EA005426B1 - Векторы для определения чувствительности вируса к противовирусному лекарственному соединению и способы их применения - Google Patents
Векторы для определения чувствительности вируса к противовирусному лекарственному соединению и способы их применения Download PDFInfo
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- EA005426B1 EA005426B1 EA199800669A EA199800669A EA005426B1 EA 005426 B1 EA005426 B1 EA 005426B1 EA 199800669 A EA199800669 A EA 199800669A EA 199800669 A EA199800669 A EA 199800669A EA 005426 B1 EA005426 B1 EA 005426B1
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PL (1) | PL328068A1 (enExample) |
| RO (1) | RO118887B1 (enExample) |
| WO (1) | WO1997027319A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2646472C1 (ru) * | 2016-10-07 | 2018-03-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации | Способ оценки эффективности терапии инфекции вызванной вирусом герпеса человека 6 типа у детей |
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| DE122007000045I2 (de) | 1992-08-25 | 2011-07-21 | Gd Searle Llc Gd Searle Llc | Darunavir oder pharmazeutisch vertragliche Salze, Hydroxyethylaminosulfonamide verwendbar als InhibiEster oder Prodrugs davon. toren retroviraler Proteasen. |
| HU226203B1 (en) | 1996-01-26 | 2008-06-30 | Virco B V B A | Method for determining of the chemotherapy of patients who are hiv positive based on the phenotypic drug sensitivity of human hiv strains |
| US6242187B1 (en) | 1996-01-29 | 2001-06-05 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| CA2298102A1 (en) * | 1997-07-30 | 1999-02-11 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| WO1999051776A1 (en) * | 1998-04-07 | 1999-10-14 | Southern Research Institute | High-throughput method for screening for antiviral activity |
| BR9911600A (pt) * | 1998-05-26 | 2001-02-13 | Virologic Inc | Recursos e métodos para monitoração de terapia antiretroviral inibidora de transcriptase reversa de não nucleosìdeo |
| US7037644B1 (en) | 1998-05-26 | 2006-05-02 | Virologic, Inc. | Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
| US6787126B1 (en) | 1998-06-19 | 2004-09-07 | The United States Of America As Represented By The Department Of Health And Human Services | Method and kit for detecting resistance to antiviral drugs |
| EP1100959B1 (en) * | 1998-06-19 | 2005-03-09 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by The Secretary, Department of Health and Human Services | Method and kit for detecting resistance to antiviral drugs |
| US20030148307A1 (en) | 1998-06-19 | 2003-08-07 | Department Of Health & Human Services, C/O Centers Of Disease Control And Prevention | Method and kit for detecting resistance to antiviral drugs |
| CN1154747C (zh) * | 1998-06-24 | 2004-06-23 | 病毒科学公司 | 监控核苷类逆转录酶抑制剂抗逆转录病毒治疗和在治疗hiv/aids中指导治疗决定的途径与方法 |
| MXPA01012270A (es) | 1999-05-28 | 2003-06-24 | Virco Nv | Nuevos perfiles mutacionales en la transcriptasa reversa de vih-1 correlacionadas con resistencia fenotipica a farmacos. |
| WO2002022781A2 (en) * | 2000-09-15 | 2002-03-21 | Virologic, Inc. | Non-nucleoside reverse transcriptase inhibitor as antiretroviral therapy |
| AU2002226316B2 (en) | 2000-10-20 | 2008-06-26 | Virco Bvba | Mutational profiles in HIV-1 reverse transcriptase correlated with phenotypic drug resistance |
| ATE422049T1 (de) * | 2000-10-20 | 2009-02-15 | Virco Bvba | Festlegen von kritischen biologischen werten zur voraussage einer therapieresistenz |
| US7247439B1 (en) | 2001-06-04 | 2007-07-24 | Monogram Biosciences, Inc. | Method of evaluating a patient antibody response to envelope proteins of a virus |
| US7097970B2 (en) | 2001-06-04 | 2006-08-29 | Monogram Biosciences, Inc. | Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs |
| US7320878B2 (en) | 2001-11-08 | 2008-01-22 | Tibotec Pharmaceuticals, Ltd. | Protease assay for therapeutic drug monitoring |
| EP1520247B1 (en) | 2002-07-01 | 2009-05-27 | Tibotec Pharmaceuticals Ltd. | Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance |
| CA2490764C (en) | 2002-07-01 | 2011-11-22 | Tibotec Pharmaceuticals Ltd. | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
| DE20218008U1 (de) | 2002-11-21 | 2003-03-06 | FESTO AG & Co., 73734 Esslingen | Anordnung von mehreren Handhabungsvorrichtungen |
| US8603736B2 (en) | 2004-06-07 | 2013-12-10 | Monogram Biosciences, Inc. | Compositions and methods for determining resistance to inhibitors of virus entry using recombinant virus assays |
| US8178291B2 (en) | 2005-02-18 | 2012-05-15 | Monogram Biosciences, Inc. | Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors |
| EP1856298B1 (en) | 2005-02-18 | 2017-09-27 | Monogram BioSciences, Inc. | Methods and compositions for determining anti-hiv drug susceptibility and replication capacity of hiv |
| EP2458019A3 (en) | 2005-05-27 | 2012-07-25 | Monogram BioSciences, Inc. | Methods and compositions for determining resistance of HIV-1 to protease inhibitors |
