EA021951B1 - Противораковая комбинация - Google Patents

Противораковая комбинация Download PDF

Info

Publication number
EA021951B1
EA021951B1 EA201270445A EA201270445A EA021951B1 EA 021951 B1 EA021951 B1 EA 021951B1 EA 201270445 A EA201270445 A EA 201270445A EA 201270445 A EA201270445 A EA 201270445A EA 021951 B1 EA021951 B1 EA 021951B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
administered
days
followed
administration
Prior art date
Application number
EA201270445A
Other languages
English (en)
Russian (ru)
Other versions
EA201270445A1 (ru
Inventor
Мелисса Дамбл
Тона Джилмер
Ракеш Кумар
Питер Ф. Лебовиц
Шэннон Рене Моррис
Сильви Лакерр
Original Assignee
ГЛЭКСОСМИТКЛАЙН ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ГЛЭКСОСМИТКЛАЙН ЭлЭлСи filed Critical ГЛЭКСОСМИТКЛАЙН ЭлЭлСи
Publication of EA201270445A1 publication Critical patent/EA201270445A1/ru
Publication of EA021951B1 publication Critical patent/EA021951B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EA201270445A 2009-09-23 2010-09-23 Противораковая комбинация EA021951B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24501909P 2009-09-23 2009-09-23
PCT/US2010/049946 WO2011038082A1 (en) 2009-09-23 2010-09-23 Combination

Publications (2)

Publication Number Publication Date
EA201270445A1 EA201270445A1 (ru) 2013-03-29
EA021951B1 true EA021951B1 (ru) 2015-10-30

Family

ID=43796197

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270445A EA021951B1 (ru) 2009-09-23 2010-09-23 Противораковая комбинация

Country Status (14)

Country Link
US (2) US20120322817A1 (enExample)
EP (1) EP2480084B1 (enExample)
JP (2) JP2013505939A (enExample)
KR (1) KR20120099219A (enExample)
CN (1) CN102770026B (enExample)
AU (1) AU2010298277B2 (enExample)
BR (1) BR112012006693A2 (enExample)
CA (1) CA2775124A1 (enExample)
EA (1) EA021951B1 (enExample)
ES (1) ES2527625T3 (enExample)
IL (1) IL218797A (enExample)
MX (1) MX2012003546A (enExample)
WO (1) WO2011038082A1 (enExample)
ZA (1) ZA201202173B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012061683A2 (en) * 2010-11-05 2012-05-10 Glaxosmithkline Llc Methods for treating cancer
TWI505828B (zh) 2010-12-20 2015-11-01 葛蘭素史克智慧財產(第二)有限公司 新穎醫藥組成物
US9682082B2 (en) * 2011-04-01 2017-06-20 Genentech, Inc. Combinations of AKT and MEK inhibitor compounds, and methods of use
EP2913048A1 (en) 2014-02-27 2015-09-02 ratiopharm GmbH Pharmaceutical composition comprising trametinib
CN111201023A (zh) * 2017-08-11 2020-05-26 启码策有限公司 用于靶向癌症中的多个突变的药物组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060014768A1 (en) * 2004-06-11 2006-01-19 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
WO2008098104A1 (en) * 2007-02-07 2008-08-14 Smithkline Beecham Corporation Inhibitors of akt activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1301472T1 (sl) * 2000-07-19 2014-05-30 Warner-Lambert Company Llc Oksigenirani estri 4-jodo fenilamino benzihidroksamskih kislin
DE602005004286T2 (de) * 2004-06-11 2009-01-02 Japan Tobacco Inc. 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyridoä2,3-düpyrimidinderivate und verwandte verbindungen zur behandlung von krebs
JP3821154B1 (ja) * 2005-03-16 2006-09-13 いすゞ自動車株式会社 排気ガス浄化方法及び排気ガス浄化システム

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060014768A1 (en) * 2004-06-11 2006-01-19 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
WO2008098104A1 (en) * 2007-02-07 2008-08-14 Smithkline Beecham Corporation Inhibitors of akt activity

Also Published As

Publication number Publication date
KR20120099219A (ko) 2012-09-07
CN102770026B (zh) 2015-04-01
EP2480084A4 (en) 2013-02-20
ES2527625T3 (es) 2015-01-27
IL218797A0 (en) 2012-06-28
JP2013505939A (ja) 2013-02-21
WO2011038082A1 (en) 2011-03-31
AU2010298277A1 (en) 2012-04-19
IL218797A (en) 2014-11-30
ZA201202173B (en) 2012-11-28
US20120322817A1 (en) 2012-12-20
BR112012006693A2 (pt) 2015-09-08
CA2775124A1 (en) 2011-03-31
EP2480084B1 (en) 2014-11-12
AU2010298277B2 (en) 2014-07-03
JP2016106092A (ja) 2016-06-16
CN102770026A (zh) 2012-11-07
US20150094321A1 (en) 2015-04-02
EA201270445A1 (ru) 2013-03-29
MX2012003546A (es) 2012-09-07
EP2480084A1 (en) 2012-08-01

Similar Documents

Publication Publication Date Title
TWI607754B (zh) 醫藥組合
CA3180314A1 (en) Methods of treating cancer in patients with an anomalous kras gene or deletions within chromosome 9
WO2020024820A1 (en) Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases
JP6644042B2 (ja) PI3Kインヒビターとc−Metインヒビターの組み合わせ
EA028462B1 (ru) Способы лечения немелкоклеточного рака легких на поздних стадиях c применением комбинированного лечения с ингибитором киназы tor
MX2013009351A (es) Terapia de combinacion de inhibidor de objetivo de rapamicina en mamifero/janus cinasa (mtor/jak).
US10322128B2 (en) Combinations for the treatment of neoplasms using quiescent cell targeting with EGFR inhibitors
EA028414B1 (ru) Лечение рака ингибиторами tor киназы
JP2016529285A (ja) 細胞増殖性疾患を治療するためのalk阻害剤とcdk阻害剤との組合せ
US20120202822A1 (en) Combination
CN110652514A (zh) 第三代egfr抑制剂的制药用途
CN113164779A (zh) 治疗cdk4/6抑制剂耐药性癌症的方法
CA3103995A1 (en) Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
EA021951B1 (ru) Противораковая комбинация
US8748428B2 (en) Use of a PKC inhibitor
AU2016308704B2 (en) MDM2 inhibitors for treating uveal melanoma
KR20160090814A (ko) Jak, cdk 및 pim의 억제제를 포함하는 조합 요법
EP2754441A2 (en) Composition for preventing and treating non-small cell lung cancer, containing pyrazino-triazine derivatives
JP6148320B2 (ja) 組合せ
WO2023202563A1 (en) Akt inhibitor in combination with pim kinase inhibitor
JP2013505962A (ja) 組合せ
JP6708634B2 (ja) 急性骨髄性白血病及び骨髄異形成症候群の併用療法iii
WO2024088192A1 (en) An aurora a inhibitor for use in treatments of cancers
TWI904148B (zh) 包含蛋白激酶抑制劑和化療藥物的藥物組合物及其用途
US8906879B2 (en) Combination for the treatment of cancer

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU