AU2007336061B2 - CB1 receptor modulators - Google Patents
CB1 receptor modulators Download PDFInfo
- Publication number
- AU2007336061B2 AU2007336061B2 AU2007336061A AU2007336061A AU2007336061B2 AU 2007336061 B2 AU2007336061 B2 AU 2007336061B2 AU 2007336061 A AU2007336061 A AU 2007336061A AU 2007336061 A AU2007336061 A AU 2007336061A AU 2007336061 B2 AU2007336061 B2 AU 2007336061B2
- Authority
- AU
- Australia
- Prior art keywords
- phenyl
- chloro
- compound
- hydrogen
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000009132 CB1 Cannabinoid Receptor Human genes 0.000 title abstract 3
- 108010073366 CB1 Cannabinoid Receptor Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 12
- 201000010099 disease Diseases 0.000 claims abstract 8
- 208000008589 Obesity Diseases 0.000 claims abstract 5
- 206010033307 Overweight Diseases 0.000 claims abstract 5
- 235000020824 obesity Nutrition 0.000 claims abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 9
- 208000019423 liver disease Diseases 0.000 claims 6
- 208000030159 metabolic disease Diseases 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 5
- 150000003254 radicals Chemical class 0.000 claims 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- 150000001721 carbon Chemical group 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- -1 2-oxo-pyrrolidine radical Chemical class 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 208000030814 Eating disease Diseases 0.000 claims 3
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 3
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 3
- 201000001880 Sexual dysfunction Diseases 0.000 claims 3
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 208000016097 disease of metabolism Diseases 0.000 claims 3
- 235000014632 disordered eating Nutrition 0.000 claims 3
- 230000004064 dysfunction Effects 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims 3
- 230000003818 metabolic dysfunction Effects 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000020016 psychiatric disease Diseases 0.000 claims 3
- 230000001850 reproductive effect Effects 0.000 claims 3
- 231100000872 sexual dysfunction Toxicity 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- VTLIABOHZPSHRN-ZCFIWIBFSA-N (1r)-1-[4-(trifluoromethoxy)phenyl]ethanamine Chemical compound C[C@@H](N)C1=CC=C(OC(F)(F)F)C=C1 VTLIABOHZPSHRN-ZCFIWIBFSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- SRVZZCBLNXFARS-RXMQYKEDSA-N (1r)-1-(4-chloro-3-fluorophenyl)ethanamine Chemical compound C[C@@H](N)C1=CC=C(Cl)C(F)=C1 SRVZZCBLNXFARS-RXMQYKEDSA-N 0.000 claims 1
- ODZXRBRYQGYVJY-ZCFIWIBFSA-N (1r)-1-[3-(trifluoromethyl)phenyl]ethanamine Chemical compound C[C@@H](N)C1=CC=CC(C(F)(F)F)=C1 ODZXRBRYQGYVJY-ZCFIWIBFSA-N 0.000 claims 1
- DANBLBWVACCFGQ-OAHLLOKOSA-N 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(2h-tetrazol-5-ylmethyl)-n-[(1r)-1-[4-(trifluoromethyl)phenyl]ethyl]pyrazole-3-carboxamide Chemical compound N([C@H](C)C=1C=CC(=CC=1)C(F)(F)F)C(=O)C1=NN(C=2C(=CC=CC=2)Cl)C(C=2C=CC(Cl)=CC=2)=C1CC=1N=NNN=1 DANBLBWVACCFGQ-OAHLLOKOSA-N 0.000 claims 1
- KGSHVAJICCZWIY-UHFFFAOYSA-N 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(2h-tetrazol-5-ylmethyl)pyrazole-3-carboxylic acid Chemical compound OC(=O)C1=NN(C=2C(=CC=CC=2)Cl)C(C=2C=CC(Cl)=CC=2)=C1CC=1N=NNN=1 KGSHVAJICCZWIY-UHFFFAOYSA-N 0.000 claims 1
- XIEINPMUURJODF-OAHLLOKOSA-N 2-[3-[[(1r)-1-(4-bromophenyl)ethyl]carbamoyl]-1-(2-chlorophenyl)-5-(4-chlorophenyl)pyrazol-4-yl]acetic acid Chemical compound N([C@H](C)C=1C=CC(Br)=CC=1)C(=O)C(C=1CC(O)=O)=NN(C=2C(=CC=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 XIEINPMUURJODF-OAHLLOKOSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical compound C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N gamma-butyrolactam Natural products O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- ZZFNGYQHBWPHOV-OAHLLOKOSA-N n-[(1r)-1-(3-chloro-4-fluorophenyl)ethyl]-1-(2-chlorophenyl)-5-(4-chlorophenyl)-n-methyl-4-(2h-tetrazol-5-ylmethyl)pyrazole-3-carboxamide Chemical compound CN([C@H](C)C=1C=C(Cl)C(F)=CC=1)C(=O)C1=NN(C=2C(=CC=CC=2)Cl)C(C=2C=CC(Cl)=CC=2)=C1CC1=NN=NN1 ZZFNGYQHBWPHOV-OAHLLOKOSA-N 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229940099990 ogen Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0625197.9 | 2006-12-18 | ||
| GB0625197A GB0625197D0 (en) | 2006-12-18 | 2006-12-18 | Cannabinoid receptor modulators |
| GB0717998A GB0717998D0 (en) | 2007-09-14 | 2007-09-14 | Canabinoid receptor modulators |
| GB0717998.9 | 2007-09-14 | ||
| PCT/GB2007/004831 WO2008075012A1 (en) | 2006-12-18 | 2007-12-17 | Cb1 receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2007336061A1 AU2007336061A1 (en) | 2008-06-26 |
| AU2007336061B2 true AU2007336061B2 (en) | 2013-06-27 |
Family
ID=39156232
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007336061A Ceased AU2007336061B2 (en) | 2006-12-18 | 2007-12-17 | CB1 receptor modulators |
| AU2007336068A Ceased AU2007336068B2 (en) | 2006-12-18 | 2007-12-17 | Modulators of CB1 receptors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007336068A Ceased AU2007336068B2 (en) | 2006-12-18 | 2007-12-17 | Modulators of CB1 receptors |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8148404B2 (enExample) |
| EP (2) | EP2121659B1 (enExample) |
| JP (2) | JP5437812B2 (enExample) |
| CN (1) | CN103145620A (enExample) |
| AU (2) | AU2007336061B2 (enExample) |
| BR (1) | BRPI0720732A2 (enExample) |
| CA (2) | CA2673177A1 (enExample) |
| EA (1) | EA017170B1 (enExample) |
| IL (2) | IL198989A0 (enExample) |
| MX (1) | MX2009006214A (enExample) |
| NZ (1) | NZ578063A (enExample) |
| WO (3) | WO2008075012A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| US7977358B2 (en) * | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
| JP2011506410A (ja) * | 2007-12-10 | 2011-03-03 | ７ティーエム ファーマ エイ／エス | カンナビノイド受容体モジュレーター |
| GB0813144D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| EP2731561B1 (en) | 2011-07-14 | 2016-03-23 | Cook Medical Technologies LLC | A sling to be used in the treatment of obstructive sleep apnea |
| US9710644B2 (en) | 2012-02-01 | 2017-07-18 | Servicenow, Inc. | Techniques for sharing network security event information |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| WO2014189540A1 (en) | 2012-10-16 | 2014-11-27 | Catalano Peter J | Method and apparatus for treating obstructive sleep apnea (osa) |
| WO2015017749A1 (en) | 2013-08-01 | 2015-02-05 | Mohan P Arun | Tissue adjustment implant |
| AU2014306232B2 (en) | 2013-08-05 | 2018-12-06 | C2Dx, Inc. | Medical devices having a releasable tubular member and methods of using the same |
| EP2898920B1 (en) | 2014-01-24 | 2018-06-06 | Cook Medical Technologies LLC | Articulating balloon catheter |
| US9974563B2 (en) | 2014-05-28 | 2018-05-22 | Cook Medical Technologies Llc | Medical devices having a releasable member and methods of using the same |
| WO2016022454A1 (en) | 2014-08-04 | 2016-02-11 | Darin Schaeffer | Medical devices having a releasable tubular member and methods of using the same |
| AU2018294247A1 (en) | 2017-06-29 | 2020-01-23 | Cook Biotech Incorporated | Implantable medical devices for tissue repositioning |
| JP2021535202A (ja) * | 2018-08-20 | 2021-12-16 | ベッソール ファルマ、エルエルシー | 新規カンナビノイドおよびカンナビノイド酸ならびにそれらの誘導体 |
| CA3166630A1 (en) | 2020-01-03 | 2021-07-08 | Berg Llc | Polycyclic amides as ube2k modulators for treating cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006133926A1 (en) * | 2005-06-17 | 2006-12-21 | Carex Sa | Pyrazole derivates as cannabinoid receptor modulators |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2741621B1 (fr) | 1995-11-23 | 1998-02-13 | Sanofi Sa | Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant |
| FR2742148B1 (fr) | 1995-12-08 | 1999-10-22 | Sanofi Sa | Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant |
| FR2789079B3 (fr) | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
| AU780572B2 (en) | 1999-10-18 | 2005-04-07 | University Of Connecticut, The | Pyrazole derivatives as cannabinoid receptor antagonists |
| US6653304B2 (en) | 2000-02-11 | 2003-11-25 | Bristol-Myers Squibb Co. | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| ES2272449T3 (es) * | 2000-03-23 | 2007-05-01 | Solvay Pharmaceuticals B.V. | Derivados de 4,5-dihidro-1h-pirazol con actividad antagosnista de cb-1. |
| CA2439152C (en) * | 2001-02-28 | 2008-06-17 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
| EP1421077A4 (en) | 2001-08-31 | 2004-11-17 | Univ Connecticut | NEW PYRAZOLANALOGS ON CANNABINOID RECEPTORS |
| FR2831883B1 (fr) * | 2001-11-08 | 2004-07-23 | Sanofi Synthelabo | Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| US6825209B2 (en) | 2002-04-15 | 2004-11-30 | Research Triangle Institute | Compounds having unique CB1 receptor binding selectivity and methods for their production and use |
| NZ540515A (en) * | 2002-12-02 | 2008-01-31 | Astellas Pharma Inc | Pyrazole derivatives useful as COX-I inhibitors |
| US7247628B2 (en) | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| WO2004099157A1 (en) | 2003-05-07 | 2004-11-18 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| FR2856683A1 (fr) | 2003-06-25 | 2004-12-31 | Sanofi Synthelabo | Derives de 4-cyanopyrazole-3-carboxamide, leur preparation et leur application en therapeutique |
| BRPI0507786A (pt) | 2004-02-20 | 2007-07-17 | Astrazeneca Ab | composto e sais farmaceuticamente aceitáveis do mesmo, formulação farmacêutica, uso de um composto, método de tratar uma doença, e, processo para a preparação de compostos |
| FR2867685B1 (fr) * | 2004-03-17 | 2008-05-23 | Sanofi Synthelabo | Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement de la bronchite chronique et de la broncho-pneumopathie chronique obstructive |
| WO2006067443A1 (en) | 2004-12-23 | 2006-06-29 | Astrazeneca Ab | Therapeutic agents |
| US7687481B2 (en) * | 2006-03-10 | 2010-03-30 | Jenrin Discovery, Inc. | Cannabinoid receptor antagonists/inverse agonists useful for treating obesity |
-
2007
- 2007-12-17 CN CN2012103916453A patent/CN103145620A/zh active Pending
- 2007-12-17 AU AU2007336061A patent/AU2007336061B2/en not_active Ceased
- 2007-12-17 EP EP07848579.4A patent/EP2121659B1/en not_active Not-in-force
