EA022346B1 - СПОСОБ ПОЛУЧЕНИЯ ЭКСТРАКТА Ginkgo biloba, ЭКСТРАКТ, ПОЛУЧЕННЫЙ ЭТИМ СПОСОБОМ, И ЕГО ПРИМЕНЕНИЕ - Google Patents
СПОСОБ ПОЛУЧЕНИЯ ЭКСТРАКТА Ginkgo biloba, ЭКСТРАКТ, ПОЛУЧЕННЫЙ ЭТИМ СПОСОБОМ, И ЕГО ПРИМЕНЕНИЕ Download PDFInfo
- Publication number
- EA022346B1 EA022346B1 EA201070924A EA201070924A EA022346B1 EA 022346 B1 EA022346 B1 EA 022346B1 EA 201070924 A EA201070924 A EA 201070924A EA 201070924 A EA201070924 A EA 201070924A EA 022346 B1 EA022346 B1 EA 022346B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- content
- extract
- aqueous solution
- solution
- adsorbent
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 79
- 239000000284 extract Substances 0.000 title claims abstract description 65
- 235000008100 Ginkgo biloba Nutrition 0.000 title abstract 3
- 244000194101 Ginkgo biloba Species 0.000 title abstract 3
- 239000002957 persistent organic pollutant Substances 0.000 claims abstract description 32
- 206010012289 Dementia Diseases 0.000 claims abstract description 10
- 230000002490 cerebral effect Effects 0.000 claims abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 5
- 208000035475 disorder Diseases 0.000 claims abstract description 5
- 230000002093 peripheral effect Effects 0.000 claims abstract description 5
- 208000011580 syndromic disease Diseases 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 96
- 239000000243 solution Substances 0.000 claims description 70
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 69
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 68
- 239000003463 adsorbent Substances 0.000 claims description 55
- 239000007864 aqueous solution Substances 0.000 claims description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
- 239000007787 solid Substances 0.000 claims description 48
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 34
- 239000012074 organic phase Substances 0.000 claims description 29
- 239000002904 solvent Substances 0.000 claims description 29
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 21
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 21
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 21
- -1 alkyl phenol compounds Chemical class 0.000 claims description 15
- MOLPUWBMSBJXER-YDGSQGCISA-N bilobalide Chemical compound O([C@H]1OC2=O)C(=O)[C@H](O)[C@@]11[C@@](C(C)(C)C)(O)C[C@H]3[C@@]21CC(=O)O3 MOLPUWBMSBJXER-YDGSQGCISA-N 0.000 claims description 14
- 239000003960 organic solvent Substances 0.000 claims description 12
- 239000002244 precipitate Substances 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 229940046892 lead acetate Drugs 0.000 claims description 11
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 125000000524 functional group Chemical group 0.000 claims description 10
- 238000011002 quantification Methods 0.000 claims description 10
- 239000013557 residual solvent Substances 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 9
- 229930184727 ginkgolide Natural products 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 229920002770 condensed tannin Polymers 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000008020 evaporation Effects 0.000 claims description 5
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 claims description 5
- 231100000770 Toxic Equivalency Factor Toxicity 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 229910021514 lead(II) hydroxide Inorganic materials 0.000 claims description 4
- 238000005191 phase separation Methods 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- 238000010908 decantation Methods 0.000 claims description 3
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 238000004821 distillation Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- RLJMLMKIBZAXJO-UHFFFAOYSA-N lead nitrate Chemical compound [O-][N+](=O)O[Pb]O[N+]([O-])=O RLJMLMKIBZAXJO-UHFFFAOYSA-N 0.000 claims description 2
- VLOJXAQYHIVPFI-UHFFFAOYSA-H lead(2+);diacetate;tetrahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[Pb+2].[Pb+2].[Pb+2].CC([O-])=O.CC([O-])=O VLOJXAQYHIVPFI-UHFFFAOYSA-H 0.000 claims description 2
- 150000002634 lipophilic molecules Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000012071 phase Substances 0.000 claims description 2
- 150000003071 polychlorinated biphenyls Chemical class 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 150000004826 dibenzofurans Chemical class 0.000 claims 1
- 229910000464 lead oxide Inorganic materials 0.000 claims 1
- BBEAQIROQSPTKN-UHFFFAOYSA-N pyrene Chemical compound C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 description 30
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthene Chemical compound C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 19
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 10
- 125000005605 benzo group Chemical group 0.000 description 9
- WDECIBYCCFPHNR-UHFFFAOYSA-N chrysene Chemical compound C1=CC=CC2=CC=C3C4=CC=CC=C4C=CC3=C21 WDECIBYCCFPHNR-UHFFFAOYSA-N 0.000 description 8
- DXBHBZVCASKNBY-UHFFFAOYSA-N 1,2-Benz(a)anthracene Chemical compound C1=CC=C2C3=CC4=CC=CC=C4C=C3C=CC2=C1 DXBHBZVCASKNBY-UHFFFAOYSA-N 0.000 description 7
- FMMWHPNWAFZXNH-UHFFFAOYSA-N Benz[a]pyrene Chemical compound C1=C2C3=CC=CC=C3C=C(C=C3)C2=C2C3=CC=CC2=C1 FMMWHPNWAFZXNH-UHFFFAOYSA-N 0.000 description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
- SLGBZMMZGDRARJ-UHFFFAOYSA-N Triphenylene Natural products C1=CC=C2C3=CC=CC=C3C3=CC=CC=C3C2=C1 SLGBZMMZGDRARJ-UHFFFAOYSA-N 0.000 description 4
- 239000003344 environmental pollutant Substances 0.000 description 4
- 231100000719 pollutant Toxicity 0.000 description 4
- 125000005580 triphenylene group Chemical group 0.000 description 4
- GOHBXWHNJHENRX-UHFFFAOYSA-N 5-Methylchrysene Chemical compound C1=CC=CC2=C3C(C)=CC4=CC=CC=C4C3=CC=C21 GOHBXWHNJHENRX-UHFFFAOYSA-N 0.000 description 3
- TXVHTIQJNYSSKO-UHFFFAOYSA-N BeP Natural products C1=CC=C2C3=CC=CC=C3C3=CC=CC4=CC=C1C2=C34 TXVHTIQJNYSSKO-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- FTOVXSOBNPWTSH-UHFFFAOYSA-N benzo[b]fluoranthene Chemical compound C12=CC=CC=C1C1=CC3=CC=CC=C3C3=C1C2=CC=C3 FTOVXSOBNPWTSH-UHFFFAOYSA-N 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001491 aromatic compounds Chemical class 0.000 description 2
- 231100000693 bioaccumulation Toxicity 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 125000002080 perylenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC5=CC=CC(C1=C23)=C45)* 0.000 description 2
- CSHWQDPOILHKBI-UHFFFAOYSA-N peryrene Natural products C1=CC(C2=CC=CC=3C2=C2C=CC=3)=C3C2=CC=CC3=C1 CSHWQDPOILHKBI-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003220 pyrenes Chemical class 0.000 description 2
- 229920003002 synthetic resin Polymers 0.000 description 2
- 239000000057 synthetic resin Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- VGGGRWRBGXENKI-UHFFFAOYSA-N 1-chlorodibenzo-p-dioxin Chemical compound O1C2=CC=CC=C2OC2=C1C=CC=C2Cl VGGGRWRBGXENKI-UHFFFAOYSA-N 0.000 description 1
- WRSMJZYBNIAAEE-UHFFFAOYSA-N 1-chlorodibenzofuran Chemical group O1C2=CC=CC=C2C2=C1C=CC=C2Cl WRSMJZYBNIAAEE-UHFFFAOYSA-N 0.000 description 1
- HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachloro-dibenzo-p-dioxin Chemical compound O1C2=CC(Cl)=C(Cl)C=C2OC2=C1C=C(Cl)C(Cl)=C2 HGUFODBRKLSHSI-UHFFFAOYSA-N 0.000 description 1
- 101100010343 Drosophila melanogaster lobo gene Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 241000207836 Olea <angiosperm> Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 235000010722 Vigna unguiculata Nutrition 0.000 description 1
- 244000042314 Vigna unguiculata Species 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- XCCFFFKHURGHGL-UHFFFAOYSA-N hexacyclo[11.6.2.12,9.03,8.010,20.017,21]docosa-1(20),2(22),3,5,7,9,11,13,15,17(21),18-undecaene Chemical compound C1=C2C(C=3C4=CC=CC=3)=CC4=C(C=C3)C2=C2C3=CC=CC2=C1 XCCFFFKHURGHGL-UHFFFAOYSA-N 0.000 description 1
- LHUXTLSUUUXNEK-UHFFFAOYSA-N hexacyclo[11.9.1.114,18.04,9.09,23.022,24]tetracosa-1(23),2,4,6,10,12,14,16,18(24),19,21-undecaene Chemical group C1C=CC=C2C=CC=3C=4C=CC=C5C=CC=C(C6=CC=CC21C6=3)C5=4 LHUXTLSUUUXNEK-UHFFFAOYSA-N 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- GKROKAVBUIADBS-UHFFFAOYSA-N phenanthrene-2-carbaldehyde Chemical compound C1=CC=C2C3=CC=C(C=O)C=C3C=CC2=C1 GKROKAVBUIADBS-UHFFFAOYSA-N 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000767 polyaniline Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800625A FR2926994B1 (fr) | 2008-02-06 | 2008-02-06 | Nouveau procede pour la preparation d'extraits de ginkgo biloba |
| PCT/FR2009/000137 WO2009112709A2 (fr) | 2008-02-06 | 2009-02-06 | Nouveau procede pour la preparation d'extraits de ginkgo biloba |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201070924A1 EA201070924A1 (ru) | 2010-12-30 |
| EA022346B1 true EA022346B1 (ru) | 2015-12-30 |
Family
ID=39731553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201070924A EA022346B1 (ru) | 2008-02-06 | 2009-02-06 | СПОСОБ ПОЛУЧЕНИЯ ЭКСТРАКТА Ginkgo biloba, ЭКСТРАКТ, ПОЛУЧЕННЫЙ ЭТИМ СПОСОБОМ, И ЕГО ПРИМЕНЕНИЕ |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2249847B1 (https=) |
| JP (1) | JP5710271B2 (https=) |
| KR (1) | KR20100113619A (https=) |
| CN (1) | CN101939016B (https=) |
| EA (1) | EA022346B1 (https=) |
| ES (1) | ES2632507T3 (https=) |
| FR (1) | FR2926994B1 (https=) |
| UA (1) | UA100257C2 (https=) |
| WO (1) | WO2009112709A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20090548A1 (it) * | 2009-04-06 | 2010-10-07 | Indena Spa | Processo di rimozione di pesticidi da estratti di ginkgo biloba e estratti ottenibili da detto processo |
| KR101898709B1 (ko) * | 2016-09-27 | 2018-09-13 | 주식회사 한성바이오파마 | 수용성 은행잎 추출액 및 추출분말의 제조방법 |
| DE102023131617A1 (de) | 2023-11-14 | 2025-05-15 | Dr. Willmar Schwabe Gmbh & Co. Kg | Verfahren zur Herstellung von Ginkgoextrakten mit hohem Gehalt an Proanthocyanidinen und Nahrungsergänzungsmittel und Arzneimittel enthaltend Ginkgoextrakte |
| FR3156652A1 (fr) * | 2023-12-18 | 2025-06-20 | Beng Poon Teng | Procédé de préparation d’un extrait de feuilles de ginkgo biloba hautement enrichi en proanthocyanidins depourvu de flavonoïdes et de trilactones terpéniques |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002083158A1 (fr) * | 2001-04-10 | 2002-10-24 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Procede de preparation d'un extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs |
| WO2006117170A1 (en) * | 2005-05-03 | 2006-11-09 | Dr. Willmar Schwabe Gmbh & Co. Kg | Improved method for preparing ginkgo extracts having a reduced content of polycyclic aromatic hydrocarbons |
| WO2006117168A2 (de) * | 2005-05-03 | 2006-11-09 | Dr. Willmar Schwabe Gmbh & Co. Kg | Verfahren zur herstellung von ginkgoextrakten mit vermindertem gehalt an unpolaren pflanzeninhaltsstoffen und umweltbedingten unpolaren fremdstoffen |
| CN1891242A (zh) * | 2005-07-06 | 2007-01-10 | 徐州技源天然保健品有限公司 | 一种从银杏叶提取物中脱除多环芳烃的生产工艺 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR940002796B1 (ko) * | 1989-06-16 | 1994-04-02 | 주식회사 선경인더스트리 | 은행잎에서 징코라이드를 분리 및 정제하는 방법 |
| DE3940091A1 (de) | 1989-12-04 | 1991-06-06 | Schwabe Willmar Gmbh & Co | Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel |
| DE19756848C2 (de) | 1997-12-19 | 2003-01-16 | Schwabe Willmar Gmbh & Co | Extrakte aus Blättern von Ginkgo biloba mit vermindertem Gehalt an 4'-O-Methylpyridoxin und Biflavonen |
| US20060006765A1 (en) * | 2004-07-09 | 2006-01-12 | Jongtae Yuk | Apparatus and method to transmit and receive acoustic wave energy |
-
2008
- 2008-02-06 FR FR0800625A patent/FR2926994B1/fr active Active
-
2009
- 2009-02-06 EP EP09720028.1A patent/EP2249847B1/fr not_active Revoked
- 2009-02-06 WO PCT/FR2009/000137 patent/WO2009112709A2/fr not_active Ceased
- 2009-02-06 JP JP2010545526A patent/JP5710271B2/ja active Active
- 2009-02-06 ES ES09720028.1T patent/ES2632507T3/es active Active
- 2009-02-06 EA EA201070924A patent/EA022346B1/ru not_active IP Right Cessation
- 2009-02-06 KR KR1020107019665A patent/KR20100113619A/ko not_active Ceased
- 2009-02-06 CN CN2009801044220A patent/CN101939016B/zh active Active
- 2009-06-02 UA UAA201010750A patent/UA100257C2/uk unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002083158A1 (fr) * | 2001-04-10 | 2002-10-24 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Procede de preparation d'un extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs |
| WO2006117170A1 (en) * | 2005-05-03 | 2006-11-09 | Dr. Willmar Schwabe Gmbh & Co. Kg | Improved method for preparing ginkgo extracts having a reduced content of polycyclic aromatic hydrocarbons |
| WO2006117168A2 (de) * | 2005-05-03 | 2006-11-09 | Dr. Willmar Schwabe Gmbh & Co. Kg | Verfahren zur herstellung von ginkgoextrakten mit vermindertem gehalt an unpolaren pflanzeninhaltsstoffen und umweltbedingten unpolaren fremdstoffen |
| CN1891242A (zh) * | 2005-07-06 | 2007-01-10 | 徐州技源天然保健品有限公司 | 一种从银杏叶提取物中脱除多环芳烃的生产工艺 |
Non-Patent Citations (2)
| Title |
|---|
| DATABASE WPI Week 19962, Thomson Scientific, London, GB; AN 1996-018388, XP002495405 & KR 94002796 B1 (SUN KYONG IND LTD), 2 April 1994 (1994-04-02), abstract * |
| DATABASE WPI Week 200739, Thomson Scientific, London, GB; AN 2007-404841, XP002495406 & CN 1891242 A (XUZHOU JIYUAN NATURAL HEALTHCARE PROD CO LTD), 10 January 2007 (2007-01-10), abstract * |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201070924A1 (ru) | 2010-12-30 |
| EP2249847A2 (fr) | 2010-11-17 |
| CN101939016B (zh) | 2013-09-18 |
| WO2009112709A2 (fr) | 2009-09-17 |
| UA100257C2 (uk) | 2012-12-10 |
| FR2926994A1 (fr) | 2009-08-07 |
| JP5710271B2 (ja) | 2015-04-30 |
| KR20100113619A (ko) | 2010-10-21 |
| WO2009112709A3 (fr) | 2010-05-06 |
| EP2249847B1 (fr) | 2017-04-12 |
| ES2632507T3 (es) | 2017-09-13 |
| CN101939016A (zh) | 2011-01-05 |
| FR2926994B1 (fr) | 2010-08-27 |
| JP2011511047A (ja) | 2011-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1326598B1 (de) | Verfahren zur herstellung eines tetrahydrocannabinol- und cannabidiol-haltigen extraktes aus cannabis-pflanzenmaterial sowie cannabis-extrakte | |
| KR0169957B1 (ko) | 신규한 은행나무의 추출물 및 이것의 제조방법 | |
| WO1999026643A1 (en) | Methods of preparation of bioginkgo | |
| EA022346B1 (ru) | СПОСОБ ПОЛУЧЕНИЯ ЭКСТРАКТА Ginkgo biloba, ЭКСТРАКТ, ПОЛУЧЕННЫЙ ЭТИМ СПОСОБОМ, И ЕГО ПРИМЕНЕНИЕ | |
| CA2688410A1 (en) | A composition comprising camomile and black cumin oil and therapeutic uses thereof | |
| EP0702957A1 (de) | Johanniskrautextrakte | |
| BRPI0614917A2 (pt) | proceso para a obtenção de um concentrado natural, rico em hidroxitirosol, a partir de resìduos de oliveiras e de subprodutos, utilizando tecnologias limpas | |
| CA3221865A1 (en) | Enriched mineral pitch resin products and methods of manufacturing enriched mineral pitch resin products | |
| KR20250134118A (ko) | 신경퇴행성 질환 또는 장애 및 암 치료에 있어서의 칸나비노이드 조성물 및 이의 용도 | |
| KR20110090415A (ko) | 고농축 마카추출물의 제조방법 및 그 조성물 | |
| EP0975572B1 (en) | A novel process to produce stabilized carnosic acid in high concentration | |
| CH693499A5 (de) | Pharmazeutische Antidepressions-Zusammensetzung, die einen Polygala-Extrakt enthält. | |
| WO2006117168A2 (de) | Verfahren zur herstellung von ginkgoextrakten mit vermindertem gehalt an unpolaren pflanzeninhaltsstoffen und umweltbedingten unpolaren fremdstoffen | |
| KR20150020466A (ko) | 천년초 열매 추출물을 유효성분으로 포함하는 항염증용 조성물 | |
| EP1868626B1 (en) | Improved method for preparing ginkgo extracts having a reduced content of polycyclic aromatic hydrocarbons | |
| HK1150539A (en) | Novel method for preparing extracts of ginkgo biloba | |
| Fathiazad et al. | Phytochemical analysis of Danae racemosa L. Moench leaves | |
| HK1150539B (en) | Novel method for preparing extracts of ginkgo biloba | |
| JP5441433B2 (ja) | カムカムフルーツ果汁含有肝機能改善剤 | |
| US20250222052A1 (en) | High yield extraction method for and products of amanita muscaria | |
| DE10014674B4 (de) | Verfahren für die Extraktion und Isolierung von Phyllanthin | |
| IT201700016726A1 (it) | Frazioni arricchite in terpeni esenti da politerpeni estratte dal mastice di chios, dispositivi cosmetici, nutraceutici e medici, e composizioni farmaceutiche che le contengono | |
| WO2025104088A1 (de) | Verfahren zur herstellung von ginkgoextrakten mit hohem gehalt an proanthocyanidinen und nahrungsergänzungsmittel und arzneimittel enthaltend ginkgoextrakte | |
| KR101684356B1 (ko) | 솔잎 추출 오일을 포함하는 고형 제제, 이의 제조방법, 및 이를 포함하는 식용소금 | |
| KR20250029455A (ko) | 백하수오 추출물로부터 카우다틴을 수득하는 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| PC4A | Registration of transfer of a eurasian patent by assignment |