EA026209B1 - Соединения, ингибирующие металлоферменты - Google Patents

Соединения, ингибирующие металлоферменты Download PDF

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Publication number
EA026209B1
EA026209B1 EA201491385A EA201491385A EA026209B1 EA 026209 B1 EA026209 B1 EA 026209B1 EA 201491385 A EA201491385 A EA 201491385A EA 201491385 A EA201491385 A EA 201491385A EA 026209 B1 EA026209 B1 EA 026209B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
difluorophenyl
tetrazol
pyridin
difluoro
Prior art date
Application number
EA201491385A
Other languages
English (en)
Russian (ru)
Other versions
EA201491385A1 (ru
Inventor
Уиллиам Дж. Хекстра
Роберт Дж. Шотцингер
Стивен В. Рафферти
Original Assignee
Ваймет Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ваймет Фармасьютикалс, Инк. filed Critical Ваймет Фармасьютикалс, Инк.
Publication of EA201491385A1 publication Critical patent/EA201491385A1/ru
Publication of EA026209B1 publication Critical patent/EA026209B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201491385A 2012-01-20 2013-01-18 Соединения, ингибирующие металлоферменты EA026209B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261589076P 2012-01-20 2012-01-20
PCT/US2013/022313 WO2013109998A1 (en) 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds

Publications (2)

Publication Number Publication Date
EA201491385A1 EA201491385A1 (ru) 2015-02-27
EA026209B1 true EA026209B1 (ru) 2017-03-31

Family

ID=48799718

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491385A EA026209B1 (ru) 2012-01-20 2013-01-18 Соединения, ингибирующие металлоферменты

Country Status (14)

Country Link
US (3) US10221160B2 (cg-RX-API-DMAC10.html)
EP (1) EP2804858B1 (cg-RX-API-DMAC10.html)
JP (1) JP6189865B2 (cg-RX-API-DMAC10.html)
KR (1) KR102061137B1 (cg-RX-API-DMAC10.html)
CN (1) CN104136427B (cg-RX-API-DMAC10.html)
AU (2) AU2013209516A1 (cg-RX-API-DMAC10.html)
BR (1) BR112014017751B1 (cg-RX-API-DMAC10.html)
CA (1) CA2861339C (cg-RX-API-DMAC10.html)
DK (1) DK2804858T3 (cg-RX-API-DMAC10.html)
EA (1) EA026209B1 (cg-RX-API-DMAC10.html)
ES (1) ES2774267T3 (cg-RX-API-DMAC10.html)
IN (1) IN2014DN06792A (cg-RX-API-DMAC10.html)
PL (1) PL2804858T3 (cg-RX-API-DMAC10.html)
WO (1) WO2013109998A1 (cg-RX-API-DMAC10.html)

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ES2774267T3 (es) * 2012-01-20 2020-07-20 Mycovia Pharmaceuticals Inc Compuestos inhibidores de metaloenzimas
AU2015231270B2 (en) * 2014-03-19 2019-03-07 Viamet Pharmaceuticals (NC), Inc. Antifungal compound process
JP2017514790A (ja) * 2014-03-19 2017-06-08 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
US9981943B2 (en) 2014-03-19 2018-05-29 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119754A4 (en) * 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
MX382905B (es) 2014-03-19 2025-03-13 Viamet Pharmaceuticals Nc Inc 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.
BR112016021257B1 (pt) 2014-03-19 2021-03-02 Viamet Pharmaceuticals (NC), Inc. 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos
JP6509897B2 (ja) * 2014-03-19 2019-05-08 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 抗真菌化合物の調製方法
EP3119748A4 (en) * 2014-03-19 2017-08-30 Viamet Pharmaceuticals, Inc. Antifungal compound process
JP6606508B2 (ja) * 2014-03-19 2019-11-13 マイコヴィア ファーマシューティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
US10000465B2 (en) 2014-03-19 2018-06-19 Mycovia Pharmaceuticals, Inc. Antifungal compound process
AU2016233113B2 (en) 2015-03-19 2020-05-07 Mycovia Pharmaceuticals, Inc. Antifungal compounds and processes for making
EP3349753A4 (en) 2015-09-18 2019-01-23 VPS-3, Inc. FUNGICIDE COMPOUNDS AND METHOD OF PREPARING THEREOF
EP3397629B1 (en) * 2015-12-30 2023-04-19 NQP 1598, Ltd. Metalloenzyme inhibitor compounds
SG10201911243WA (en) 2016-12-22 2020-02-27 Calithera Biosciences Inc Compositions and methods for inhibiting arginase activity
CN109666019B (zh) * 2017-10-14 2021-04-06 朱允涛 一种氘代的氮唑醇类化合物及其制备方法和用途
CN109810049B (zh) * 2018-11-30 2021-01-15 深圳大学 一种含吡啶的化合物及其提取方法
TW202140445A (zh) * 2020-01-17 2021-11-01 大陸商上海森輝醫藥有限公司 四氮唑類化合物的可藥用鹽及其結晶形式、製備方法和用途
JP2023546295A (ja) * 2020-10-16 2023-11-01 ミラログクス エルエルシー がん、アルツハイマー病、ヘモクロマトーシスおよび他の障害を治療するための金属酵素阻害剤
WO2026006142A1 (en) * 2024-06-24 2026-01-02 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Azole compounds useful as inhibitors of voltage-dependent anion channel oligomerization

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US4616026A (en) * 1983-02-16 1986-10-07 Pfizer Inc. Antifungal 2-aryl-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)2-propanols
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Also Published As

Publication number Publication date
CN104136427A (zh) 2014-11-05
WO2013109998A1 (en) 2013-07-25
BR112014017751A8 (pt) 2021-03-09
AU2017232080B2 (en) 2019-02-14
JP2015504095A (ja) 2015-02-05
EA201491385A1 (ru) 2015-02-27
EP2804858A1 (en) 2014-11-26
US20200247779A1 (en) 2020-08-06
IN2014DN06792A (cg-RX-API-DMAC10.html) 2015-05-22
CN104136427B (zh) 2017-03-01
US20190169159A1 (en) 2019-06-06
US20150004666A1 (en) 2015-01-01
ES2774267T3 (es) 2020-07-20
EP2804858A4 (en) 2015-07-29
KR102061137B1 (ko) 2019-12-31
CA2861339C (en) 2020-08-25
BR112014017751B1 (pt) 2021-12-07
DK2804858T3 (da) 2020-03-16
JP6189865B2 (ja) 2017-08-30
CA2861339A1 (en) 2013-07-25
AU2013209516A1 (en) 2014-08-28
EP2804858B1 (en) 2019-12-25
PL2804858T3 (pl) 2020-06-29
US10221160B2 (en) 2019-03-05
US10526312B2 (en) 2020-01-07
KR20140116939A (ko) 2014-10-06
US11247981B2 (en) 2022-02-15
AU2017232080A1 (en) 2017-10-12

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