EA005426B1 - Векторы для определения чувствительности вируса к противовирусному лекарственному соединению и способы их применения - Google Patents
Векторы для определения чувствительности вируса к противовирусному лекарственному соединению и способы их применения Download PDFInfo
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- EA005426B1 EA005426B1 EA199800669A EA199800669A EA005426B1 EA 005426 B1 EA005426 B1 EA 005426B1 EA 199800669 A EA199800669 A EA 199800669A EA 199800669 A EA199800669 A EA 199800669A EA 005426 B1 EA005426 B1 EA 005426B1
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2646472C1 (ru) * | 2016-10-07 | 2018-03-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации | Способ оценки эффективности терапии инфекции вызванной вирусом герпеса человека 6 типа у детей |
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| EP0656887B1 (en) | 1992-08-25 | 1998-10-28 | G.D. Searle & Co. | Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| KR100495690B1 (ko) | 1996-01-26 | 2005-11-08 | 비르코 비브이비에이 | 인체 hiv 계통의 표현형적 약제 감수성에 기초한 하나 이상의 최적한 hiv 저해제를 선발하는 방법 |
| US6242187B1 (en) | 1996-01-29 | 2001-06-05 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| JP2001512036A (ja) * | 1997-07-30 | 2001-08-21 | バイアラジック・インコーポレーテッド | 抗ウイルス薬剤感受性および耐性を測定するための組成物および方法、並びに抗ウイルス薬剤をスクリーニングするための組成物および方法 |
| WO1999051776A1 (en) * | 1998-04-07 | 1999-10-14 | Southern Research Institute | High-throughput method for screening for antiviral activity |
| AU772511B2 (en) * | 1998-05-26 | 2004-04-29 | Virologic, Inc. | Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy |
| US7037644B1 (en) | 1998-05-26 | 2006-05-02 | Virologic, Inc. | Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
| DE69924118T2 (de) * | 1998-06-19 | 2005-12-22 | The Government of the United States of America, as represented by the Secretary Centers for Disease and Prevention, Office of Technology | Verfahren und reagentiensatz zur erkennung von antiviralen wirkstoff resistenzen |
| US6787126B1 (en) | 1998-06-19 | 2004-09-07 | The United States Of America As Represented By The Department Of Health And Human Services | Method and kit for detecting resistance to antiviral drugs |
| US20030148307A1 (en) | 1998-06-19 | 2003-08-07 | Department Of Health & Human Services, C/O Centers Of Disease Control And Prevention | Method and kit for detecting resistance to antiviral drugs |
| EP1015642A4 (en) * | 1998-06-24 | 2005-03-23 | Virologic Inc | Means and methods for monitoring nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of hiv/aids |
| DE60022036T2 (de) | 1999-05-28 | 2006-06-08 | Virco N.V. | Neue mutationsprofile der hiv-1 reverse transcriptase in verbindung mit phänotypischem medikamentresistenz |
| CA2422489A1 (en) * | 2000-09-15 | 2002-03-21 | Virologic, Inc. | Non-nucleoside reverse transcriptase inhibitor as antiretroviral therapy |
| DE60137580D1 (de) | 2000-10-20 | 2009-03-19 | Virco Bvba | Festlegen von kritischen biologischen werten zur voraussage einer therapieresistenz |
| AU2002226316B2 (en) | 2000-10-20 | 2008-06-26 | Virco Bvba | Mutational profiles in HIV-1 reverse transcriptase correlated with phenotypic drug resistance |
| US7247439B1 (en) | 2001-06-04 | 2007-07-24 | Monogram Biosciences, Inc. | Method of evaluating a patient antibody response to envelope proteins of a virus |
| US7097970B2 (en) | 2001-06-04 | 2006-08-29 | Monogram Biosciences, Inc. | Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs |
| CA2466497A1 (en) | 2001-11-08 | 2003-05-15 | Tibotec Pharmaceuticals Ltd. | Protease assay for therapeutic drug monitoring |
| WO2004003223A2 (en) | 2002-07-01 | 2004-01-08 | Tibotec Pharmaceuticals Ltd. | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
| EP1520247B1 (en) | 2002-07-01 | 2009-05-27 | Tibotec Pharmaceuticals Ltd. | Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance |
| DE20218008U1 (de) | 2002-11-21 | 2003-03-06 | FESTO AG & Co., 73734 Esslingen | Anordnung von mehreren Handhabungsvorrichtungen |
| US8603736B2 (en) | 2004-06-07 | 2013-12-10 | Monogram Biosciences, Inc. | Compositions and methods for determining resistance to inhibitors of virus entry using recombinant virus assays |
| WO2006089046A2 (en) | 2005-02-18 | 2006-08-24 | Monogram Biosciences, Inc. | Methods and compositions for determining anti-hiv drug susceptibility and replication capacity of hiv |
| US8178291B2 (en) | 2005-02-18 | 2012-05-15 | Monogram Biosciences, Inc. | Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors |
| EP2458019A3 (en) | 2005-05-27 | 2012-07-25 | Monogram BioSciences, Inc. | Methods and compositions for determining resistance of HIV-1 to protease inhibitors |
