EA017170B1 - Модуляторы рецептора св1 - Google Patents

Info

Publication number

EA017170B1

EA017170B1 EA200900838A EA200900838A EA017170B1 EA 017170 B1 EA017170 B1 EA 017170B1 EA 200900838 A EA200900838 A EA 200900838A EA 200900838 A EA200900838 A EA 200900838A EA 017170 B1 EA017170 B1 EA 017170B1

Authority

EA

Eurasian Patent Office

Prior art keywords

chlorophenyl

hydrogen

pyrazole

ethyl

methyl

Prior art date

2006-12-18

Links

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• 150000001875 compounds Chemical class 0.000 claims abstract description 125
• 239000001257 hydrogen Substances 0.000 claims abstract description 49
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 49
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 45
• 208000008589 Obesity Diseases 0.000 claims abstract description 43
• 235000020824 obesity Nutrition 0.000 claims abstract description 43
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 35
• 201000010099 disease Diseases 0.000 claims abstract description 33
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 19
• 206010033307 Overweight Diseases 0.000 claims abstract description 18
• 229910052799 carbon Inorganic materials 0.000 claims abstract description 12
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims abstract description 12
• 150000002431 hydrogen Chemical class 0.000 claims abstract description 12
• 125000003831 tetrazolyl group Chemical group 0.000 claims abstract description 10
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 9
• 125000003226 pyrazolyl group Chemical group 0.000 claims abstract description 9
• 125000004076 pyridyl group Chemical group 0.000 claims abstract description 6
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 56
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 53
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 51
• -1 -OI 9 Chemical group 0.000 claims description 39
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 38
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 33
• 150000001408 amides Chemical class 0.000 claims description 28
• 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims description 18
• 150000003839 salts Chemical class 0.000 claims description 17
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• 208000001145 Metabolic Syndrome Diseases 0.000 claims description 15
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
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• 150000001721 carbon Chemical group 0.000 claims description 9
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 8
• KOPFEFZSAMLEHK-UHFFFAOYSA-N 1h-pyrazole-5-carboxylic acid Chemical compound OC(=O)C=1C=CNN=1 KOPFEFZSAMLEHK-UHFFFAOYSA-N 0.000 claims description 8
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 8
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• 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 7
• CYAYCOCJAVHQSD-UHFFFAOYSA-N 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid Chemical compound CC=1C(C(O)=O)=NN(C=2C(=CC(Cl)=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 CYAYCOCJAVHQSD-UHFFFAOYSA-N 0.000 claims description 7
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• 125000004863 4-trifluoromethoxyphenyl group Chemical group [H]C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1* 0.000 claims description 5
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• WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
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• 239000000543 intermediate Substances 0.000 description 23
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