИЕ ИНГИБИТОРА Wnt/β-КАТЕНИНОВОГО МЕХАНИЗМА ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЯ И РАССТРОЙСТВА, СВЯЗАННОГО С АКТИВНОСТЬЮ ТРАНСДУЦИН β-ПОДОБНОГО БЕЛКА 1 (TBL1), ПРЕДСТАВЛЯЮЩЕГО СОБОЙ МИЕЛОПРОЛИФЕРАТИВНУЮ НЕОПЛАЗИЮ ИЛИ ХРОНИЧЕСКИЙ МИЕЛОИДНЫЙ ЛЕЙКОЗ

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US (1) US9238030B2 (enExample)
EP (1) EP2773607B1 (enExample)
JP (1) JP6063472B2 (enExample)
KR (1) KR102336767B1 (enExample)
CN (1) CN103917514B (enExample)
AU (1) AU2012332111B2 (enExample)
BR (1) BR112014010584A2 (enExample)
CA (1) CA2853491C (enExample)
EA (1) EA027770B1 (enExample)
ES (1) ES2624427T3 (enExample)
IL (1) IL232452A (enExample)
MX (1) MX354653B (enExample)
SG (1) SG11201402056XA (enExample)
WO (1) WO2013067547A1 (enExample)
ZA (1) ZA201403003B (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
US9963475B2 (en) * 2015-07-28 2018-05-08 Beta Cat Pharmaceuticals, Inc. Anthracene-9, 10-dione dioxime compound prodrugs and their uses
US9725473B2 (en) * 2015-07-28 2017-08-08 Beta Cat Pharmaceuticals, Inc. Anthracene-9, 10-dione dioxime compound prodrugs and their uses
CA3065318A1 (en) * 2017-06-02 2018-12-06 Iterion Therapeutics, Inc. The use of tegavivint to treat fibrotic disease
WO2019099836A1 (en) * 2017-11-16 2019-05-23 Northwestern University Inhaled formulation of a molecular inhibitor of wnt/beta-catenin signaling for treating interstitial lung diseases
WO2019229001A1 (en) * 2018-05-30 2019-12-05 Otto-Von-Guericke-Universität Magdeburg Compounds for the treatment of jak2-v617f-associated cmn
CN119215047A (zh) * 2024-10-11 2024-12-31 浙江大学 一种芳香磺酰胺类化合物在制备防治肝损伤药物中的应用

Citations (2)

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WO2010059142A1 (en) * 2008-11-21 2010-05-27 Avalon Pharmaceuticals Anthraquinone dioximes and uses thereof
US20110034441A1 (en) * 2009-08-10 2011-02-10 Epitherix, Llc Indazoles as wnt/b-catenin signaling pathway inhibitors and therapeutic uses thereof

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CN108314663B (zh) * 2007-05-10 2022-05-13 多格伍德药品公司 芴、蒽、呫吨、二苯并环庚酮和吖啶的衍生物及其用途
WO2008147713A1 (en) 2007-05-24 2008-12-04 The Regents Of The University Of California Wnt signaling inhibitors, and methods for making and using them
US20120157500A1 (en) 2009-08-24 2012-06-21 Weikang Tao Jak inhibition blocks rna interference associated toxicities
JP2013505968A (ja) * 2009-10-01 2013-02-21 シーエスエル、リミテッド フィラデルフィア染色体陽性白血病の治療方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010059142A1 (en) * 2008-11-21 2010-05-27 Avalon Pharmaceuticals Anthraquinone dioximes and uses thereof
US20110034441A1 (en) * 2009-08-10 2011-02-10 Epitherix, Llc Indazoles as wnt/b-catenin signaling pathway inhibitors and therapeutic uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI et al., TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis, Nature Cell Biology 10(2), pp. 160-169, 2008, pg. 160, col. 1, para 2 - col. 2, para 1; pg. 161, col. 1, para 1; pg. 162, col. 2, para 2; pg. 164, col. 1, para 4; pg. 166, col. 1, para 2 – pg. 168, col 1, para 2. Downloaded at http://basicmed.med.ncku.edu.tw/admin/up_img/970411-1.pdf *
THIELEN et al., New insights into the pathogenesis of chronic myeloid leukaemia: towards a path to cure, The Netherlands Journal of Medicine 69(10), pp. 430-440, October 2011, pg. 430, col. 1, para 1 - col. 2, para 1; pg. 433, col. 1, para 3 - col. 2, para 1; pg. 438, col. 1, para 3. Downloaded at http://www.njmonline.nl/getpdf.php?t=a&id=10000767 *

Also Published As

Publication number Publication date
US20130143920A1 (en) 2013-06-06
JP6063472B2 (ja) 2017-01-18
ES2624427T3 (es) 2017-07-14
IL232452A (en) 2017-01-31
KR102336767B1 (ko) 2021-12-10
MX354653B (es) 2018-03-07
ZA201403003B (en) 2017-08-30
CN103917514B (zh) 2016-11-16
CN103917514A (zh) 2014-07-09
EP2773607A1 (en) 2014-09-10
CA2853491C (en) 2019-12-10
AU2012332111B2 (en) 2016-11-17
BR112014010584A2 (pt) 2017-05-02
AU2012332111A1 (en) 2014-05-22
HK1198440A1 (en) 2015-04-24
US9238030B2 (en) 2016-01-19
JP2014534229A (ja) 2014-12-18
WO2013067547A1 (en) 2013-05-10
SG11201402056XA (en) 2014-10-30
KR102336767B9 (ko) 2025-01-08
EP2773607B1 (en) 2017-03-29
EA201490937A1 (ru) 2014-08-29
CA2853491A1 (en) 2013-05-10
IL232452A0 (en) 2014-06-30
MX2014005498A (es) 2016-05-05
EP2773607A4 (en) 2015-03-11
NZ624446A (en) 2016-01-29
KR20140089418A (ko) 2014-07-14

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