MX354215B - Inhibidores de la proteina 90 de choque termico (hsp90). - Google Patents
Inhibidores de la proteina 90 de choque termico (hsp90).Info
- Publication number
- MX354215B MX354215B MX2013011531A MX2013011531A MX354215B MX 354215 B MX354215 B MX 354215B MX 2013011531 A MX2013011531 A MX 2013011531A MX 2013011531 A MX2013011531 A MX 2013011531A MX 354215 B MX354215 B MX 354215B
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- pharmaceutically acceptable
- independently
- compound
- effective amount
- Prior art date
Links
- 239000003481 heat shock protein 90 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161472061P | 2011-04-05 | 2011-04-05 | |
| PCT/US2012/032373 WO2012138896A1 (en) | 2011-04-05 | 2012-04-05 | Hsp90 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013011531A MX2013011531A (es) | 2014-08-22 |
| MX354215B true MX354215B (es) | 2018-02-19 |
Family
ID=46018086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013011531A MX354215B (es) | 2011-04-05 | 2012-04-05 | Inhibidores de la proteina 90 de choque termico (hsp90). |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9546170B2 (enExample) |
| EP (1) | EP2694506B1 (enExample) |
| JP (1) | JP5961683B2 (enExample) |
| KR (1) | KR101984480B1 (enExample) |
| CN (1) | CN103596955B (enExample) |
| AU (1) | AU2012240079B2 (enExample) |
| BR (1) | BR112013025761A2 (enExample) |
| CA (1) | CA2832099C (enExample) |
| EA (1) | EA024647B1 (enExample) |
| ES (1) | ES2647889T3 (enExample) |
| MX (1) | MX354215B (enExample) |
| WO (1) | WO2012138896A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| US7834181B2 (en) | 2005-02-01 | 2010-11-16 | Slaon-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| CA2656202C (en) | 2006-06-30 | 2018-01-16 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases through inhibition of hsp90 |
| DK2486039T3 (en) | 2009-10-07 | 2016-09-12 | Sloan Kettering Inst For Cancer Res | Purine derivatives that are useful as HSP90 INHIBITORS |
| AU2012240079B2 (en) | 2011-04-05 | 2017-05-18 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| WO2012138894A1 (en) | 2011-04-05 | 2012-10-11 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| JP6218147B2 (ja) | 2011-07-08 | 2017-10-25 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 標識されたｈｓｐ９０阻害剤の使用 |
| SI3656758T1 (sl) | 2012-02-09 | 2024-06-28 | The University Of Kansas | Intermediati za pripravo c-terminalnih inhibitorjev hsp90 |
| TW201533043A (zh) | 2013-04-18 | 2015-09-01 | Lundbeck & Co As H | 作爲ｌｒｒｋ２抑制劑的芳基吡咯并吡啶衍生化合物 |
| WO2015023976A2 (en) | 2013-08-16 | 2015-02-19 | Memorial Sloan-Kettering Cancer Center | Selective grp94 inhibitors and uses thereof |
| US9994573B2 (en) | 2013-12-23 | 2018-06-12 | Memorial Sloan-Kettering Cancer Center | Methods and reagents for radiolabeling |
| EP4494702A3 (en) | 2014-06-24 | 2025-02-26 | The University of Kansas | Biphenyl amides with modified ether groups as hsp90 inhibitors and hsp70 inducers |
| BR112017005313A2 (pt) | 2014-09-17 | 2017-12-05 | Memorial Sloan Kettering Cancer Center | formação de imagem e terapia para inflamação e infecção direcionadas por hsp90 |
| MA47474A (fr) | 2015-10-05 | 2019-12-25 | Memorial Sloan Kettering Cancer Center | Polythérapie rationelle pour le traitement du cancer |
| BR112020023277A2 (pt) | 2018-05-14 | 2021-02-23 | Reata Pharmaceuticals, Inc. | biaril amidas com grupos açúcar modificados para tratamento de doenças associadas à trajetória da proteína de choque térmico |
| WO2023006993A1 (en) | 2021-07-30 | 2023-02-02 | Atmosr | Fused amino pyridine or pyrimidine derivatives for the treatment of congenital central hypoventilation syndrome |
| WO2024194175A1 (en) * | 2023-03-17 | 2024-09-26 | Atmosr | Adenine derivatives as hsp90 inhibitors |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1023315B1 (en) | 1997-05-14 | 2010-03-10 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
| JP2002541255A (ja) | 1999-04-09 | 2002-12-03 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | Ｈｅｒ族チロシンキナーゼの分解および／または阻害方法および組成物 |
| JP2005519848A (ja) | 2000-11-02 | 2005-07-07 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | Ｈｓｐ９０に結合するための小分子組成物 |
| US7067507B2 (en) * | 2001-06-12 | 2006-06-27 | Pharmacia & Upjohn Company | Macrocycles useful in the treatment of Alzheimer's disease |
| AU2002343604C1 (en) | 2001-10-30 | 2009-09-17 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
| AU2002356922A1 (en) | 2001-11-09 | 2003-05-26 | Conforma Therapeutics Corporation | Hsp90-inhibiting zearalanol compounds and methods of producing and using same |
| KR20040087329A (ko) | 2002-02-28 | 2004-10-13 | 아스트라제네카 아베 | 3-시클릴-5-(질소-함유 5-원 고리) 메틸-옥사졸리디논유도체 및 그의 항균제로서의 용도 |
| EP1620564A4 (en) | 2003-04-18 | 2008-03-12 | Cytovia Inc | METHODS FOR TREATING DISEASES INDUCING APOPTOSIS INDUCTION AND SCREENING ASSAYS |
| US7138401B2 (en) | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | 2-aminopurine analogs having HSP90-inhibiting activity |
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| US7834181B2 (en) | 2005-02-01 | 2010-11-16 | Slaon-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| BRPI0615233A2 (pt) | 2005-08-26 | 2011-05-10 | Serono Lab | derivados de pirazina e uso dos mesmos como inibidores p13k |
| WO2007075572A2 (en) | 2005-12-22 | 2007-07-05 | Conforma Therapeutics Corporation | Orally active purine-based inhibitors of heat shock protein 90 |
| CN101490052B (zh) | 2006-05-12 | 2012-08-08 | 美瑞德生物工程公司 | 治疗性化合物及其在癌症中的用途 |
| CA2656202C (en) | 2006-06-30 | 2018-01-16 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases through inhibition of hsp90 |
| KR20090077914A (ko) | 2006-09-11 | 2009-07-16 | 쿠리스 인코퍼레이션 | 항증식제로서의 다작용성 소분자 |
| FR2906824B1 (fr) | 2006-10-09 | 2008-12-26 | Roger Mondelin Sas Soc Par Act | Dispositif support de butees pour la pose de plaques de platre de largeur variable avec des appareils de levage et de manutention desdites plaques |
| CL2007002994A1 (es) | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
| GB0622084D0 (en) | 2006-11-06 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of HSP90 |
| CN101679347B (zh) * | 2007-03-20 | 2014-10-22 | 柯瑞斯公司 | 作为hsp90抑制剂的稠和的氨基吡啶 |
| US20080234297A1 (en) | 2007-03-20 | 2008-09-25 | Changgeng Qian | HSP90 Inhibitors Containing a Zinc Binding Moiety |
| EP2183221A1 (en) | 2007-07-12 | 2010-05-12 | Crystax Pharmaceuticals S.L. | New compounds as hsp90 inhibitors |
| WO2009042646A1 (en) | 2007-09-24 | 2009-04-02 | Curis, Inc. | Anti-proliferative agents |
| EP2219448A4 (en) | 2007-11-14 | 2011-10-12 | Myriad Pharmaceuticals Inc | THERAPEUTIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASES AND SUFFERINGS |
| EP2387316A4 (en) | 2009-01-16 | 2012-06-13 | Curis Inc | CONDENSED AMINOPYRIDINE FOR THE TREATMENT OF BRAIN TUMORS |
| DK2486039T3 (en) | 2009-10-07 | 2016-09-12 | Sloan Kettering Inst For Cancer Res | Purine derivatives that are useful as HSP90 INHIBITORS |
| WO2012138894A1 (en) | 2011-04-05 | 2012-10-11 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| AU2012240079B2 (en) | 2011-04-05 | 2017-05-18 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| WO2015023976A2 (en) | 2013-08-16 | 2015-02-19 | Memorial Sloan-Kettering Cancer Center | Selective grp94 inhibitors and uses thereof |
-
2012
- 2012-04-05 AU AU2012240079A patent/AU2012240079B2/en not_active Ceased
- 2012-04-05 MX MX2013011531A patent/MX354215B/es active IP Right Grant
- 2012-04-05 US US14/110,095 patent/US9546170B2/en active Active
- 2012-04-05 KR KR1020137029258A patent/KR101984480B1/ko not_active Expired - Fee Related
- 2012-04-05 CA CA2832099A patent/CA2832099C/en active Active
- 2012-04-05 EP EP12717521.4A patent/EP2694506B1/en active Active
- 2012-04-05 JP JP2014503996A patent/JP5961683B2/ja not_active Expired - Fee Related
- 2012-04-05 ES ES12717521.4T patent/ES2647889T3/es active Active
- 2012-04-05 CN CN201280027360.XA patent/CN103596955B/zh not_active Expired - Fee Related
- 2012-04-05 BR BR112013025761A patent/BR112013025761A2/pt not_active IP Right Cessation
- 2012-04-05 EA EA201391337A patent/EA024647B1/ru not_active IP Right Cessation
- 2012-04-05 WO PCT/US2012/032373 patent/WO2012138896A1/en not_active Ceased
-
2016
- 2016-12-09 US US15/374,007 patent/US10064867B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170151247A1 (en) | 2017-06-01 |
| CA2832099A1 (en) | 2012-10-11 |
| AU2012240079A1 (en) | 2013-11-07 |
| ES2647889T3 (es) | 2017-12-27 |
| EP2694506A1 (en) | 2014-02-12 |
| EA024647B1 (ru) | 2016-10-31 |
| EA201391337A1 (ru) | 2014-05-30 |
| EP2694506B1 (en) | 2017-09-20 |
| US10064867B2 (en) | 2018-09-04 |
| KR20140073464A (ko) | 2014-06-16 |
| MX2013011531A (es) | 2014-08-22 |
| BR112013025761A2 (pt) | 2018-05-29 |
| JP5961683B2 (ja) | 2016-08-02 |
| CN103596955A (zh) | 2014-02-19 |
| US20140045867A1 (en) | 2014-02-13 |
| US9546170B2 (en) | 2017-01-17 |
| AU2012240079B2 (en) | 2017-05-18 |
| CN103596955B (zh) | 2016-11-16 |
| JP2014510149A (ja) | 2014-04-24 |
| CA2832099C (en) | 2019-07-09 |
| WO2012138896A1 (en) | 2012-10-11 |
| NZ616890A (en) | 2016-01-29 |
| KR101984480B1 (ko) | 2019-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |