EA024809B1 - Замещенные соединения пиридазинкарбоксамида - Google Patents

Info

Publication number

EA024809B1

EA024809B1 EA201390520A EA201390520A EA024809B1 EA 024809 B1 EA024809 B1 EA 024809B1 EA 201390520 A EA201390520 A EA 201390520A EA 201390520 A EA201390520 A EA 201390520A EA 024809 B1 EA024809 B1 EA 024809B1

Authority

EA

Eurasian Patent Office

Prior art keywords

compound

disease

fluorophenyl

ethoxy

dichloro

Prior art date

2010-10-08

Links

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• Global Dossier
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• DMYLUKNFEYWGCH-UHFFFAOYSA-N pyridazine-3-carboxamide Chemical class NC(=O)C1=CC=CN=N1 DMYLUKNFEYWGCH-UHFFFAOYSA-N 0.000 title description 2
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• 208000020016 psychiatric disease Diseases 0.000 claims abstract 3
• 150000001875 compounds Chemical class 0.000 claims description 160
• 238000000034 method Methods 0.000 claims description 75
• -1 methylpiperazinyl Chemical group 0.000 claims description 73
• 201000010099 disease Diseases 0.000 claims description 56
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• 238000011282 treatment Methods 0.000 claims description 31
• 125000000623 heterocyclic group Chemical group 0.000 claims description 23
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• 150000003839 salts Chemical class 0.000 claims description 20
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• 125000000217 alkyl group Chemical group 0.000 claims description 14
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• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 9
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• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
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• DVWOYOSIEJRHKW-UIRZNSHLSA-M sodium (2S)-2-[[(2S)-2-[[(4,4-difluorocyclohexyl)-phenylmethoxy]carbonylamino]-4-methylpentanoyl]amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonate Chemical compound FC1(CCC(CC1)C(OC(=O)N[C@H](C(=O)N[C@H](C(S(=O)(=O)[O-])O)C[C@H]1C(NCC1)=O)CC(C)C)C1=CC=CC=C1)F.[Na+] DVWOYOSIEJRHKW-UIRZNSHLSA-M 0.000 description 6
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