- 2007-12-17 JP JP2009542195A patent/JP5437812B2/ja not_active Expired - Fee Related
- 2007-12-17 CA CA002673177A patent/CA2673177A1/en not_active Abandoned
- 2007-12-17 MX MX2009006214A patent/MX2009006214A/es active IP Right Grant
- 2007-12-17 WO PCT/GB2007/004831 patent/WO2008075012A1/en not_active Ceased
- 2007-12-17 BR BRPI0720732-8A patent/BRPI0720732A2/pt not_active IP Right Cessation
- 2007-12-17 EP EP07848570.3A patent/EP2121617B1/en not_active Not-in-force
- 2007-12-17 US US12/518,446 patent/US8148404B2/en not_active Expired - Fee Related
- 2007-12-17 NZ NZ578063A patent/NZ578063A/en not_active IP Right Cessation
- 2007-12-17 EA EA200900838A patent/EA017170B1/ru not_active IP Right Cessation
- 2007-12-17 US US12/519,432 patent/US8124634B2/en not_active Expired - Fee Related
- 2007-12-17 WO PCT/GB2007/004835 patent/WO2008075013A1/en not_active Ceased
- 2007-12-17 WO PCT/GB2007/004842 patent/WO2008075019A1/en not_active Ceased
- 2007-12-17 AU AU2007336068A patent/AU2007336068B2/en not_active Ceased
- 2007-12-17 JP JP2009542200A patent/JP5222855B2/ja not_active Expired - Fee Related
- 2007-12-17 CA CA002673359A patent/CA2673359A1/en not_active Abandoned
-
2009
- 2009-05-27 IL IL198989A patent/IL198989A0/en unknown
- 2009-05-27 IL IL198990A patent/IL198990A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006133926A1 (en) * | 2005-06-17 | 2006-12-21 | Carex Sa | Pyrazole derivates as cannabinoid receptor modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008075019A1 (en) | 2008-06-26 |
| AU2007336068B2 (en) | 2013-05-02 |
| US8148404B2 (en) | 2012-04-03 |
| IL198989A0 (en) | 2010-02-17 |
| AU2007336068A1 (en) | 2008-06-26 |
| EA200900838A1 (ru) | 2010-02-26 |
| EP2121617B1 (en) | 2014-01-22 |
| NZ578063A (en) | 2011-09-30 |
| CN103145620A (zh) | 2013-06-12 |
| JP2010513435A (ja) | 2010-04-30 |
| CA2673177A1 (en) | 2008-06-26 |
| US8124634B2 (en) | 2012-02-28 |
| CA2673359A1 (en) | 2008-06-26 |
| MX2009006214A (es) | 2009-06-22 |
| WO2008075012A1 (en) | 2008-06-26 |
| JP5437812B2 (ja) | 2014-03-12 |
| EP2121659B1 (en) | 2013-05-15 |
| JP2010513438A (ja) | 2010-04-30 |
| EP2121659A1 (en) | 2009-11-25 |
| US20100010061A1 (en) | 2010-01-14 |
| EA017170B1 (ru) | 2012-10-30 |
| US20100144701A1 (en) | 2010-06-10 |
| BRPI0720732A2 (pt) | 2014-04-08 |
| IL198990A0 (en) | 2010-02-17 |
| EP2121617A1 (en) | 2009-11-25 |
| AU2007336061A1 (en) | 2008-06-26 |
| WO2008075013A1 (en) | 2008-06-26 |
| JP5222855B2 (ja) | 2013-06-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2007336061B2 (en) | CB1 receptor modulators | |
| US20080200527A1 (en) | Cannabinoid Receptor Modulators | |
| CA2693457C (en) | Inhibitors of 11b-hydroxysteroid dehydrogenase | |
| CA2673358A1 (en) | Pyrazole derivatives as modulators of cannabinoid receptor | |
| US8173680B2 (en) | Cannabinoid receptor modulators | |
| WO2008092681A1 (en) | Ghrelin receptor modulators | |
| WO2008059207A1 (en) | Cannabinoid receptor modulators | |
| US20090131497A1 (en) | Indoline-substituted pyrazoline derivatives, their preparation and use as medicaments | |
| WO2009153569A2 (en) | Cb1 receptor modulators | |
| CN101568525A (zh) | Cb1受体调节剂 | |
| EP1849783A1 (en) | Octahydropentalene-substituted pyrazoline compounds, their preparation and use as medicaments | |
| EP1849784A1 (en) | Indoline-substituted pyrazoline compounds, their preparation and use as medicaments |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |