EA015263B1 - Производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов - Google Patents
Производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов Download PDFInfo
- Publication number
- EA015263B1 EA015263B1 EA200702468A EA200702468A EA015263B1 EA 015263 B1 EA015263 B1 EA 015263B1 EA 200702468 A EA200702468 A EA 200702468A EA 200702468 A EA200702468 A EA 200702468A EA 015263 B1 EA015263 B1 EA 015263B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- oxadiazol
- piperidin
- methanone
- fluorophenyl
- difluorophenyl
- Prior art date
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Classifications
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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| PCT/IB2006/001674 WO2006123249A2 (en) | 2005-05-18 | 2006-05-17 | Novel oxadiazole derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
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| WO2006123255A2 (en) * | 2005-05-18 | 2006-11-23 | Addex Pharma Sa | Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
| TW200911255A (en) | 2007-06-07 | 2009-03-16 | Astrazeneca Ab | Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841 |
| TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途 |
| US20100144756A1 (en) | 2007-07-13 | 2010-06-10 | Bolea Christelle | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
| WO2009099177A1 (ja) * | 2008-02-06 | 2009-08-13 | Taisho Pharmaceutical Co., Ltd. | アミノイミダゾール誘導体 |
| SA109300358B1 (ar) | 2008-06-06 | 2012-11-03 | استرازينيكا ايه بي | مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| WO2010098866A1 (en) | 2009-02-27 | 2010-09-02 | Supergen, Inc. | Cyclopentathiophene/cyclohexathiophene dna methyltransferase inhibitors |
| WO2010124055A1 (en) * | 2009-04-23 | 2010-10-28 | Merck Sharp & Dohme Corp. | 2-alkyl piperidine mglur5 receptor modulators |
| CA2784830C (en) | 2009-12-18 | 2018-03-27 | Sunovion Pharmaceuticals Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| CN102762572A (zh) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物 |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
| ES2610362T3 (es) | 2011-01-25 | 2017-04-27 | Viviabiotech, S.L. | Derivados de 1,2,4-oxadiazol como fármacos moduladores del receptor para el péptido glp-1 |
| DK2855453T3 (en) | 2012-06-04 | 2017-02-06 | Actelion Pharmaceuticals Ltd | Benzimidazol-proline derivatives |
| BR112015007516A2 (pt) | 2012-10-10 | 2017-07-04 | Actelion Pharmaceuticals Ltd | antagonistas do receptor de orexina que são derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)- pirrolidin-1-il]-metanona |
| CN105051040A (zh) | 2013-03-12 | 2015-11-11 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物 |
| SI3077391T1 (sl) | 2013-12-04 | 2018-11-30 | Idorsia Pharmaceuticals Ltd | Uporaba benzimidazol-prolinskih derivatov |
| EP3275440B1 (en) * | 2015-03-25 | 2022-05-04 | National Center for Geriatrics and Gerontology | Novel oxadiazole derivative and pharmaceutical containing same |
| US12590083B2 (en) | 2019-01-25 | 2026-03-31 | University Of Virginia Patent Foundation | Inhibitors of spinster homolog 2 (SPNS2) for use in therapy |
| WO2022056042A1 (en) * | 2020-09-09 | 2022-03-17 | University Of Virginia Patent Foundation | Inhibitors of spinster homolog 2 (spns2) for use in therapy |
| IL291418B2 (en) | 2022-03-16 | 2024-05-01 | Anima Biotech Inc | Substances that function as modulators of cMYC-mRNA translation and their uses for cancer treatment |
| CN117756793A (zh) * | 2022-12-16 | 2024-03-26 | 四川大学 | 1,2,4-杂二唑衍生物及其用途 |
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| WO1998017652A1 (de) * | 1996-10-18 | 1998-04-30 | Boehringer Ingelheim Pharma Kg | Oxadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
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- 2006-05-17 EA EA200702468A patent/EA015263B1/ru not_active IP Right Cessation
- 2006-05-17 EP EP06779742A patent/EP1896463A2/en not_active Withdrawn
- 2006-05-17 UA UAA200714073A patent/UA92496C2/ru unknown
- 2006-05-17 AU AU2006248649A patent/AU2006248649B2/en not_active Ceased
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- 2006-05-17 US US11/920,489 patent/US20090197897A1/en not_active Abandoned
- 2006-05-17 WO PCT/IB2006/001674 patent/WO2006123249A2/en not_active Ceased
- 2006-05-17 CN CN2006800251728A patent/CN101218232B/zh not_active Expired - Fee Related
- 2006-05-17 JP JP2008511819A patent/JP2008540634A/ja active Pending
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2007
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- 2007-11-28 ZA ZA200710277A patent/ZA200710277B/xx unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| EA200702468A1 (ru) | 2008-06-30 |
| ZA200710277B (en) | 2009-03-25 |
| KR20080031676A (ko) | 2008-04-10 |
| IL187190A0 (en) | 2008-02-09 |
| EP1896463A2 (en) | 2008-03-12 |
| NZ564253A (en) | 2011-04-29 |
| CN101218232B (zh) | 2012-06-27 |
| MX2007014405A (es) | 2008-04-21 |
| AU2006248649B2 (en) | 2012-04-26 |
| UA92496C2 (ru) | 2010-11-10 |
| US20090197897A1 (en) | 2009-08-06 |
| BRPI0610681A2 (pt) | 2010-07-20 |
| WO2006123249A3 (en) | 2007-02-08 |
| CA2608012A1 (en) | 2006-11-23 |
| CN101218232A (zh) | 2008-07-09 |
| GB0510142D0 (en) | 2005-06-22 |
| AU2006248649A1 (en) | 2006-11-23 |
| JP2008540634A (ja) | 2008-11-20 |
| WO2006123249A2 (en) | 2006-11-23 |
| NO20076479L (no) | 2008-01-29 |
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