| WO2006133266A2 (en) | 2005-06-06 | 2006-12-14 | Monogram Biosciences, Inc. | Methods for determining resistance or susceptibility to hiv entry inhibitors |
| WO2006133267A2 (en) | 2005-06-06 | 2006-12-14 | Monogram Biosciences, Inc. | Methods and compositions for determining altered susceptibility of hiv-1 to anti-hiv drugs |
| US8114585B2 (en) | 2006-06-13 | 2012-02-14 | Monogram Biosciences, Inc. | Method for determining human immunodeficiency virus (HIV) coreceptor utilization by examining gp41 molecular determinants |
| WO2008090185A1 (en) * | 2007-01-23 | 2008-07-31 | Virco Bvba | Method for designing a drug regime for hiv-infected patients |
| US9581595B2 (en) | 2007-02-26 | 2017-02-28 | Laboratory Corporation Of America Holdings | Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy |
| JPWO2018030534A1 (ja) | 2016-08-10 | 2019-06-13 | 国立研究開発法人理化学研究所 | Ｂ型肝炎治療用組成物、及びｂ型肝炎ウイルスの複製活性の評価方法 |
| WO2018126042A1 (en) * | 2016-12-29 | 2018-07-05 | Virongy L.L.C. | Retro- and lenti-hbv hybrid vectors and constructs |
| CN109722465B (zh) * | 2019-01-07 | 2022-02-01 | 福建省疾病预防控制中心(福建省健康教育促进中心、福建省卫生检验检测中心) | 一种hiv耐药检测载体和构建方法 |
| JP7773731B2 (ja) * | 2020-06-24 | 2025-11-20 | シァメン・ユニヴァーシティ | 薬物スクリーニングモデル及びＨＢＶ ｃｃｃＤＮＡを標的化する方法 |
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| EP0291893A1 (en) * | 1987-05-19 | 1988-11-23 | The Du Pont Merck Pharmaceutical Company | Stable human cell lines expressing an indicator gene product under virus-specific genetic controls |
| DE68921034D1 (de) * | 1988-09-27 | 1995-03-23 | Dana Farber Cancer Inst Inc | Vektor, der ein replikationskompetentes HIV-I-Provirus und ein heterologes Gen enthält. |
| HU209835B (en) * | 1988-12-07 | 1994-11-28 | Univ Osaka Res Found | Method for producing of retrovirus protease, reverse transcriptase and integrase |
| ATE161041T1 (de) * | 1989-08-25 | 1997-12-15 | Chiron Corp | Verfahren zur hcv-züchtung in zell-linien aus b- oder t-lymphozyten |
| GB8923123D0 (en) * | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| FR2700169B1 (fr) * | 1993-01-04 | 1995-03-24 | Transgene Sa | Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine. |
| US5645982A (en) * | 1993-08-19 | 1997-07-08 | Systemix, Inc. | Method for screening potential therapeutically effective antiviral agents |
| WO1995022622A1 (en) * | 1994-02-18 | 1995-08-24 | University Of Washington | Methods and compositions for screening for anti-aids drugs |
| US5733543A (en) * | 1994-04-29 | 1998-03-31 | Nabel; Gary J. | Introduction of HIV-protective genes into cells by particle-mediated gene transfer |
| DE69535669T2 (de) * | 1994-05-09 | 2008-12-04 | Oxford Biomedica (Uk) Ltd. | Retrovirale vektoren mit verminderter rekombinationsrate |
| US5837464A (en) * | 1996-01-29 | 1998-11-17 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| CA2298102A1 (en) * | 1997-07-30 | 1999-02-11 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
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- 1997-01-29 WO PCT/US1997/001609 patent/WO1997027319A1/en not_active Ceased
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- 1997-01-29 EA EA199800669A patent/EA005426B1/ru not_active IP Right Cessation
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1998
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| KELLAM P. et al. Recombinant Virus Assay: a Rapid, Phenotypic Assay for Assessment of Drug Susceptibility of Human Immunodeficiency Virus Type 1 Isolates. Antimicrobial Agents and Chemotherapy. January 1994, Vol. 38, pages 23-30 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2646472C1 (ru) * | 2016-10-07 | 2018-03-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации | Способ оценки эффективности терапии инфекции вызванной вирусом герпеса человека 6 типа у детей |
Also Published As
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|---|---|
| PL328068A1 (en) | 1999-01-04 |
| ATE447621T1 (de) | 2009-11-15 |
| KR100537153B1 (ko) | 2006-12-15 |
| EP0852626A4 (en) | 1999-08-25 |
| CN1263867C (zh) | 2006-07-12 |
| WO1997027319A1 (en) | 1997-07-31 |
| EP1170380B1 (en) | 2009-11-04 |
| EA199800669A1 (ru) | 1999-02-25 |
| HUP9900388A2 (hu) | 1999-05-28 |
| CN1213407A (zh) | 1999-04-07 |
| EP1170380A2 (en) | 2002-01-09 |
| IL125464A (en) | 2007-12-03 |
| AP9801360A0 (en) | 1998-12-31 |
| HUP9900388A3 (en) | 2005-03-29 |
| IL125464A0 (en) | 1999-03-12 |
| NO983421L (no) | 1998-09-25 |
| RO118887B1 (ro) | 2003-12-30 |
| DE69739645D1 (de) | 2009-12-17 |
| JP2000503849A (ja) | 2000-04-04 |
| CA2216126C (en) | 2009-03-31 |
| JP4183749B2 (ja) | 2008-11-19 |
| NO983421D0 (no) | 1998-07-24 |
| EP1170380A3 (en) | 2003-05-02 |
| ES2175355T3 (es) | 2002-11-16 |
| DE69711584T2 (de) | 2002-11-07 |
| EP0852626B1 (en) | 2002-04-03 |
| NZ331376A (en) | 2000-03-27 |
| DE69711584D1 (de) | 2002-05-08 |
| CA2216126A1 (en) | 1997-07-31 |
| AU732255B2 (en) | 2001-04-12 |
| KR19990082129A (ko) | 1999-11-15 |
| AU1952897A (en) | 1997-08-20 |
| EP0852626A1 (en) | 1998-07-15 |
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