EA009198B1 - ПРОИЗВОДНЫЕ ЗАМЕЩЕННОГО 8-ПЕРФТОРАЛКИЛ-6,7,8,9-ТЕТРАГИДРОПИРИМИДО[1,2-a]ПИРИМИДИН-4-ОНА - Google Patents
ПРОИЗВОДНЫЕ ЗАМЕЩЕННОГО 8-ПЕРФТОРАЛКИЛ-6,7,8,9-ТЕТРАГИДРОПИРИМИДО[1,2-a]ПИРИМИДИН-4-ОНА Download PDFInfo
- Publication number
- EA009198B1 EA009198B1 EA200501311A EA200501311A EA009198B1 EA 009198 B1 EA009198 B1 EA 009198B1 EA 200501311 A EA200501311 A EA 200501311A EA 200501311 A EA200501311 A EA 200501311A EA 009198 B1 EA009198 B1 EA 009198B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- trifluoromethyl
- tetrahydro
- pyrimidin
- pyrimido
- Prior art date
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290728A EP1460076A1 (en) | 2003-03-21 | 2003-03-21 | Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives |
| PCT/EP2004/004013 WO2004083210A1 (en) | 2003-03-21 | 2004-03-19 | SUBSTITUTED 8-PERFLUOROALKYL-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200501311A1 EA200501311A1 (ru) | 2006-04-28 |
| EA009198B1 true EA009198B1 (ru) | 2007-12-28 |
Family
ID=32799141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200501311A EA009198B1 (ru) | 2003-03-21 | 2004-03-19 | ПРОИЗВОДНЫЕ ЗАМЕЩЕННОГО 8-ПЕРФТОРАЛКИЛ-6,7,8,9-ТЕТРАГИДРОПИРИМИДО[1,2-a]ПИРИМИДИН-4-ОНА |
Country Status (25)
| Country | Link |
|---|---|
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| EP (2) | EP1460076A1 (enExample) |
| JP (1) | JP4572194B2 (enExample) |
| KR (1) | KR101070075B1 (enExample) |
| CN (1) | CN100368412C (enExample) |
| AR (1) | AR053082A1 (enExample) |
| AT (1) | ATE433977T1 (enExample) |
| AU (1) | AU2004222105B2 (enExample) |
| BR (1) | BRPI0408605A (enExample) |
| CA (1) | CA2517774C (enExample) |
| CY (1) | CY1109345T1 (enExample) |
| DE (1) | DE602004021572D1 (enExample) |
| DK (1) | DK1608653T3 (enExample) |
| EA (1) | EA009198B1 (enExample) |
| ES (1) | ES2328812T3 (enExample) |
| IL (1) | IL170634A (enExample) |
| MX (1) | MXPA05010112A (enExample) |
| NO (1) | NO20054331L (enExample) |
| NZ (1) | NZ542224A (enExample) |
| PL (1) | PL1608653T3 (enExample) |
| PT (1) | PT1608653E (enExample) |
| SI (1) | SI1608653T1 (enExample) |
| TW (1) | TWI322809B (enExample) |
| WO (1) | WO2004083210A1 (enExample) |
| ZA (1) | ZA200507192B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1460076A1 (en) * | 2003-03-21 | 2004-09-22 | Sanofi-Synthelabo | Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives |
| US8771552B2 (en) * | 2005-06-23 | 2014-07-08 | Sumitomo Electric Industries, Ltd. | Group III nitride crystal substrate, epilayer-containing group III nitride crystal substrate, semiconductor device and method of manufacturing the same |
| JP4277826B2 (ja) | 2005-06-23 | 2009-06-10 | 住友電気工業株式会社 | 窒化物結晶、窒化物結晶基板、エピ層付窒化物結晶基板、ならびに半導体デバイスおよびその製造方法 |
| US9708735B2 (en) | 2005-06-23 | 2017-07-18 | Sumitomo Electric Industries, Ltd. | Group III nitride crystal substrate, epilayer-containing group III nitride crystal substrate, semiconductor device and method of manufacturing the same |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| EP1790649A1 (en) * | 2005-11-21 | 2007-05-30 | Sanofi-Aventis | Substituted bicyclic pyrimidone derivatives |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| CA2651813A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP1939187A1 (en) * | 2006-12-20 | 2008-07-02 | Sanofi-Aventis | Substituted heteroaryl pyridopyrimidone derivatives |
| EP2138492A1 (en) | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted pyrimidin-4-one derivatives |
| EP2138485A1 (en) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Substituted N-Oxide pyrazine derivatives |
| EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
| EP2138493A1 (en) | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted pyrimidone derivatives |
| EP2138488A1 (en) | 2008-06-26 | 2009-12-30 | sanofi-aventis | 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases |
| EP2138495A1 (en) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives |
| EP2138498A1 (en) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Substituted tricyclic derivatives against neurodegenerative diseases |
| SI2448940T1 (sl) | 2009-07-02 | 2014-10-30 | Sanofi | Derivati 6,7,8,9-tetrahidro-pirimido(1,2-a)pirimidin-4-ona, njihova priprava in njihova farmacevtska uporaba |
| WO2012085244A1 (fr) | 2010-12-23 | 2012-06-28 | Sanofi | Derives de pyrimidinone, leur preparation et leur utilisation pharmaceutique |
| FR2992314B1 (fr) | 2012-06-22 | 2015-10-16 | Sanofi Sa | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique |
| FR2992316A1 (fr) | 2012-06-22 | 2013-12-27 | Sanofi Sa | Derives de pyrimidinones, leur preparation et leur application en therapeutique |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1184383A1 (en) * | 2000-09-01 | 2002-03-06 | Sanofi-Synthelabo | 9-[Alkyl], 9-[(heteroaryl)alkyl] and 9-[(aryl)alkyl]-2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one derivatives |
| WO2002018386A1 (en) * | 2000-09-01 | 2002-03-07 | Sanofi-Synthelabo | 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a]PYRIMIDIN-4-ONE AND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO[1,2-a]PYRIMIDIN-5(1H)ONE DERIVATI VES |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001270884A (ja) * | 2000-03-23 | 2001-10-02 | Mitsubishi-Tokyo Pharmaceuticals Inc | ピリミドン誘導体 |
| EP1136482A1 (en) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-Amino-3-(alkyl)-pyrimidone derivatives as GSK3beta inhibitors |
| EP1460076A1 (en) * | 2003-03-21 | 2004-09-22 | Sanofi-Synthelabo | Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives |
-
2003
- 2003-03-21 EP EP03290728A patent/EP1460076A1/en not_active Withdrawn
-
2004
- 2004-03-17 TW TW093107078A patent/TWI322809B/zh not_active IP Right Cessation
- 2004-03-19 BR BRPI0408605-8A patent/BRPI0408605A/pt not_active IP Right Cessation
- 2004-03-19 DE DE602004021572T patent/DE602004021572D1/de not_active Expired - Lifetime
- 2004-03-19 AU AU2004222105A patent/AU2004222105B2/en not_active Ceased
- 2004-03-19 CA CA2517774A patent/CA2517774C/en not_active Expired - Fee Related
- 2004-03-19 WO PCT/EP2004/004013 patent/WO2004083210A1/en not_active Ceased
- 2004-03-19 SI SI200431223T patent/SI1608653T1/sl unknown
- 2004-03-19 PT PT04721905T patent/PT1608653E/pt unknown
- 2004-03-19 DK DK04721905T patent/DK1608653T3/da active
- 2004-03-19 NZ NZ542224A patent/NZ542224A/en not_active IP Right Cessation
- 2004-03-19 CN CNB2004800120101A patent/CN100368412C/zh not_active Expired - Fee Related
- 2004-03-19 EP EP04721905A patent/EP1608653B1/en not_active Expired - Lifetime
- 2004-03-19 JP JP2006505151A patent/JP4572194B2/ja not_active Expired - Fee Related
- 2004-03-19 AR ARP040100918A patent/AR053082A1/es unknown
- 2004-03-19 EA EA200501311A patent/EA009198B1/ru not_active IP Right Cessation
- 2004-03-19 MX MXPA05010112A patent/MXPA05010112A/es active IP Right Grant
- 2004-03-19 ZA ZA200507192A patent/ZA200507192B/xx unknown
- 2004-03-19 KR KR1020057017571A patent/KR101070075B1/ko not_active Expired - Fee Related
- 2004-03-19 AT AT04721905T patent/ATE433977T1/de active
- 2004-03-19 ES ES04721905T patent/ES2328812T3/es not_active Expired - Lifetime
- 2004-03-19 PL PL04721905T patent/PL1608653T3/pl unknown
-
2005
- 2005-09-01 IL IL170634A patent/IL170634A/en not_active IP Right Cessation
- 2005-09-13 US US11/224,873 patent/US7217715B2/en not_active Expired - Fee Related
- 2005-09-20 NO NO20054331A patent/NO20054331L/no not_active Application Discontinuation
-
2007
- 2007-04-04 US US11/696,256 patent/US7393853B2/en not_active Expired - Fee Related
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- 2009-09-02 CY CY20091100926T patent/CY1109345T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1184383A1 (en) * | 2000-09-01 | 2002-03-06 | Sanofi-Synthelabo | 9-[Alkyl], 9-[(heteroaryl)alkyl] and 9-[(aryl)alkyl]-2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one derivatives |
| WO2002018386A1 (en) * | 2000-09-01 | 2002-03-07 | Sanofi-Synthelabo | 2-PYRIDINYL-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a]PYRIMIDIN-4-ONE AND 7-PYRIDINYL-2,3-DIHYDROIMIDAZO[1,2-a]PYRIMIDIN-5(1H)ONE DERIVATI VES |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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