EA026669B1 - Производные пиридина - Google Patents

Производные пиридина Download PDF

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Publication number
EA026669B1
EA026669B1 EA201591064A EA201591064A EA026669B1 EA 026669 B1 EA026669 B1 EA 026669B1 EA 201591064 A EA201591064 A EA 201591064A EA 201591064 A EA201591064 A EA 201591064A EA 026669 B1 EA026669 B1 EA 026669B1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyclopropylmethoxy
carboxylic acid
amide
amino
pyridine
Prior art date
Application number
EA201591064A
Other languages
English (en)
Russian (ru)
Other versions
EA201591064A1 (ru
Inventor
Беат Фрай
Лука Гобби
Уве Гретер
Ацуси Кимбара
Маттиас Неттекофен
Штефан Рёфер
Марк Роджерс-Эванс
Танья Шульц-Гаш
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201591064A1 publication Critical patent/EA201591064A1/ru
Publication of EA026669B1 publication Critical patent/EA026669B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EA201591064A 2012-12-07 2013-12-02 Производные пиридина EA026669B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12196022 2012-12-07
PCT/EP2013/075225 WO2014086705A1 (en) 2012-12-07 2013-12-02 Novel pyridine derivatives

Publications (2)

Publication Number Publication Date
EA201591064A1 EA201591064A1 (ru) 2015-09-30
EA026669B1 true EA026669B1 (ru) 2017-05-31

Family

ID=47290804

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591064A EA026669B1 (ru) 2012-12-07 2013-12-02 Производные пиридина

Country Status (33)

Country Link
US (1) US9522886B2 (enExample)
EP (2) EP2928881B1 (enExample)
JP (1) JP6426618B2 (enExample)
KR (1) KR20150092282A (enExample)
CN (2) CN104837831B (enExample)
AR (1) AR093843A1 (enExample)
AU (2) AU2013354278B2 (enExample)
BR (1) BR112015012919A2 (enExample)
CA (1) CA2890100A1 (enExample)
CL (1) CL2015001536A1 (enExample)
CO (1) CO7350620A2 (enExample)
CR (1) CR20150250A (enExample)
DK (1) DK2928881T3 (enExample)
EA (1) EA026669B1 (enExample)
ES (1) ES2668690T3 (enExample)
HR (1) HRP20180672T1 (enExample)
HU (1) HUE036911T2 (enExample)
IL (1) IL239075B (enExample)
LT (1) LT2928881T (enExample)
MA (1) MA38239A1 (enExample)
MX (1) MX2015007155A (enExample)
NO (1) NO2928881T3 (enExample)
PE (1) PE20151025A1 (enExample)
PH (1) PH12015501083B1 (enExample)
PL (1) PL2928881T3 (enExample)
PT (1) PT2928881T (enExample)
RS (1) RS57143B1 (enExample)
SG (2) SG10201800170YA (enExample)
SI (1) SI2928881T1 (enExample)
TW (1) TWI600645B (enExample)
UA (1) UA114656C2 (enExample)
WO (1) WO2014086705A1 (enExample)
ZA (1) ZA201503969B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2964646B1 (en) 2013-03-07 2017-04-19 F. Hoffmann-La Roche AG Novel pyrazol derivatives
MA38404B1 (fr) 2013-03-26 2017-09-29 Hoffmann La Roche Nouveaux dérivés de pyridine
EP2991987B1 (en) 2013-05-02 2018-05-23 F.Hoffmann-La Roche Ag Purine derivatives as cb2 receptor agonists
KR20160002857A (ko) 2013-05-02 2016-01-08 에프. 호프만-라 로슈 아게 CB2 수용체 작용제로서의 피롤로[2,3-d]피리미딘 유도체
MX391724B (es) 2013-09-06 2025-03-21 Hoffmann La Roche Nuevos derivados de triazolo[4,5-d]pirimidina.
EP3126349B1 (en) * 2014-04-04 2019-06-26 F. Hoffmann-La Roche AG 5,6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists
WO2015190564A1 (ja) * 2014-06-13 2015-12-17 武田薬品工業株式会社 含窒素複素環化合物
MY195889A (en) * 2015-12-09 2023-02-27 Hoffmann La Roche Phenyl Derivatives as Cannabinoid Receptor 2 Agonists
WO2017107089A1 (en) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
WO2018234284A1 (en) 2017-06-20 2018-12-27 F. Hoffmann-La Roche Ag Pyridine derivatives
CN112041309A (zh) * 2018-04-18 2020-12-04 巴斯夫欧洲公司 D-葡糖二酸-6,3-内酯单酯及其制备方法
CN112119068A (zh) * 2018-06-27 2020-12-22 豪夫迈·罗氏有限公司 作为大麻素受体2的抑制剂的新型氮杂环丁烷-取代的吡啶和吡嗪化合物
WO2020002270A1 (en) 2018-06-27 2020-01-02 F. Hoffmann-La Roche Ag Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
CN119161323A (zh) 2018-06-27 2024-12-20 豪夫迈·罗氏有限公司 作为大麻素受体2的抑制剂的新型吡啶和吡嗪化合物
CN116640118B (zh) 2018-06-27 2025-12-19 豪夫迈·罗氏有限公司 放射性标记的大麻素受体2配体
US20220388969A1 (en) * 2019-09-30 2022-12-08 Hoffmann-La Roche Inc. Substituted 3,4-dihydroquinazoline for the treatment and prophylaxis of hepatitis b virus infection
WO2022053651A2 (en) 2020-09-10 2022-03-17 Precirix N.V. Antibody fragment against fap
US12448373B2 (en) 2021-04-19 2025-10-21 Amgen Inc. Azetidinyl-acetamides as CXCR7 inhibitors
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080085905A1 (en) * 2006-10-04 2008-04-10 Michel Dietz Pyrazine-2-carboxamide derivatives
US20120065212A1 (en) * 2010-09-09 2012-03-15 Paul Hebeisen Heteroarylmethyl amides
WO2012168350A1 (en) * 2011-06-10 2012-12-13 F. Hoffmann-La Roche Ag Pyridin- 2 -amides useful as cb2 agonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8669370B2 (en) * 2011-01-26 2014-03-11 Sanofi Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080085905A1 (en) * 2006-10-04 2008-04-10 Michel Dietz Pyrazine-2-carboxamide derivatives
US20120065212A1 (en) * 2010-09-09 2012-03-15 Paul Hebeisen Heteroarylmethyl amides
WO2012168350A1 (en) * 2011-06-10 2012-12-13 F. Hoffmann-La Roche Ag Pyridin- 2 -amides useful as cb2 agonists

Also Published As

Publication number Publication date
EP2928881A1 (en) 2015-10-14
CR20150250A (es) 2015-06-11
WO2014086705A1 (en) 2014-06-12
EP2928881B1 (en) 2018-03-14
EP3357918A1 (en) 2018-08-08
SG10201800170YA (en) 2018-02-27
ES2668690T3 (es) 2018-05-21
CN104837831B (zh) 2017-10-31
EA201591064A1 (ru) 2015-09-30
IL239075B (en) 2018-11-29
IL239075A0 (en) 2015-07-30
PH12015501083A1 (en) 2015-08-03
ZA201503969B (en) 2016-04-28
CN104837831A (zh) 2015-08-12
CL2015001536A1 (es) 2015-10-23
AU2013354278B2 (en) 2017-10-12
PE20151025A1 (es) 2015-07-15
PT2928881T (pt) 2018-05-07
HK1208031A1 (en) 2016-02-19
BR112015012919A2 (pt) 2017-07-11
KR20150092282A (ko) 2015-08-12
TW201427951A (zh) 2014-07-16
SG11201504416XA (en) 2015-07-30
AU2013354278A1 (en) 2015-05-14
CA2890100A1 (en) 2014-06-12
UA114656C2 (uk) 2017-07-10
LT2928881T (lt) 2018-06-11
SI2928881T1 (en) 2018-07-31
PH12015501083B1 (en) 2015-08-03
AR093843A1 (es) 2015-06-24
PL2928881T3 (pl) 2018-07-31
DK2928881T3 (en) 2018-05-28
JP6426618B2 (ja) 2018-11-21
TWI600645B (zh) 2017-10-01
HUE036911T2 (hu) 2018-08-28
JP2016501240A (ja) 2016-01-18
CN107674061A (zh) 2018-02-09
AU2017279648A1 (en) 2018-01-18
MA38239A1 (fr) 2017-03-31
RS57143B1 (sr) 2018-07-31
MX2015007155A (es) 2015-10-14
US20150307452A1 (en) 2015-10-29
US9522886B2 (en) 2016-12-20
NO2928881T3 (enExample) 2018-08-11
CO7350620A2 (es) 2015-08-10
HRP20180672T1 (hr) 2018-06-01

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU