AU2008235566B2 - Anti-EpCAM antibody and uses thereof - Google Patents
Anti-EpCAM antibody and uses thereof Download PDFInfo
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- AU2008235566B2 AU2008235566B2 AU2008235566A AU2008235566A AU2008235566B2 AU 2008235566 B2 AU2008235566 B2 AU 2008235566B2 AU 2008235566 A AU2008235566 A AU 2008235566A AU 2008235566 A AU2008235566 A AU 2008235566A AU 2008235566 B2 AU2008235566 B2 AU 2008235566B2
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07105628.7 | 2007-04-04 | ||
| EP07105628 | 2007-04-04 | ||
| PCT/EP2008/053913 WO2008122551A2 (en) | 2007-04-04 | 2008-04-02 | Anti-epcam antibody and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008235566A1 AU2008235566A1 (en) | 2008-10-16 |
| AU2008235566B2 true AU2008235566B2 (en) | 2013-06-06 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008235566A Ceased AU2008235566B2 (en) | 2007-04-04 | 2008-04-02 | Anti-EpCAM antibody and uses thereof |
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|---|---|
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| EP (1) | EP2142570B1 (enExample) |
| JP (1) | JP5631733B2 (enExample) |
| KR (1) | KR101683884B1 (enExample) |
| CN (1) | CN101970497B (enExample) |
| AT (1) | ATE512988T1 (enExample) |
| AU (1) | AU2008235566B2 (enExample) |
| BR (1) | BRPI0810096A8 (enExample) |
| CA (1) | CA2682296C (enExample) |
| CY (1) | CY1111819T1 (enExample) |
| DK (1) | DK2142570T3 (enExample) |
| EA (1) | EA023679B1 (enExample) |
| ES (1) | ES2367675T3 (enExample) |
| HR (1) | HRP20110620T1 (enExample) |
| IL (1) | IL201196A0 (enExample) |
| MX (1) | MX2009010444A (enExample) |
| PL (1) | PL2142570T3 (enExample) |
| PT (1) | PT2142570E (enExample) |
| RS (1) | RS52040B (enExample) |
| SI (1) | SI2142570T1 (enExample) |
| WO (1) | WO2008122551A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2474822A1 (en) | 2003-01-24 | 2012-07-11 | University of Utah | Methods of predicting mortality risk by determining telomere length |
| CA2748265C (en) | 2008-12-22 | 2018-04-03 | University Of Utah Research Foundation | Monochrome multiplex quantitative pcr |
| GB0909904D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Product |
| CA2830349C (en) | 2011-03-17 | 2019-07-16 | The University Of Birmingham | Re-directed immunotherapy |
| EP2710042A2 (en) * | 2011-05-16 | 2014-03-26 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| WO2013003624A2 (en) | 2011-06-29 | 2013-01-03 | Academia Sinica | The capture, purification and release of biological substance using a surface coating |
| EP2819695B1 (en) * | 2012-03-02 | 2018-06-27 | Academia Sinica | ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF |
| US9494500B2 (en) | 2012-10-29 | 2016-11-15 | Academia Sinica | Collection and concentration system for biologic substance of interest and use thereof |
| EP2999800B1 (en) | 2013-05-22 | 2019-09-25 | Telomere Diagnostics Inc. | Measures of short telomere abundance |
| EP3126814B1 (en) | 2014-04-01 | 2019-06-12 | Academia Sinica | Methods and systems for cancer diagnosis and prognosis |
| US10112198B2 (en) | 2014-08-26 | 2018-10-30 | Academia Sinica | Collector architecture layout design |
| CA2971169A1 (en) | 2014-12-30 | 2016-07-07 | Telomere Diagnostics, Inc. | Multiplex quantitative pcr |
| WO2017023704A1 (en) * | 2015-07-31 | 2017-02-09 | Sutro Biopharma, Inc. | ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EpCAM ANTIBODIES |
| US10107726B2 (en) | 2016-03-16 | 2018-10-23 | Cellmax, Ltd. | Collection of suspended cells using a transferable membrane |
| US11046782B2 (en) | 2016-03-30 | 2021-06-29 | Musc Foundation For Research Development | Methods for treatment and diagnosis of cancer by targeting glycoprotein A repetitions predominant (GARP) and for providing effective immunotherapy alone or in combination |
| KR20190038567A (ko) | 2016-07-26 | 2019-04-08 | 테사 테라퓨틱스 피티이. 엘티디. | 키메라 항원 수용체 |
| WO2020018964A1 (en) | 2018-07-20 | 2020-01-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for controlled expression of antigen-specific receptors |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| AU2019402097A1 (en) | 2018-12-17 | 2021-06-10 | Revitope Limited | Twin immune cell engager |
| WO2020216210A1 (zh) * | 2019-04-22 | 2020-10-29 | 江苏恒瑞医药股份有限公司 | 抗EpCAM抗体及其应用 |
| AU2020292304B2 (en) * | 2019-06-11 | 2023-03-30 | Bioatla, Inc. | Conditionally active anti-EpCam antibodies, antibody fragments, their immunoconjugates and uses thereof |
| CN110950959B (zh) * | 2020-02-25 | 2020-07-03 | 和铂医药(上海)有限责任公司 | 靶向EpCAM的抗体及其制备和应用 |
| CN112094350B (zh) * | 2020-06-01 | 2024-01-05 | 普众发现医药科技(上海)有限公司 | 可应用于肿瘤细胞捕获的小鼠抗细胞表面糖蛋白cd326的单克隆抗体 |
| EP4190808A4 (en) * | 2020-08-19 | 2024-07-31 | Suzhou Immunofoco Biotechnology Co., Ltd. | Humanized antibody, chimeric antigen receptor, nucleic acid, vector, cell and use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675187A (en) | 1983-05-16 | 1987-06-23 | Bristol-Myers Company | BBM-1675, a new antibiotic complex |
| US5525338A (en) | 1992-08-21 | 1996-06-11 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin conjugates |
| IT1245748B (it) | 1990-12-21 | 1994-10-14 | Mini Ricerca Scient Tecnolog | Preparazione includente anticorpi monoclonali biotinilati, avidina e biotina, per la diagnosi di affezioni tumorali e suo impiego |
| US5578287A (en) | 1992-06-09 | 1996-11-26 | Neorx Corporation | Three-step pretargeting methods using improved biotin-active agent |
| JP3427871B2 (ja) | 1996-06-24 | 2003-07-22 | 戸田工業株式会社 | コバルト被着型針状磁性酸化鉄粒子粉末 |
| ITRM20010079A1 (it) | 2001-02-16 | 2002-08-16 | Sigma Tau Ind Farmaceuti | Amminoderivati della biotina e loro coniugati con chelanti macrociclici. |
| US20050180979A1 (en) * | 2004-02-13 | 2005-08-18 | Micromet Ag | Anti-EpCAM immunoglobulins |
| US7435804B2 (en) * | 2004-10-19 | 2008-10-14 | Phage Biotechnology, Inc. | Method for obtaining single chain antibodies to human interferon α2b |
-
2008
- 2008-04-02 EP EP08759374A patent/EP2142570B1/en active Active
- 2008-04-02 AU AU2008235566A patent/AU2008235566B2/en not_active Ceased
- 2008-04-02 PT PT08759374T patent/PT2142570E/pt unknown
- 2008-04-02 CA CA2682296A patent/CA2682296C/en not_active Expired - Fee Related
- 2008-04-02 SI SI200830364T patent/SI2142570T1/sl unknown
- 2008-04-02 HR HR20110620T patent/HRP20110620T1/hr unknown
- 2008-04-02 ES ES08759374T patent/ES2367675T3/es active Active
- 2008-04-02 MX MX2009010444A patent/MX2009010444A/es active IP Right Grant
- 2008-04-02 KR KR1020097023099A patent/KR101683884B1/ko not_active Expired - Fee Related
- 2008-04-02 AT AT08759374T patent/ATE512988T1/de active
- 2008-04-02 DK DK08759374.5T patent/DK2142570T3/da active
- 2008-04-02 JP JP2010501503A patent/JP5631733B2/ja not_active Expired - Fee Related
- 2008-04-02 EA EA200970923A patent/EA023679B1/ru not_active IP Right Cessation
- 2008-04-02 CN CN200880015767.4A patent/CN101970497B/zh not_active Expired - Fee Related
- 2008-04-02 WO PCT/EP2008/053913 patent/WO2008122551A2/en not_active Ceased
- 2008-04-02 RS RS20110388A patent/RS52040B/sr unknown
- 2008-04-02 BR BRPI0810096A patent/BRPI0810096A8/pt not_active Application Discontinuation
- 2008-04-02 PL PL08759374T patent/PL2142570T3/pl unknown
- 2008-04-02 US US12/594,559 patent/US8318911B2/en not_active Expired - Fee Related
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2009
- 2009-09-24 IL IL201196A patent/IL201196A0/en active IP Right Grant
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2011
- 2011-09-06 CY CY20111100854T patent/CY1111819T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101970497A (zh) | 2011-02-09 |
| RS52040B (sr) | 2012-04-30 |
| IL201196A0 (en) | 2010-05-17 |
| EP2142570B1 (en) | 2011-06-15 |
| WO2008122551A3 (en) | 2008-12-04 |
| ATE512988T1 (de) | 2011-07-15 |
| AU2008235566A1 (en) | 2008-10-16 |
| MX2009010444A (es) | 2009-10-20 |
| SI2142570T1 (sl) | 2012-01-31 |
| JP5631733B2 (ja) | 2014-11-26 |
| EA200970923A1 (ru) | 2010-04-30 |
| KR101683884B1 (ko) | 2016-12-07 |
| BRPI0810096A2 (pt) | 2014-10-21 |
| PT2142570E (pt) | 2011-09-13 |
| WO2008122551A2 (en) | 2008-10-16 |
| US20100092491A1 (en) | 2010-04-15 |
| CN101970497B (zh) | 2017-05-10 |
| ES2367675T3 (es) | 2011-11-07 |
| CA2682296C (en) | 2017-02-28 |
| EP2142570A2 (en) | 2010-01-13 |
| PL2142570T3 (pl) | 2011-11-30 |
| BRPI0810096A8 (pt) | 2017-12-26 |
| CA2682296A1 (en) | 2008-10-16 |
| JP2010523096A (ja) | 2010-07-15 |
| CY1111819T1 (el) | 2015-10-07 |
| DK2142570T3 (da) | 2011-10-03 |
| KR20100016237A (ko) | 2010-02-12 |
| EA023679B1 (ru) | 2016-06-30 |
| WO2008122551A9 (en) | 2009-02-05 |
| HRP20110620T1 (hr) | 2011-09-30 |
| US8318911B2 (en) | 2012-11-27 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: ALFASIGMA S.P.A Free format text: FORMER OWNER(S): SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |