EA017333B1 - Новый способ синтеза 7,8-диметокси-1,3-дигидро-2h-3-бензазепин-2-она и его применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой - Google Patents

Новый способ синтеза 7,8-диметокси-1,3-дигидро-2h-3-бензазепин-2-она и его применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой Download PDF

Info

Publication number
EA017333B1
EA017333B1 EA200900707A EA200900707A EA017333B1 EA 017333 B1 EA017333 B1 EA 017333B1 EA 200900707 A EA200900707 A EA 200900707A EA 200900707 A EA200900707 A EA 200900707A EA 017333 B1 EA017333 B1 EA 017333B1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
synthesis method
reaction
vii
Prior art date
Application number
EA200900707A
Other languages
English (en)
Russian (ru)
Other versions
EA200900707A1 (ru
Inventor
Жан-Мишель Лерестиф
Жан-Пьер Лекув
Даниель Бриго
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40347797&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA017333(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200900707A1 publication Critical patent/EA200900707A1/ru
Publication of EA017333B1 publication Critical patent/EA017333B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA200900707A 2008-06-20 2009-06-19 Новый способ синтеза 7,8-диметокси-1,3-дигидро-2h-3-бензазепин-2-она и его применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой EA017333B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803452A FR2932800B1 (fr) 2008-06-20 2008-06-20 Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
EA200900707A1 EA200900707A1 (ru) 2010-04-30
EA017333B1 true EA017333B1 (ru) 2012-11-30

Family

ID=40347797

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900707A EA017333B1 (ru) 2008-06-20 2009-06-19 Новый способ синтеза 7,8-диметокси-1,3-дигидро-2h-3-бензазепин-2-она и его применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой

Country Status (36)

Country Link
US (1) US7928223B2 (zh)
EP (1) EP2135861B2 (zh)
JP (1) JP5216697B2 (zh)
KR (1) KR101119296B1 (zh)
CN (1) CN101607939B (zh)
AR (1) AR072175A1 (zh)
AU (1) AU2009202314B2 (zh)
BR (1) BRPI0902105A2 (zh)
CA (1) CA2668524C (zh)
CL (1) CL2009001414A1 (zh)
CY (1) CY1115623T1 (zh)
DK (1) DK2135861T4 (zh)
EA (1) EA017333B1 (zh)
ES (1) ES2522625T5 (zh)
FR (1) FR2932800B1 (zh)
GE (1) GEP20125407B (zh)
HK (1) HK1140188A1 (zh)
HR (1) HRP20140928T4 (zh)
JO (1) JO3806B1 (zh)
MA (1) MA31071B1 (zh)
ME (1) ME00814B (zh)
MX (1) MX2009006288A (zh)
MY (1) MY146245A (zh)
NZ (1) NZ577540A (zh)
PE (1) PE20100051A1 (zh)
PL (1) PL2135861T5 (zh)
PT (1) PT2135861E (zh)
RS (1) RS53495B2 (zh)
SA (1) SA109300396B1 (zh)
SG (1) SG158026A1 (zh)
SI (1) SI2135861T2 (zh)
TW (1) TWI374134B (zh)
UA (1) UA107779C2 (zh)
UY (1) UY31883A (zh)
WO (1) WO2009153461A2 (zh)
ZA (1) ZA200904316B (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2162438A4 (en) * 2007-05-30 2011-07-06 Ind Swift Lab Ltd PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND CORRESPONDING POLYMORPHIDE
CN101774969B (zh) * 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
EA201290772A1 (ru) 2010-02-12 2013-02-28 КРКА, д.д., НОВО МЕСТО Новые формы ивабрадина гидрохлорида
FR2956401B1 (fr) 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2011104723A2 (en) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Acid addition salts of ivabradine and preparation thereof
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR3003859B1 (fr) 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
HU230826B1 (hu) * 2014-11-19 2018-07-30 Richter Gedeon Nyrt. Eljárás benzazepin származékok előállítására
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN108424389A (zh) * 2017-02-13 2018-08-21 浙江京新药业股份有限公司 一种伊伐布雷定杂质的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0204349A2 (de) * 1985-06-01 1986-12-10 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5296482A (en) * 1991-09-27 1994-03-22 Adir Et Compagnie (Benzocycloalkyl) alkylamines
RU2006117366A (ru) * 2003-10-23 2007-12-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные бензазепина в качестве ингибиторов мао-в

