EA023679B1 - АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ - Google Patents

АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ Download PDF

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Publication number
EA023679B1
EA023679B1 EA200970923A EA200970923A EA023679B1 EA 023679 B1 EA023679 B1 EA 023679B1 EA 200970923 A EA200970923 A EA 200970923A EA 200970923 A EA200970923 A EA 200970923A EA 023679 B1 EA023679 B1 EA 023679B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
ersam
epcam
fragment
tumor
Prior art date
Application number
EA200970923A
Other languages
English (en)
Russian (ru)
Other versions
EA200970923A1 (ru
Inventor
Анна Мария Анастаси
Фиорелла Петронцелли
Рита Де Сантис
Саверио Альберти
Original Assignee
Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. filed Critical Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.
Publication of EA200970923A1 publication Critical patent/EA200970923A1/ru
Publication of EA023679B1 publication Critical patent/EA023679B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EA200970923A 2007-04-04 2008-04-02 АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ EA023679B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07105628 2007-04-04
PCT/EP2008/053913 WO2008122551A2 (en) 2007-04-04 2008-04-02 Anti-epcam antibody and uses thereof

Publications (2)

Publication Number Publication Date
EA200970923A1 EA200970923A1 (ru) 2010-04-30
EA023679B1 true EA023679B1 (ru) 2016-06-30

Family

ID=38458122

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970923A EA023679B1 (ru) 2007-04-04 2008-04-02 АНТИ-EpCAM АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ

Country Status (21)

Country Link
US (1) US8318911B2 (enExample)
EP (1) EP2142570B1 (enExample)
JP (1) JP5631733B2 (enExample)
KR (1) KR101683884B1 (enExample)
CN (1) CN101970497B (enExample)
AT (1) ATE512988T1 (enExample)
AU (1) AU2008235566B2 (enExample)
BR (1) BRPI0810096A8 (enExample)
CA (1) CA2682296C (enExample)
CY (1) CY1111819T1 (enExample)
DK (1) DK2142570T3 (enExample)
EA (1) EA023679B1 (enExample)
ES (1) ES2367675T3 (enExample)
HR (1) HRP20110620T1 (enExample)
IL (1) IL201196A0 (enExample)
MX (1) MX2009010444A (enExample)
PL (1) PL2142570T3 (enExample)
PT (1) PT2142570E (enExample)
RS (1) RS52040B (enExample)
SI (1) SI2142570T1 (enExample)
WO (1) WO2008122551A2 (enExample)

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US9169516B2 (en) 2003-01-24 2015-10-27 University Of Utah Research Foundation Methods of predicting mortality risk by determining telomere length
EP2379747B1 (en) 2008-12-22 2013-07-03 University of Utah Research Foundation Monochrome multiplex quantitative pcr
GB0909904D0 (en) * 2009-06-09 2009-07-22 Affitech As Product
US9402916B2 (en) 2011-03-17 2016-08-02 The University Of Birmingham Re-directed immunotherapy
WO2012158818A2 (en) * 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Multi-specific fab fusion proteins and methods of use
US9541480B2 (en) 2011-06-29 2017-01-10 Academia Sinica Capture, purification, and release of biological substances using a surface coating
WO2013131001A1 (en) * 2012-03-02 2013-09-06 Academia Sinica ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF
US9494500B2 (en) 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof
CA2912216A1 (en) 2013-05-22 2014-11-27 Telomere Diagnostics, Inc. Measures of short telomere abundance
TW201623605A (zh) 2014-04-01 2016-07-01 中央研究院 用於癌症診斷及預後之方法及系統
CN105381824B (zh) 2014-08-26 2019-04-23 中央研究院 收集器架构布局设计
WO2016108954A1 (en) 2014-12-30 2016-07-07 Telomere Diagnostics, Inc. Multiplex quantitative pcr
WO2017023704A1 (en) * 2015-07-31 2017-02-09 Sutro Biopharma, Inc. ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EpCAM ANTIBODIES
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
WO2017173091A1 (en) * 2016-03-30 2017-10-05 Musc Foundation For Research Development Methods for treatment and diagnosis of cancer by targeting glycoprotein a repetitions predominant (garp) and for providing effective immunotherapy alone or in combination
EP3490589A1 (en) 2016-07-26 2019-06-05 Tessa Therapeutics Pte. Ltd. Chimeric antigen receptor
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
US12460000B2 (en) 2018-09-07 2025-11-04 Itabmed (Hk) Limited Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof
CA3120800A1 (en) 2018-12-17 2020-06-25 Revitope Limited Twin immune cell engager
WO2020132810A1 (en) 2018-12-24 2020-07-02 Generon (Shanghai) Corporation Ltd. Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof
CN113597432B (zh) * 2019-04-22 2023-05-02 江苏恒瑞医药股份有限公司 抗EpCAM抗体及其应用
MX2021015356A (es) 2019-06-11 2022-04-06 Bioatla Inc Anticuerpos y fragmentos de anticuerpos anti-epcam condicionalmente activos, sus inmunoconjugados y usos de estos.
CN110950959B (zh) * 2020-02-25 2020-07-03 和铂医药(上海)有限责任公司 靶向EpCAM的抗体及其制备和应用
CN112094350B (zh) * 2020-06-01 2024-01-05 普众发现医药科技(上海)有限公司 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体
EP4190808A4 (en) * 2020-08-19 2024-07-31 Suzhou Immunofoco Biotechnology Co., Ltd. Humanized antibody, chimeric antigen receptor, nucleic acid, vector, cell and use

Citations (2)

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WO2005080428A2 (en) * 2004-02-13 2005-09-01 Micromet Ag Anti-epcam immunoglobulins
US20060105389A1 (en) * 2004-10-19 2006-05-18 Kordyum Vitaliy A Method for obtaining single chain antibodies to human interferon alpha2b

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Patent Citations (2)

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WO2005080428A2 (en) * 2004-02-13 2005-09-01 Micromet Ag Anti-epcam immunoglobulins
US20060105389A1 (en) * 2004-10-19 2006-05-18 Kordyum Vitaliy A Method for obtaining single chain antibodies to human interferon alpha2b

Non-Patent Citations (4)

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FRODIN JAN-ERIK ET AL: "MAb17-1A and cytokines for the treatment of patients with colorectal carcinoma." HYBRIDOMA AND HYBRIDOMICS APR 2002, vol. 21, no. 2, April 2002 (2002-04), pages 99-101, XP002450070. ISSN: 1536-8599 the whole document *
NAUNDORF S ET AL: "In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment". INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 100, no. 1, 2002, pages 101-110, XP002253132. ISSN: 0020-7136 the whole document *
PRANG N ET AL: "Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 92, no. 2, 31 January 2005 (2005-01-31), pages 342-349, XP002437689 ISSN: 0007-0920 the whole document *
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Also Published As

Publication number Publication date
DK2142570T3 (da) 2011-10-03
WO2008122551A2 (en) 2008-10-16
CA2682296A1 (en) 2008-10-16
MX2009010444A (es) 2009-10-20
EP2142570B1 (en) 2011-06-15
CN101970497B (zh) 2017-05-10
IL201196A0 (en) 2010-05-17
BRPI0810096A8 (pt) 2017-12-26
ATE512988T1 (de) 2011-07-15
BRPI0810096A2 (pt) 2014-10-21
KR101683884B1 (ko) 2016-12-07
PL2142570T3 (pl) 2011-11-30
KR20100016237A (ko) 2010-02-12
WO2008122551A3 (en) 2008-12-04
SI2142570T1 (sl) 2012-01-31
JP5631733B2 (ja) 2014-11-26
CN101970497A (zh) 2011-02-09
HRP20110620T1 (hr) 2011-09-30
RS52040B (sr) 2012-04-30
AU2008235566B2 (en) 2013-06-06
EA200970923A1 (ru) 2010-04-30
CA2682296C (en) 2017-02-28
US8318911B2 (en) 2012-11-27
JP2010523096A (ja) 2010-07-15
US20100092491A1 (en) 2010-04-15
WO2008122551A9 (en) 2009-02-05
ES2367675T3 (es) 2011-11-07
CY1111819T1 (el) 2015-10-07
EP2142570A2 (en) 2010-01-13
PT2142570E (pt) 2011-09-13
AU2008235566A1 (en) 2008-10-16

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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