EA023679B1 - АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ - Google Patents

АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ Download PDF

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Publication number
EA023679B1
EA023679B1 EA200970923A EA200970923A EA023679B1 EA 023679 B1 EA023679 B1 EA 023679B1 EA 200970923 A EA200970923 A EA 200970923A EA 200970923 A EA200970923 A EA 200970923A EA 023679 B1 EA023679 B1 EA 023679B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
ersam
epcam
fragment
tumor
Prior art date
Application number
EA200970923A
Other languages
English (en)
Russian (ru)
Other versions
EA200970923A1 (ru
Inventor
Анна Мария Анастаси
Фиорелла Петронцелли
Рита Де Сантис
Саверио Альберти
Original Assignee
Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. filed Critical Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Publication of EA200970923A1 publication Critical patent/EA200970923A1/ru
Publication of EA023679B1 publication Critical patent/EA023679B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EA200970923A 2007-04-04 2008-04-02 АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ EA023679B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07105628 2007-04-04
PCT/EP2008/053913 WO2008122551A2 (en) 2007-04-04 2008-04-02 Anti-epcam antibody and uses thereof

Publications (2)

Publication Number Publication Date
EA200970923A1 EA200970923A1 (ru) 2010-04-30
EA023679B1 true EA023679B1 (ru) 2016-06-30

Family

ID=38458122

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970923A EA023679B1 (ru) 2007-04-04 2008-04-02 АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ

Country Status (21)

Country Link
US (1) US8318911B2 (enExample)
EP (1) EP2142570B1 (enExample)
JP (1) JP5631733B2 (enExample)
KR (1) KR101683884B1 (enExample)
CN (1) CN101970497B (enExample)
AT (1) ATE512988T1 (enExample)
AU (1) AU2008235566B2 (enExample)
BR (1) BRPI0810096A8 (enExample)
CA (1) CA2682296C (enExample)
CY (1) CY1111819T1 (enExample)
DK (1) DK2142570T3 (enExample)
EA (1) EA023679B1 (enExample)
ES (1) ES2367675T3 (enExample)
HR (1) HRP20110620T1 (enExample)
IL (1) IL201196A0 (enExample)
MX (1) MX2009010444A (enExample)
PL (1) PL2142570T3 (enExample)
PT (1) PT2142570E (enExample)
RS (1) RS52040B (enExample)
SI (1) SI2142570T1 (enExample)
WO (1) WO2008122551A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004068110A2 (en) 2003-01-24 2004-08-12 University Of Utah Methods of predicting mortality risk by determining telomere length
ES2433718T3 (es) 2008-12-22 2013-12-12 University Of Utah Research Foundation PCR multiplex monocromática cuantitativa
GB0909904D0 (en) * 2009-06-09 2009-07-22 Affitech As Product
WO2012123755A1 (en) 2011-03-17 2012-09-20 The University Of Birmingham Re-directed immunotherapy
JP6400470B2 (ja) * 2011-05-16 2018-10-03 ジェネロン（シャンハイ）コーポレイション リミテッド 多重特異性Ｆａｂ融合タンパク質および使用法
CN107315086B (zh) * 2011-06-29 2019-09-10 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
EP2819695B1 (en) * 2012-03-02 2018-06-27 Academia Sinica ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF
US9494500B2 (en) 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof
JP6546158B2 (ja) 2013-05-22 2019-07-17 テロメア ダイアグノスティクス インコーポレイテッド 短いテロメアの存在量の測定
TW201623605A (zh) 2014-04-01 2016-07-01 中央研究院 用於癌症診斷及預後之方法及系統
US10112198B2 (en) 2014-08-26 2018-10-30 Academia Sinica Collector architecture layout design
WO2016108954A1 (en) 2014-12-30 2016-07-07 Telomere Diagnostics, Inc. Multiplex quantitative pcr
EP3328897A1 (en) 2015-07-31 2018-06-06 Sutro Biopharma, Inc. ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EPCAM ANTIBODIES
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
WO2017173091A1 (en) * 2016-03-30 2017-10-05 Musc Foundation For Research Development Methods for treatment and diagnosis of cancer by targeting glycoprotein a repetitions predominant (garp) and for providing effective immunotherapy alone or in combination
CN110035768A (zh) 2016-07-26 2019-07-19 泰莎治疗私人有限公司 嵌合抗原受体
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
JP7728701B2 (ja) 2018-12-17 2025-08-25 レビトープ リミテッド 双子型免疫細胞エンゲージャー
WO2020132810A1 (en) 2018-12-24 2020-07-02 Generon (Shanghai) Corporation Ltd. Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof
CN113597432B (zh) * 2019-04-22 2023-05-02 江苏恒瑞医药股份有限公司 抗EpCAM抗体及其应用
CN114026127B (zh) * 2019-06-11 2024-10-29 生物蛋白有限公司 条件活性抗epcam抗体、抗体片段、其免疫缀合物以及其用途
CN110950959B (zh) * 2020-02-25 2020-07-03 和铂医药(上海)有限责任公司 靶向EpCAM的抗体及其制备和应用
CN112094350B (zh) * 2020-06-01 2024-01-05 普众发现医药科技(上海)有限公司 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体
WO2022037323A1 (zh) * 2020-08-19 2022-02-24 上海易慕峰生物科技有限公司 人源化抗体、嵌合抗原受体、核酸、载体、细胞及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005080428A2 (en) * 2004-02-13 2005-09-01 Micromet Ag Anti-epcam immunoglobulins
US20060105389A1 (en) * 2004-10-19 2006-05-18 Kordyum Vitaliy A Method for obtaining single chain antibodies to human interferon alpha2b

