EA024826B1 - Способ лечения латентного туберкулеза - Google Patents

Способ лечения латентного туберкулеза Download PDF

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Publication number
EA024826B1
EA024826B1 EA201100072A EA201100072A EA024826B1 EA 024826 B1 EA024826 B1 EA 024826B1 EA 201100072 A EA201100072 A EA 201100072A EA 201100072 A EA201100072 A EA 201100072A EA 024826 B1 EA024826 B1 EA 024826B1
Authority
EA
Eurasian Patent Office
Prior art keywords
sequence
protein
polypeptide
ku3616c
cells
Prior art date
Application number
EA201100072A
Other languages
English (en)
Russian (ru)
Other versions
EA201100072A1 (ru
Inventor
Джеймс Браун
Паскаль Меттенс
Деннис Мерфи
Original Assignee
Глаксосмитклайн Байолоджикалс С.А.
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксосмитклайн Байолоджикалс С.А., Глаксо Груп Лимитед filed Critical Глаксосмитклайн Байолоджикалс С.А.
Publication of EA201100072A1 publication Critical patent/EA201100072A1/ru
Publication of EA024826B1 publication Critical patent/EA024826B1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
EA201100072A 2008-07-25 2009-07-24 Способ лечения латентного туберкулеза EA024826B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8372008P 2008-07-25 2008-07-25
PCT/EP2009/059580 WO2010010177A1 (en) 2008-07-25 2009-07-24 Novel compositions and methods

Publications (2)

Publication Number Publication Date
EA201100072A1 EA201100072A1 (ru) 2011-10-31
EA024826B1 true EA024826B1 (ru) 2016-10-31

Family

ID=41217660

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100072A EA024826B1 (ru) 2008-07-25 2009-07-24 Способ лечения латентного туберкулеза

Country Status (24)

Country Link
US (2) US20110117119A1 (https=)
EP (1) EP2315773B1 (https=)
JP (1) JP5873332B2 (https=)
KR (1) KR20110044883A (https=)
CN (1) CN102164952B (https=)
AU (1) AU2009273130B2 (https=)
BR (1) BRPI0916703A2 (https=)
CA (1) CA2731499C (https=)
CO (1) CO6341637A2 (https=)
CY (1) CY1118200T1 (https=)
DK (1) DK2315773T3 (https=)
EA (1) EA024826B1 (https=)
ES (1) ES2602430T3 (https=)
HR (1) HRP20161458T1 (https=)
HU (1) HUE031044T2 (https=)
IL (1) IL210559A0 (https=)
LT (1) LT2315773T (https=)
MX (1) MX2011000983A (https=)
PL (1) PL2315773T3 (https=)
PT (1) PT2315773T (https=)
SG (1) SG192456A1 (https=)
SI (1) SI2315773T1 (https=)
UA (1) UA107330C2 (https=)
WO (1) WO2010010177A1 (https=)

Families Citing this family (18)