| WO2006133266A2 (en) | 2005-06-06 | 2006-12-14 | Monogram Biosciences, Inc. | Methods for determining resistance or susceptibility to hiv entry inhibitors |
| US8071284B2 (en) | 2005-06-06 | 2011-12-06 | Monogram Biosciences, Inc. | Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs |
| WO2007146336A2 (en) | 2006-06-13 | 2007-12-21 | Monogram Biosciences, Inc. | Molecular determinants associated with enhanced ability to enter cells expressing cxcr4 |
| US8338101B2 (en) * | 2007-01-23 | 2012-12-25 | Virco Bvba | Method for designing a drug regime for HIV-infected patients |
| US9581595B2 (en) | 2007-02-26 | 2017-02-28 | Laboratory Corporation Of America Holdings | Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy |
| JPWO2018030534A1 (ja) * | 2016-08-10 | 2019-06-13 | 国立研究開発法人理化学研究所 | Ｂ型肝炎治療用組成物、及びｂ型肝炎ウイルスの複製活性の評価方法 |
| CN110382009A (zh) * | 2016-12-29 | 2019-10-25 | 富荣吉有限责任公司 | Retro-HBV和Lenti-HBV的混合载体及构建体 |
| CN109722465B (zh) * | 2019-01-07 | 2022-02-01 | 福建省疾病预防控制中心(福建省健康教育促进中心、福建省卫生检验检测中心) | 一种hiv耐药检测载体和构建方法 |
| WO2021259345A1 (zh) * | 2020-06-24 | 2021-12-30 | 厦门大学 | 靶向HBV cccDNA的药物筛选模型及方法 |
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| EP0291893A1 (en) * | 1987-05-19 | 1988-11-23 | The Du Pont Merck Pharmaceutical Company | Stable human cell lines expressing an indicator gene product under virus-specific genetic controls |
| EP0361749B1 (en) * | 1988-09-27 | 1995-02-08 | Dana Farber Cancer Institute | A vector comprising a replication competent HIV-I provirus and a heterologous gene |
| HU209835B (en) * | 1988-12-07 | 1994-11-28 | Univ Osaka Res Found | Method for producing of retrovirus protease, reverse transcriptase and integrase |
| EP0414475B1 (en) * | 1989-08-25 | 1997-12-10 | Chiron Corporation | Methods for culturing HCV in B- or T-lymphocyte cell lines |
| GB8923123D0 (en) * | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| FR2700169B1 (fr) * | 1993-01-04 | 1995-03-24 | Transgene Sa | Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine. |
| US5645982A (en) * | 1993-08-19 | 1997-07-08 | Systemix, Inc. | Method for screening potential therapeutically effective antiviral agents |
| WO1995022622A1 (en) * | 1994-02-18 | 1995-08-24 | University Of Washington | Methods and compositions for screening for anti-aids drugs |
| US5733543A (en) * | 1994-04-29 | 1998-03-31 | Nabel; Gary J. | Introduction of HIV-protective genes into cells by particle-mediated gene transfer |
| AU2585395A (en) * | 1994-05-09 | 1995-11-29 | Chiron Corporation | Retroviral vectors having a reduced recombination rate |
| US5837464A (en) * | 1996-01-29 | 1998-11-17 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| JP2001512036A (ja) * | 1997-07-30 | 2001-08-21 | バイアラジック・インコーポレーテッド | 抗ウイルス薬剤感受性および耐性を測定するための組成物および方法、並びに抗ウイルス薬剤をスクリーニングするための組成物および方法 |
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1998
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| KELLAM P. et al. Recombinant Virus Assay: a Rapid, Phenotypic Assay for Assessment of Drug Susceptibility of Human Immunodeficiency Virus Type 1 Isolates. Antimicrobial Agents and Chemotherapy. January 1994, Vol. 38, pages 23-30 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2646472C1 (ru) * | 2016-10-07 | 2018-03-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации | Способ оценки эффективности терапии инфекции вызванной вирусом герпеса человека 6 типа у детей |
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| Publication number | Publication date |
|---|---|
| EA199800669A1 (ru) | 1999-02-25 |
| HUP9900388A3 (en) | 2005-03-29 |
| NO983421D0 (no) | 1998-07-24 |
| RO118887B1 (ro) | 2003-12-30 |
| ATE447621T1 (de) | 2009-11-15 |
| IL125464A0 (en) | 1999-03-12 |
| AP9801360A0 (en) | 1998-12-31 |
| HUP9900388A2 (hu) | 1999-05-28 |
| DE69739645D1 (de) | 2009-12-17 |
| JP2000503849A (ja) | 2000-04-04 |
| ES2175355T3 (es) | 2002-11-16 |
| CA2216126C (en) | 2009-03-31 |
| EP1170380A3 (en) | 2003-05-02 |
| PL328068A1 (en) | 1999-01-04 |
| AU732255B2 (en) | 2001-04-12 |
| NO983421L (no) | 1998-09-25 |
| CN1213407A (zh) | 1999-04-07 |
| KR100537153B1 (ko) | 2006-12-15 |
| AU1952897A (en) | 1997-08-20 |
| EP0852626A1 (en) | 1998-07-15 |
| EP1170380A2 (en) | 2002-01-09 |
| EP0852626A4 (en) | 1999-08-25 |
| EP1170380B1 (en) | 2009-11-04 |
| JP4183749B2 (ja) | 2008-11-19 |
| CA2216126A1 (en) | 1997-07-31 |
| NZ331376A (en) | 2000-03-27 |
| DE69711584T2 (de) | 2002-11-07 |
| CN1263867C (zh) | 2006-07-12 |
| DE69711584D1 (de) | 2002-05-08 |
| IL125464A (en) | 2007-12-03 |
| KR19990082129A (ko) | 1999-11-15 |
| WO1997027319A1 (en) | 1997-07-31 |
| EP0852626B1 (en) | 2002-04-03 |
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