EA024794B1 - Вариант эндолизина со встроенным катионным пептидом с активностью, разрушающей липополисахарид - Google Patents
Вариант эндолизина со встроенным катионным пептидом с активностью, разрушающей липополисахарид Download PDFInfo
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- EA024794B1 EA024794B1 EA201100312A EA201100312A EA024794B1 EA 024794 B1 EA024794 B1 EA 024794B1 EA 201100312 A EA201100312 A EA 201100312A EA 201100312 A EA201100312 A EA 201100312A EA 024794 B1 EA024794 B1 EA 024794B1
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- endolysin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| PCT/EP2009/060947 WO2010023207A2 (en) | 2008-08-26 | 2009-08-25 | Antimicrobial agents |
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| PL (1) | PL2331687T3 (https=) |
| WO (1) | WO2010023207A2 (https=) |
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| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| AU2010264659B2 (en) * | 2009-06-26 | 2016-08-04 | Lysando Aktiengesellschaft | Antimicrobial agents |
| PL2445515T3 (pl) | 2009-06-26 | 2016-10-31 | Środki przeciwdrobnoustrojowe | |
| KR20120059576A (ko) * | 2009-08-24 | 2012-06-08 | 뤼산도 홀딩 아게 | 신규한 엔도리신 ＯＢＰｇｐＬＹＳ |
| SG184836A1 (en) * | 2010-04-27 | 2012-11-29 | Lysando Ag | Method of reducing biofilms |
| CA3048783C (en) | 2010-09-17 | 2022-05-24 | Tecnifar-Industria Tecnica Farmaceutica, S.A. | Antibacterial phage, phage peptides and methods of use thereof |
| GB201018518D0 (en) * | 2010-11-03 | 2010-12-15 | Univ Leuven Kath | Novel endolysin |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| DK2699253T3 (en) * | 2011-04-21 | 2018-07-16 | Univ Rockefeller | STREPTOCOCCUS BACTERYPHAGIC LYSINES FOR THE DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIES |
| EP2702070B1 (en) * | 2011-04-27 | 2015-09-30 | Lysando AG | New antimicrobial agents |
| US9068204B2 (en) | 2013-03-15 | 2015-06-30 | The United States Of America, As Represented By The Secretary Of Agriculture | Peptidoglycan hydrolase antimicrobials for eradicating lactobacilli that contaminate and reduce ethanol yields in biofuel fermentation |
| WO2015070912A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| WO2015070911A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| EP3105322B1 (en) | 2014-02-14 | 2018-12-12 | Lysando AG | Antimicrobial agents |
| US20170106058A1 (en) * | 2014-04-08 | 2017-04-20 | Lysando Ag | Pharmaceutical composition against chronic bacterial infections |
| WO2015200783A2 (en) | 2014-06-26 | 2015-12-30 | The Rockefeller University | Acinetobacter lysins |
| CN104762285B (zh) * | 2015-04-23 | 2017-10-27 | 武汉菲吉乐科生物科技有限公司 | 一种自内裂解大肠杆菌的裂解酶及其应用 |
| CN110300760B (zh) * | 2016-12-16 | 2023-10-20 | 米尼奥大学 | 新的内溶素 |
| MX2019011808A (es) * | 2017-04-03 | 2020-01-09 | Sasinapas Co Ltd | Endolisinas de gram-negativas modificadas. |
| WO2019118632A1 (en) * | 2017-12-12 | 2019-06-20 | Contrafect Corporation | Identification of lysins and derivatives thereof with bacterial activity against pseudomonas aeruginosa |
| AU2019276253A1 (en) | 2018-05-30 | 2020-11-26 | Lysando Ag | Novel antimicrobial proteins |
| WO2019229184A1 (en) | 2018-05-30 | 2019-12-05 | Lysando Ag | Novel antimicrobial fusion proteins |
| MX2021013491A (es) * | 2019-05-08 | 2022-02-21 | Phagomed Biopharma Gmbh | Nuevas endolisinas de gardnerella y usos de las mismas. |
| WO2023225518A2 (en) * | 2022-05-16 | 2023-11-23 | The Broad Institute, Inc. | Engineered pnma proteins and delivery systems thereof |
| CN117737001B (zh) * | 2022-12-27 | 2024-08-09 | 菲吉乐科(南京)生物科技有限公司 | 一种防治犬细菌性腹泻的大肠杆菌噬菌体及其应用 |
| CN118620800B (zh) * | 2024-08-08 | 2024-11-12 | 中国兽医药品监察所 | 一株鼻疽伯克霍尔德氏菌及其应用 |
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| KR970006154B1 (ko) | 1987-07-06 | 1997-04-24 | 루이지아나 스테이트 유니버시티 아그리컬춰럴 앤드 메카니칼 컬리지 | 용해성 펩티드에 의한 진핵 병원체와 신생물의 억제 및 섬유아세포와 임파구의 자극 |
| EP0656952B1 (en) | 1992-08-21 | 2003-03-05 | The University Of British Columbia | Cationic peptides and method for production |
| ATE198119T1 (de) | 1994-09-01 | 2001-01-15 | Novo Nordisk As | Eine grundlegende proteinzusammensetzung zur abtötung oder inhibierung mikrobieller zellen |
| US6503881B2 (en) | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US6288212B1 (en) | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| US5993809A (en) | 1998-11-18 | 1999-11-30 | Children's Hospital Medical Center | Lysozyme fusion proteins in infections |
| WO2001000855A1 (en) | 1999-06-23 | 2001-01-04 | Ppl Therapeutics (Scotland) Ltd. | Fusion proteins incorporating lysozyme |
| ATE443767T1 (de) | 2002-04-22 | 2009-10-15 | Dow Global Technologies Inc | Kostengünstige herstellung von peptiden |
| US7566447B2 (en) | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
| BRPI0413833A (pt) | 2003-09-11 | 2006-10-24 | Novozymes As | célula hospedeira microbiana recombinante, construção de ácido nucleico, método para produzir uma enzima e/ou um agente antimicrobiano, produto de fusão, aditivo e composição de ração animal, animal não humano transgênico ou produtos ou elementos deste, usos do produto de fusão, da co-expressão de um agente antimicrobiano e uma enzima, e de um peptìdeo de proteção, e, método para identificar um peptìdeo de proteção |
| WO2005108563A2 (en) | 2004-04-19 | 2005-11-17 | University Of Chicago | Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4 |
| US7572602B1 (en) | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| DE102005040347A1 (de) | 2005-08-25 | 2007-03-01 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von Listerien |
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| SG184836A1 (en) | 2010-04-27 | 2012-11-29 | Lysando Ag | Method of reducing biofilms |
-
2008
- 2008-08-26 GB GBGB0815484.1A patent/GB0815484D0/en not_active Ceased
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2009
- 2009-08-25 KR KR1020117006983A patent/KR101473271B1/ko active Active
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| EP0510907A2 (en) * | 1991-04-20 | 1992-10-28 | Agricultural And Food Research Council | Bacteriophage lysins and their applications in destroying and testing for bacteria |
| US5985271A (en) * | 1997-10-31 | 1999-11-16 | New Horizons Diagnostics Corp. | Prophylactic and theraputic treatment of group A streptococcal infection |
| US20020127220A1 (en) * | 1997-10-31 | 2002-09-12 | Vincent Fiochetti | Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract- |
| DE102006061002A1 (de) * | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102197132B (zh) | 2016-01-13 |
| DK2331687T3 (da) | 2013-01-07 |
| MX2011001957A (es) | 2011-06-20 |
| BRPI0917508A2 (pt) | 2015-08-04 |
| KR20110049883A (ko) | 2011-05-12 |
| AU2009286760A1 (en) | 2010-03-04 |
| AU2009286760B2 (en) | 2015-08-27 |
| CA2735077A1 (en) | 2010-03-04 |
| EP2331687A2 (en) | 2011-06-15 |
| HK1157818A1 (en) | 2012-07-06 |
| KR101473271B1 (ko) | 2014-12-16 |
| US20110243915A1 (en) | 2011-10-06 |
| CA2735077C (en) | 2019-04-09 |
| JP2012500642A (ja) | 2012-01-12 |
| ES2395357T3 (es) | 2013-02-12 |
| JP5153943B2 (ja) | 2013-02-27 |
| EP2331687B1 (en) | 2012-09-19 |
| WO2010023207A3 (en) | 2010-07-15 |
| JP5571757B2 (ja) | 2014-08-13 |
| JP2013081465A (ja) | 2013-05-09 |
| CN102197132A (zh) | 2011-09-21 |
| PL2331687T3 (pl) | 2013-02-28 |
| WO2010023207A2 (en) | 2010-03-04 |
| IL211441A (en) | 2015-04-30 |
| US9809808B2 (en) | 2017-11-07 |
| EA201100312A1 (ru) | 2011-10-31 |
| GB0815484D0 (en) | 2008-10-01 |
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