RO118887B1 - Metodă pentru determinarea sensibilităţii sau eficacităţii biologice şi rezistenţei omului la medicamentele antivirale - Google Patents
Metodă pentru determinarea sensibilităţii sau eficacităţii biologice şi rezistenţei omului la medicamentele antivirale Download PDFInfo
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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Landscapes
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- Biophysics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US59300996A | 1996-01-29 | 1996-01-29 | |
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| RO118887B1 true RO118887B1 (ro) | 2003-12-30 |
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| WO (1) | WO1997027319A1 (enExample) |
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| DK0810209T3 (da) | 1992-08-25 | 2002-08-12 | Monsanto Co | Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
| DE69712731T2 (de) | 1996-01-26 | 2003-02-06 | Virco N.V., Mechelen | Verfahren zur überwachung der chemotherapie von hiv-positiven patienten basierend auf der phenotypischen medikamentempfindlichkeit vom hiv stamm des patienten |
| US6242187B1 (en) | 1996-01-29 | 2001-06-05 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| JP2001512036A (ja) * | 1997-07-30 | 2001-08-21 | バイアラジック・インコーポレーテッド | 抗ウイルス薬剤感受性および耐性を測定するための組成物および方法、並びに抗ウイルス薬剤をスクリーニングするための組成物および方法 |
| AU3474499A (en) * | 1998-04-07 | 1999-10-25 | Southern Research Institute | High-throughput method for screening for antiviral activity |
| CA2329140A1 (en) * | 1998-05-26 | 1999-12-02 | Virologic, Inc. | Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy |
| US7037644B1 (en) | 1998-05-26 | 2006-05-02 | Virologic, Inc. | Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
| DE69924118T2 (de) * | 1998-06-19 | 2005-12-22 | The Government of the United States of America, as represented by the Secretary Centers for Disease and Prevention, Office of Technology | Verfahren und reagentiensatz zur erkennung von antiviralen wirkstoff resistenzen |
| US20030148307A1 (en) | 1998-06-19 | 2003-08-07 | Department Of Health & Human Services, C/O Centers Of Disease Control And Prevention | Method and kit for detecting resistance to antiviral drugs |
| US6787126B1 (en) | 1998-06-19 | 2004-09-07 | The United States Of America As Represented By The Department Of Health And Human Services | Method and kit for detecting resistance to antiviral drugs |
| CN1154747C (zh) * | 1998-06-24 | 2004-06-23 | 病毒科学公司 | 监控核苷类逆转录酶抑制剂抗逆转录病毒治疗和在治疗hiv/aids中指导治疗决定的途径与方法 |
| AU783235B2 (en) | 1999-05-28 | 2005-10-06 | Virco Bvba | New mutational profiles in HIV-1 reverse transcriptase correlated with phenotypic drug resistance |
| AU2001290911A1 (en) * | 2000-09-15 | 2002-03-26 | Virologic, Inc. | Non-nucleoside reverse transcriptase inhibitor as antiretroviral therapy |
| JP4264256B2 (ja) * | 2000-10-20 | 2009-05-13 | ビルコ・ビーブイビーエイ | 治療に対する耐性を予測するための生物学的カット−オフ値の確立 |
| AU2631602A (en) | 2000-10-20 | 2002-04-29 | Virco Nv | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
| US7247439B1 (en) | 2001-06-04 | 2007-07-24 | Monogram Biosciences, Inc. | Method of evaluating a patient antibody response to envelope proteins of a virus |
| US7097970B2 (en) | 2001-06-04 | 2006-08-29 | Monogram Biosciences, Inc. | Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs |
| JP2005513420A (ja) | 2001-11-08 | 2005-05-12 | テイボテク・フアーマシユーチカルズ・リミテツド | 治療薬をモニタリングするためのプロテアーゼアッセイ |
| US7217506B2 (en) | 2002-07-01 | 2007-05-15 | Tibotec Pharmaceuticals, Ltd. | Mutational profiles in HIV-1 protease correlated with phenotypic protease inhibitor resistance |
| WO2004003223A2 (en) | 2002-07-01 | 2004-01-08 | Tibotec Pharmaceuticals Ltd. | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
| DE20218008U1 (de) | 2002-11-21 | 2003-03-06 | FESTO AG & Co., 73734 Esslingen | Anordnung von mehreren Handhabungsvorrichtungen |
| US8603736B2 (en) | 2004-06-07 | 2013-12-10 | Monogram Biosciences, Inc. | Compositions and methods for determining resistance to inhibitors of virus entry using recombinant virus assays |
| WO2006089045A2 (en) | 2005-02-18 | 2006-08-24 | Monogram Biosciences, Inc. | Methods and compositions for determining hypersusceptibility of hiv-1 to non-nucleoside reverse transcriptase inhibitors |
| US20090215028A1 (en) | 2005-02-18 | 2009-08-27 | Ellen Paxinos | Methods and Compositions for Determining Anti-HIV Drug Susceptibility and Replication Capacity of HIV |
| US20090087841A1 (en) | 2005-05-27 | 2009-04-02 | Monogram Biosciences, Inc. | Methods and compositions for determining resistance of hiv-1 to protease inhibitors |