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DK1144447T3 (da) * 1998-11-04 2010-02-08 Isis Innovation Dianostisk tuberkulosetest
AU2009273132B2 (en) 2008-07-25 2015-09-03 Glaxo Group Limited The tuberculosis Rv2386c protein, compositions and uses thereof
CA2731549C (en) 2008-07-25 2018-07-17 Glaxo Group Limited Compositions and methods for treating tuberculosis
EP2156945A1 (en) 2008-08-13 2010-02-24 Novelis Inc. Clad automotive sheet product
MX2011011186A (es) 2009-04-24 2012-02-13 Una vacuna antituberculosis tb para evitar la reactivacion.
BR112012018669A2 (pt) 2010-01-27 2017-09-05 Glaxosmithkline Biologicals Sa Proteína rv3616c modificada, uso de uma proteína rv3616c modificada, polinucleotídeo, uso de um polinucleotídeo, composição farmacêutica, composição imunogênica, proteína de fusão, e, polipeptídeo.
BR112016006284B1 (pt) 2013-09-27 2022-07-26 Codexis, Inc Método implementado por computador, produto de programa de computador, e, sistema de computador
RU2016116253A (ru) 2013-09-27 2017-11-01 Кодексис, Инк. Автоматизированный скрининг вариантов фермента
GB201405921D0 (en) * 2014-04-02 2014-05-14 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
CN106546737A (zh) * 2016-10-24 2017-03-29 广州迪澳医疗科技有限公司 一种体外检测活动性结核的方法
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
GB201707700D0 (en) 2017-05-12 2017-06-28 Glaxosmithkline Biologicals Sa Dried composition
GB2600653B (en) 2017-05-30 2022-11-02 Glaxosmithkline Biologicals Sa Novel methods
BR112020010790A2 (pt) 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. purificação da saponina
WO2020210630A1 (en) 2019-04-12 2020-10-15 C4 Therapeutics, Inc. Tricyclic degraders of ikaros and aiolos
WO2020245207A1 (en) 2019-06-05 2020-12-10 Glaxosmithkline Biologicals Sa Saponin purification
CN115073612B (zh) * 2022-06-22 2024-09-27 宁夏大学 一种结核分枝杆菌Zera-71cA蛋白纳米颗粒、制备方法及其用途
GB202318595D0 (en) * 2023-12-05 2024-01-17 Sec Dep For Environment Food And Rural Affairs Acting Through Animal And Plant Health Agency Diagnostic proteins and reagents

Citations (5)

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WO1998053075A2 (en) * 1997-05-20 1998-11-26 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
WO2001062893A2 (en) * 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
US20040086523A1 (en) * 2000-06-20 2004-05-06 Yasir Skeiky Fusion proteins of mycobacterium tuberculosis
US20040197896A1 (en) * 2001-02-22 2004-10-07 Stewart Cole Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses
WO2008007942A1 (en) * 2006-07-10 2008-01-17 Het Nederlands Kanker Instituut Means and methods for manipulating sequential phagolysomal-cytosolic translocation of mycobacteria, and uses thereof

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PL202844B1 (pl) * 1998-04-07 2009-07-31 Corixa Corp Immunogeniczny polipeptyd, polinukleotyd, polipeptyd, kompozycja farmaceutyczna, wektor ekspresji, kompozycja szczepionki, polipeptyd do stosowania w leczeniu lub zapobieganiu infekcjom Mycobacterium tuberculosis, polinukleotyd do stosowania w leczeniu lub zapobieganiu infekcjom Mycobacterium tuberculosis i sposób wytwarzania polipeptydu
NZ526807A (en) * 2001-01-08 2005-03-24 Isis Innovation Assay to determine efficacy of treatment for mycobacterial infection
US20030236393A1 (en) * 2002-03-22 2003-12-25 United States Of America Dept Of Vetrans Affairs Virulence genes of M. marinum and M. tuberculosis
EP2226332A1 (en) * 2004-06-17 2010-09-08 Beckman Coulter, Inc. Mycobacterium tuberculosis epitopes and methods of use thereof
DK2457926T3 (da) 2005-04-29 2015-01-05 Glaxosmithkline Biolog Sa Ny fremgangsmåde til forebyggelse eller behandling af M. tuberkulose-infektion
BRPI0612833A2 (pt) * 2005-06-23 2010-11-30 Statens Seruminstitut composição imunogênica, vacina, composição farmacêutica, polipeptìdeo de fusão e uso das três primeiras
US9297803B2 (en) * 2006-11-01 2016-03-29 Immport Therapeutics, Inc. Compositions and methods for immunodominant antigens
MX2011011186A (es) * 2009-04-24 2012-02-13 Una vacuna antituberculosis tb para evitar la reactivacion.
BR112012018669A2 (pt) 2010-01-27 2017-09-05 Glaxosmithkline Biologicals Sa Proteína rv3616c modificada, uso de uma proteína rv3616c modificada, polinucleotídeo, uso de um polinucleotídeo, composição farmacêutica, composição imunogênica, proteína de fusão, e, polipeptídeo.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053075A2 (en) * 1997-05-20 1998-11-26 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
WO2001062893A2 (en) * 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
US20040086523A1 (en) * 2000-06-20 2004-05-06 Yasir Skeiky Fusion proteins of mycobacterium tuberculosis
US20040197896A1 (en) * 2001-02-22 2004-10-07 Stewart Cole Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses
WO2008007942A1 (en) * 2006-07-10 2008-01-17 Het Nederlands Kanker Instituut Means and methods for manipulating sequential phagolysomal-cytosolic translocation of mycobacteria, and uses thereof

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"Harrison's Principles of Internal Medicine (16th Edition)", vol. 1, 1 January 2005, MCGRAW-HILL, MEDICAL PUBLISHING DIVISION, ISBN: 978-0-07-139140-5, article RAVIGLIONE MC, O�BRIEN RJ: "Chapter 150: Tuberculosis + TITELSEITE + ISBN SEITE", pages: 953 - 966, XP009125114 *
AL TTIYAH R. ET AL.: "In vitro cellular immune responses to complex and newly defined recombinant antigens of Mycobacterium tuberculosis", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 138, no. 1, October 2004 (2004-10), pages 139-144, XP002554333, ISSN: 0009-9104, the whole document, in particular, Tables 1, 3, 4 and 5 *
FORTUNE S M ET AL: "Mutually dependent secretion of proteins required for mycobacterial virulence", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 102, no. 30, 26 July 2005 (2005-07-26), US, pages 10676 - 10681, XP002554331, ISSN: 0027-8424, DOI: 10.1073/pnas.0504922102 *
MCLAUGHLIN BRYANT ET AL: "A mycobacterium ESX-1-Secreted virulence factor with unique requirements for export", PL O S PATHOGENS (PRINT), PUBLIC LIBRARY OF SCIENCE, US, vol. 3, no. 8, 1 August 2007 (2007-08-01), US, pages 1051 - 1061, XP002554334, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.0030105 *
MUSTAFA A S ET AL: "Immunogenicity of Mycobacterium tuberculosis antigens in Mycobacterium bovis BCG-vaccinated and M-bovis-infected cattle", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 74, no. 8, 1 August 2006 (2006-08-01), US, pages 4566 - 4572, XP002554332, ISSN: 0019-9567, DOI: 10.1128/IAI.01660-05 *
RAGHAVAN SRIDHARAN ET AL: "Secreted transcription factor controls Mycobacterium tuberculosis virulence", NATURE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 454, no. 7205, 7 August 2008 (2008-08-07), United Kingdom, pages 717 - 722, XP002554335, ISSN: 0028-0836, DOI: 10.1038/nature07219 *
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Also Published As

Publication number Publication date
UA107330C2 (uk) 2014-12-25
AU2009273130A1 (en) 2010-01-28
SI2315773T1 (sl) 2016-12-30
CO6341637A2 (es) 2011-11-21
PL2315773T3 (pl) 2017-07-31
EP2315773A1 (en) 2011-05-04
CY1118200T1 (el) 2017-06-28
US20140178423A1 (en) 2014-06-26
HUE031044T2 (en) 2017-06-28
EP2315773B1 (en) 2016-08-24
JP2011528895A (ja) 2011-12-01
LT2315773T (lt) 2016-11-10
DK2315773T3 (en) 2016-12-12
CN102164952A (zh) 2011-08-24
US9795663B2 (en) 2017-10-24
BRPI0916703A2 (pt) 2019-12-24
CA2731499A1 (en) 2010-01-28
EA201100072A1 (ru) 2011-10-31
ES2602430T3 (es) 2017-02-21
SG192456A1 (en) 2013-08-30
US20110117119A1 (en) 2011-05-19
WO2010010177A1 (en) 2010-01-28
AU2009273130B2 (en) 2014-10-16
CN102164952B (zh) 2016-05-25
HRP20161458T1 (hr) 2016-12-16
JP5873332B2 (ja) 2016-03-01
IL210559A0 (en) 2011-03-31
CA2731499C (en) 2017-01-10
KR20110044883A (ko) 2011-05-02
PT2315773T (pt) 2016-11-23
MX2011000983A (es) 2011-03-02

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU