EA200702468A1 - Новые производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов - Google Patents

Новые производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов

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Publication number
EA200702468A1
EA200702468A1 EA200702468A EA200702468A EA200702468A1 EA 200702468 A1 EA200702468 A1 EA 200702468A1 EA 200702468 A EA200702468 A EA 200702468A EA 200702468 A EA200702468 A EA 200702468A EA 200702468 A1 EA200702468 A1 EA 200702468A1
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new
application
metabotropic glutamate
positive allosteric
glutamate receptors
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EA200702468A
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English (en)
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EA015263B1 (ru
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Пиерджилиано Бугада
Стефания Гаглиарди
Эммануэль Ле Поул
Винсент Матель
Джиованни Паломби
Джен-Филиппе Рошер
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Аддекс Фарма Са
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Publication of EA200702468A1 publication Critical patent/EA200702468A1/ru
Publication of EA015263B1 publication Critical patent/EA015263B1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P25/36—Opioid-abuse
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Настоящее изобретение относится к новым соединениям, которые представляют собой производные оксадиазола формулы (I) в которой значения В, Р, Q, W, Rи Rопределены в описании. Соединения согласно настоящему изобретению пригодны для предотвращения или лечения расстройств центральной или периферической нервной системы, а также других расстройств, регулируемых рецепторами mGluR5.
EA200702468A 2005-05-18 2006-05-17 Производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов EA015263B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0510142.3A GB0510142D0 (en) 2005-05-18 2005-05-18 Novel compounds A1
PCT/IB2006/001674 WO2006123249A2 (en) 2005-05-18 2006-05-17 Novel oxadiazole derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors

Publications (2)

Publication Number Publication Date
EA200702468A1 true EA200702468A1 (ru) 2008-06-30
EA015263B1 EA015263B1 (ru) 2011-06-30

Family

ID=34708380

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702468A EA015263B1 (ru) 2005-05-18 2006-05-17 Производные оксадиазола и их применение в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов

Country Status (17)

Country Link
US (1) US20090197897A1 (ru)
EP (1) EP1896463A2 (ru)
JP (1) JP2008540634A (ru)
KR (1) KR20080031676A (ru)
CN (1) CN101218232B (ru)
AU (1) AU2006248649B2 (ru)
BR (1) BRPI0610681A2 (ru)
CA (1) CA2608012A1 (ru)
EA (1) EA015263B1 (ru)
GB (1) GB0510142D0 (ru)
IL (1) IL187190A0 (ru)
MX (1) MX2007014405A (ru)
NO (1) NO20076479L (ru)
NZ (1) NZ564253A (ru)
UA (1) UA92496C2 (ru)
WO (1) WO2006123249A2 (ru)
ZA (1) ZA200710277B (ru)

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NZ564254A (en) * 2005-05-18 2011-04-29 Addex Pharma Sa Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
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Publication number Publication date
GB0510142D0 (en) 2005-06-22
CA2608012A1 (en) 2006-11-23
AU2006248649B2 (en) 2012-04-26
WO2006123249A3 (en) 2007-02-08
NZ564253A (en) 2011-04-29
KR20080031676A (ko) 2008-04-10
US20090197897A1 (en) 2009-08-06
MX2007014405A (es) 2008-04-21
ZA200710277B (en) 2009-03-25
EA015263B1 (ru) 2011-06-30
NO20076479L (no) 2008-01-29
CN101218232B (zh) 2012-06-27
UA92496C2 (ru) 2010-11-10
BRPI0610681A2 (pt) 2010-07-20
JP2008540634A (ja) 2008-11-20
EP1896463A2 (en) 2008-03-12
AU2006248649A1 (en) 2006-11-23
CN101218232A (zh) 2008-07-09
WO2006123249A2 (en) 2006-11-23
IL187190A0 (en) 2008-02-09

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