CN104136427A - 金属酶抑制剂化合物 - Google Patents
金属酶抑制剂化合物 Download PDFInfo
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- CN104136427A CN104136427A CN201380010231.4A CN201380010231A CN104136427A CN 104136427 A CN104136427 A CN 104136427A CN 201380010231 A CN201380010231 A CN 201380010231A CN 104136427 A CN104136427 A CN 104136427A
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- compound
- alkyl
- fluoro
- tetrazole
- enzyme
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
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- Pain & Pain Management (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
实施例 | 念珠菌MIC* | CYP2C9 IC50 | CYP2C19 IC50 | CYP3A4 IC50 |
1 | ≤0.016 | >60 | 35 | 16 |
2 | ≤0.016 | >60 | >60 | >60 |
氟康唑 | 0.5 | 29 | 8.2 | 8.0 |
伏立康唑 | 0.016 | 14 | 15 | 13 |
MIC(μg/mL) | 评级 |
≤0.5 | A |
>0.5–1.5 | B |
>1.5–4 | C |
>4 | D |
没有测试 | E |
实施例编号 | 念珠菌MIC评级 |
1 | A |
2 | A |
3 | A |
4 | A |
5 | A |
6 | A |
7 | A |
8 | A |
9 | A |
10 | A |
11 | A |
12 | A |
13 | E |
14 | E |
15 | A |
16 | A |
17 | E |
18 | A |
19 | E |
20 | D |
21 | C |
22 | C |
23 | A |
24 | A |
25 | A |
26 | A |
27 | A |
28 | A |
29 | A |
30 | A |
31 | A |
32 | A |
33 | A |
34 | A |
35 | A |
36 | A |
37 | A |
38 | A |
39 | C |
40 | A |
41 | A |
42 | A |
43 | A |
44 | A |
45 | A |
46 | B |
47 | A |
48 | C |
49 | C |
50 | C |
51 | A |
52 | C |
53 | B |
54 | C |
55 | A |
56 | C |
57 | A |
58 | A |
Claims (52)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261589076P | 2012-01-20 | 2012-01-20 | |
US61/589,076 | 2012-01-20 | ||
PCT/US2013/022313 WO2013109998A1 (en) | 2012-01-20 | 2013-01-18 | Metalloenzyme inhibitor compounds |
Publications (2)
Publication Number | Publication Date |
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CN104136427A true CN104136427A (zh) | 2014-11-05 |
CN104136427B CN104136427B (zh) | 2017-03-01 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CN201380010231.4A Active CN104136427B (zh) | 2012-01-20 | 2013-01-18 | 金属酶抑制剂化合物 |
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Country | Link |
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US (3) | US10221160B2 (zh) |
EP (1) | EP2804858B1 (zh) |
JP (1) | JP6189865B2 (zh) |
KR (1) | KR102061137B1 (zh) |
CN (1) | CN104136427B (zh) |
AU (2) | AU2013209516A1 (zh) |
BR (1) | BR112014017751B1 (zh) |
CA (1) | CA2861339C (zh) |
DK (1) | DK2804858T3 (zh) |
EA (1) | EA026209B1 (zh) |
ES (1) | ES2774267T3 (zh) |
IN (1) | IN2014DN06792A (zh) |
PL (1) | PL2804858T3 (zh) |
WO (1) | WO2013109998A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108779094A (zh) * | 2015-12-30 | 2018-11-09 | Vps-3有限公司 | 金属酶抑制剂化合物 |
WO2019072199A1 (zh) * | 2017-10-14 | 2019-04-18 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
CN109810049A (zh) * | 2018-11-30 | 2019-05-28 | 深圳大学 | 一种含吡啶的化合物及其提取方法 |
WO2021143811A1 (zh) * | 2020-01-17 | 2021-07-22 | 上海森辉医药有限公司 | 四氮唑类化合物的可药用盐及其结晶形式、制备方法和用途 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103764646A (zh) * | 2011-06-19 | 2014-04-30 | 威尔金制药有限公司 | 金属酶抑制剂化合物 |
IN2014DN06792A (zh) * | 2012-01-20 | 2015-05-22 | Viamet Pharmaceuticals Inc | |
EP3119748A4 (en) | 2014-03-19 | 2017-08-30 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
EP3119754A4 (en) * | 2014-03-19 | 2017-12-13 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
US10017494B2 (en) | 2014-03-19 | 2018-07-10 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
HUE052446T2 (hu) * | 2014-03-19 | 2021-04-28 | Mycovia Pharmaceuticals Inc | Eljárás gombaellenes vegyület elõállítása céljából |
AU2015231216B2 (en) * | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
EP3119749A4 (en) * | 2014-03-19 | 2017-12-13 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
KR102441242B1 (ko) | 2014-03-19 | 2022-09-07 | 브이피에스-3, 엘엘씨 | 2-(2,4-디플루오로페닐)-1,1-디플루오로-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법 |
US9988365B2 (en) | 2014-03-19 | 2018-06-05 | Vps-3, Inc. | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation |
MX369357B (es) | 2014-03-19 | 2019-11-06 | Mycovia Pharmaceuticals Inc | Procedimiento de compuesto antifungico. |
EP3119755B1 (en) | 2014-03-19 | 2019-03-06 | Viamet Pharmaceuticals (NC), Inc. | Antifungal compound process |
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CN108779094A (zh) * | 2015-12-30 | 2018-11-09 | Vps-3有限公司 | 金属酶抑制剂化合物 |
CN108779094B (zh) * | 2015-12-30 | 2021-11-16 | Nqp 1598公司 | 金属酶抑制剂化合物 |
WO2019072199A1 (zh) * | 2017-10-14 | 2019-04-18 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
CN109666019A (zh) * | 2017-10-14 | 2019-04-23 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
CN109810049A (zh) * | 2018-11-30 | 2019-05-28 | 深圳大学 | 一种含吡啶的化合物及其提取方法 |
CN109810049B (zh) * | 2018-11-30 | 2021-01-15 | 深圳大学 | 一种含吡啶的化合物及其提取方法 |
WO2021143811A1 (zh) * | 2020-01-17 | 2021-07-22 | 上海森辉医药有限公司 | 四氮唑类化合物的可药用盐及其结晶形式、制备方法和用途 |
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EP2804858A1 (en) | 2014-11-26 |
US10526312B2 (en) | 2020-01-07 |
EA026209B1 (ru) | 2017-03-31 |
AU2013209516A1 (en) | 2014-08-28 |
ES2774267T3 (es) | 2020-07-20 |
US11247981B2 (en) | 2022-02-15 |
CA2861339C (en) | 2020-08-25 |
KR102061137B1 (ko) | 2019-12-31 |
AU2017232080A1 (en) | 2017-10-12 |
JP6189865B2 (ja) | 2017-08-30 |
WO2013109998A1 (en) | 2013-07-25 |
US10221160B2 (en) | 2019-03-05 |
KR20140116939A (ko) | 2014-10-06 |
EA201491385A1 (ru) | 2015-02-27 |
AU2017232080B2 (en) | 2019-02-14 |
EP2804858A4 (en) | 2015-07-29 |
DK2804858T3 (da) | 2020-03-16 |
CN104136427B (zh) | 2017-03-01 |
BR112014017751B1 (pt) | 2021-12-07 |
PL2804858T3 (pl) | 2020-06-29 |
IN2014DN06792A (zh) | 2015-05-22 |
EP2804858B1 (en) | 2019-12-25 |
CA2861339A1 (en) | 2013-07-25 |
US20200247779A1 (en) | 2020-08-06 |
US20150004666A1 (en) | 2015-01-01 |
BR112014017751A8 (pt) | 2021-03-09 |
JP2015504095A (ja) | 2015-02-05 |
US20190169159A1 (en) | 2019-06-06 |
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