| WO2006133266A2 (en) | 2005-06-06 | 2006-12-14 | Monogram Biosciences, Inc. | Methods for determining resistance or susceptibility to hiv entry inhibitors |
| US8071284B2 (en) | 2005-06-06 | 2011-12-06 | Monogram Biosciences, Inc. | Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs |
| US8114585B2 (en) | 2006-06-13 | 2012-02-14 | Monogram Biosciences, Inc. | Method for determining human immunodeficiency virus (HIV) coreceptor utilization by examining gp41 molecular determinants |
| US8338101B2 (en) * | 2007-01-23 | 2012-12-25 | Virco Bvba | Method for designing a drug regime for HIV-infected patients |
| US9581595B2 (en) | 2007-02-26 | 2017-02-28 | Laboratory Corporation Of America Holdings | Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy |
| US20190183855A1 (en) * | 2016-08-10 | 2019-06-20 | Riken | Composition for treating hepatitis b, and method for evaluating replication activity of hepatitis b virus |
| RU2646472C1 (ru) * | 2016-10-07 | 2018-03-05 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации | Способ оценки эффективности терапии инфекции вызванной вирусом герпеса человека 6 типа у детей |
| CN110382009A (zh) * | 2016-12-29 | 2019-10-25 | 富荣吉有限责任公司 | Retro-HBV和Lenti-HBV的混合载体及构建体 |
| CN109722465B (zh) * | 2019-01-07 | 2022-02-01 | 福建省疾病预防控制中心(福建省健康教育促进中心、福建省卫生检验检测中心) | 一种hiv耐药检测载体和构建方法 |
| JP7773731B2 (ja) * | 2020-06-24 | 2025-11-20 | シァメン・ユニヴァーシティ | 薬物スクリーニングモデル及びＨＢＶ ｃｃｃＤＮＡを標的化する方法 |
Family Cites Families (12)
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| EP0291893A1 (en) * | 1987-05-19 | 1988-11-23 | The Du Pont Merck Pharmaceutical Company | Stable human cell lines expressing an indicator gene product under virus-specific genetic controls |
| ATE118247T1 (de) * | 1988-09-27 | 1995-02-15 | Dana Farber Cancer Inst Inc | Vektor, der ein replikationskompetentes hiv-i- provirus und ein heterologes gen enthält. |
| HU209835B (en) * | 1988-12-07 | 1994-11-28 | Univ Osaka Res Found | Method for producing of retrovirus protease, reverse transcriptase and integrase |
| DK0414475T3 (da) * | 1989-08-25 | 1998-02-09 | Chiron Corp | Fremgangsmåder til dyrkning af HCV i B- eller T-lymfocyt-cellelinier |
| GB8923123D0 (en) * | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| FR2700169B1 (fr) * | 1993-01-04 | 1995-03-24 | Transgene Sa | Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine. |
| US5645982A (en) * | 1993-08-19 | 1997-07-08 | Systemix, Inc. | Method for screening potential therapeutically effective antiviral agents |
| AU1923795A (en) * | 1994-02-18 | 1995-09-04 | University Of Washington | Methods and compositions for screening for anti-aids drugs |
| US5733543A (en) * | 1994-04-29 | 1998-03-31 | Nabel; Gary J. | Introduction of HIV-protective genes into cells by particle-mediated gene transfer |
| CA2158977A1 (en) * | 1994-05-09 | 1995-11-10 | James G. Respess | Retroviral vectors having a reduced recombination rate |
| US5837464A (en) * | 1996-01-29 | 1998-11-17 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| JP2001512036A (ja) * | 1997-07-30 | 2001-08-21 | バイアラジック・インコーポレーテッド | 抗ウイルス薬剤感受性および耐性を測定するための組成物および方法、並びに抗ウイルス薬剤をスクリーニングするための組成物および方法 |
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1998
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Also Published As
| Publication number | Publication date |
|---|---|
| PL328068A1 (en) | 1999-01-04 |
| CN1213407A (zh) | 1999-04-07 |
| DE69711584D1 (de) | 2002-05-08 |
| DE69739645D1 (de) | 2009-12-17 |
| AP9801360A0 (en) | 1998-12-31 |
| EA005426B1 (ru) | 2005-02-24 |
| EP1170380A3 (en) | 2003-05-02 |
| NO983421D0 (no) | 1998-07-24 |
| AU1952897A (en) | 1997-08-20 |
| NZ331376A (en) | 2000-03-27 |
| AU732255B2 (en) | 2001-04-12 |
| CA2216126C (en) | 2009-03-31 |
| ES2175355T3 (es) | 2002-11-16 |
| HUP9900388A3 (en) | 2005-03-29 |
| KR100537153B1 (ko) | 2006-12-15 |
| NO983421L (no) | 1998-09-25 |
| CN1263867C (zh) | 2006-07-12 |
| JP4183749B2 (ja) | 2008-11-19 |
| WO1997027319A1 (en) | 1997-07-31 |
| EP1170380A2 (en) | 2002-01-09 |
| ATE447621T1 (de) | 2009-11-15 |
| IL125464A (en) | 2007-12-03 |
| EP0852626A1 (en) | 1998-07-15 |
| KR19990082129A (ko) | 1999-11-15 |
| EP1170380B1 (en) | 2009-11-04 |
| JP2000503849A (ja) | 2000-04-04 |
| IL125464A0 (en) | 1999-03-12 |
| EP0852626A4 (en) | 1999-08-25 |
| EP0852626B1 (en) | 2002-04-03 |
| DE69711584T2 (de) | 2002-11-07 |
| CA2216126A1 (en) | 1997-07-31 |
| EA199800669A1 (ru) | 1999-02-25 |
| HUP9900388A2 (hu) | 1999-05-28 |
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