EA015736B1 - Производные пролинамида в качестве модуляторов натриевых каналов - Google Patents

Производные пролинамида в качестве модуляторов натриевых каналов Download PDF

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Publication number
EA015736B1
EA015736B1 EA200801054A EA200801054A EA015736B1 EA 015736 B1 EA015736 B1 EA 015736B1 EA 200801054 A EA200801054 A EA 200801054A EA 200801054 A EA200801054 A EA 200801054A EA 015736 B1 EA015736 B1 EA 015736B1
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EA
Eurasian Patent Office
Prior art keywords
disorder
compound
disease
condition
oxy
Prior art date
Application number
EA200801054A
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English (en)
Russian (ru)
Other versions
EA200801054A1 (ru
Inventor
Джузеппе Альваро
Маркус Бергауэр
Риккардо Джованнини
Роберто Профета
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0520581A external-priority patent/GB0520581D0/en
Priority claimed from GB0523045A external-priority patent/GB0523045D0/en
Priority claimed from GB0603900A external-priority patent/GB0603900D0/en
Priority claimed from GB0618336A external-priority patent/GB0618336D0/en
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of EA200801054A1 publication Critical patent/EA200801054A1/ru
Publication of EA015736B1 publication Critical patent/EA015736B1/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401Proline; Derivatives thereof, e.g. captopril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
EA200801054A 2005-10-10 2006-10-06 Производные пролинамида в качестве модуляторов натриевых каналов EA015736B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0520581A GB0520581D0 (en) 2005-10-10 2005-10-10 Novel compounds
GB0523045A GB0523045D0 (en) 2005-11-11 2005-11-11 Novel compounds
GB0603900A GB0603900D0 (en) 2006-02-27 2006-02-27 Novel compounds
GB0618336A GB0618336D0 (en) 2006-09-18 2006-09-18 Novel compounds
PCT/EP2006/009731 WO2007042239A1 (en) 2005-10-10 2006-10-06 Prolinamide derivatives as sodium channel modulators

Publications (2)

Publication Number Publication Date
EA200801054A1 EA200801054A1 (ru) 2008-08-29
EA015736B1 true EA015736B1 (ru) 2011-10-31

Family

ID=37546777

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801054A EA015736B1 (ru) 2005-10-10 2006-10-06 Производные пролинамида в качестве модуляторов натриевых каналов

Country Status (20)

Country Link
US (2) US7655693B2 (enExample)
EP (1) EP1934177B8 (enExample)
JP (1) JP5139305B2 (enExample)
KR (1) KR101282464B1 (enExample)
AR (1) AR056575A1 (enExample)
AT (1) ATE556049T1 (enExample)
AU (1) AU2006301470B2 (enExample)
BR (1) BRPI0616944B8 (enExample)
CA (1) CA2625642C (enExample)
CR (1) CR9898A (enExample)
EA (1) EA015736B1 (enExample)
ES (1) ES2387405T3 (enExample)
IL (1) IL192627A0 (enExample)
MA (1) MA29817B1 (enExample)
NO (1) NO20082145L (enExample)
NZ (1) NZ567051A (enExample)
PE (1) PE20070592A1 (enExample)
PL (1) PL1934177T3 (enExample)
TW (1) TW200730494A (enExample)
WO (1) WO2007042239A1 (enExample)

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US8143306B2 (en) * 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
US7855218B2 (en) * 2005-10-10 2010-12-21 Convergence Pharmaceuticals Limited Compounds
GB0701365D0 (en) * 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
WO2011015537A1 (en) 2009-08-05 2011-02-10 Glaxo Group Limited Co-therapy for the treatment of epilepsy and related disorders
HRP20150491T1 (hr) 2009-09-14 2015-08-14 Convergence Pharmaceuticals Limited PROCES PRIPREME DERIVATA α-KARBOKSAMIDA
ES2786298T3 (es) 2011-03-03 2020-10-09 Zalicus Pharmaceuticals Ltd Inhibidores de benzimidazol del canal de sodio
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
CN106255679B (zh) 2014-02-27 2019-09-06 默克专利有限公司 用作nav通道抑制剂的杂环化合物及其用途
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
ES2912881T3 (es) 2014-12-23 2022-05-30 Convergence Pharmaceuticals Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
CA3042384A1 (en) * 2016-11-02 2018-05-11 Biogen Ma Inc. Novel dosage regimen
CA3062884A1 (en) * 2017-05-19 2018-11-22 Biogen Ma Inc. Novel crystalline forms
EP3691634A4 (en) * 2017-10-05 2021-03-31 Biogen Inc. PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES
CA3077088A1 (en) 2017-10-10 2019-04-18 Biogen Inc. Process for preparing spiro derivatives
AU2019255519A1 (en) * 2018-04-16 2020-10-01 Biogen Ma Inc. Methods of treating neuropathic pain
MX2021012421A (es) * 2019-04-10 2022-02-10 Biogen Inc Procesos para preparar derivados de pirrolidina alfa-carboxamida.
EA202192762A1 (ru) * 2019-04-10 2022-03-21 Байоджен Ма Инк. Способ получения производных альфа-карбоксамид пирролидина
EP4096508A4 (en) 2020-01-30 2024-03-27 Javed, Mohammad COMBINATION MEDICINAL THERAPIES FOR CNS DISEASES

Citations (4)

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WO2004026826A1 (en) * 2002-09-20 2004-04-01 F. Hoffmann-La Roche Ag 4-pyrrolidino-phenyl-benzyl ether derivatives
WO2004094395A2 (en) * 2003-04-18 2004-11-04 Merck & Co., Inc. Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
WO2005000309A2 (en) * 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
EP1524265A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors

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US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
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US6136131A (en) * 1998-06-02 2000-10-24 Instrument Specialties Company, Inc. Method of shielding and obtaining access to a component on a printed circuit board
RU2001129155A (ru) 1999-03-26 2003-08-10 Еро-Сельтик С.А. (Lu) Соединения с арильными заместителями (варианты), фармацевтическая композиция и способ лечения расстройства, чувствительного к блокаде натриевых каналов у млекопитающего, способ лечения, профилактики различных заболеваний или уменьшения интенсивности гибели или потери нейронов (варианты), способ облегчения или предупреждения эпилептических припадков у животного (варианты), соединение - радиоактивный лиганд для участка связывания в натриевом канале
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JP2008540665A (ja) 2005-05-19 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なビアリール
PT1928886E (pt) * 2005-09-09 2011-07-14 Glaxosmithkline Llc Derivados de piridina e sua utilização para o tratamento de distúrbios psicóticos
US7855218B2 (en) 2005-10-10 2010-12-21 Convergence Pharmaceuticals Limited Compounds
TW200728258A (en) * 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026826A1 (en) * 2002-09-20 2004-04-01 F. Hoffmann-La Roche Ag 4-pyrrolidino-phenyl-benzyl ether derivatives
WO2004094395A2 (en) * 2003-04-18 2004-11-04 Merck & Co., Inc. Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
WO2005000309A2 (en) * 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
EP1524265A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors

Also Published As

Publication number Publication date
JP2009511519A (ja) 2009-03-19
EP1934177A1 (en) 2008-06-25
ES2387405T3 (es) 2012-09-21
CA2625642A1 (en) 2007-04-19
JP5139305B2 (ja) 2013-02-06
PE20070592A1 (es) 2007-06-23
KR101282464B1 (ko) 2013-07-04
PL1934177T3 (pl) 2013-03-29
AU2006301470B2 (en) 2012-06-14
NZ567051A (en) 2011-03-31
MA29817B1 (fr) 2008-09-01
TW200730494A (en) 2007-08-16
AU2006301470A1 (en) 2007-04-19
AR056575A1 (es) 2007-10-10
CR9898A (es) 2008-07-29
US8153681B2 (en) 2012-04-10
BRPI0616944B1 (pt) 2020-04-14
BRPI0616944A2 (pt) 2011-07-05
EA200801054A1 (ru) 2008-08-29
US7655693B2 (en) 2010-02-02
US20080280969A1 (en) 2008-11-13
IL192627A0 (en) 2011-08-01
ATE556049T1 (de) 2012-05-15
BRPI0616944B8 (pt) 2021-05-25
WO2007042239A1 (en) 2007-04-19
EP1934177B1 (en) 2012-05-02
US20100105754A1 (en) 2010-04-29
CA2625642C (en) 2013-12-24
NO20082145L (no) 2008-05-07
KR20080059296A (ko) 2008-06-26
EP1934177B8 (en) 2012-09-05

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): MD