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
US5525338A (en) 1992-08-21 1996-06-11 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin conjugates
IT1245748B (it) 1990-12-21 1994-10-14 Mini Ricerca Scient Tecnolog Preparazione includente anticorpi monoclonali biotinilati, avidina e biotina, per la diagnosi di affezioni tumorali e suo impiego
US5578287A (en) * 1992-06-09 1996-11-26 Neorx Corporation Three-step pretargeting methods using improved biotin-active agent
JP3427871B2 (ja) * 1996-06-24 2003-07-22 戸田工業株式会社 コバルト被着型針状磁性酸化鉄粒子粉末
ITRM20010079A1 (it) 2001-02-16 2002-08-16 Sigma Tau Ind Farmaceuti Amminoderivati della biotina e loro coniugati con chelanti macrociclici.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005080428A2 (en) * 2004-02-13 2005-09-01 Micromet Ag Anti-epcam immunoglobulins
US20060105389A1 (en) * 2004-10-19 2006-05-18 Kordyum Vitaliy A Method for obtaining single chain antibodies to human interferon alpha2b

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FRODIN JAN-ERIK ET AL: "MAb17-1A and cytokines for the treatment of patients with colorectal carcinoma." HYBRIDOMA AND HYBRIDOMICS APR 2002, vol. 21, no. 2, April 2002 (2002-04), pages 99-101, XP002450070. ISSN: 1536-8599 the whole document *
NAUNDORF S ET AL: "In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment". INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 100, no. 1, 2002, pages 101-110, XP002253132. ISSN: 0020-7136 the whole document *
PRANG N ET AL: "Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 92, no. 2, 31 January 2005 (2005-01-31), pages 342-349, XP002437689 ISSN: 0007-0920 the whole document *
WENT P ET AL: "Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers." BRITISH JOURNAL OF CANCER 16 JAN 2006, vol. 94, no. 1, 16 January 2006 (2006-01-16), pages 128-135, XP002450071. ISSN: 0007-0920 the whole document *

Also Published As

Publication number Publication date
US20100092491A1 (en) 2010-04-15
CA2682296A1 (en) 2008-10-16
CN101970497B (zh) 2017-05-10
AU2008235566B2 (en) 2013-06-06
BRPI0810096A8 (pt) 2017-12-26
DK2142570T3 (da) 2011-10-03
CY1111819T1 (el) 2015-10-07
EA200970923A1 (ru) 2010-04-30
HRP20110620T1 (hr) 2011-09-30
WO2008122551A3 (en) 2008-12-04
BRPI0810096A2 (pt) 2014-10-21
CN101970497A (zh) 2011-02-09
CA2682296C (en) 2017-02-28
WO2008122551A9 (en) 2009-02-05
US8318911B2 (en) 2012-11-27
JP5631733B2 (ja) 2014-11-26
AU2008235566A1 (en) 2008-10-16
SI2142570T1 (sl) 2012-01-31
PT2142570E (pt) 2011-09-13
RS52040B (sr) 2012-04-30
EP2142570B1 (en) 2011-06-15
KR20100016237A (ko) 2010-02-12
WO2008122551A2 (en) 2008-10-16
EP2142570A2 (en) 2010-01-13
PL2142570T3 (pl) 2011-11-30
ATE512988T1 (de) 2011-07-15
JP2010523096A (ja) 2010-07-15
ES2367675T3 (es) 2011-11-07
KR101683884B1 (ko) 2016-12-07
IL201196A0 (en) 2010-05-17
MX2009010444A (es) 2009-10-20

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Designated state(s): TJ

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TM RU