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
ZA84758B (en) * 1983-02-04 1985-09-25 Lilly Co Eli Benzazepines
DE3343801A1 (de) * 1983-12-03 1985-06-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418271A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
UA77165C2 (en) * 2000-11-17 2006-11-15 Lilly Co Eli (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
WO2002074746A1 (fr) * 2001-03-16 2002-09-26 Yamanouchi Pharmaceutical Co., Ltd. Derives de benzazepine
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN101495184A (zh) * 2005-07-15 2009-07-29 Amr科技公司 芳基和杂芳基取代的四氢苯并氮杂及其在阻断去甲肾上腺素多巴胺和血清素的重摄取中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0204349A2 (de) * 1985-06-01 1986-12-10 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5296482A (en) * 1991-09-27 1994-03-22 Adir Et Compagnie (Benzocycloalkyl) alkylamines
RU2006117366A (ru) * 2003-10-23 2007-12-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные бензазепина в качестве ингибиторов мао-в

Also Published As

Publication number Publication date
WO2009153461A2 (fr) 2009-12-23
EA200900707A1 (ru) 2010-04-30
TWI374134B (en) 2012-10-11
PE20100051A1 (es) 2010-02-06
SG158026A1 (en) 2010-01-29
FR2932800A1 (fr) 2009-12-25
MA31071B1 (fr) 2010-01-04
HRP20140928T1 (en) 2014-11-21
BRPI0902105A2 (pt) 2010-04-13
KR20090132544A (ko) 2009-12-30
EP2135861B1 (fr) 2014-07-30
RS53495B1 (en) 2015-02-27
CA2668524C (fr) 2012-09-11
UA107779C2 (en) 2015-02-25
AU2009202314A1 (en) 2010-01-14
JO3806B1 (ar) 2021-01-31
AR072175A1 (es) 2010-08-11
TW201002671A (en) 2010-01-16
ZA200904316B (en) 2010-05-26
MY146245A (en) 2012-07-31
JP2010006807A (ja) 2010-01-14
AU2009202314B2 (en) 2013-01-24
HK1140188A1 (en) 2010-10-08
DK2135861T4 (da) 2021-03-22
SA109300396B1 (ar) 2013-09-08
SI2135861T2 (sl) 2021-04-30
GEP20125407B (en) 2012-02-27
UY31883A (es) 2010-01-29
PL2135861T3 (pl) 2014-11-28
RS53495B2 (sr) 2021-02-26
EP2135861A1 (fr) 2009-12-23
PL2135861T5 (pl) 2022-07-18
ES2522625T5 (es) 2021-07-29
CN101607939A (zh) 2009-12-23
CN101607939B (zh) 2012-05-02
ME00814B (me) 2012-03-20
WO2009153461A3 (fr) 2010-04-29
US20090318682A1 (en) 2009-12-24
FR2932800B1 (fr) 2015-02-20
CY1115623T1 (el) 2017-01-04
US7928223B2 (en) 2011-04-19
MX2009006288A (es) 2010-02-17
CL2009001414A1 (es) 2010-06-04
DK2135861T3 (da) 2014-10-20
CA2668524A1 (fr) 2009-12-20
SI2135861T1 (sl) 2014-10-30
HRP20140928T4 (hr) 2021-03-05
JP5216697B2 (ja) 2013-06-19
ES2522625T3 (es) 2014-11-17
KR101119296B1 (ko) 2012-03-15
NZ577540A (en) 2010-10-29
PT2135861E (pt) 2014-09-02
EP2135861B2 (fr) 2020-12-16

Similar Documents

Publication Publication Date Title
EA017333B1 (ru) Новый способ синтеза 7,8-диметокси-1,3-дигидро-2h-3-бензазепин-2-она и его применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
AU2010210054B2 (en) Novel method for the synthesis of ivabradine and the pharmaceutically acceptable acid addition salts thereof
AU2005200860B2 (en) New process for the synthesis of 1,3-dihydro-2H-3-benzepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
EA019380B1 (ru) Способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
AU2010201058B2 (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
EA020735B1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
AU2011200403B2 (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
EA023329B1 (ru) Способ синтеза 3-(2-бром-4,5-диметоксифенил)пропаннитрила и применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей