EA022395B1 - Соединение пиперидинила в качестве модулятора активности хемокинового рецептора - Google Patents

Соединение пиперидинила в качестве модулятора активности хемокинового рецептора Download PDF

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Publication number
EA022395B1
EA022395B1 EA201270790A EA201270790A EA022395B1 EA 022395 B1 EA022395 B1 EA 022395B1 EA 201270790 A EA201270790 A EA 201270790A EA 201270790 A EA201270790 A EA 201270790A EA 022395 B1 EA022395 B1 EA 022395B1
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Eurasian Patent Office
Prior art keywords
compound
inflammatory
disease
patient
chemokine
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EA201270790A
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English (en)
Russian (ru)
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EA201270790A1 (ru
Inventor
Роберт Дж. Черней
Джон В. Дунсиа
Даниел С. Гарднер
Джосеф Б. Сантелла
Чжунюй Ван
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Бристол-Майерс Сквибб Компани
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Publication of EA201270790A1 publication Critical patent/EA201270790A1/ru
Publication of EA022395B1 publication Critical patent/EA022395B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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EA201270790A 2010-06-16 2011-06-16 Соединение пиперидинила в качестве модулятора активности хемокинового рецептора EA022395B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35522510P 2010-06-16 2010-06-16
PCT/US2011/040605 WO2011159852A1 (en) 2010-06-16 2011-06-16 Piperidinyl compound as a modulator of chemokine receptor activity

Publications (2)

Publication Number Publication Date
EA201270790A1 EA201270790A1 (ru) 2013-04-30
EA022395B1 true EA022395B1 (ru) 2015-12-30

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EA201270790A EA022395B1 (ru) 2010-06-16 2011-06-16 Соединение пиперидинила в качестве модулятора активности хемокинового рецептора

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US (1) US8642622B2 (https=)
EP (1) EP2582670B1 (https=)
JP (1) JP5795797B2 (https=)
KR (1) KR20130032357A (https=)
CN (1) CN103068800B (https=)
AR (1) AR081943A1 (https=)
AU (1) AU2011268373B2 (https=)
BR (1) BR112012031768A2 (https=)
CL (1) CL2012003521A1 (https=)
CO (1) CO6650362A2 (https=)
EA (1) EA022395B1 (https=)
IL (1) IL223368A0 (https=)
MA (1) MA34377B1 (https=)
MX (1) MX2012014068A (https=)
NZ (1) NZ605741A (https=)
SG (1) SG186064A1 (https=)
TN (1) TN2012000581A1 (https=)
TW (1) TW201206435A (https=)
WO (1) WO2011159852A1 (https=)
ZA (1) ZA201300380B (https=)

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CN109983012B (zh) 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂
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CN118267479A (zh) 2017-09-25 2024-07-02 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
KR102037494B1 (ko) 2017-12-11 2019-10-28 씨제이헬스케어 주식회사 광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
IL275898B2 (en) 2018-01-08 2025-05-01 Chemocentryx Inc Methods for treating solid tumors with CCR2 antagonists
CN120344538A (zh) 2022-11-09 2025-07-18 勃林格殷格翰国际有限公司 作为cGAS抑制剂的环状吡啶衍生物

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EP2049486A2 (en) * 2006-01-27 2009-04-22 Bristol-Myers Squibb Company Piperidinyl derivatives as modulators of chemokine receptor activity
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WO2009015166A1 (en) * 2007-07-24 2009-01-29 Bristol-Myers Squibb Company Piperidine derivatives as modulators of chemokine receptor activity
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