EA022226B1 - Способ получения изотопа радия - Google Patents

Способ получения изотопа радия Download PDF

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Publication number
EA022226B1
EA022226B1 EA201291061A EA201291061A EA022226B1 EA 022226 B1 EA022226 B1 EA 022226B1 EA 201291061 A EA201291061 A EA 201291061A EA 201291061 A EA201291061 A EA 201291061A EA 022226 B1 EA022226 B1 EA 022226B1
Authority
EA
Eurasian Patent Office
Prior art keywords
dha
resin
ions
separation medium
elution
Prior art date
Application number
EA201291061A
Other languages
English (en)
Russian (ru)
Other versions
EA201291061A1 (ru
Inventor
Ян Рогер Карлсон
Пеер Бёрретзен
Original Assignee
Алгета Аса
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алгета Аса filed Critical Алгета Аса
Publication of EA201291061A1 publication Critical patent/EA201291061A1/ru
Publication of EA022226B1 publication Critical patent/EA022226B1/ru

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Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0042—Technetium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Medicinal Preparation (AREA)
  • Radiation-Therapy Devices (AREA)
EA201291061A 2010-04-30 2011-04-29 Способ получения изотопа радия EA022226B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1007353.4A GB201007353D0 (en) 2010-04-30 2010-04-30 Method
PCT/EP2011/002156 WO2011134672A1 (en) 2010-04-30 2011-04-29 Isotope production method

Publications (2)

Publication Number Publication Date
EA201291061A1 EA201291061A1 (ru) 2013-05-30
EA022226B1 true EA022226B1 (ru) 2015-11-30

Family

ID=42289983

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291061A EA022226B1 (ru) 2010-04-30 2011-04-29 Способ получения изотопа радия

Country Status (21)

Country Link
US (1) US9056142B2 (pt)
EP (2) EP2733705A1 (pt)
JP (1) JP5969462B2 (pt)
KR (1) KR101886883B1 (pt)
CN (1) CN102985980B (pt)
AU (1) AU2011247362B2 (pt)
BR (1) BR112012027945B1 (pt)
CA (1) CA2797901C (pt)
CY (1) CY1115352T1 (pt)
DK (1) DK2564397T3 (pt)
EA (1) EA022226B1 (pt)
ES (1) ES2473266T3 (pt)
GB (1) GB201007353D0 (pt)
HK (1) HK1183557A1 (pt)
IL (1) IL222764A (pt)
MX (1) MX2012012669A (pt)
NZ (1) NZ603460A (pt)
PL (1) PL2564397T3 (pt)
PT (1) PT2564397E (pt)
SG (1) SG185106A1 (pt)
WO (1) WO2011134672A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2752845C1 (ru) * 2020-05-13 2021-08-11 Акционерное Общество "Наука И Инновации" Способ получения высокочистого радия-223

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
WO2014095833A1 (en) 2012-12-19 2014-06-26 Bayer Pharma Aktiengesellschaft Combination comprising radium-223 for the treatment of cancer
GB201314718D0 (en) * 2013-08-16 2013-10-02 Algeta As Quantification method
EP3077003A1 (en) 2013-12-03 2016-10-12 Bayer Pharma Aktiengesellschaft Combination of pi3k-inhibitors
CA2932221C (en) 2013-12-03 2022-02-22 Bayer Pharma Aktiengesellschaft Combination of pi3k-inhibitors
WO2015137451A1 (ja) * 2014-03-13 2015-09-17 株式会社クラレ 重合体、吸着材、並びにその製造方法
CN106415734B (zh) * 2014-05-13 2019-02-15 保罗·谢勒学院 生产43Sc放射性核素及其放射性药物用于正电子发射断层显像
WO2016083739A1 (fr) 2014-11-26 2016-06-02 Rhodia Operations Composition de lanthane et d'actinium-227
GB201600153D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
CZ2016151A3 (cs) * 2016-03-16 2017-05-24 ÄŚeskĂ© vysokĂ© uÄŤenĂ­ technickĂ© v Praze Způsob izolace Ac ze směsi radia, aktinia a thoria
WO2018035020A1 (en) * 2016-08-16 2018-02-22 Mallinckrodt Nuclear Medicine Llc Chromatographic separation of mo-99 from w-187
US10704123B2 (en) 2016-08-22 2020-07-07 Uchicago Argonne, Llc Process for the separation and purification of medical isotopes
US10344355B2 (en) * 2016-08-22 2019-07-09 Uchicago Argonne, Llc Process for the separation and purification of scandium medical isotopes
AR110995A1 (es) 2017-02-24 2019-05-22 Bayer Ag Combinación de inhibidores de quinasa atr con sal de radio-223
CN114873626B (zh) * 2021-12-31 2023-09-19 中国工程物理研究院核物理与化学研究所 一种176Yb2O3和160Gd2O3靶料回收方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5809394A (en) * 1996-12-13 1998-09-15 Battelle Memorial Institute Methods of separating short half-life radionuclides from a mixture of radionuclides
US6635234B1 (en) * 1999-01-04 2003-10-21 Anticancer Therapeutic Inventions As Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
US20070131618A1 (en) * 2002-09-30 2007-06-14 Horwitz E P Multivalent metal ion extraction using diglycolamide-coated particles

Family Cites Families (10)

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US4390517A (en) 1979-12-19 1983-06-28 New England Nuclear Corporation Method, composition and kit for stabilizing radiolabeled compounds
JP3832961B2 (ja) * 1998-03-10 2006-10-11 ユニチカ株式会社 ラジウム吸着剤の再生方法
JP4380875B2 (ja) * 2000-02-29 2009-12-09 株式会社東芝 液体処理装置
JP2001318087A (ja) * 2000-05-11 2001-11-16 Kawasaki Steel Corp 液体クロマトグラフィー用カラム及びその使用方法
CA2451156C (en) * 2001-06-22 2008-05-20 Pg Research Foundation, Inc. Automated radionuclide separation system and method
EA007452B1 (ru) * 2002-04-12 2006-10-27 Пи Джи Рисерч Фаундейшн, Инк. Многоколоночный генератор с инверсией избирательности для производства сверхчистых радионуклидов
US7087206B2 (en) * 2002-04-12 2006-08-08 Pg Research Foundation Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
US20070009409A1 (en) 2005-07-11 2007-01-11 Hariprasad Gali 212Bi or 213Bi Generator from supported parent isotope
EP2796575B8 (en) * 2006-09-08 2020-04-01 Actinium Pharmaceuticals, Inc. Method for the purification of radium from different sources
GB201007354D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5809394A (en) * 1996-12-13 1998-09-15 Battelle Memorial Institute Methods of separating short half-life radionuclides from a mixture of radionuclides
US6635234B1 (en) * 1999-01-04 2003-10-21 Anticancer Therapeutic Inventions As Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
US20030206857A1 (en) * 1999-01-04 2003-11-06 Larsen Roy H. Preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning
US20070131618A1 (en) * 2002-09-30 2007-06-14 Horwitz E P Multivalent metal ion extraction using diglycolamide-coated particles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HOWELL R.W. ET AL. "RADIOTOXICITY OF GADOLINIUM-148 AND RADIUM-223 IN MOUSE TESTES: RELATIVE BIOLOGICAL EFFECTIVENESS OF ALPHA-PARTICLE EMITTERS IN VIVO", RADIATION RESEARCH, ACADEMIC PRESS INC, US, vol. 147, 1 March 1997 (1997-03-01), pages 342-348, XP000973825, ISSN: 0033-7587, page 343; figure 1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2752845C1 (ru) * 2020-05-13 2021-08-11 Акционерное Общество "Наука И Инновации" Способ получения высокочистого радия-223

Also Published As

Publication number Publication date
US20130095031A1 (en) 2013-04-18
IL222764A0 (en) 2012-12-31
PL2564397T3 (pl) 2014-10-31
JP2013533459A (ja) 2013-08-22
EP2564397B1 (en) 2014-03-19
IL222764A (en) 2016-07-31
KR20130111930A (ko) 2013-10-11
SG185106A1 (en) 2012-12-28
ES2473266T3 (es) 2014-07-04
CA2797901A1 (en) 2011-11-03
CN102985980B (zh) 2015-08-12
AU2011247362B2 (en) 2014-11-27
EA201291061A1 (ru) 2013-05-30
NZ603460A (en) 2014-09-26
WO2011134672A1 (en) 2011-11-03
JP5969462B2 (ja) 2016-08-17
GB201007353D0 (en) 2010-06-16
HK1183557A1 (en) 2013-12-27
MX2012012669A (es) 2013-03-08
CY1115352T1 (el) 2017-01-04
US9056142B2 (en) 2015-06-16
PT2564397E (pt) 2014-06-25
BR112012027945A2 (pt) 2017-08-15
CN102985980A (zh) 2013-03-20
EP2733705A1 (en) 2014-05-21
EP2564397A1 (en) 2013-03-06
BR112012027945B1 (pt) 2022-07-26
KR101886883B1 (ko) 2018-08-08
DK2564397T3 (da) 2014-06-23
CA2797901C (en) 2019-02-26

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM