EA024794B1 - Вариант эндолизина со встроенным катионным пептидом с активностью, разрушающей липополисахарид - Google Patents
Вариант эндолизина со встроенным катионным пептидом с активностью, разрушающей липополисахарид Download PDFInfo
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- EA024794B1 EA024794B1 EA201100312A EA201100312A EA024794B1 EA 024794 B1 EA024794 B1 EA 024794B1 EA 201100312 A EA201100312 A EA 201100312A EA 201100312 A EA201100312 A EA 201100312A EA 024794 B1 EA024794 B1 EA 024794B1
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- endolysin
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- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- General Health & Medical Sciences (AREA)
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- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0815484.1A GB0815484D0 (en) | 2008-08-26 | 2008-08-26 | Antibacterial agents |
| PCT/EP2009/060947 WO2010023207A2 (en) | 2008-08-26 | 2009-08-25 | Antimicrobial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201100312A1 EA201100312A1 (ru) | 2011-10-31 |
| EA024794B1 true EA024794B1 (ru) | 2016-10-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201100312A EA024794B1 (ru) | 2008-08-26 | 2009-08-25 | Вариант эндолизина со встроенным катионным пептидом с активностью, разрушающей липополисахарид |
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Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| US20120195872A1 (en) * | 2009-06-26 | 2012-08-02 | Lysando Ag | Antimicrobial agents |
| PL2445515T3 (pl) | 2009-06-26 | 2016-10-31 | Środki przeciwdrobnoustrojowe | |
| JP5847081B2 (ja) | 2009-08-24 | 2016-01-20 | カトリック ユニバーシテイト ルーベン ケイ．ユー． ルーベン アール アンド ディー | エンドリシンＯＢＰｇｐＬＹＳ |
| DK2563916T3 (en) * | 2010-04-27 | 2015-10-05 | Lysando Ag | METHOD FOR REDUCING biofilms |
| RU2614114C2 (ru) * | 2010-09-17 | 2017-03-22 | Текнифар-Индустриа Текника Фармасьютика, С.А | Бактериофаги, фаговые пептиды и способы их применения |
| GB201018518D0 (en) * | 2010-11-03 | 2010-12-15 | Univ Leuven Kath | Novel endolysin |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| MX383544B (es) * | 2011-04-21 | 2025-03-14 | Univ Rockefeller | Lisinas de bacteriofago de streptococcus para la deteccion y tratamiento de bacterias gram positivas |
| US20140120074A1 (en) * | 2011-04-27 | 2014-05-01 | Lysando Ag | Antimicrobial agents |
| US9068204B2 (en) | 2013-03-15 | 2015-06-30 | The United States Of America, As Represented By The Secretary Of Agriculture | Peptidoglycan hydrolase antimicrobials for eradicating lactobacilli that contaminate and reduce ethanol yields in biofuel fermentation |
| WO2015070912A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| WO2015070911A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| WO2015121443A1 (en) | 2014-02-14 | 2015-08-20 | Lysando Ag | Antimicrobial agents |
| US20170106058A1 (en) * | 2014-04-08 | 2017-04-20 | Lysando Ag | Pharmaceutical composition against chronic bacterial infections |
| BR112016030580B1 (pt) * | 2014-06-26 | 2023-12-19 | The Rockefeller University | Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas |
| CN104762285B (zh) * | 2015-04-23 | 2017-10-27 | 武汉菲吉乐科生物科技有限公司 | 一种自内裂解大肠杆菌的裂解酶及其应用 |
| AU2017375050B2 (en) * | 2016-12-16 | 2021-07-22 | Universidade Do Minho | Novel endolysin |
| KR20240162610A (ko) * | 2017-04-03 | 2024-11-15 | 사시나파스 컴퍼니 리미티드 | 조작된 그람-음성 엔도리신 |
| BR112020011433A2 (pt) * | 2017-12-12 | 2020-12-01 | Contrafect Corporation | identificação de lisinas e seus derivados com atividade bacteriana contra pseudomonas aeruginosa |
| US11958890B2 (en) | 2018-05-30 | 2024-04-16 | Lysando Ag | Antimicrobial proteins |
| US20210198645A1 (en) | 2018-05-30 | 2021-07-01 | Lysando Ag | Novel antimicrobial fusion proteins |
| SG11202111067YA (en) * | 2019-05-08 | 2021-11-29 | Phagomed Biopharma Gmbh | Novel gardnerella endolysins and uses thereof |
| WO2023225518A2 (en) * | 2022-05-16 | 2023-11-23 | The Broad Institute, Inc. | Engineered pnma proteins and delivery systems thereof |
| CN117737001B (zh) * | 2022-12-27 | 2024-08-09 | 菲吉乐科(南京)生物科技有限公司 | 一种防治犬细菌性腹泻的大肠杆菌噬菌体及其应用 |
| CN118620800B (zh) * | 2024-08-08 | 2024-11-12 | 中国兽医药品监察所 | 一株鼻疽伯克霍尔德氏菌及其应用 |
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| EP0510907A2 (en) * | 1991-04-20 | 1992-10-28 | Agricultural And Food Research Council | Bacteriophage lysins and their applications in destroying and testing for bacteria |
| US5985271A (en) * | 1997-10-31 | 1999-11-16 | New Horizons Diagnostics Corp. | Prophylactic and theraputic treatment of group A streptococcal infection |
| US20020127220A1 (en) * | 1997-10-31 | 2002-09-12 | Vincent Fiochetti | Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract- |
| DE102006061002A1 (de) * | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
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| DE3854476T2 (de) | 1987-07-06 | 1996-04-04 | Univ Louisiana State | Inhibierung von eukaryotischen pathogenen und neoplasmen mit lytischen peptiden. |
| WO1994004688A2 (en) | 1992-08-21 | 1994-03-03 | The University Of British Columbia | Cationic peptides and method for production |
| ES2154344T3 (es) | 1994-09-01 | 2001-04-01 | Novozymes As | Composicion proteica basica para matar o inhibir celulas microbianas. |
| US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US6288212B1 (en) | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| US5993809A (en) | 1998-11-18 | 1999-11-30 | Children's Hospital Medical Center | Lysozyme fusion proteins in infections |
| AU5553600A (en) | 1999-06-23 | 2001-01-31 | Ppl Therapeutics (Scotland) Ltd | Fusion proteins incorporating lysozyme |
| CA2482995C (en) | 2002-04-22 | 2013-01-29 | Dow Global Technologies Inc. | Low-cost production of peptides |
| US7566447B2 (en) | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
| BRPI0413833A (pt) | 2003-09-11 | 2006-10-24 | Novozymes As | célula hospedeira microbiana recombinante, construção de ácido nucleico, método para produzir uma enzima e/ou um agente antimicrobiano, produto de fusão, aditivo e composição de ração animal, animal não humano transgênico ou produtos ou elementos deste, usos do produto de fusão, da co-expressão de um agente antimicrobiano e uma enzima, e de um peptìdeo de proteção, e, método para identificar um peptìdeo de proteção |
| WO2005108563A2 (en) | 2004-04-19 | 2005-11-17 | University Of Chicago | Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4 |
| US7572602B1 (en) | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| DE102005040347A1 (de) | 2005-08-25 | 2007-03-01 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von Listerien |
| WO2007113499A1 (en) | 2006-03-31 | 2007-10-11 | The University Court Of The University Of St Andrews | Anti-microbial compositions comprising a cationic peptide and a glycylglycine endopeptidase |
| CN107129524B (zh) | 2007-09-25 | 2023-11-21 | 田园温室气体研究有限公司 | 用于抑制微生物细胞的疫苗和疫苗组分 |
| EP2225263A1 (en) | 2007-11-26 | 2010-09-08 | Plant Bioscience Limited | Novel polypeptides having endolysin activity and uses thereof |
| WO2010011960A2 (en) | 2008-07-24 | 2010-01-28 | The United State Of America, As Represented By The Secretary Of Agriculture | Triple acting antimicrobials that are refractory to resistance development |
| EP2157100A1 (en) | 2008-08-19 | 2010-02-24 | Profos AG | Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| US8389679B2 (en) | 2009-02-05 | 2013-03-05 | The Regents Of The University Of California | Targeted antimicrobial moieties |
| PL2445515T3 (pl) | 2009-06-26 | 2016-10-31 | Środki przeciwdrobnoustrojowe | |
| JP5847081B2 (ja) | 2009-08-24 | 2016-01-20 | カトリック ユニバーシテイト ルーベン ケイ．ユー． ルーベン アール アンド ディー | エンドリシンＯＢＰｇｐＬＹＳ |
| DK2563916T3 (en) | 2010-04-27 | 2015-10-05 | Lysando Ag | METHOD FOR REDUCING biofilms |
-
2008
- 2008-08-26 GB GBGB0815484.1A patent/GB0815484D0/en not_active Ceased
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2009
- 2009-08-25 BR BRPI0917508-3A patent/BRPI0917508A2/pt not_active Application Discontinuation
