EA024647B1 - ИНГИБИТОРЫ Hsp90 - Google Patents
ИНГИБИТОРЫ Hsp90 Download PDFInfo
- Publication number
- EA024647B1 EA024647B1 EA201391337A EA201391337A EA024647B1 EA 024647 B1 EA024647 B1 EA 024647B1 EA 201391337 A EA201391337 A EA 201391337A EA 201391337 A EA201391337 A EA 201391337A EA 024647 B1 EA024647 B1 EA 024647B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- compound
- substituted
- pharmaceutically acceptable
- groups
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201161472061P | 2011-04-05 | 2011-04-05 | |
| PCT/US2012/032373 WO2012138896A1 (en) | 2011-04-05 | 2012-04-05 | Hsp90 inhibitors |
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| Publication Number | Publication Date |
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| EA201391337A1 EA201391337A1 (ru) | 2014-05-30 |
| EA024647B1 true EA024647B1 (ru) | 2016-10-31 |
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| EA201391337A EA024647B1 (ru) | 2011-04-05 | 2012-04-05 | ИНГИБИТОРЫ Hsp90 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9546170B2 (enExample) |
| EP (1) | EP2694506B1 (enExample) |
| JP (1) | JP5961683B2 (enExample) |
| KR (1) | KR101984480B1 (enExample) |
| CN (1) | CN103596955B (enExample) |
| AU (1) | AU2012240079B2 (enExample) |
| BR (1) | BR112013025761A2 (enExample) |
| CA (1) | CA2832099C (enExample) |
| EA (1) | EA024647B1 (enExample) |
| ES (1) | ES2647889T3 (enExample) |
| MX (1) | MX354215B (enExample) |
| WO (1) | WO2012138896A1 (enExample) |
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| WO2006084030A2 (en) | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| WO2008005937A2 (en) | 2006-06-30 | 2008-01-10 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases through inhibiton of hsp90 |
| CA2776308C (en) | 2009-10-07 | 2020-01-28 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| BR112013025634A2 (pt) | 2011-04-05 | 2016-07-19 | Sloan Kettering Inst Cancer | inibidores de hsp90 |
| WO2012138896A1 (en) | 2011-04-05 | 2012-10-11 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| EP3208615B1 (en) | 2011-07-08 | 2019-10-09 | Sloan Kettering Institute For Cancer Research | Uses of labeled hsp90 inhibitors |
| NZ629778A (en) | 2012-02-09 | 2016-03-31 | Univ Kansas | C-terminal hsp90 inhibitors |
| TW201533043A (zh) | 2013-04-18 | 2015-09-01 | Lundbeck & Co As H | 作爲ｌｒｒｋ２抑制劑的芳基吡咯并吡啶衍生化合物 |
| CA2921571C (en) | 2013-08-16 | 2022-04-05 | Memorial Sloan-Kettering Cancer Center | Selective grp94 inhibitors and uses thereof |
| US9994573B2 (en) | 2013-12-23 | 2018-06-12 | Memorial Sloan-Kettering Cancer Center | Methods and reagents for radiolabeling |
| EA201790070A1 (ru) * | 2014-06-24 | 2017-10-31 | Дзе Юниверсити оф Канзас | Бифениламиды, содержащие модифицированные простые эфирные группы, в качестве ингибиторов hsp90 и стимуляторов hsp70 |
| JP6835709B2 (ja) | 2014-09-17 | 2021-02-24 | メモリアル スローン ケタリング キャンサー センター | Ｈｓｐ９０を標的とした炎症及び感染のイメージング及び療法 |
| TW201722422A (zh) | 2015-10-05 | 2017-07-01 | 美國紀念斯隆-凱特琳癌症中心 | 用於治療癌症之合理組合療法 |
| JP7508375B2 (ja) | 2018-05-14 | 2024-07-01 | リアタ ファーマシューティカルズ インコーポレイテッド | 熱ショックタンパク質経路に関連する疾患の治療のための、修飾された糖基を有するビアリールアミド |
| WO2023006993A1 (en) | 2021-07-30 | 2023-02-02 | Atmosr | Fused amino pyridine or pyrimidine derivatives for the treatment of congenital central hypoventilation syndrome |
| KR20250158770A (ko) * | 2023-03-17 | 2025-11-06 | 애트모스알 | Hsp90 억제제로서의 아데닌 유도체 |
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| CA2287387C (en) | 1997-05-14 | 2010-02-16 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
| JP2002541255A (ja) | 1999-04-09 | 2002-12-03 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｅｒ族チロシンキナーゼの分解および／または阻害方法および組成物 |
| JP4406205B2 (ja) | 2000-11-02 | 2010-01-27 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | Ｈｓｐ９０に結合するための小分子組成物 |
| US7067507B2 (en) * | 2001-06-12 | 2006-06-27 | Pharmacia & Upjohn Company | Macrocycles useful in the treatment of Alzheimer's disease |
| CA2464031A1 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| EP1450784A4 (en) | 2001-11-09 | 2005-02-09 | Conforma Therapeutics Corp | HSP90-INHIBITABLE ZEARALANOL COMPOUNDS AND METHOD FOR THEIR PREPARATION AND USE |
| RU2004129276A (ru) | 2002-02-28 | 2005-06-10 | Астразенека Аб (Se) | Производные 3-циклического-5-(азотсодержащего 5-членного кольцевого) метил-оксазолидинона и их применение в качестве антибактериальных средств |
| WO2004094647A2 (en) | 2003-04-18 | 2004-11-04 | Cytovia, Inc. | Methods of treating diseases responsive to induction of apoptosis and screening assays |
| BRPI0414533A (pt) | 2003-09-18 | 2006-11-07 | Conforma Therapeutics Corp | composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90 |
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| WO2006084030A2 (en) | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| EP1917252B1 (en) | 2005-08-26 | 2014-01-01 | Merck Serono SA | Pyrazine derivatives and use as pi3k inhibitors |
| JP2009521446A (ja) | 2005-12-22 | 2009-06-04 | コンフォーマ・セラピューティクス・コーポレイション | 熱ショックタンパク質９０の経口活性なプリンベースの阻害剤 |
| AU2007249194B2 (en) | 2006-05-12 | 2012-11-22 | Myrexis, Inc. | Therapeutic compounds and their use in cancer |
| WO2008005937A2 (en) | 2006-06-30 | 2008-01-10 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases through inhibiton of hsp90 |
| KR20090077914A (ko) | 2006-09-11 | 2009-07-16 | 쿠리스 인코퍼레이션 | 항증식제로서의 다작용성 소분자 |
| FR2906824B1 (fr) | 2006-10-09 | 2008-12-26 | Roger Mondelin Sas Soc Par Act | Dispositif support de butees pour la pose de plaques de platre de largeur variable avec des appareils de levage et de manutention desdites plaques |
| CL2007002994A1 (es) | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
| GB0622084D0 (en) | 2006-11-06 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of HSP90 |
| US20080234297A1 (en) | 2007-03-20 | 2008-09-25 | Changgeng Qian | HSP90 Inhibitors Containing a Zinc Binding Moiety |
| EP2183221A1 (en) | 2007-07-12 | 2010-05-12 | Crystax Pharmaceuticals S.L. | New compounds as hsp90 inhibitors |
| WO2009042646A1 (en) | 2007-09-24 | 2009-04-02 | Curis, Inc. | Anti-proliferative agents |
| AU2008322503A1 (en) | 2007-11-14 | 2009-05-22 | Myrexis, Inc. | Therapeutic compounds and their use in treating diseases and disorders |
| CA3017874A1 (en) | 2009-01-16 | 2010-07-22 | Curis, Inc. | Fused amino pyridines for the treatment of brain tumors |
| CA2776308C (en) | 2009-10-07 | 2020-01-28 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| WO2012138896A1 (en) | 2011-04-05 | 2012-10-11 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| BR112013025634A2 (pt) | 2011-04-05 | 2016-07-19 | Sloan Kettering Inst Cancer | inibidores de hsp90 |
| CA2921571C (en) | 2013-08-16 | 2022-04-05 | Memorial Sloan-Kettering Cancer Center | Selective grp94 inhibitors and uses thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008115719A1 (en) * | 2007-03-20 | 2008-09-25 | Curis, Inc. | Fused amino pyridine as hsp90 inhibitors |
Non-Patent Citations (1)
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| AU2012240079B2 (en) | 2017-05-18 |
| ES2647889T3 (es) | 2017-12-27 |
| BR112013025761A2 (pt) | 2018-05-29 |
| US10064867B2 (en) | 2018-09-04 |
| NZ616890A (en) | 2016-01-29 |
| CA2832099C (en) | 2019-07-09 |
| CA2832099A1 (en) | 2012-10-11 |
| JP5961683B2 (ja) | 2016-08-02 |
| CN103596955B (zh) | 2016-11-16 |
| US20140045867A1 (en) | 2014-02-13 |
| JP2014510149A (ja) | 2014-04-24 |
| MX2013011531A (es) | 2014-08-22 |
| US9546170B2 (en) | 2017-01-17 |
| EP2694506B1 (en) | 2017-09-20 |
| KR20140073464A (ko) | 2014-06-16 |
| KR101984480B1 (ko) | 2019-05-31 |
| MX354215B (es) | 2018-02-19 |
| AU2012240079A1 (en) | 2013-11-07 |
| WO2012138896A1 (en) | 2012-10-11 |
| EA201391337A1 (ru) | 2014-05-30 |
| EP2694506A1 (en) | 2014-02-12 |
| CN103596955A (zh) | 2014-02-19 |
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