EA014695B1 - Модулятор рецепторов глюкокортикостероидов и его применение - Google Patents
Модулятор рецепторов глюкокортикостероидов и его применение Download PDFInfo
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- EA014695B1 EA014695B1 EA200970127A EA200970127A EA014695B1 EA 014695 B1 EA014695 B1 EA 014695B1 EA 200970127 A EA200970127 A EA 200970127A EA 200970127 A EA200970127 A EA 200970127A EA 014695 B1 EA014695 B1 EA 014695B1
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Classifications
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Immunology (AREA)
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- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83116606P | 2006-07-14 | 2006-07-14 | |
| PCT/US2007/073345 WO2008008882A2 (en) | 2006-07-14 | 2007-07-12 | Glucocorticoid receptor modulator and methods of use |
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| Publication Number | Publication Date |
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| EA200970127A1 EA200970127A1 (ru) | 2009-04-28 |
| EA014695B1 true EA014695B1 (ru) | 2010-12-30 |
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| EP (1) | EP2043646B1 (enExample) |
| JP (1) | JP5189091B2 (enExample) |
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| CN (1) | CN101489556A (enExample) |
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| ES (1) | ES2384057T3 (enExample) |
| MX (1) | MX2009000583A (enExample) |
| TW (1) | TW200902537A (enExample) |
| WO (1) | WO2008008882A2 (enExample) |
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| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| ES2370148T3 (es) | 2008-01-11 | 2011-12-13 | Eli Lilly & Company | (e)-n-{3-[fluoro-11h-10-oxa-1-aza-dibenzo-[a,d]-ciclohepten-5-iliden)-propil]-fenil}-metilsulfonamida como modulador del receptor de glucocorticoides para el tratamiento de artritis reumatoide. |
| UY31831A (es) | 2008-05-20 | 2010-01-05 | Astrazeneca Ab | Derivados de indazoles sustituidos con fenilo o piridinilo |
| JPWO2010001990A1 (ja) | 2008-07-03 | 2011-12-22 | 協和発酵キリン株式会社 | 四環系化合物 |
| WO2011081173A1 (ja) * | 2009-12-29 | 2011-07-07 | 協和発酵キリン株式会社 | 四環系化合物 |
| CN102746219A (zh) * | 2012-07-02 | 2012-10-24 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-羧基-3-溴吡啶盐酸盐的合成方法 |
| US10981918B2 (en) | 2018-07-20 | 2021-04-20 | Grünenthal GmbH | Further substituted triazolo quinoxaline derivatives |
Citations (2)
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| WO2004043965A1 (en) * | 2002-11-13 | 2004-05-27 | Millennium Pharmaceuticals, Inc. | Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease |
| WO2004052847A2 (en) * | 2002-06-26 | 2004-06-24 | Eli Lilly And Company | Tricyclic steroid hormone nuclear receptor modulators |
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| DE3730258A1 (de) | 1986-09-10 | 1988-04-07 | Canon Kk | Elektrophotographisches lichtempfindliches aufzeichnungsmaterial, 5h-dibenzo(a,d)cycloheptanylidenderivat, 5h-dibenzo(a,d)cycloheptenylidenderivat und verfahren zu ihrer herstellung |
| JPH01161245A (ja) | 1987-12-18 | 1989-06-23 | Canon Inc | 電子写真感光体 |
| US4999363A (en) | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
| US5093210A (en) | 1989-06-30 | 1992-03-03 | Ricoh Company, Ltd. | Electroluminescent device |
| US5378701A (en) | 1991-12-27 | 1995-01-03 | Kyowa Hakko Kogyo | Tricyclic compounds |
| CO4980885A1 (es) | 1997-12-29 | 2000-11-27 | Ortho Mcneil Pharm Inc | Compuestos de trifenilpropanamida utiles en el tratamiento de inflamaciones y metodos para preparar dicho compuesto |
| US7056911B1 (en) | 1999-01-26 | 2006-06-06 | Dana-Farber Cancer Institute | Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof |
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- 2007-07-12 MX MX2009000583A patent/MX2009000583A/es active IP Right Grant
- 2007-07-12 BR BRPI0714811-9A2A patent/BRPI0714811A2/pt not_active IP Right Cessation
- 2007-07-12 KR KR1020097000674A patent/KR20090020694A/ko not_active Ceased
- 2007-07-12 US US12/305,295 patent/US8101760B2/en not_active Expired - Fee Related
- 2007-07-12 WO PCT/US2007/073345 patent/WO2008008882A2/en not_active Ceased
- 2007-07-12 CN CNA2007800258079A patent/CN101489556A/zh active Pending
- 2007-07-12 EA EA200970127A patent/EA014695B1/ru not_active IP Right Cessation
- 2007-07-12 ES ES07799520T patent/ES2384057T3/es active Active
- 2007-07-12 CA CA002655202A patent/CA2655202A1/en not_active Abandoned
- 2007-07-12 JP JP2009519689A patent/JP5189091B2/ja not_active Expired - Fee Related
- 2007-12-04 TW TW096146160A patent/TW200902537A/zh unknown
- 2007-12-05 CL CL200703501A patent/CL2007003501A1/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004052847A2 (en) * | 2002-06-26 | 2004-06-24 | Eli Lilly And Company | Tricyclic steroid hormone nuclear receptor modulators |
| WO2004043965A1 (en) * | 2002-11-13 | 2004-05-27 | Millennium Pharmaceuticals, Inc. | Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2384057T3 (es) | 2012-06-28 |
| BRPI0714811A2 (pt) | 2014-02-18 |
| EA200970127A1 (ru) | 2009-04-28 |
| CL2007003501A1 (es) | 2008-07-04 |
| EP2043646A2 (en) | 2009-04-08 |
| WO2008008882A2 (en) | 2008-01-17 |
| JP5189091B2 (ja) | 2013-04-24 |
| AU2007272504B2 (en) | 2012-06-28 |
| CN101489556A (zh) | 2009-07-22 |
| TW200902537A (en) | 2009-01-16 |
| US8101760B2 (en) | 2012-01-24 |
| JP2009543804A (ja) | 2009-12-10 |
| EP2043646B1 (en) | 2012-05-16 |
| MX2009000583A (es) | 2009-01-27 |
| KR20090020694A (ko) | 2009-02-26 |
| US20100069425A1 (en) | 2010-03-18 |
| WO2008008882A3 (en) | 2008-05-02 |
| CA2655202A1 (en) | 2008-01-17 |
| AU2007272504A1 (en) | 2008-01-17 |
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