- 2009-08-25 MX MX2011001957A patent/MX2011001957A/es active IP Right Grant
- 2009-08-25 KR KR1020117006983A patent/KR101473271B1/ko active Active
- 2009-08-25 CN CN200980142373.XA patent/CN102197132B/zh active Active
- 2009-08-25 JP JP2011524360A patent/JP5153943B2/ja active Active
- 2009-08-25 ES ES09782176T patent/ES2395357T3/es active Active
- 2009-08-25 EA EA201100312A patent/EA024794B1/ru not_active IP Right Cessation
- 2009-08-25 WO PCT/EP2009/060947 patent/WO2010023207A2/en not_active Ceased
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- 2009-08-25 CA CA2735077A patent/CA2735077C/en active Active
- 2009-08-25 DK DK09782176.3T patent/DK2331687T3/da active
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- 2009-08-25 PL PL09782176T patent/PL2331687T3/pl unknown
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2011
- 2011-02-27 IL IL211441A patent/IL211441A/en active IP Right Grant
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Patent Citations (4)
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| EP0510907A2 (en) * | 1991-04-20 | 1992-10-28 | Agricultural And Food Research Council | Bacteriophage lysins and their applications in destroying and testing for bacteria |
| US5985271A (en) * | 1997-10-31 | 1999-11-16 | New Horizons Diagnostics Corp. | Prophylactic and theraputic treatment of group A streptococcal infection |
| US20020127220A1 (en) * | 1997-10-31 | 2002-09-12 | Vincent Fiochetti | Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract- |
| DE102006061002A1 (de) * | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
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| IBRAHIM H R, ET AL: "Enhanced bactericidal action of lysozyme to Escherichia coli by inserting a hydrophobic pentapeptide into its C terminus.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 269, no. 7, 18 February 1994 (1994-02-18), US, pages 5059 - 5063, XP002579297, ISSN: 0021-9258 * |
| LOESSNER, M.J.: "Bacteriophage endolysins - current state of research and applications", CURRENT OPINION IN MICROBIOLOGY, CURRENT BIOLOGY LTD, GB, vol. 8, no. 4, 1 August 2005 (2005-08-01), GB, pages 480 - 487, XP004989436, ISSN: 1369-5274, DOI: 10.1016/j.mib.2005.06.002 * |
| MORITA, M. TANJI, Y. ORITO, Y. MIZOGUCHI, K. SOEJIMA, A. UNNO, H.: "Functional analysis of antibacterial activity of Bacillus amyloliquefaciens phage endolysin against Gram-negative bacteria", FEBS LETTERS., ELSEVIER, AMSTERDAM., NL, vol. 500, no. 1-2, 29 June 2001 (2001-06-29), NL, pages 56 - 59, XP004251377, ISSN: 0014-5793, DOI: 10.1016/S0014-5793(01)02587-X * |
| ORITO Y, ET AL: "Bacillus amyloliquefaciens phage endolysin can enhance permeability of Pseudomonas aeruginosa outer membrane and induce cell lysis.", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, DE, vol. 65, no. 1, 1 July 2004 (2004-07-01), DE, pages 105 - 109, XP002579253, ISSN: 0175-7598, DOI: 10.1007/S00253-003-1522-1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL211441A (en) | 2015-04-30 |
| BRPI0917508A2 (pt) | 2015-08-04 |
| US20110243915A1 (en) | 2011-10-06 |
| DK2331687T3 (da) | 2013-01-07 |
| CN102197132A (zh) | 2011-09-21 |
| EP2331687A2 (en) | 2011-06-15 |
| US9809808B2 (en) | 2017-11-07 |
| GB0815484D0 (en) | 2008-10-01 |
| WO2010023207A3 (en) | 2010-07-15 |
| JP5571757B2 (ja) | 2014-08-13 |
| EP2331687B1 (en) | 2012-09-19 |
| JP2012500642A (ja) | 2012-01-12 |
| CA2735077C (en) | 2019-04-09 |
| AU2009286760A1 (en) | 2010-03-04 |
| JP2013081465A (ja) | 2013-05-09 |
| KR20110049883A (ko) | 2011-05-12 |
| ES2395357T3 (es) | 2013-02-12 |
| KR101473271B1 (ko) | 2014-12-16 |
| AU2009286760B2 (en) | 2015-08-27 |
| CN102197132B (zh) | 2016-01-13 |
| WO2010023207A2 (en) | 2010-03-04 |
| CA2735077A1 (en) | 2010-03-04 |
| PL2331687T3 (pl) | 2013-02-28 |
| HK1157818A1 (en) | 2012-07-06 |
| MX2011001957A (es) | 2011-06-20 |
| JP5153943B2 (ja) | 2013-02-27 |
| EA201100312A1 (ru) | 2011-10-31 |
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